74 Works

Coronavirus-associated kidney outcomes in COVID-19, SARS, and MERS: a meta-analysis and systematic review

Shoulian Zhou, Jing Xu, Cheng Xue, Bo Yang, Zhiguo Mao & Albert C. M. Ong
A meta-analysis and systematic review was conducted on kidney-related outcomes of three recent pandemics: SARS, MERS, and COVID-19, which were associated with potentially fatal acute respiratory distress syndrome (ARDS). A search of all published studies until 16 June 2020 was performed. The incidence/prevalence and mortality risk of acute and chronic renal events were evaluated, virus prevalence, and mortality in preexisting hemodialysis patients was investigated. A total of 58 eligible studies involving 13452 hospitalized patients with...

Coronavirus-associated kidney outcomes in COVID-19, SARS, and MERS: a meta-analysis and systematic review

Shoulian Zhou, Jing Xu, Cheng Xue, Bo Yang, Zhiguo Mao & Albert C. M. Ong
A meta-analysis and systematic review was conducted on kidney-related outcomes of three recent pandemics: SARS, MERS, and COVID-19, which were associated with potentially fatal acute respiratory distress syndrome (ARDS). A search of all published studies until 16 June 2020 was performed. The incidence/prevalence and mortality risk of acute and chronic renal events were evaluated, virus prevalence, and mortality in preexisting hemodialysis patients was investigated. A total of 58 eligible studies involving 13452 hospitalized patients with...

Enhanced self-powered ion-modulated photodetector based on an asymmetric composite structure of superionic conductor RbAg4I5 and graphene

Pengfei Wang, Duanhao Huang, Hao Liu, Yu Liu, Jun Yin, feng huang & Jia-Lin Sun
Traditional strategies for self-powered devices face limitations in the performance improvement due to trade-off relationship between different parameters. Here, a new kind of ion-modulation self-powered photodetector is first proposed and fabricated by depositing superionic conductor RbAg4I5 on one side of monolayer graphene. The graphene homojunction is successfully formed at the boundary of asymmetric structure due to the formation of bound states of ions and electrons at the contact interface. This kind of homojunction avoids trade...

Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations

Jing Xu, Kevin C Yang, Nancy Erro Go, Shane Colborne, Cally J Ho, Elham Hosseini-Beheshti, Alf H Lystad, Anne Simonsen, Emma Tomlinson Guns, Gregg B Morin & Sharon M Gorski
Chloroquine (CQ), a lysosomotropic agent, is commonly used to inhibit lysosomal degradation and macroautophagy/autophagy. Here we investigated the cell-extrinsic effects of CQ on secretion. We showed that lysosomal and autophagy inhibition by CQ altered the secretome, and induced the release of Atg8 orthologs and autophagy receptors. Atg8-family proteins, in particular, were secreted inside small extracellular vesicles (sEVs) in a lipidation-dependent manner. CQ treatment enhanced the release of Atg8-family proteins inside sEVs. Using full-length ATG16L1 and...

Additional file 1 of Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity

Hongsheng Wang, Xinmeng Jin, Yangfeng Zhang, Zhuoying Wang, Tao Zhang, Jing Xu, Jiakang Shen, Pengfei Zan, Mengxiong Sun, Chongren Wang, Yingqi Hua, Xiaojun Ma & Wei Sun
Additional file 1: Figure S1. a. Western blot demonstrating CRISPR/CAS9-mediated CD151 knockout in indicated cells. b. Heatmap of the sphingolipid metabolism genes regulated by CD151 depletion in ZOSM cells from RNA-seq. c. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of transcriptomic profiles of osteosarcoma patients based on the GEO database (GSE42352, n = 127). The red indicates the KEGG pathway related to sphingolipid metabolism. d. Heatmap of osteosarcoma patients showed changes of sphingolipid metabolism...

Additional file 4 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 4: Supplementary Table S2. Coding ability prediction results of the full-length transcripts.

Additional file 5 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 5: Supplementary Table S3. Transcription factor families and transcription factor genes.

