50 Works

Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy

Mingming Song, Wentao Xia, Zixuan Tao, Bin Zhu, Wenxiang Zhang, Chang Liu & Siyu Chen
Malignant melanoma is a life-threatening form of skin cancer with a low response rate to single-agent chemotherapy. Although combined therapies of metformin (MET) and doxorubicin (DOX) are effective in treating a variety of cancers, including breast cancer, their different physicochemical properties and administration routines reduce the effective co-accumulation of both drugs in tumors. Nanoparticles (NPs) have been demonstrated to potentially improve drug delivery efficiency in cancer therapy of, for example, liver and lung cancers. Hence,...

Phylogeographic and demographic modelling analyses of the multiple origins of the rheophytic goldenrod Solidago yokusaiana

Ryuuta Kyan, Takuma Kimura, Tadashi Yamashiro, Shinji Fujii, Shota Sakaguchi, Motomi Ito, Atsushi Nagano, Hiroshi Kudoh & Masayuki Maki
Understanding adaptation mechanisms is important in evolutionary biology. Parallel adaptation provides good opportunities to investigate adaptive evolution. To confirm parallel adaptation, it is effective to examine whether the phenotypic similarity has one or multiple origins and to use demographic modelling to consider the gene flow between ecotypes. Solidago yokusaiana is a rheophyte endemic to the Japanese Archipelago that diverged from Solidago virgaurea. This study examined the parallel origins of S. yokusaiana by distinguishing between multiple...

The effects of resource subsidy duration in a detritus-based stream ecosystem: a mesocosm experiment

Takuya Sato, Gaku Takimoto & Rui Ueda
1. Most resource subsidies are temporally variable, dynamically affecting the consumer populations, community structures, and ecosystem functions of recipient ecosystems. Temporally variable resource subsidies are characterized by the duration, magnitude, timing, and frequency of resource subsidy inputs. These different characteristics may have different mechanisms by which to affect recipient ecosystems. 2. Few studies have examined the duration of resource subsidy inputs on recipient ecosystems, although there exist previous studies focusing on magnitude, timing, and frequency....

Data from: Early origin of sweet perception in the songbird radiation

Yasuka Toda, Meng-Ching Ko, Qiaoyi Liang, Eliot Miller, Alejandro Rico-Guevara, Tomoya Nakagita, Ayano Sakakibara, Kana Uemura, Timothy Sackton, Takashi Hayakawa, Simon Yung Wa Sin, Yoshiro Ishimaru, Takumi Misaka, Pablo Oteiza, James Crall, Scott Edwards, Shuichi Matsumura & Maude Baldwin
Early events in the evolutionary history of a clade can shape the sensory systems of descendant lineages. Although the avian ancestor may not have had a sweet receptor, the widespread incidence of nectar-feeding birds suggests multiple acquisitions of sugar detection. In this study, we identify a single early sensory shift of the umami receptor (the T1R1-T1R3 heterodimer) that conferred sweet-sensing abilities in songbirds, a large radiation containing nearly half of all living birds. We demonstrate...

Effects of body size divergence on male mating tactics in the ground beetle Carabus japonicus

Yutaka Okuzaki
Animal body size is involved in reproduction in various ways. Carabus japonicus exhibits considerable variation in adult body size across geographical locations depending on the larval environment. To investigate the effects of body size divergence on male mating traits, spermatophore deposition and weight, copulation duration, and post-copulatory mounting were observed using male-female pairs from C. japonicus populations with different body sizes. Then, variables with high predictive power on the mating traits were identified from individual...

Emergence of structures from parasitic species in a spatially distributed molecular system

Nathanael Aubert-Kato, Guillaume Gines, Yannick Rondelez & Teruo Fujii
This dataset contains microscopy images from a microfluidic setup implementing a localized autocatalytic molecular system based on the PEN DNA toolbox. Due to the enzymatic nature of the catalytic process, a variety of parasitic species eventually emerge and compete with the legitimate molecular process for fuel. The behaviors observed range from the creation of large stable structures to that of small diffusing particles. Those results, along with the modularity of the molecular system, show that...

Biodiversity-productivity relationships are key to nature-based climate solutions

Akira Mori, Laura Dee, Andrew Gonzalez, Haruka Ohashi, Jane Cowles, Alexandra Wright, Michel Loreau, Yann Hautier, Tim Newbold, Peter Reich, Tetsuya Matsui, Wataru Takeuchi, Kei-Ichi Okada, Rupert Seidl & Forest Isbell
The global impacts of biodiversity loss and climate change are interlinked but the feedbacks between them are rarely assessed. Areas with greater tree diversity tend to be more productive, providing a greater carbon sink, and biodiversity loss could reduce these natural C sinks. Here, we quantify how tree and shrub species richness could affect biomass production at biome, national and regional scales. We find that greenhouse gas mitigation could help maintain tree diversity and thereby...

Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy

Mingming Song, Wentao Xia, Zixuan Tao, Bin Zhu, Wenxiang Zhang, Chang Liu & Siyu Chen
Malignant melanoma is a life-threatening form of skin cancer with a low response rate to single-agent chemotherapy. Although combined therapies of metformin (MET) and doxorubicin (DOX) are effective in treating a variety of cancers, including breast cancer, their different physicochemical properties and administration routines reduce the effective co-accumulation of both drugs in tumors. Nanoparticles (NPs) have been demonstrated to potentially improve drug delivery efficiency in cancer therapy of, for example, liver and lung cancers. Hence,...

The supplementary datasets of the study of free moment Induced by oblique transverse tarsal joint: investigation by constructive approach

Tsung-Yuan Chen, Kawakami Takahiro, Naomichi Ogihara & Koh Hosoda
The human foot provides numerous functions that let humans deal with various environments. Recently, study of the structure of the human foot and adjustment of an appropriate reaction force and vertical free moment during bipedal locomotion has gained attention. However, little is known about the mechanical (morphological) contribution of the foot structure to the reaction force and free moment. It is difficult to conduct a comparative experiment to investigate the contribution systematically by using conventional...

Liquid electrolyte informatics using an exhaustive search with linear regression

Keitaro Sodeyama, Yasuhiko Igarashi, Tomofumi Nakayama, Yoshitaka Tateyama & Masato Okada
Exploring new liquid electrolyte materials is a fundamental target for developing new high-performance lithium-ion batteries. In contrast to solid materials, disordered liquid solution properties have been less studied by data-driven information techniques. Here, we examined the estimation accuracy and efficiency of three information techniques, multiple linear regression (MLR), least absolute shrinkage and selection operator (LASSO), and exhaustive search with linear regression (ES-LiR), by using coordination energy and melting point as test liquid properties. We then...

A Possible Magnetic Structure of the Cluster-Based Haldane Compound Fedotovite K2Cu3O(SO4)3

Masashi Hase, Kirrily C. Rule, James R. Hester, Jaime A. Fernandez-Baca, Takatsugu Masuda & Yukari Matsuo
We carried out neutron powder diffraction experiments on the cluster-based Haldane compound fedotovite K2Cu3O(SO4)3. Weak magnetic reflections caused by a magnetic long-range order appeared below an antiferromagnetic transition temperature TN =3.1 K. We propose a possible magnetic structure that is consistent with the magnetic properties reported in the literature.

Epinephrine dosing interval and neurological outcome in out-of-hospital cardiac arrest

Tatsuma Fukuda, Hirotsugu Kaneshima, Aya Matsudaira, Takumi Chinen, Hiroshi Sekiguchi, Naoko Ohashi-Fukuda, Ryota Inokuchi & Ichiro Kukita
Objective:Current guidelines for cardiopulmonary resuscitation (CPR) recommend that standard-dose epinephrine be administered every 3–5 minutes during cardiac arrest. However, there is a knowledge gap regarding the optimal epinephrine dosing interval. This study aimed to examine the association between epinephrine dosing intervals and outcomes after out-of-hospital cardiac arrest (OHCA).Methods:This was a nationwide population-based observational study using data from a Japanese government-led registry of OHCA, including patients who experienced OHCA in Japan from 2011 to 2017. We...

Data from: Metabolic proxy for cephalopods: Stable carbon isotope values recorded in different biogenic carbonates

Ming-Tsung Chung, Ching-Yi Chen, Jen-Chieh Shiao, Kotaro Shirai & Chia-Hui Wang
1. Measuring the metabolic rate of marine animals in their natural environment is challenging, impeding our understanding of their physiological ecology. Recently, a novel metabolic proxy, namely the δ13C values of biogenic carbonates (otoliths), was experimentally validated in teleost fishes. Cephalopods possess several types of biogenic carbonates, such as statolith, cuttlebone, and other internal and external shells, which are all potential metabolic recorders, but few have been evaluated. 2. To test the feasibility of the...

