87 Works

Additional file 1 of Randomized phase 2 trial of intravenous oncolytic virus JX-594 combined with low-dose cyclophosphamide in patients with advanced soft-tissue sarcoma

Maud Toulmonde, Sophie Cousin, Michèle Kind, Jean-Philippe Guegan, Alban Bessede, Francois Le Loarer, Raul Perret, Coralie Cantarel, Carine Bellera & Antoine Italiano
Additional file 1. Supplementary methods.

Additional file 2 of Physical activity and gestational weight gain: a systematic review of observational studies

Virginie Hamann, Philippe Deruelle, Christophe Enaux, Séverine Deguen & Wahida Kihal-Talantikite
Supplementary Material 2

Additional file 3 of Physical activity and gestational weight gain: a systematic review of observational studies

Virginie Hamann, Philippe Deruelle, Christophe Enaux, Séverine Deguen & Wahida Kihal-Talantikite
Supplementary Material 3

sj-pdf-1-smm-10.1177_0962280220909986 - Supplemental material for Quantile regression for incomplete longitudinal data with selection by death

Hélène Jacqmin-Gadda, Anaïs Rouanet, Robert D Mba, Viviane Philipps & Jean-François Dartigues
Supplemental material, sj-pdf-1-smm-10.1177_0962280220909986 for Quantile regression for incomplete longitudinal data with selection by death by Hélène Jacqmin-Gadda, Anaïs Rouanet, Robert D Mba, Viviane Philipps and Jean-François Dartigues in Statistical Methods in Medical Research

Additional file 10 of CSPG4 expression in soft tissue sarcomas is associated with poor prognosis and low cytotoxic immune response

Laurys Boudin, A de Nonneville, Pascal Finetti, Léna Mescam, A Le Cesne, Antoine Italiano, Jean-Yves Blay, Daniel Birnbaum, Emilie Mamessier & François Bertucci
Additional file 10: Table S5. (File format .xls). Supervised analysis of CNA between the “CSPG4-high” (N=123) and “CSPG4-low” (N=132) tumors.

Additional file 3 of CSPG4 expression in soft tissue sarcomas is associated with poor prognosis and low cytotoxic immune response

Laurys Boudin, A de Nonneville, Pascal Finetti, Léna Mescam, A Le Cesne, Antoine Italiano, Jean-Yves Blay, Daniel Birnbaum, Emilie Mamessier & François Bertucci
Additional file 3: Figure S2. (File format .ppt). Identification and validation of the CSPG4 gene expression signature in STS samples. A/ Identification of the signature in the Chibon’s learning set (N=310). Left, Volcano-plot showing the 379 genes differentially expressed between “CSPG4-high” versus “CSPG4-low” STS samples. Middle, box plot of classification score (Pearson correlation, r) between both CSPG4 classes (Student t-test) associated with cross-table between observed and predicted CSPG4 groups (Fisher’s exact test). B/ Validation in...

Additional file 3 of CSPG4 expression in soft tissue sarcomas is associated with poor prognosis and low cytotoxic immune response

Laurys Boudin, A de Nonneville, Pascal Finetti, Léna Mescam, A Le Cesne, Antoine Italiano, Jean-Yves Blay, Daniel Birnbaum, Emilie Mamessier & François Bertucci
Additional file 3: Figure S2. (File format .ppt). Identification and validation of the CSPG4 gene expression signature in STS samples. A/ Identification of the signature in the Chibon’s learning set (N=310). Left, Volcano-plot showing the 379 genes differentially expressed between “CSPG4-high” versus “CSPG4-low” STS samples. Middle, box plot of classification score (Pearson correlation, r) between both CSPG4 classes (Student t-test) associated with cross-table between observed and predicted CSPG4 groups (Fisher’s exact test). B/ Validation in...

Additional file 7 of CSPG4 expression in soft tissue sarcomas is associated with poor prognosis and low cytotoxic immune response

Laurys Boudin, A de Nonneville, Pascal Finetti, Léna Mescam, A Le Cesne, Antoine Italiano, Jean-Yves Blay, Daniel Birnbaum, Emilie Mamessier & François Bertucci
Additional file 7: Table S2. (File format .xls). Uni- and multivariate prognostic analyses for DFS including the ICR signature.