Additional file 9 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 9: Supplementary Table S7. Primers for qRT-PCR analysis.

Impact of acute kidney injury on the risk of mortality in patients with cirrhosis: a systematic review and meta-analysis

Yunfeng Ning, Xiaoyue Zou, Jing Xu, Xiao Wang, Min Ding & Hulin Lu
To compare the risk of mortality in patients with cirrhosis with and without the associated acute kidney injury (AKI). We performed a systematic search in the PubMed, Embase, and Scopus databases for observational studies that were done on patients with cirrhosis. Eligible studies reported AKI in patients with cirrhosis and compared mortality among patients with and without AKI. We used a random-effects model, using STATA version 16.0, for deriving pooled effect sizes that were reported...

Additional file 1 of CD206+CD68+ mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis

Xiao-Ning An, Zhao-Nan Wei, Yin-Yin Xie, Jing Xu, Yan Shen, Li-Yan Ni, Hao Shi, Ping-Yan Shen, Wen Zhang & Yong-Xi Chen
Additional file 1: Table S1. Clinical and laboratory presentation of kidney-function adjusted controls. Table S2. PCR primer sequence. Table S3. Clinical and laboratory presentation of disease controls. Figure S1. The original images of Fig. 4E. Figure S2. The original images of Fig. 4G. Figure S3. The original picture of Fig. 4J.

Additional file 4 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 4: Supplementary Table S2. Coding ability prediction results of the full-length transcripts.

Additional file 6 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 6: Supplementary Table S4. Differential expression of genes involved in PS, PM and TM pathways.

Additional file 8 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 8: Supplementary Table S6. KEGG pathways of DEGs between HS2 and YS1.

Additional file 9 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 9: Supplementary Table S7. Primers for qRT-PCR analysis.

Additional file 1 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 1: Supplementary Figure S1. BUSCO assembly evaluation results. C (complete): matches the BUSCO database sequence; F (fragmented): only part of the sequence can be compared with the BUSCO database; D (duplicate): multiple genes are compared with the same BUSCO; M (missing): the filtered sequence.

Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway

Hongchao Wang, Lijie Wang, Fuli Hu, Pengfei Wang, Yanan Xie, Fang Li & Bingyan Guo
Abstract Background Diabetic cardiomyopathy is characterized by left ventricle dysfunction, cardiomyocyte apoptosis, and interstitial fibrosis and is a serious complication of diabetes mellitus (DM). Autophagy is a mechanism that is essential for maintaining normal heart morphology and function, and its dysregulation can produce pathological effects on diabetic hearts. Neuregulin-4 (Nrg4) is an adipokine that exerts protective effects against metabolic disorders and insulin resistance. The aim of this study was to explore whether Nrg4 could ameliorate...

Additional file 1 of Tumour-associated macrophages enhance breast cancer malignancy via inducing ZEB1-mediated DNMT1 transcriptional activation

Zhongwei Li, Pengfei Wang, Wenjie Cui, Hongmei Yong, Diandian Wang, Tiesuo Zhao, Wenwen Wang, Ming Shi, Junnian Zheng & Jin Bai
Additional file 1: Fig. S1. The DNMT1 promoter WT and mutant DNA sequences

CD206+CD68+ mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis

Xiao-Ning An, Zhao-Nan Wei, Yin-Yin Xie, Jing Xu, Yan Shen, Li-Yan Ni, Hao Shi, Ping-Yan Shen, Wen Zhang & Yong-Xi Chen
Abstract Background Antineutrophil Cytoplasmic Antibodies (ANCA) associated glomerulonephritis (AGN) is a group of autoimmune diseases and mono-macrophages are involved in its glomerular injuries. In this study, we aim to investigate the role of CD206+ mono-macrophages in AGN. Methods 27 AGN patients (14 active AGN, 13 remissive AGN) together with healthy controls (n = 9), disease controls (n = 6) and kidney function adjusted controls (n = 9) from Department of Nephrology, Ruijin hospital were recruited....