GPS tracks and behaviour detection of chick-rearing streaked shearwaters at Funakoshi Oshima Island, Japan, 2018 & 2019

Aran Garrod, Sei Yamamoto, Kentaro Sakamoto & Katsufumi Sato
The study of seabird behaviour has largely relied on animal-borne tags to gather information, requiring interpretation to estimate at-sea behaviours. Details of shallow-diving birds’ foraging are less known than deep-diving species due to difficulty in identifying shallow dives from biologging devices. Development of smaller video loggers allow a direct view of these birds’ behaviours, at the cost of short battery life. However, recordings from video loggers combined with relatively low power usage accelerometers give a...

Epinephrine dosing interval and neurological outcome in out-of-hospital cardiac arrest

Tatsuma Fukuda, Hirotsugu Kaneshima, Aya Matsudaira, Takumi Chinen, Hiroshi Sekiguchi, Naoko Ohashi-Fukuda, Ryota Inokuchi & Ichiro Kukita
Objective:Current guidelines for cardiopulmonary resuscitation (CPR) recommend that standard-dose epinephrine be administered every 3–5 minutes during cardiac arrest. However, there is a knowledge gap regarding the optimal epinephrine dosing interval. This study aimed to examine the association between epinephrine dosing intervals and outcomes after out-of-hospital cardiac arrest (OHCA).Methods:This was a nationwide population-based observational study using data from a Japanese government-led registry of OHCA, including patients who experienced OHCA in Japan from 2011 to 2017. We...

Rotary catalysis of bovine mitochondrial F1-ATPase studied by single-molecule experiments

Ryohei Kobayashi, Hiroshi Ueno, Chun-Biu Li & Hiroyuki Noji
The reaction scheme of rotary catalysis and the torque generation mechanism of bovine mitochondrial F1 (bMF1) were studied in single-molecule experiments. Under ATP-saturated concentrations, high-speed imaging of single 40 nm gold bead attached to the γ subunit of bMF1 showed two types of intervening pauses during the rotation that were discriminated by short dwell and long dwell. Using ATPgS as a slowly hydrolyzing ATP derivative as well as using a functional mutant bE188D with slowed...

Data from: Phylogeny of gracillariid leaf-mining moths: evolution of larval behaviour inferred from phylogenomic and Sanger data

Xuankun Li, Ryan St Laurent, Chandra Earl, Camiel Doorenweerd, Erik Van Nieukerken, Don Davis, Atsushi Kawakita, Shigeki Kobayashi, Andreas Zwick, Carlos Lopez-Vaamonde, Issei Ohshima & Akito Kawahara
Gracillariidae is the most taxonomically diverse cosmopolitan leaf-mining moth family, consisting of nearly 2000 named species in 105 described genera, classified into eight extant subfamilies. The majority of gracillariid species are internal plant feeders as larvae, creating mines and galls in plant tissue. Despite their diversity and ecological adaptations, their phylogenetic relationships, especially at the subfamily level, remain largely uncertain. Genomic data (83 taxa and 589 loci) were integrated with Sanger data (130 taxa and...

Sperm competition risk affects ejaculate strategy in terms of sperm number but not sperm size in squid

Yoko Iwata, Noriyosi Sato, Noritaka Hirohashi, Yoshiro Watanabe, Warwick Sauer & Paul Shaw
In polygamous species, the mode of sperm storage in females influences evolution of sperm quantitative and qualitative traits because it provides the arena for sperm competition, cryptic female choice and fertilization processes. In this study, we compared ejaculate traits of two squid species, Heterololigo bleekeri and Loligo reynaudii. Both species show dimorphic sperm traits associated with alternative reproductive tactics where consort and sneaker males transfer sperm to different storage sites within a female (on the...

Data from: Effectiveness of signs of activity as relative abundance indices for wild boar

Daishi Higashide, Takeo Kuriyama, Shun Takagi, Yoshihiro Nakashima, Keita Fukasawa, Gota Yajima, Minoru Kasada & Mayumi Yokoyama
Population growth in wild boars and feral pigs (Sus scrofa) has negative environmental and economic implications worldwide. Accordingly, it is necessary to monitor population trends for appropriate management. Despite the potential for bias, relative abundance indices based on signs of activity have the potential to be practical, low-cost monitoring tools for data collection at a local scale and over large areas. However, few studies have examined the effectiveness of specific signs as measures of relative...

Comprehensive comparative morphology and developmental staging of final instar larvae toward metamorphosis in the insect order Odonata

Genta Okude, Takema Fukatsu & Ryo Futahashi
The order Odonata (dragonflies and damselflies) is among the most ancestral groups of winged insects with drastic morphological changes upon metamorphosis, and thus important for understanding evo-devo aspects of insects. However, basic developmental descriptions of Odonata have been scarce. In an attempt to establish the foundation of developmental and experimental biology of Odonata, we present an unprecedentedly comprehensive survey of dragonflies and damselflies, in total 158 larvae representing 49 species and 14 families, wherein morphological...

