2 Works
Data from: Common genetic variation in ETV6 is associated with colorectal cancer susceptibility
Meilin Wang, Dongying Gu, Mulong Du, Zhi Xu, Suzhan Zhang, Lingjun Zhu, Jiachun Lu, Rui Zhang, Jinliang Xing, Xiaoping Miao, Haiyan Chu, Zhibin Hu, Lei Yang, Cuiju Tang, Lei Pan, Haina Du, Jian Zhao, Jiangbo Du, Na Tong, Jielin Sun, Hongbing Shen, Jianfeng Xu, Zhengdong Zhang & Jinfei Chen
Genome-wide association studies (GWAS) have identified multiple susceptibility loci for colorectal cancer, but much of heritability remains unexplained. To identify additional susceptibility loci for colorectal cancer, here we perform a GWAS in 1,023 cases and 1,306 controls and replicate the findings in seven independent samples from China, comprising 5,317 cases and 6,887 controls. We find a variant at 12p13.2 associated with colorectal cancer risk (rs2238126 in ETV6, P = 2.67 × 10-10). We replicate this...
Data from: Association of low-density lipoprotein cholesterol within the normal range and NAFLD in the non-obese Chinese population: a cross-sectional and longitudinal study
Dan-Qin Sun, Sheng-Jie Wu, Wen-Yue Liu, Li-Ren Wang, Yi-Ran Chen, Dong-Chu Zhang, Martin Braddock, Ke-Qing Shi, Dan Song & Ming-Hua Zheng
OBJECTIVES: The relationship between normal low-density lipoprotein cholesterol (LDL-c) levels and nonalcoholic fatty liver disease (NAFLD) in non-obese subjects remains unclear. We aimed to investigate the precise prevalence and incidence of NAFLD within the normal LDL-c range in non-obese subjects. Design: Cross-sectional and longitudinal study. Setting: Wenzhou Medical Center of Wenzhou People’s Hospital from 2010 to 2014. Participants: 183903 non-obese individuals were enrolled from a cross-sectional population and a total of 16173 initially NAFLD-free non-obese...