Supplementary document for An enhanced self-powered ion-modulated photodetector based on asymmetric composite structure of superionic conductor RbAg4I5 and graphene - 6021357.pdf

Pengfei Wang, Duanhao Huang, Hao Liu, Yu Liu, Jun Yin, feng huang & Jia-Lin Sun
Supplement 1

Cross-watershed distribution pattern challenging the elimination of Oncomelania hupensis, the intermediate host of Schistosoma japonica, in Sichuan province, China

Shen Chen, Ding Lu, Lei Duan, Ben Ma, Chao Lv, Yin-long Li, Shen-ning Lu, Lan-hua Li, Liang Xu, Zi-song Wu, Shang Xia, Jing Xu, Yang Liu & Shan Lv
Abstract Background Snail control is critical to schistosomiasis control efforts in China. However, re-emergence of Oncomelania hupensis is challenging the achievements of schistosomiasis control. The present study aimed to test whether the amphibious snails can spread across watersheds using a combination of population genetics and geographic statistics. Methods The digital maps and attributes of snail habitats were obtained from the national survey on O. hupensis. Snail sampling was performed in 45 counties of Sichuan Province....

Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin

Yan Wang, Zhiqiang Cheng, Jing Xu, Meina Lai, Liming Liu, Min Zuo & Lin Dang
Excessive activation of signal transducer and activator of transcription 3 (STAT3) is implicated in breast cancer (BC) chemoresistance, but its underlying mechanism is not fully understood. There are STAT3 binding sites in fat mass and obesity-associated protein (FTO) promoter region, thus STAT3 may regulate the transcription of FTO. This study aimed to investigate the correlation between FTO and STAT3 in BC chemoresistance. Herein, FTO and STAT3 were highly expressed in doxorubicin-resistant BC (BC-DoxR) cells. CHIP...

Data from: Assessing species boundaries and the phylogenetic position of the rare Szechwan Ratsnake, Euprepiophis perlacea (Serpentes: Colubridae), using coalescent-based methods

Xin Chen, Ke Jiang, Peng Guo, Song Huang, Dingqi Rao, Li Ding, Hirohiko Takeuchi, Jing Che, Yaping Zhang, Edward A. Myers, Frank T. Burbrink & Ya-Ping Zhang
Delimiting species and clarifying phylogenetic relationships are the main goals of systematics. For species with questionable taxonomic status, species delimitation approaches using multi-species coalescent models with multiple loci are recommended if morphological data are unavailable or unhelpful. Moreover, these methods will also reduce subjectivity based on genetic distance or requirement of monophyletic genetic lineages. We determine the validity and phylogenetic position of a rare and long controversial species of Chinese reptile, the Szechwan ratsnake (Euprepiophis...

Data from: A new moth-preying alpine pitviper species from Qinghai-Tibetan plateau (Viperidae, Crotalinae)

Jingsong Shi, Gang Wang, Xi'er Chen, Li Ding, Song Huang, Mian Hou, Jun Liu, Pipeng Li, Xi’er Chen & Yihao Fang
The Sanjiangyuan region of Qinghai-Tibetan Plateau is recognized as a biodiversity hotspot of alpine mammals but a barren area in terms of amphibians and reptiles. Here, we describe a new pit viper species, Gloydius rubromaculatus sp. n. Shi, Li and Liu, 2017 that was discovered in this region, with a brief taxonomic revision of the genus Gloydius. The new species can be distinguished from the other congeneric species by the following characteristics: cardinal crossbands on...

Additional file 1 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 1: Supplementary Figure S1. BUSCO assembly evaluation results. C (complete): matches the BUSCO database sequence; F (fragmented): only part of the sequence can be compared with the BUSCO database; D (duplicate): multiple genes are compared with the same BUSCO; M (missing): the filtered sequence.

Additional file 2 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 2: Supplementary Figure S2. Transcription factor family classification. The X-axis represents the corresponding number of isoforms, the Y-axis represents the transcription factor family classification.

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  • Chinese Academy of Medical Sciences & Peking Union Medical College
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  • Northeast Forestry University
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