Abstract Background Safe medication management for older adults after hospital discharge requires a well-coordinated, interprofessional, patient-centered approach. This study aimed to describe the perceived needs for collaborative medication management for older adults taking several different medications at home after hospital discharge. Methods A qualitative descriptive study was conducted using semi-structured interviews with older adults (n = 28), informal (n = 17), and professional caregivers (n = 13). Results Findings revealed four main needs: older adults...

Supplemental Material for A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin–Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay by Ryan Wang, Daniel Katz, Hung-Mo Lin, Yuxia Ouyang, Jonathan Gal, Sumanth Suresh, Ismail Labgaa, Parissa Tabrizian, Samuel Demaria, Jeron Zerillo, and Natalie K. Smith in Seminars in Cardiothoracic and Vascular Anesthesia

Additional file 1: Supplementary Methods, Results, Tables and Figures.

Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) was a phase 2, randomised, parallel-group, double-blind, placebo-controlled study in Europe, Turkey, Israel, and the USA. Subjects ≥ 18 years old, mechanically ventilated, tracheally colonised with PA, and without new-onset pneumonia, were randomised (1:1:1)...

Additional file 1. Table S1: Median fluid accumulation through Day 14, in the modified intention to treat population, stratified by subgroups. Table S2: The effect of accelerated vs standard RRT strategy on outcomes across deciles of baseline fluid balance. Table S3: The effect of accelerated vs standard RRT strategy on outcomes in patients with ≤ or > 10% fluid overload at baseline.

Additional file 2. Differences and concordance among free-breathing and data-driven gating PET/CT for all radiomics features. The relative difference in percentage (DIFF%) and the concordance bias coefficient (Cb) are presented for each of the 141 radiomics features as derived from the QuantImage Excel output (see Cid et al. (2017)).

Additional file 3. Differences and concordance among free-breathing and data-driven gating PET/CT for all radiomics features calculated separately based on pulmonary lesions localisation. The relative difference in percentage (DIFF%) and the concordance bias coefficient (Cb) are presented for each of the 141 radiomics features derived separately on each group “superior” and “inferior” depending on their anatomical localisation: lesions in the superior lobes versus the inferior regions. Non-reproducible features are marked with a star.

Abstract Background Betaine is an “alternate” methyl donor for homocysteine remethylation catalyzed by betaine homocysteine methyltransferase (BHMT), an enzyme mainly expressed in the liver and kidney. Betaine has been used for more than 30 years in pyridoxine non-responsive cystathionine beta-synthase (pnrCBS) and cobalamin C (cblC) deficiencies to lower the hyperhomocysteinemia, although little is known about the optimal therapeutic dosage and its pharmacokinetic in these patients. Aims We compared 2 betaine doses (100 mg/kg/day vs. 250...

Additional file 1: Table S1. Common observed PPTFs by medication. Table S2. Reason for erenumab dose discontinuation/interruption before month 6.

Abstract Background The fully human monoclonal antibody erenumab, which targets the calcitonin gene-related peptide (CGRP) receptor, was licensed in Switzerland in July 2018 for the prophylactic treatment of migraine. To complement findings from the pivotal program, this observational study was designed to collect and evaluate clinical data on the impact of erenumab on several endpoints, such as quality of life, migraine-related impairment and treatment satisfaction in a real-world setting. Methods An interim analysis was conducted...

Additional file 4. Differences and concordance among free-breathing and data-driven gating PET/CT for all radiomics features calculated separately based on pulmonary lesions size. The relative difference in percentage (DIFF%) and the concordance bias coefficient (Cb) are presented for each of the 141 radiomics features derived separately on two lesions groups “big” and “small” depending on their long-axis length < or > median. Non-reproducible features are marked with a star.

