806 Works

Simultaneous visualization of DNA loci in single cells by combinatorial multi-color iFISH

Magda Bienko
We describe a dataset obtained by applying our recently developed iFISH pipeline to simultaneously visualize 16 small (size range: 62–73 kilobases, kb) evenly spaced DNA loci on chromosome 2 in human cells, in a single round of hybridization. We show how, using combinatorial color coding, multiple loci can be precisely 3D localized in single cells, and how inter-loci distances scale inversely with chromosome contact frequencies determined by Hi-C, as expected. We provide raw images and...

Additional file 1 of PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients

Daniele Giardiello, Maartje J. Hooning, Michael Hauptmann, Renske Keeman, B. A. M. Heemskerk-Gerritsen, Heiko Becher, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Nicola J. Camp, Kamila Czene, Peter Devilee, Diana M. Eccles, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Montserrat García-Closas, Christopher A. Haiman, Ute Hamann, John L. Hopper, Anna Jakubowska, Floor E. Leeuwen, Annika Lindblom, Jan Lubiński, Sara Margolin … & Marjanka K. Schmidt
Additional file 1. Supplementary methods also including the following tables and figures Table S2. List of BCAC studies (including ABCS source) with the corresponding country and geographic area. Table S4: Clinical utility of the 5-year contralateral breast cancer risk prediction models (PredictCBC-1A with PredictCBC-2.0A and PredictCBC-1B with PredictCBC-2.0B). Figure S1. Visual assessment of calibration through calibration plots in the internal–external cross-validation at 5 years for the PredictCBC-2.0A model. Figure S2. Visual assessment of calibration through...

Additional file 2 of PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients

Daniele Giardiello, Maartje J. Hooning, Michael Hauptmann, Renske Keeman, B. A. M. Heemskerk-Gerritsen, Heiko Becher, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Nicola J. Camp, Kamila Czene, Peter Devilee, Diana M. Eccles, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Montserrat García-Closas, Christopher A. Haiman, Ute Hamann, John L. Hopper, Anna Jakubowska, Floor E. Leeuwen, Annika Lindblom, Jan Lubiński, Sara Margolin … & Marjanka K. Schmidt
Additional file 2: Table S1. Description of the studies included in the analyses.

Additional file 2 of Patient and public involvement in an international rheumatology translational research project: an evaluation

Savia de Souza, Eva C. Johansson, Susanne Karlfeldt, Karim Raza & Ruth Williams
Additional file 2. Patient-Public Research Partner Survey.

Additional file 1 of Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies

Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao & Wei Zhang
Additional file 1: Table S1. Clinical improvements in rituximab cohort and control cohort

Additional file 3 of Patient and public involvement in an international rheumatology translational research project: an evaluation

Savia de Souza, Eva C. Johansson, Susanne Karlfeldt, Karim Raza & Ruth Williams
Additional file 3. GRIPP2-LF.

Additional file 1 of Identification and validation of a fatty acid metabolism-related lncRNA signature as a predictor for prognosis and immunotherapy in patients with liver cancer

Erbao Chen, Jing Yi, Jing Jiang, Zhilin Zou, Yuqian Mo, Qingqi Ren, Zewei Lin, Yi Lu, Jian Zhang & Jikui Liu
Additional file1: Supplementary excel 1. Detailed clinical features in the two HCC cohorts.

Additional file 3 of Identification and validation of a fatty acid metabolism-related lncRNA signature as a predictor for prognosis and immunotherapy in patients with liver cancer

Erbao Chen, Jing Yi, Jing Jiang, Zhilin Zou, Yuqian Mo, Qingqi Ren, Zewei Lin, Yi Lu, Jian Zhang & Jikui Liu
Additional file3: Supplementary excel 3. The correlation analysis between FA scores and lncRNAs in the GSE76427 cohort.

Additional file 8 of Identification and validation of a fatty acid metabolism-related lncRNA signature as a predictor for prognosis and immunotherapy in patients with liver cancer

Erbao Chen, Jing Yi, Jing Jiang, Zhilin Zou, Yuqian Mo, Qingqi Ren, Zewei Lin, Yi Lu, Jian Zhang & Jikui Liu
Additional file8: Supplementary figure 3. Original gels images for all western blots in Figure 9.

Additional file 7 of Identification and validation of a fatty acid metabolism-related lncRNA signature as a predictor for prognosis and immunotherapy in patients with liver cancer

Erbao Chen, Jing Yi, Jing Jiang, Zhilin Zou, Yuqian Mo, Qingqi Ren, Zewei Lin, Yi Lu, Jian Zhang & Jikui Liu
Additional file7: Supplementary figure 2. Original gels for all western blots in Figure 9 Original gel image measuring immunopositivity against ferroptosis markers in HCC cells. ACTIN was used as loading control. Bands used in the manuscript have been boxed in red.

