Iron oxide nanoparticles (IONPs) are mostly intended to be administrated intravenously, understanding the interaction of IONPs with vascular endothelial cells is extremely crucial for developing safe application regimes of IONPs. In this work, interactions of three kinds of IONPs to endothelial cells were investigated both in human umbilical vein endothelial cells (HUVECs) and in healthy mice. Both meso-2,3-dimercaptosuccinic acid (DMSA) coated Fe3O4 NPs (DMSA-Fe3O4 NPs) and DMSA-Fe2O3 NPs induced cell growth inhibition, while polyglucose sorbitol...

Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 105 genome copies per ml plasma, SIVhi) but...

The blockchain-based traceability system (BTS) can reduce product losses in the perishable goods market, which yields a loss-reduction effect, and offer authentic information, which triggers a premium effect. In a dual-channel perishable goods supply chain (DPGSC), including one supplier and retailer each, the supplier can operate the price of the direct channel, different or non-different from that of the traditional channel. To study the adoption of BTS in the supplier-led DPGSC, we employed a game-theoretical...

Multimode interference (MMI) based power splitters are fundamental building blocks for integrated photonic devices consisting of interferometer structure. In order to forestall the ‘capacity crunch’ in optical communications, integrated devices capable of operating in multiple spectral bands (e.g., conventional telecom window and the emerging 2 µm waveband) have since been proposed and are attracting increasing interest. Here we demonstrate for the first time, to the best of our knowledge, the realization of a dual-band MMI-based...

We propose and theoretically investigate the coupled concentric ring resonators on a thickness-constrained GaP on Insulator (GaP-OI) integrated photonic platform. Anomalous dispersion is fulfilled by mode hybridization in the coupled structure on a 200 nm thick GaP-OI resonator which originally only exhibits normal dispersion. The anomalous dispersion profile for the anti-symmetric mode is flattened and broadened in favor of Kerr frequency comb generation by optimizing the waveguide width and the coupling gap size synergistically. We...

In order to the improvement of steel quality and dephosphorization capacity, it is vital to realize the microscopic essence of dephosphorization reaction of the slags. In this work, the temperature dependence of phosphorus distribution ratio and phosphate capacity is discussed with respect to the structure characterized by Raman and MAS-NMR. As the temperature increases from 1550°C to 1600°C, the reduction of Q0(Si) and Q0(P) weakens the formation of the Si–O–Ca–O–P linkages that can stabilize the...

We propose a nonparametric bivariate time-varying coefficient model for longitudinal measurements with the occurrence of a terminal event that is subject to right censoring. The time-varying coefficients capture the longitudinal trajectories of covariate effects along with both the followup time and the residual lifetime. The proposed model extends the parametric conditional approach given terminal event time in recent literature, and thus avoids potential model misspecification. We consider a kernel smoothing method for estimating regression coefficients...

We propose a nonparametric bivariate time-varying coefficient model for longitudinal measurements with the occurrence of a terminal event that is subject to right censoring. The time-varying coefficients capture the longitudinal trajectories of covariate effects along with both the followup time and the residual lifetime. The proposed model extends the parametric conditional approach given terminal event time in recent literature, and thus avoids potential model misspecification. We consider a kernel smoothing method for estimating regression coefficients...

Polymer-containing oily sludge (PCOS) has caused tremendous hazards with the broad application of polymer flooding technology. Traditional methods cannot meet the treatment demand due to the high-water content of PCOS. In this work, the degradation of PCOS in sub-/supercritical water is studied to explore an appropriate treatment method. The influence of residence time (15–90 min), temperature (340–700°C), catalysts (sulfates, carbonates, and alkalis), and co-solvents (methanol-water and ethanol-water) on the distribution of end products is studied...

Bambusa tuldoides f. swolleninternode is an attractive ornamental bamboo species of southern China, with highly shortened and swollen at the base of internodes. In this study, the complete chloroplast genome of B. tuldoides was sequenced and reported for the first time. The complete genome size is 139,460 base pairs (bp), including a large single-copy (LSC) region of 82,996 bp, a small single-copy (SSC) region of 12,876 bp and a pair of invert repeats (IR) regions...