Additional file 9 of CSPG4 expression in soft tissue sarcomas is associated with poor prognosis and low cytotoxic immune response

Laurys Boudin, A de Nonneville, Pascal Finetti, Léna Mescam, A Le Cesne, Antoine Italiano, Jean-Yves Blay, Daniel Birnbaum, Emilie Mamessier & François Bertucci
Additional file 9: Table S4. (File format .xls). Ontologies associated with the 379 genes differentially expressed between the “CSPG4-high” and “CSPG4-low” tumors.

Quantile regression for incomplete longitudinal data with selection by death

Hélène Jacqmin-Gadda, Anaïs Rouanet, Robert D Mba, Viviane Philipps & Jean-François Dartigues
Quantile regressions are increasingly used to provide population norms for quantitative variables. Indeed, they do not require any Gaussian assumption for the response and allow to characterize its entire distribution through different quantiles. Quantile regressions are especially useful to provide norms of cognitive scores in the elderly that may help general practitioners to identify subjects with unexpectedly low cognitive level in routine examinations. These norms may be estimated from cohorts of elderly using quantile regression...

Additional file 2 of Management after initial surgery of nonfunctioning pituitary adenoma: surveillance, radiotherapy or surgery?

Thomas Charleux, Véronique Vendrely, Aymeri Huchet, Renaud Trouette, Amandine Ferrière, Antoine Tabarin, Vincent Jecko, Hugues Loiseau & Charles Dupin
Additional file 2. Table S1: Patient and tumor characteristics according to treatment strategy.

Additional file 3 of Management after initial surgery of nonfunctioning pituitary adenoma: surveillance, radiotherapy or surgery?

Thomas Charleux, Véronique Vendrely, Aymeri Huchet, Renaud Trouette, Amandine Ferrière, Antoine Tabarin, Vincent Jecko, Hugues Loiseau & Charles Dupin
Additional file 3. Table S2: Final deficiencies according to intervention. (Radiotherapy encompasses adjuvant and salvage radiotherapy).

Additional file 1 of Leukocyte telomere length, allelic variations in related genes and risk of coronary heart disease in people with long-standing type 1 diabetes

Manuel Sanchez, Caroline Kannengiesser, Sophie Hoang, Louis Potier, Frédéric Fumeron, Nicolas Venteclef, André Scheen, Jean-François Gautier, Samy Hadjadj, Michel Marre, Ronan Roussel, Kamel Mohammedi & Gilberto Velho
Additional file 1: Table S1. Baseline characteristics of GENEDIAB and GENESIS participants included in the present investigation. Table S2. Baseline characteristics of participants included or not in the LTL or the SNP studies. Table S3. SNPs in LTL-related genes genotyped in GENEDIAB and GENESIS participants. Table S4. Baseline characteristics of GENEDIAB participant by LTL tertiles of LTL distribution. Table S5. CHD risk during follow-up in the GENEDIAB cohort by baseline LTL with all-cause death as...

Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M. Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou, Maria-Camilla Calvo-Cortes, Corine Chazallon, Vanessa Machault, Xavier Anglaret & Fabrice Bonnet
Abstract Background Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-induced morbidity and mortality, the INTENSE-TBM trial evaluates two interventions in both HIV-infected and uninfected patients: an anti-TB treatment intensification using oral high-dose rifampicin (35 mg/kg daily) and linezolid (1200 mg daily and...