Additional file 6 of Identification and validation of a fatty acid metabolism-related lncRNA signature as a predictor for prognosis and immunotherapy in patients with liver cancer

Erbao Chen, Jing Yi, Jing Jiang, Zhilin Zou, Yuqian Mo, Qingqi Ren, Zewei Lin, Yi Lu, Jian Zhang & Jikui Liu
Additional file6: Supplementary figure 1. The expression of immune checkpoint genes between FA metabolism-related lncRNA subgroups. (A, B) The boxplots display the dysregulation of immune checkpoint genes in the TCGA and GSE76427 cohorts.

Preliminary evaluation of the online course “I Care” targeting eating disorder knowledge and attitudes among sports coaches and fitness instructors

Sofia Selenius, Andreas Birgegård & Emma Forsén Mantilla
Abstract Background Fitness instructors, coaches and trainers are often looked up to and seen as role-models within their sporting community. Since problematic exercise is a common symptom of eating disorders, they are also highly likely to meet individuals at risk for developing eating disorders within their profession. Thus, educating coaches about how to promote healthy ideals within their sports/training context and equipping them with knowledge to be able to detect and approach individuals at risk,...

Additional file 2 of Ethnic differences between South Asians and White Caucasians in cardiovascular disease-related mortality in developed countries: a systematic literature review

Mubarak Patel, Salim Abatcha & Olalekan Uthman
Additional file 2. OVID MEDLINE search strategy.

Additional file 5 of Ethnic differences between South Asians and White Caucasians in cardiovascular disease-related mortality in developed countries: a systematic literature review

Mubarak Patel, Salim Abatcha & Olalekan Uthman
Additional file 5: Supplementary Figure 1. Forest plot showing the relative effect of exploratory analyses for CVD-related mortality between other ethnicities and Whites.

Ethnic differences between South Asians and White Caucasians in cardiovascular disease-related mortality in developed countries: a systematic literature review

Mubarak Patel, Salim Abatcha & Olalekan Uthman
Abstract Background Cardiovascular disease is the leading cause of death worldwide, with significantly worse mortality-related outcomes in ethnic minorities in developed countries. A systematic literature review and meta-analysis of observational studies was conducted to investigate cardiovascular disease-related mortality inequalities between South Asian and White Caucasian ethnic groups. Methods Published studies on mortality between South Asians and Whites in developed countries were retrieved from MEDLINE, PubMed, Embase, Web of Science, and grey literature sources (inception—April 2021)...

Supplemental Material - Leukocyte and Platelet Related Inflammatory Indicators and Risk of Carotid and Femoral Plaques: A Population-Based Cross-Sectional Study in Southeast China

Ruimei Feng, Yiquan Dai, Shanshan Du, Wenbin Liang, Hongyu Chen, Cheng Chen, Tianmin He, Tao Tao, Zhijian Hu, Pingfan Guo & Weimin Ye
Supplemental Material for Leukocyte and Platelet Related Inflammatory Indicators and Risk of Carotid and Femoral Plaques: A Population-Based Cross-Sectional Study in Southeast China by Ruimei Feng, PhD, Yiquan Dai, MM, Shanshan Du, PhD, Wenbin Liang, PhD, Hongyu Chen, MM, Cheng Chen, MM, Tianmin He, MM, Tao Tao, PhD, Zhijian Hu, PhD, Pingfan Guo, MD, and Weimin Ye, PhD, MD in Angiology

Supplemental Material - Disturbed sleep and patterns of psychiatric symptoms and function in a school-based sample of adolescents

Lie Åslund, Anna Andreasson, Mats Lekander, Eva Henje & Inga Dennhag
Supplemental Material for Disturbed sleep and patterns of psychiatric symptoms and function in a school-based sample of adolescents by Lie Åslund, Anna Andreasson, Mats Lekander, Eva Henje, Inga Dennhag Child Psychology and Psychiatry

Disturbed sleep and patterns of psychiatric symptoms and function in a school-based sample of adolescents

Lie Åslund, Anna Andreasson, Mats Lekander, Eva Henje & Inga Dennhag
BackgroundSleep problems are common in adolescence and often related to psychopathology and impaired functioning. However, most studies have used summative scores, and little is known about how adolescents with disrupted sleep perceive their specific symptoms and dysfunctions. This study explored differences in levels of psychiatric symptoms and functional ability between Swedish adolescents with and without self-reported disturbed sleep in a school-based sample.MethodsSwedish adolescents (n = 618, mean age 15.7+/-1.9yrs) answered the PROMIS pediatric measures for...