Three new tyrosol derivatives from Huangjing wine

Yan-Bin Ren, Xing-Wen Wang, Jia-Xuan Bai, Chang Liu, Si-Lin Yu, Yue Zhou, Cong-Cong Lin, Da-Hong Yao, Jian Huang & Jin-Hui Wang
Phytochemical investigation on the concentrate of Huangjing wine, resulted in the isolation of three new tyrosol derivatives 4′′′-hydroxyphenethyl 2-(R)-hydroxy-3-phenylpropionate (1), 4′′′-hydroxyphenethyl(4′-hydroxy-3′-methoxyphenyl)propionate (2) and 4′′-hydroxyphenethyl ethyl succinate (3), together with 5 known compounds, ferulic acid (4), L-phenyllactic acid (5), hydroxytyrosol (6), dihydroferulic acid (7), cyclo(L-Pro-D-Tyr) (8). Their structures were elucidated using spectroscopic analysis and by comparison with the literature data. All compounds displayed antioxidant effect in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical. Among them, the new compound 2...

EnKF Analyses and Forecasts of Hurricane Harvey (2017)

Y. Zhang, S.B. Sieron, Y. Lu, X. Chen, R.G. Nystrom, M. Minamide, M. Chan, C.M. Hartman, Z. Yao, J.H. Ruppert, A. Okazaki, S.J. Greybush & E.E. Clothiaux
Ensemble-based data assimilation of radar observations across inner-core regions of tropical cyclones (TCs) in tandem with satellite all-sky infrared radiances across the TC domain improves TC track and intensity forecasts. This study further investigates potential enhancements in TC track, intensity, and rainfall forecasts via assimilation of all-sky microwave radiances using Hurricane Harvey (2017) as an example. Assimilating GPM constellation all-sky microwave radiances in addition to GOES-16 all-sky infrared radiances reduces the forecast errors in the...

MiR-3138 deteriorates the insulin resistance of HUVECs via KSR2/AMPK/GLUT4 signaling pathway

Yan Chen, Da Lin, Changxuan Shi, Liang Guo, Linhua Liu, Lin Chen, Ting Li, Ying Liu, Chengchao Zheng, Xintong Chi, Chun Meng & Yaoming Xue
Insulin resistance (IR) is a complex pathological condition resulting from the dysregulation of cellular response to insulin hormone in insulin-dependent cells and is recognized as a pathogenic hallmark and strong risk factor for metabolic syndrome. The present study aims to elucidate the molecular mechanism of the pathogenesis of IR. Here, we used human umbilical vein endothelial cells (HUVECs) to establish the IR cell model induced by 1 × 10−6 mmol/L insulin. After 48 h, reactive...

Data from: Intrinsic growth heterogeneity of mouse leukemia cells underlies differential susceptibility to a growth-inhibiting anticancer drug

Akihisa Seita, Hidenori Nakaoka, Reiko Okura & Yuichi Wakamoto
Cancer cell populations consist of phenotypically heterogeneous cells. Growing evidence suggests that pre-existing phenotypic differences among cancer cells correlate with differential susceptibility to anticancer drugs and eventually lead to a relapse. Such phenotypic differences can arise not only externally driven by the environmental heterogeneity around individual cells but also internally by the intrinsic fluctuation of cells. However, the quantitative characteristics of intrinsic phenotypic heterogeneity emerging even under constant environments and their relevance to drug susceptibility...

Data from: Polyandry and paternity affect disease resistance in eusocial wasps

Tatsuya Saga, Masaki Okuno, Kevin Loope, Koji Tsuchida, Kako Ohbayashi, Masakazu Shimada & Yasukazu Okada
One of several hypotheses proposed to explain polyandry in eusocial insects is the parasite–pathogen hypothesis (PPH), in which a colony of workers with multiple patrilines due to queen polyandry is less likely to fall victim to a parasite or pathogen threat because of genetic variability of the colony’s workforce. We challenged colonies with different strains of an entomopathogenic fungus to determine pathogen virulence and worker survival. We found that workers from different patrilines differed in...

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  • University of Tokyo
    49
  • Sichuan University
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  • Nanjing University
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  • Shandong University
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  • Shanghai Jiao Tong University
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  • University of Chicago
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  • Peking University Cancer Hospital
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