Objective: To investigate staff attitudes toward assisted suicide in the hospital and factors influencing its practices in Switzerland. Design: Cross-sectional study Setting: Two University Hospitals in French speaking regions of Switzerland. Participants: 13’834 health care professionals including all personal caring for patients were invited to participate. Main outcome measures and other variables: Attitudes towards the participation of hospital health care professionals in assisted suicide were investigated with an online questionnaire. Results: Among all invited professionals,...

Additional file 1: Fig. S1. Flowchart illustrating the inclusion/exclusion of individuals in the study. Orange boxes indicate the number of included antigens and pathogens.

Additional file 2: Fig. S2. Scatterplot and regression line (with 95% confidence intervals) to describe the relationship of hs-CRP with characteristics of study participants. Relationship between hs-CRP and A) age, B) sex, C) BMI and D) polygenic risk score (PRS). For linear regressions, linear regression equation, R-squared and P-value are shown.

Additional file 4: Fig. S4. Distribution of polygenic risk score (PRS) values. Density distribution of standardized PRS values by subcohort (CoLaus|PsyCoLaus and UKB) and across all participants (combined).

Additional file 5: Fig. S5. Polygenic risk score for hs-CRP (CRP-PRS) was significantly associated with hs-CRP levels. Scatter plots with linear regression line of polygenic risk scores predicting hs-CRP levels for individuals in the cohort. 95% confidence interval is showed in grey shade.

Additional file 5: Fig. S5. Polygenic risk score for hs-CRP (CRP-PRS) was significantly associated with hs-CRP levels. Scatter plots with linear regression line of polygenic risk scores predicting hs-CRP levels for individuals in the cohort. 95% confidence interval is showed in grey shade.

Abstract Background Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder which affects up to 3% of children and adolescents. OCD in children and adolescents is generally treated with cognitive behavioural therapy (CBT), which, in more severely affected patients, can be combined with antidepressant medication. The TECTO trial aims to compare the benefits and harms of family-based CBT (FCBT) versus family-based psychoeducation/relaxation training (FPRT) in children and adolescents aged 8 to 17 years. This statistical analysis...

Abstract Background Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder which affects up to 3% of children and adolescents. OCD in children and adolescents is generally treated with cognitive behavioural therapy (CBT), which, in more severely affected patients, can be combined with antidepressant medication. The TECTO trial aims to compare the benefits and harms of family-based CBT (FCBT) versus family-based psychoeducation/relaxation training (FPRT) in children and adolescents aged 8 to 17 years. This statistical analysis...

Additional file 1: Table S1. Common observed PPTFs by medication. Table S2. Reason for erenumab dose discontinuation/interruption before month 6.

Abstract Background Perioperative decrease of albumin (ΔAlb) appeared as a promising predictor of complications after digestive surgery, but its role after liver surgery remains unclear. This study aimed to analyze whether and how ΔAlb can be used to predict complications after liver surgery. Methods A bicentric retrospective analysis of patients undergoing liver surgery (2010–2016) was performed, following TRIPOD guidelines. The preoperative and postoperative difference of albumin was calculated on POD 0 and defined as ΔAlb....

Abstract Background Perioperative decrease of albumin (ΔAlb) appeared as a promising predictor of complications after digestive surgery, but its role after liver surgery remains unclear. This study aimed to analyze whether and how ΔAlb can be used to predict complications after liver surgery. Methods A bicentric retrospective analysis of patients undergoing liver surgery (2010–2016) was performed, following TRIPOD guidelines. The preoperative and postoperative difference of albumin was calculated on POD 0 and defined as ΔAlb....

Abstract Background Among critically ill patients with acute kidney injury (AKI), earlier initiation of renal replacement therapy (RRT) may mitigate fluid accumulation and confer better outcomes among individuals with greater fluid overload at randomization. Methods We conducted a pre-planned post hoc analysis of the STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. We evaluated the effect of accelerated RRT initiation on cumulative fluid balance over the course of 14...

Objective: The principal aim of this study was to identify, systematically and transparently, clinical practice guidelines (CPGs) on palliative sedation from around the world. Methods: A systematic search was performed using 5 databases, grey literature search tools, citation tracking, and contact with palliative care experts across the world. Current CPGs accredited by an international, national, or regional authority, published in English, German, French, or Italian, were subjected to content analysis. Results: In total, 35 CPGs...

Supplemental material, sj-pdf-2-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-2-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-8-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-10-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-14-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-14-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Objective: The principal aim of this study was to identify, systematically and transparently, clinical practice guidelines (CPGs) on palliative sedation from around the world. Methods: A systematic search was performed using 5 databases, grey literature search tools, citation tracking, and contact with palliative care experts across the world. Current CPGs accredited by an international, national, or regional authority, published in English, German, French, or Italian, were subjected to content analysis. Results: In total, 35 CPGs...

Ex vivo lung perfusion (EVLP) with pharmacological reconditioning may increase donor lung utilization for transplantation (LTx). 3-Aminobenzamide (3-AB), an inhibitor of poly (ADP-ribose) polymerase (PARP), reduces ex vivo lung injury in rat lungs damaged by warm ischemia (WI). Here we determined the effects of 3-AB reconditioning on graft outcome after LTx. Three groups of donor lungs were studied: Control (Ctrl): 1 hour WI + 3 hours cold ischemia (CI) + LTx; EVLP: 1 hour WI...

Supplemental material, sj-pdf-6-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-8-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-10-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care

Supplemental material, sj-pdf-12-pal-10.1177_08258597221138674 for Clinical Practice Guidelines on Palliative Sedation Around the World: A Systematic Review by Martyna Tomczyk, Cécile Jaques and Ralf J. Jox in Journal of Palliative Care