Additional file 4. Differences and concordance among free-breathing and data-driven gating PET/CT for all radiomics features calculated separately based on pulmonary lesions size. The relative difference in percentage (DIFF%) and the concordance bias coefficient (Cb) are presented for each of the 141 radiomics features derived separately on two lesions groups “big” and “small” depending on their long-axis length < or > median. Non-reproducible features are marked with a star.

Abstract Background Quality and reproducibility of radiomics studies are essential requirements for the standardisation of radiomics models. As recent data-driven respiratory gating (DDG) [18F]-FDG has shown superior diagnostic performance in lung cancer, we evaluated the impact of DDG on the reproducibility of radiomics features derived from [18F]-FDG PET/CT in comparison to free-breathing flow (FB) imaging. Methods Twenty four lung nodules from 20 patients were delineated. Radiomics features were derived on FB flow PET/CT and on...

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Abstract Background Safe medication management for older adults after hospital discharge requires a well-coordinated, interprofessional, patient-centered approach. This study aimed to describe the perceived needs for collaborative medication management for older adults taking several different medications at home after hospital discharge. Methods A qualitative descriptive study was conducted using semi-structured interviews with older adults (n = 28), informal (n = 17), and professional caregivers (n = 13). Results Findings revealed four main needs: older adults...

Additional file 6: Fig. S6. Seroprevalence of tested antigens in the CoLaus|PsyCoLaus. List of the 27 antigens available from the CoLaus|PsyCoLaus study that are shared with the UK Biobank. The percentages indicate the seroprevalence of antibodies against infectious disease antigens tested using Multiplex Serology platform. The grey boxes indicate the pathogen on which the antigen protein is found, and the family to which the pathogen belongs.

Supplemental Material for A Retrospective Study of the Role of Perioperative Serum Albumin and the Albumin-Bilirubin Grade in Predicting Post-Liver Transplant Length of Stay by Ryan Wang, Daniel Katz, Hung-Mo Lin, Yuxia Ouyang, Jonathan Gal, Sumanth Suresh, Ismail Labgaa, Parissa Tabrizian, Samuel Demaria, Jeron Zerillo, and Natalie K. Smith in Seminars in Cardiothoracic and Vascular Anesthesia

Additional file 1. Table S1: Median fluid accumulation through Day 14, in the modified intention to treat population, stratified by subgroups. Table S2: The effect of accelerated vs standard RRT strategy on outcomes across deciles of baseline fluid balance. Table S3: The effect of accelerated vs standard RRT strategy on outcomes in patients with ≤ or > 10% fluid overload at baseline.

Abstract Background COVID-19 related acute respiratory distress syndrome (ARDS) has specific characteristics compared to ARDS in other populations. Proning is recommended by analogy with other forms of ARDS, but few data are available regarding its physiological effects in this population. This study aimed to assess the effects of proning on oxygenation parameters (PaO2/FiO2 and alveolo-arterial gradient (Aa-gradient)), blood gas analysis, ventilatory ratio (VR), respiratory system compliance (CRS) and estimated dead space fraction (VD/VT HB). We...

Abstract: The medical staff performing interventional cardiology and radiology (IC/IR) procedures stand close to the patient and thus close to the primary radiation beam. Although they wear a lead apron and thyroid collar, their hands, legs and eyes are not protected. Therefore, these parts could receive significantly high doses. Moreover, thedose ranges for the same kind of procedures vary a lot, as many factors affect extremity and eye lens doses. Additionally, there is evidence that...

We report the development of a semi-automated image analysis plug-in, MarrowQuant, which employs the open-source software QuPath, to systematically quantify multiple bone components in H&E sections in an unbiased manner. MarrowQuant discerns and quantifies the areas occupied by bone, adipocyte ghosts, hematopoietic cells and the interstitial/microvascular compartment. A separate feature, AdipoQuant, fragments adipocyte ghosts in H&E-stained sections of extramedullary adipose tissue sections to render adipocyte area and size distribution. Quantification of BM hematopoietic cellularity with...

Supplementary Material 1 - The IMSA questionnaire.