136 Works

Drinking during low-risk labor: monocentric randomized clinical trial on patients’ satisfaction, and maternal and neonatal outcomes

Justine Nadal, Fabrice Pierre, Anna Fernandez, Emilie Boussac, Thibaut Loupec & David Desseauve
This study aimed to assess satisfaction of patients affected by various fluid regimes during uncomplicated labor; to identify factors possibly associated with the level of satisfaction; to compare obstetrical and neonatal outcomes between the intervention groups. Between October and December 2014, 40 women were included in the study set at the Poitiers University Hospital, France. Women were randomly allocated to two study arms: 20 to strict and 20 to liberal fluid regime group. Women’s satisfaction...

Treatment with 3-aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation

Roumen Parapanov, Xingyu Wang, Anne Debonneville, Jérôme Lugrin, Yabo Wang, Etienne Abdelnour, Michel Gonzalez, Jean Perentes, Fabrizio Gronchi, Philippe Eckert, Lise Piquilloud Piquilloud, Igor Letovanec, Thorsten Krueger & Lucas Liaudet
Ex vivo lung perfusion (EVLP) with pharmacological reconditioning may increase donor lung utilization for transplantation (LTx). 3-Aminobenzamide (3-AB), an inhibitor of poly (ADP-ribose) polymerase (PARP), reduces ex vivo lung injury in rat lungs damaged by warm ischemia (WI). Here we determined the effects of 3-AB reconditioning on graft outcome after LTx. Three groups of donor lungs were studied: Control (Ctrl): 1 hour WI + 3 hours cold ischemia (CI) + LTx; EVLP: 1 hour WI...

Data from: Influence of periaqueductal gray on other salience network nodes predicts social sensitivity

Myrthe Rijpma, Winson Yang, Gianina Toller, Giovanni Battistella, Arseny Sokolov, Virginia Sturm, William Seeley, Joel Kramer, Bruce Miller & Katherine Rankin
The intrinsic connectivity of the salience network (SN) plays an important role in social behavior, however the directional influence that individual nodes have on each other has not yet been fully determined. In this study, we used spectral Dynamic Causal Modeling to characterize the effective connectivity patterns in the SN for 44 healthy older adults and for 44 patients with behavioral variant frontotemporal dementia (bvFTD) who have focal SN dysfunction. We examined the relationship of...

Using in vivo transcriptomics and RNA enrichment to identify genes involved in virulence of Candida glabrata

Sanne Schrevens, Eric Durandau, Van Du T. Tran & Dominique Sanglard
Candida species are the most commonly isolated opportunistic fungal pathogens in humans. These species exhibit very different infection strategies, since they acquired pathogenesis independently throughout evolution. Candida albicans causes most of the diagnosed infections, closely followed by Candida glabrata. C. albicans is well studied, and many genes have been shown to be important for infection and colonization of the host. It is, however, less clear how C. glabrata infects the host. With the help of...

Temporary cervical sling and uterine twist before B-Lynch for massive uterine bleeding after delivery

Basile Pache, Vincent Balaya & David Desseauve
Massive uterine bleeding occurring after delivery is in most cases unpredictable and can have fatal consequences. This article presents the technique of combining the twisting of uterus on a 90° rotation on its axis and positioning a sling around the cervix, allowing to decrease incoming blood flow from uterine and ovarian arteries. The aim of this easy-to-use procedure is to enable surgeons and anaesthesiologists to respectively ensure the presence of an experienced surgeon and to...

Additional file 1 of Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial

Apolline Imbard, Artemis Toumazi, Sophie Magréault, Nuria Garcia-Segarra, Dimitri Schlemmer, Florentia Kaguelidou, Isabelle Perronneau, Jérémie Haignere, Hélène Ogier de Baulny, Alice Kuster, François Feillet, Corinne Alberti, Sophie Guilmin-Crépon, Jean-François Benoist & Manuel Schiff
Additional file 1: Table S1: Patients’ characteristics. Table S2: Detail of patient current treatment. Table S3: Clinical data at inclusion. Figure S1: Carry-over effect. Figure S2: plasma total homocysteine (tHcy) before and after one month treatment with 100 mg/kg/day) (A, D) or 250 mg/kg/day (B, E) in pnrCBS patients (A, B) and cblC patients (B, E) and the corresponding difference (ΔtHcy) for each pnrCBS (C) and cblC (F) patient. Figure S3: SAM (A, B), SAH...

Additional file 1 of Reproducibility of lung cancer radiomics features extracted from data-driven respiratory gating and free-breathing flow imaging in [18F]-FDG PET/CT

Daphné Faist, Mario Jreige, Valentin Oreiller, Marie Nicod Lalonde, Niklaus Schaefer, Adrien Depeursinge & John O. Prior
Additional file 1. Individual radiomics features for the free-breathing and data-driven gating PET/CT data sets. Individual radiomics features values for the free-breathing (flow) and data-driven gating (DDG) PET/CT reconstruction of each pulmonary lesion. The radiomics features table is the output from the QuantImage platform (see Cid et al. (2017)).