Additional file 1 of Body-weight variability and risk of cardiovascular outcomes in patients with type 1 diabetes: a retrospective observational analysis of data from the DCCT/EDIC population

Iulia Petria, Samuel Albuquerque, Gaël Varoquaux, Jill-Jênn Vie, Nicolas Venteclef, Kamel Mohammedi, Ronan Roussel, Marion Camoin, Gianluca Perseghin, Gilberto Velho & Louis Potier
Additional file 1: Table S1. Characteristics of participants at EDIC baseline by the incidence of MACE during EDIC follow-up. Table S2. Risk of outcomes in adult participants during EDIC follow-up by indices of intraindividual variability of body-weight during the DCCT. Table S3. Risk of outcomes during EDIC follow-up by indices of intraindividual variability of body-weight computed with body-weight measures from baseline to the end of DCCT follow-up. Figure S1. Flowchart of participants. Figure S2. Forest...

Body-weight variability and risk of cardiovascular outcomes in patients with type 1 diabetes: a retrospective observational analysis of data from the DCCT/EDIC population

Iulia Petria, Samuel Albuquerque, Gaël Varoquaux, Jill-Jênn Vie, Nicolas Venteclef, Kamel Mohammedi, Ronan Roussel, Marion Camoin, Gianluca Perseghin, Gilberto Velho & Louis Potier
Abstract Background Cardiovascular risk and body-weight management are both emerging challenges of type 1 diabetes care. We evaluated the association between intraindividual variability of body-weight and risk of cardiovascular events in people with type 1 diabetes. Methods We analyzed 1,398 participants from the DCCT/EDIC studies. Five indices of intraindividual variability of body-weight were calculated for each participant taking into account body-weight measures obtained during the DCCT follow-up (average 6 ± 2 years). The Average Successive...

Emerging stability of forest productivity by mixing two species buffers temperature destabilizing effect

Miren Del Rio, Ricardo Ruiz‐Peinado, Stig‐Olof Holm, Aris Jansons, Thomas Nord‐Larsen, Kris Verheyen, Andrés Bravo‐Oviedo, Hans Pretzsch, Ricardo Ruiz-Peinado, Hervé Jactel, Lluís Coll, Magnus Löf, Jorge Aldea, Christian Ammer, Admir Avdagić, Ignacio Barbeito, Kamil Bielak, Felipe Bravo, Gediminas Brazaitis, Jakub Cerný, Catherine Collet, Sonia Condés, Lars Drössler, Marek Fabrika, Michael Heym … & Andrés Bravo-Oviedo
The increasing disturbances in monocultures around the world are testimony to their instability under global change. Many studies have claimed that temporal stability of productivity increase with species richness, although the ecological fundaments have mainly been investigated through diversity experiments. To adequately manage forest ecosystems, it is necessary to have a comprehensive understanding of the effect of mixing species on the temporal stability of productivity and the way in which this it is influenced by...

Disentangling the effects of biomass and productivity in plant competition

Richard Michalet, Florian Delerue & Pierre Liancourt
The relationship between competition and productivity in plant communities is unclear, likely due to (i) a confusion in the literature between productivity and biomass, (ii) the lack of studies assessing variation in competition in all combinations of biomass and productivity. We assessed the outcome of plant-plant interactions by removing neighbors around five focal species in 14 herbaceous communities with contrasting biomasses and productivities: meadows with high biomass and productivity, heathlands with high biomass and low...

Data from: Variation in red fox Vulpes vulpes diet in five continents

Irene Castañeda, Tim S. Doherty, Patricia A. Fleming, Alyson M. Stobo-Wilson, John C. Z. Woinarski & Thomas M. Newsome
Understanding variation in the diet of widely distributed species can help us to predict how they respond to future environmental and anthropogenic changes. We studied the diet of the red fox Vulpes vulpes, one of the world’s most widely distributed carnivores. We compiled dietary data from 217 studies at 276 locations in five continents to assess how fox diet composition varied according to geographic location, climate, anthropogenic impact and sampling method. The diet of foxes...

