Additional file 3: Fig. S3. Principal component analysis (PCA) of combined genotyping data. A) PCA plot of the first ten PCs of the genotyping data. Samples are colored by cohort. B) Histogram explaining the variance of each PC component. In the histogram, the variance explained by each eigenvalue is labeled on top.

Additional file 3: Fig. S3. Principal component analysis (PCA) of combined genotyping data. A) PCA plot of the first ten PCs of the genotyping data. Samples are colored by cohort. B) Histogram explaining the variance of each PC component. In the histogram, the variance explained by each eigenvalue is labeled on top.

Abstract Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomplete understanding of the potential contribution of both persistent infections and human genetic variation on chronic low-grade inflammation. We searched for potential associations between seropositivity for 13 persistent pathogens and the plasma levels of the inflammatory biomarker C-reactive protein (CRP),...

Additional file 1. Individual radiomics features for the free-breathing and data-driven gating PET/CT data sets. Individual radiomics features values for the free-breathing (flow) and data-driven gating (DDG) PET/CT reconstruction of each pulmonary lesion. The radiomics features table is the output from the QuantImage platform (see Cid et al. (2017)).

Additional file 2. Differences and concordance among free-breathing and data-driven gating PET/CT for all radiomics features. The relative difference in percentage (DIFF%) and the concordance bias coefficient (Cb) are presented for each of the 141 radiomics features as derived from the QuantImage Excel output (see Cid et al. (2017)).

IDH1/2 mutations, intervening in epigenetic procedures, are frequently encountered in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Knowledge of the genetics, immunophenotypes, and mutational kinetics of IDH1/2-mutated AML can contribute to the understanding of AML clonal architecture and inform therapeutics and monitoring. We retrospectively analyzed 50 IDH1/2-mutated AML/MDS-EB cases of our institution, to identify recurrent co-mutations, immunophenotypes, patterns of co-variance of IDH1/2 allele burdens with those of recurrent co-mutations, frequency of persistent IDH1/2 mutation...

To compare maternal outcomes using Carbetocin versus Oxytocin for the active management of the third stage of labor, given a temporary national shortage of Oxytocin. We conducted a retrospective observational study on a cohort of 866 women with vaginal deliveries at our center, >36 weeks of gestation, between November 2018 and March 2019. During the shortage period, each woman received a single slow intravenous injection of Carbetocin 100 µg at delivery of the anterior shoulder,...

Massive uterine bleeding occurring after delivery is in most cases unpredictable and can have fatal consequences. This article presents the technique of combining the twisting of uterus on a 90° rotation on its axis and positioning a sling around the cervix, allowing to decrease incoming blood flow from uterine and ovarian arteries. The aim of this easy-to-use procedure is to enable surgeons and anaesthesiologists to respectively ensure the presence of an experienced surgeon and to...

Abstract Background COVID-19 related acute respiratory distress syndrome (ARDS) has specific characteristics compared to ARDS in other populations. Proning is recommended by analogy with other forms of ARDS, but few data are available regarding its physiological effects in this population. This study aimed to assess the effects of proning on oxygenation parameters (PaO2/FiO2 and alveolo-arterial gradient (Aa-gradient)), blood gas analysis, ventilatory ratio (VR), respiratory system compliance (CRS) and estimated dead space fraction (VD/VT HB). We...

Additional file 1: Table S1. Physiological, ventilatory and hemodynamic data for all the sessions considered together (n=191) and for the first (n=42), the second (n=37), the third (n=31), the fourth (n=18) and the fifth (n=14) proning sessions). Table S2. Variations in physiological and ventilatory parameters during the fourth (n=18), the fifth (n=14) proning sessions. Comparisons between the success and failure group.

Additional file 2: Supplementary Figure 1. Intraoperative fluid [mL].

Additional file 1: Table 1. Participant characteristics. Figure 1. CONSORT flow diagram. Figure 2. Psychopathology and family burden. Figure 3. Response status at 16 weeks. Figure 4. Negative effects questionnaire. Supplemental Table 1. Detailed comorbidities. Supplemental Table 2. Psychopathology and family burden. Supplemental Table 3. Kidscreen-52. Supplemental Timeline. Supplemental Assumptions.

Supplementary Material 1 - The IMSA questionnaire.

Abstract Purpose To investigate how useful the Intermed-Self Assessment (IMSA) questionnaire and its components were for identifying which patient candidates would benefit most from case management (CM) in general practice. Methods The study was carried out in a group family medicine practice in Lausanne comprising seven GPs and four medical assistants, from February to April 2019. All the patients attending the practice between February and April 2019 were invited to complete the IMSA questionnaire. Additionally,...

Supplemental material, sj-pdf-1-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-3-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-6-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-7-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-7-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-9-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-9-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-11-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-11-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental Material for A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin–Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay by Ryan Wang, Daniel Katz, Hung-Mo Lin, Yuxia Ouyang, Jonathan Gal, Sumanth Suresh, Ismail Labgaa, Parissa Tabrizian, Samuel Demaria, Jeron Zerillo, and Natalie K. Smith in Seminars in Cardiothoracic and Vascular Anesthesia

The aim of the present study was to investigate the genetic structure of the Valais shrew (Sorex antinorii) by a combined phylogeographical and landscape genetic approach, and thereby to infer the locations of glacial refugia and establish the influence of geographical barriers. We sequenced part of the mitochondrial cytochrome b (cyt b) gene of 179 individuals of S. antinorii sampled across the entire species' range. Six specimens attributed to S. arunchi were included in the...