COVID-19 in working-class neighborhoods of two Argentine cities

Andrea Mastrangelo, Silvia Hirsch & Flavia Demonte
Abstract This paper presents a synchronic analysis of the diseases during the emergence of COVID-19, the management and impact of the lockdown, and how the media narrated these events in working-class neighborhoods of the metropolitan areas of Buenos Aires and Gran Resistencia from March to November 2020. We resorted to quantitative methods on secondary sources to describe poverty and syndemics and conducted week-by-week ethnographic and media research on 38 neighborhoods with water shortages and critical...

sj-pdf-6-pal-10.1177_08258597221138674 - Supplemental material for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review

Martyna Tomczyk, Cécile Jaques & Ralf J. Jox
Supplemental material, sj-pdf-6-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

sj-pdf-8-pal-10.1177_08258597221138674 - Supplemental material for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review

Martyna Tomczyk, Cécile Jaques & Ralf J. Jox
Supplemental material, sj-pdf-8-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

sj-pdf-10-pal-10.1177_08258597221138674 - Supplemental material for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review

Martyna Tomczyk, Cécile Jaques & Ralf J. Jox
Supplemental material, sj-pdf-10-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

sj-pdf-12-pal-10.1177_08258597221138674 - Supplemental material for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review

Martyna Tomczyk, Cécile Jaques & Ralf J. Jox
Supplemental material, sj-pdf-12-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

sj-pdf-13-pal-10.1177_08258597221138674 - Supplemental material for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review

Martyna Tomczyk, Cécile Jaques & Ralf J. Jox
Supplemental material, sj-pdf-13-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review

Martyna Tomczyk, Cécile Jaques & Ralf J. Jox
Objective: The principal aim of this study was to identify, systematically and transparently, clinical practice guidelines (CPGs) on palliative sedation from around the world. Methods: A systematic search was performed using 5 databases, grey literature search tools, citation tracking, and contact with palliative care experts across the world. Current CPGs accredited by an international, national, or regional authority, published in English, German, French, or Italian, were subjected to content analysis. Results: In total, 35 CPGs...

Additional file 1 of VoiceS: voice quality after transoral CO2 laser surgery versus single vocal cord irradiation for unilateral stage 0 and I glottic larynx cancer—a randomized phase III trial

Philipp Reinhardt, Roland Giger, Eberhard Seifert, Mohamed Shelan, Elena Riggenbach, Dario Terribilini, Andreas Joosten, Daniel H. Schanne, Daniel M. Aebersold, Peter Manser, Matthias S. Dettmer, Christian Simon, Esat M. Ozsahin, Raphaël Moeckli, Andreas Limacher, Francesca Caparrotti, Deepa Nair, Jean Bourhis, Martina A. Broglie, Abrahim Al-Mamgani & Olgun Elicin
Additional file 1. Full study protocol

Additional file 2 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 2: Fig. S2. Scatterplot and regression line (with 95% confidence intervals) to describe the relationship of hs-CRP with characteristics of study participants. Relationship between hs-CRP and A) age, B) sex, C) BMI and D) polygenic risk score (PRS). For linear regressions, linear regression equation, R-squared and P-value are shown.

Additional file 4 of The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider & Jacques Fellay
Additional file 4: Fig. S4. Distribution of polygenic risk score (PRS) values. Density distribution of standardized PRS values by subcohort (CoLaus|PsyCoLaus and UKB) and across all participants (combined).

Additional file 1 of Collaborative medication management for older adults after hospital discharge: a qualitative descriptive study

Filipa Pereira, Marion Bieri, Maria del Rio Carral, Maria Manuela Martins & Henk Verloo
Supplementary Material 1

Additional file 2 of Collaborative medication management for older adults after hospital discharge: a qualitative descriptive study

Filipa Pereira, Marion Bieri, Maria del Rio Carral, Maria Manuela Martins & Henk Verloo
Supplementary Material 2

Additional file 1 of Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial

Jean Chastre, Bruno François, Marc Bourgeois, Apostolos Komnos, Ricard Ferrer, Galia Rahav, Nicolas De Schryver, Alain Lepape, Iftihar Koksal, Charles-Edouard Luyt, Miguel Sánchez-García, Antoni Torres, Philippe Eggimann, Despoina Koulenti, Thomas L. Holland, Omar Ali, Kathryn Shoemaker, Pin Ren, Julien Sauser, Alexey Ruzin, David E. Tabor, Ahmad Akhgar, Yuling Wu, Yu Jiang, Antonio DiGiandomenico … & Hasan S. Jafri
Additional file 1: Supplementary Methods, Results, Tables and Figures.

Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial

Jean Chastre, Bruno François, Marc Bourgeois, Apostolos Komnos, Ricard Ferrer, Galia Rahav, Nicolas De Schryver, Alain Lepape, Iftihar Koksal, Charles-Edouard Luyt, Miguel Sánchez-García, Antoni Torres, Philippe Eggimann, Despoina Koulenti, Thomas L. Holland, Omar Ali, Kathryn Shoemaker, Pin Ren, Julien Sauser, Alexey Ruzin, David E. Tabor, Ahmad Akhgar, Yuling Wu, Yu Jiang, Antonio DiGiandomenico … & Hasan S. Jafri
Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) was a phase 2, randomised, parallel-group, double-blind, placebo-controlled study in Europe, Turkey, Israel, and the USA. Subjects ≥ 18 years old, mechanically ventilated, tracheally colonised with PA, and without new-onset pneumonia, were randomised (1:1:1)...

Supplemental Material - A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin-Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay

Ryan Wang, Daniel Katz, Hung-Mo Lin, Yuxia Ouyang, Jonathan Gal, Sumanth Suresh, Ismail Labgaa, Parissa Tabrizian, Samuel Demaria, Jeron Zerillo & Natalie K. Smith
Supplemental Material for A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin-Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay by Ryan Wang, Daniel Katz, Hung-Mo Lin, Yuxia Ouyang, Jonathan Gal, Sumanth Suresh, Ismail Labgaa, Parissa Tabrizian, Samuel Demaria, Jeron Zerillo, and Natalie K. Smith in Seminars in Cardiothoracic and Vascular Anesthesia

A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin–Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay

Ryan Wang, Daniel Katz, Hung-Mo Lin, Yuxia Ouyang, Jonathan Gal, Sumanth Suresh, Ismail Labgaa, Parissa Tabrizian, Samuel Demaria, Jeron Zerillo & Natalie K. Smith
IntroductionSerum albumin’s association with liver transplant outcomes has been investigated with mixed findings. This study aimed to evaluate perioperative albumin level, independently and as part of the albumin–bilirubin (ALBI) grade, as a predictor of post-liver transplant hospital and intensive care unit (ICU) length of stay (LOS).MethodsAdult liver-only transplant recipients at our institution from September 2011 to May 2019 were included in this retrospective study. Repeat transplants were excluded. Demographic, laboratory, and hospital course data were...

A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin–Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay

Ryan Wang, Daniel Katz, Hung-Mo Lin, Yuxia Ouyang, Jonathan Gal, Sumanth Suresh, Ismail Labgaa, Parissa Tabrizian, Samuel Demaria, Jeron Zerillo & Natalie K. Smith
IntroductionSerum albumin’s association with liver transplant outcomes has been investigated with mixed findings. This study aimed to evaluate perioperative albumin level, independently and as part of the albumin–bilirubin (ALBI) grade, as a predictor of post-liver transplant hospital and intensive care unit (ICU) length of stay (LOS).MethodsAdult liver-only transplant recipients at our institution from September 2011 to May 2019 were included in this retrospective study. Repeat transplants were excluded. Demographic, laboratory, and hospital course data were...

Data from: Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP)

Laura Vilella, Nuria Lacuey, Johnson P. Hampson, M.R. Sandhya Rani, Rup K. Sanju, Daniel Friedman, Maromi Nei, Kingman Strohl, Catherine Scott, Brian K. Gehlbach, Bilal Zony, Norma J. Hupp, Anita Zaremba, Nassim Shafiabadi, Xihue Zhao, Victoria Reick-Mitrisin, Stephan Schuele, Jennifer Ogren, Ronald M. Harper, Beate Diehl, Lisa Bateman, Orrin Devinsky, George B. Richerson, Philippe Ryvlin & Samden D. Lhatoo
Objective: To characterize peri-ictal apnea and post-ictal asystole in generalized convulsive seizures (GCS) of intractable epilepsy. Methods: Prospective, multi-center epilepsy monitoring study of autonomic and breathing biomarkers of SUDEP in patient’s ≥18 years old with intractable epilepsy and monitored GCS. Video EEG, thoraco-abdominal excursions, nasal airflow, capillary oxygen saturation and electrocardiography were analyzed. Results: We studied 148 GCS in 87 patients. Nineteen patients had generalized epilepsy, 65 had focal, one had both and in two,...

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Affiliations

  • University Hospital of Lausanne
    136
  • University of Lausanne
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  • HES-SO Valais-Wallis
    20
  • Swiss Institute of Bioinformatics
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  • École Polytechnique Fédérale de Lausanne
    15
  • German Cancer Research Center
    13
  • University Hospital of Geneva
    10
  • University Hospital of Zurich
    9
  • University Hospital of Bern
    9
  • Inserm
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