Joint analysis of microsatellites and flanking sequences enlightens complex demographic history of interspecific gene flow and vicariance in rear-edge oak populations

Olivier Lepais, Abdeldjalil Aissi, Errol Véla & Yassine Beghami
Inference of recent population divergence requires fast evolving markers and necessitates to differentiate shared genetic variation caused by ancestral polymorphism and gene flow. Theoretical research shows that the use of compound marker systems integrating linked polymorphisms with different mutational dynamics, such as a microsatellite and its flanking sequences, can improve estimation of population structure and inference of demographic history, especially in the case of complex population dynamics. However, empirical application in natural populations has so...

openCARP (v12.0)

, Christoph Augustin, Luca Azzolin, Jason Bayer, Martin Bishop, Patrick M. Boyle, Federica Caforio, Fernando Campos, Caroline Mendonca Costa, Andrew Crozier, Thomas Fastl, Karli Gillette, Matthias Gsell, Marie Houillon, Yung-Lin (Cary) Huang, Kristian Gregorius Hustad, Elias Karabelas, Jonathan Krauß, Axel Loewe, Laura Marx, Aurel Neic, Mark Nothstein, Gernot Plank, Anton Prassl, Gunnar Seemann … & Eike Moritz Wülfers
openCARP is an open cardiac electrophysiology simulator for in-silico experiments

High variation in hydraulic efficiency but not xylem safety between roots and branches in four temperate broad-leaved tree species

Torben Lübbe, Laurent J. Lamarque, Sylvain Delzon, José M. Torres-Ruiz, Régis Burlett, Christoph Leuschner & Bernhard Schuldt
Xylem hydraulic safety and efficiency are key traits determining tree fitness in a warmer and drier world. While numerous plant hydraulic studies have focused on branches, our understanding of root hydraulic functioning remains limited, although roots control water uptake, influence stomatal regulation and have commonly been considered as the most vulnerable organ along the hydraulic pathway. We investigated 11 traits related to xylem safety and efficiency along the hydraulic pathway in four temperate broad-leaved tree...

Randomized phase 2 trial of intravenous oncolytic virus JX-594 combined with low-dose cyclophosphamide in patients with advanced soft-tissue sarcoma

Maud Toulmonde, Sophie Cousin, Michèle Kind, Jean-Philippe Guegan, Alban Bessede, Francois Le Loarer, Raul Perret, Coralie Cantarel, Carine Bellera & Antoine Italiano
Abstract JX-594 is an oncolytic vaccinia virus genetically modified to replicate selectively in tumor cells. Metronomic chemotherapy has shown preclinical synergy with oncolytic viruses. We report here the results of the METROMAJX which is a randomized phase II clinical trial investigating the combination of JX-594 combined with metronomic cyclophosphamide (arm 1) or metronomic cyclophosphamide (arm 2) in patients with advanced STS. A two-stage Simon design was used. JX-594 was administered intra-venously at the dose 1.109...

Additional file 1 of Physical activity and gestational weight gain: a systematic review of observational studies

Virginie Hamann, Philippe Deruelle, Christophe Enaux, Séverine Deguen & Wahida Kihal-Talantikite
Supplementary Material 1

Quantile regression for incomplete longitudinal data with selection by death

Hélène Jacqmin-Gadda, Anaïs Rouanet, Robert D Mba, Viviane Philipps & Jean-François Dartigues
Quantile regressions are increasingly used to provide population norms for quantitative variables. Indeed, they do not require any Gaussian assumption for the response and allow to characterize its entire distribution through different quantiles. Quantile regressions are especially useful to provide norms of cognitive scores in the elderly that may help general practitioners to identify subjects with unexpectedly low cognitive level in routine examinations. These norms may be estimated from cohorts of elderly using quantile regression...

Registration Year

  • 2022
    87

Resource Types

  • Text
    29
  • Dataset
    26
  • Collection
    18
  • Audiovisual
    12
  • Book Chapter
    1
  • Software
    1

Affiliations

  • University of Bordeaux
    87
  • Centre Léon Bérard
    28
  • Claude Bernard University Lyon 1
    28
  • Centre de Recherche en Cancérologie de Marseille
    28
  • Institute Paoli-Calmettes
    28
  • UniCancer Group
    28
  • Centre Hospitalier Universitaire de Bordeaux
    20
  • University of Paris
    14
  • University of Strasbourg
    9
  • Hôpitaux Universitaires de Strasbourg
    9