Supplementary figure 1 Supplementary tables 1-6

Particulate matter with an aerodynamic diameter ≤2.5 μm (PM2.5) is a public health risk. We investigate PM2.5 on metabolites in cardiomyocytes and the influence of vitamin C on PM2.5 toxicity. For 24 hours, H9C2 were exposed to various concentrations of PM2.5 (0, 100, 200, 400, 800 μg/ml), after which the levels of reactive oxygen species (ROS) and cell viability were measured using the cell counting kit-8 (CCK-8) and 2′,7′-dichlorofluoresceindiacetate (DCFH2-DA), respectively. H9C2 were treated with...

Particulate matter with an aerodynamic diameter ≤2.5 μm (PM2.5) is a public health risk. We investigate PM2.5 on metabolites in cardiomyocytes and the influence of vitamin C on PM2.5 toxicity. For 24 hours, H9C2 were exposed to various concentrations of PM2.5 (0, 100, 200, 400, 800 μg/ml), after which the levels of reactive oxygen species (ROS) and cell viability were measured using the cell counting kit-8 (CCK-8) and 2′,7′-dichlorofluoresceindiacetate (DCFH2-DA), respectively. H9C2 were treated with...

The aim of the study was to systematically explore the relationships between various adipokines and risks of endometrial atypical hyperplasia (EAH), type I endometrial cancer (EC), and type II EC. We enrolled 219 patients in this study, including 39 EAH, 87 type I EC, 38 type II EC and 55 control individuals. We subsequently explored the association of adipokine levels and the leptin-to-adiponectin (L/A) ratio with EAH, type I EC, and type II EC. The...

To evaluate dry eye and anterior segment inflammation after small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK), and investigate their association. This prospective and observational study included 96 eyes from 48 myopic patients. The evaluation was performed at baseline, postoperative day 1, week 1, month 1 and month 3. Outcome measures included anterior chamber flare, bulbar redness (BR), limbal redness (LR), ocular surface disease index (OSDI), tear meniscus height (TMH), the...

To evaluate dry eye and anterior segment inflammation after small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (FS-LASIK), and investigate their association. This prospective and observational study included 96 eyes from 48 myopic patients. The evaluation was performed at baseline, postoperative day 1, week 1, month 1 and month 3. Outcome measures included anterior chamber flare, bulbar redness (BR), limbal redness (LR), ocular surface disease index (OSDI), tear meniscus height (TMH), the...

Using bolts as shear connectors of the steel-concrete composite beams enables prefabricated assembly and makes it possible to demountable and reuse the prefabricated components. However, studies on the fire resistance of prefabricated demountable composite beams (PDCBs) connected by bolts are limited. In this paper, four full-scale fire resistance tests were conducted to investigate the fire resistance of PDCBs connected by shear bolts with profiled sheet ribs parallel to the steel beam. Test phenomena, heating curves,...

Supplemental material, sj-docx-1-oed-10.1177_25158414221139002 for A medication-wide association study to identify medications associated with incident clinically significant diabetic retinopathy by Ruilin Xiong, Wei Wang, Xianwen Shang, Yixiong Yuan, Yifan Chen, Lei Zhang, Katerina V Kiburg, Zhuoting Zhu and Mingguang He in Therapeutic Advances in Ophthalmology

Supplementary Material

This is the dataset for paper "Overestimated nitrogen loss from denitrification for natural terrestrial ecosystems in CMIP6 Earth System Models" authored by Feng et al.
The dataset contains six .nc files, and each file contains soil_N15, fgas, and N loss and their quantiles derived with different combinations of N weathering, N depostion and BNF.
Figure1_data.nc is the data for Figure 1 in the main.

Soil d15N and isotope benchmarking based fdenit and N loss

soil d15N and isotope benchmarking based fdenit and N loss

Really Interesting New Gene (RING) proteins are referred to as CHY zinc and ring finger protein (CHYR) members because they have the CHY domain, a type of protein that responds to abiotic stress. However, there are scant data on CHYR members in Phaseolus vulgaris (common bean). This study identified eight CHYR members (PvCHYRs) in the reference genome. A comprehensive analysis was performed to determine function, location, basic information, evolution, motifs, gene structure, cis-acting elements, collinearity,...

Really Interesting New Gene (RING) proteins are referred to as CHY zinc and ring finger protein (CHYR) members because they have the CHY domain, a type of protein that responds to abiotic stress. However, there are scant data on CHYR members in Phaseolus vulgaris (common bean). This study identified eight CHYR members (PvCHYRs) in the reference genome. A comprehensive analysis was performed to determine function, location, basic information, evolution, motifs, gene structure, cis-acting elements, collinearity,...

Detailed parameter