Additional file 1 of Transplantation of maternal intestinal flora to the newborn after elective cesarean section (SECFLOR): study protocol for a double blinded randomized controlled trial

Noora Carpén, Petter Brodin, Willem M. de Vos, Anne Salonen, Kaija-Leena Kolho, Sture Andersson & Otto Helve
Additional file 1.

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with...

Resilience of people with chronic medical conditions during the COVID-19 pandemic: a 1-year longitudinal prospective survey

Lorenzo Tarsitani, Irene Pinucci, Federico Tedeschi, Martina Patanè, Davide Papola, Christina Palantza, Ceren Acarturk, Emma Björkenstam, Richard Bryant, Sebastian Burchert, Camille Davisse-Paturet, Amanda Díaz-García, Rachel Farrel, Daniela C. Fuhr, Brian J. Hall, Anja C. Huizink, Agnes Iok Fong Lam, Gülşah Kurt, Ingmar Leijen, Ellenor Mittendorfer-Rutz, Naser Morina, Catherine Panter-Brick, Fredrick Dermawan Purba, Soledad Quero, Soraya Seedat … & Corrado Barbui
Abstract Backgrounds Individuals with chronic medical conditions are considered highly exposed to COVID-19 pandemic stress, but emerging evidence is demonstrating that resilience is common even among them. We aimed at identifying sustained resilient outcomes and their predictors in chronically ill people during the first year of the pandemic. Methods This international 4-wave 1-year longitudinal online survey included items on socio-demographic characteristics, economic and living situation, lifestyle and habits, pandemic-related issues, and history of mental disorders....

Additional file 2 of High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain

Huan Yang, Timir Datta-Chaudhuri, Sam J. George, Bilal Haider, Jason Wong, Tyler D. Hepler, Ulf Andersson, Michael Brines, Kevin J. Tracey & Sangeeta S. Chavan
Additional file 2: Supplementary Figure 2. Experimental setup for optogenetic and HFES. (A) Animals were induced and maintained under anesthesia using isoflurane (1.5-2%). The right hind paw was extended and secured to minimize movement during stimulation. (B) The LED (470 or 595 nm) was positioned 1 cm above the right hind paw. (C) Optogenetic stimulation was applied to the right hind paw for 15 min (3 Hz, 20% Duty Cycle). (D) Immediately after optogenetic stimulation,...

Additional file 3 of High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain

Huan Yang, Timir Datta-Chaudhuri, Sam J. George, Bilal Haider, Jason Wong, Tyler D. Hepler, Ulf Andersson, Michael Brines, Kevin J. Tracey & Sangeeta S. Chavan
Additional file 3: Supplementary Figure 3. Acute optogenetic stimulation does not induce hyperalgesia or the release of inflammatory mediators in wild type mice or primary sensory neurons. Wild type (C57BL/6) mice were anesthetized and subjected to optogenetic stimulation using 470 nm LED (blue) or 595 nm LED (yellow light) for 15 min on the dorsum of the right hind paw. (A) Mechanical hypersensitivity was assessed 5 h later, using von Frey filaments. Blue or yellow...

Additional file 2 of Metabolomic profiling of bovine leucocytes transformed by Theileria annulata under BW720c treatment

Hong-xi Zhao, Xia Li, Jun-long Liu, Gui-quan Guan & Xin-gang Dan
Additional file 2: Table S2. All differential metabolites at 48 h and 72 h in both modes (neg and pos).

German translation of the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer

Petros Grivas, John A. Blake-Haskins, Nuno Costa, Bo Huang, Robert J. Laliberte, Daniel P. Petrylak, Jeanny B. Aragon-Ching, Joaquim Bellmunt, Cora N. Sternberg, Evgeny Kopyltsov, Norihiko Tsuchiya, Srikala S. Sridhar, Yohann Loriot, Anders Ullén, Wim Demey, Sinisa Radulović, Haralabos Kalofonos, Howard Gurney, Begoña P. Valderrama, Claudia Caserta, Eric Voog, Se-Hoon Park & Thomas Powles
German translation of the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer

Registration Year

  • 2022
    806

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Affiliations

  • Karolinska Institute
    806
  • Sichuan University
    305
  • Capital Medical University
    299
  • Zhejiang University
    265
  • Fudan University
    259
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    256
  • Huazhong University of Science and Technology
    243
  • Shanghai Jiao Tong University
    231
  • Air Force Medical University
    197
  • Sun Yat-sen University
    194