69 Works

LINC00857 regulated by ZNF460 enhances the expression of CLDN12 by sponging miR-150-5p and recruiting SRSF1 for alternative splicing to promote epithelial-mesenchymal transformation of pancreatic adenocarcinoma cells

Yong Zhang, Yuan Fang, Lijie Ma, Jing Xu, Chentao Lv, Li Deng & Guanghui Zhu
Recent research unveiled that LINC00857 plays a regulatory role in multiple human cancers, such as lung adenocarcinoma and gastric cancer. Nevertheless, the function of LINC00857 in pancreatic adenocarcinoma (PAAD) remains unclear. This study concentrates on LINC00857 to discuss the relevant molecular mechanism of this gene in PAAD. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) and western blot were implemented for measuring the expressions of RNAs and proteins. Wound healing and Transwell assays were used to...

CD206+CD68+ mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis

Xiao-Ning An, Zhao-Nan Wei, Yin-Yin Xie, Jing Xu, Yan Shen, Li-Yan Ni, Hao Shi, Ping-Yan Shen, Wen Zhang & Yong-Xi Chen
Abstract Background Antineutrophil Cytoplasmic Antibodies (ANCA) associated glomerulonephritis (AGN) is a group of autoimmune diseases and mono-macrophages are involved in its glomerular injuries. In this study, we aim to investigate the role of CD206+ mono-macrophages in AGN. Methods 27 AGN patients (14 active AGN, 13 remissive AGN) together with healthy controls (n = 9), disease controls (n = 6) and kidney function adjusted controls (n = 9) from Department of Nephrology, Ruijin hospital were recruited....

Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway

Hongchao Wang, Lijie Wang, Fuli Hu, Pengfei Wang, Yanan Xie, Fang Li & Bingyan Guo
Abstract Background Diabetic cardiomyopathy is characterized by left ventricle dysfunction, cardiomyocyte apoptosis, and interstitial fibrosis and is a serious complication of diabetes mellitus (DM). Autophagy is a mechanism that is essential for maintaining normal heart morphology and function, and its dysregulation can produce pathological effects on diabetic hearts. Neuregulin-4 (Nrg4) is an adipokine that exerts protective effects against metabolic disorders and insulin resistance. The aim of this study was to explore whether Nrg4 could ameliorate...

Additional file 1 of Tumour-associated macrophages enhance breast cancer malignancy via inducing ZEB1-mediated DNMT1 transcriptional activation

Zhongwei Li, Pengfei Wang, Wenjie Cui, Hongmei Yong, Diandian Wang, Tiesuo Zhao, Wenwen Wang, Ming Shi, Junnian Zheng & Jin Bai
Additional file 1: Fig. S1. The DNMT1 promoter WT and mutant DNA sequences

Cross-watershed distribution pattern challenging the elimination of Oncomelania hupensis, the intermediate host of Schistosoma japonica, in Sichuan province, China

Shen Chen, Ding Lu, Lei Duan, Ben Ma, Chao Lv, Yin-long Li, Shen-ning Lu, Lan-hua Li, Liang Xu, Zi-song Wu, Shang Xia, Jing Xu, Yang Liu & Shan Lv
Abstract Background Snail control is critical to schistosomiasis control efforts in China. However, re-emergence of Oncomelania hupensis is challenging the achievements of schistosomiasis control. The present study aimed to test whether the amphibious snails can spread across watersheds using a combination of population genetics and geographic statistics. Methods The digital maps and attributes of snail habitats were obtained from the national survey on O. hupensis. Snail sampling was performed in 45 counties of Sichuan Province....

Supplementary document for An enhanced self-powered ion-modulated photodetector based on asymmetric composite structure of superionic conductor RbAg4I5 and graphene - 6021357.pdf

Pengfei Wang, Duanhao Huang, Hao Liu, Yu Liu, Jun Yin, feng huang & Jia-Lin Sun
Supplement 1

Additional file 1 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 1: Supplementary Figure S1. BUSCO assembly evaluation results. C (complete): matches the BUSCO database sequence; F (fragmented): only part of the sequence can be compared with the BUSCO database; D (duplicate): multiple genes are compared with the same BUSCO; M (missing): the filtered sequence.

Additional file 4 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 4: Supplementary Table S2. Coding ability prediction results of the full-length transcripts.

Additional file 6 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 6: Supplementary Table S4. Differential expression of genes involved in PS, PM and TM pathways.

Additional file 8 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 8: Supplementary Table S6. KEGG pathways of DEGs between HS2 and YS1.

Additional file 9 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 9: Supplementary Table S7. Primers for qRT-PCR analysis.

Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations

Jing Xu, Kevin C Yang, Nancy Erro Go, Shane Colborne, Cally J Ho, Elham Hosseini-Beheshti, Alf H Lystad, Anne Simonsen, Emma Tomlinson Guns, Gregg B Morin & Sharon M Gorski
Chloroquine (CQ), a lysosomotropic agent, is commonly used to inhibit lysosomal degradation and macroautophagy/autophagy. Here we investigated the cell-extrinsic effects of CQ on secretion. We showed that lysosomal and autophagy inhibition by CQ altered the secretome, and induced the release of Atg8 orthologs and autophagy receptors. Atg8-family proteins, in particular, were secreted inside small extracellular vesicles (sEVs) in a lipidation-dependent manner. CQ treatment enhanced the release of Atg8-family proteins inside sEVs. Using full-length ATG16L1 and...

Additional file 1 of Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity

Hongsheng Wang, Xinmeng Jin, Yangfeng Zhang, Zhuoying Wang, Tao Zhang, Jing Xu, Jiakang Shen, Pengfei Zan, Mengxiong Sun, Chongren Wang, Yingqi Hua, Xiaojun Ma & Wei Sun
Additional file 1: Figure S1. a. Western blot demonstrating CRISPR/CAS9-mediated CD151 knockout in indicated cells. b. Heatmap of the sphingolipid metabolism genes regulated by CD151 depletion in ZOSM cells from RNA-seq. c. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of transcriptomic profiles of osteosarcoma patients based on the GEO database (GSE42352, n = 127). The red indicates the KEGG pathway related to sphingolipid metabolism. d. Heatmap of osteosarcoma patients showed changes of sphingolipid metabolism...

Additional file 4 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 4: Supplementary Table S2. Coding ability prediction results of the full-length transcripts.

Additional file 5 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 5: Supplementary Table S3. Transcription factor families and transcription factor genes.

Additional file 9 of De novo full length transcriptome analysis and gene expression profiling to identify genes involved in phenylethanol glycosides biosynthesis in Cistanche tubulosa

Lei Hou, Guanghui Li, Qingliang Chen, JinJin Zhao, Jiaowen Pan, Ruxia Lin, Xiujin Zhu, Pengfei Wang & Xingjun Wang
Additional file 9: Supplementary Table S7. Primers for qRT-PCR analysis.

Enhanced self-powered ion-modulated photodetector based on an asymmetric composite structure of superionic conductor RbAg4I5 and graphene

Pengfei Wang, Duanhao Huang, Hao Liu, Yu Liu, Jun Yin, feng huang & Jia-Lin Sun
Traditional strategies for self-powered devices face limitations in the performance improvement due to trade-off relationship between different parameters. Here, a new kind of ion-modulation self-powered photodetector is first proposed and fabricated by depositing superionic conductor RbAg4I5 on one side of monolayer graphene. The graphene homojunction is successfully formed at the boundary of asymmetric structure due to the formation of bound states of ions and electrons at the contact interface. This kind of homojunction avoids trade...

Impact of acute kidney injury on the risk of mortality in patients with cirrhosis: a systematic review and meta-analysis

Yunfeng Ning, Xiaoyue Zou, Jing Xu, Xiao Wang, Min Ding & Hulin Lu
To compare the risk of mortality in patients with cirrhosis with and without the associated acute kidney injury (AKI). We performed a systematic search in the PubMed, Embase, and Scopus databases for observational studies that were done on patients with cirrhosis. Eligible studies reported AKI in patients with cirrhosis and compared mortality among patients with and without AKI. We used a random-effects model, using STATA version 16.0, for deriving pooled effect sizes that were reported...

Additional file 1 of CD206+CD68+ mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis

Xiao-Ning An, Zhao-Nan Wei, Yin-Yin Xie, Jing Xu, Yan Shen, Li-Yan Ni, Hao Shi, Ping-Yan Shen, Wen Zhang & Yong-Xi Chen
Additional file 1: Table S1. Clinical and laboratory presentation of kidney-function adjusted controls. Table S2. PCR primer sequence. Table S3. Clinical and laboratory presentation of disease controls. Figure S1. The original images of Fig. 4E. Figure S2. The original images of Fig. 4G. Figure S3. The original picture of Fig. 4J.

Chloroquine treatment induces secretion of autophagy-related proteins and inclusion of Atg8-family proteins in distinct extracellular vesicle populations

Jing Xu, Kevin C Yang, Nancy Erro Go, Shane Colborne, Cally J Ho, Elham Hosseini-Beheshti, Alf H Lystad, Anne Simonsen, Emma Tomlinson Guns, Gregg B Morin & Sharon M Gorski
Chloroquine (CQ), a lysosomotropic agent, is commonly used to inhibit lysosomal degradation and macroautophagy/autophagy. Here we investigated the cell-extrinsic effects of CQ on secretion. We showed that lysosomal and autophagy inhibition by CQ altered the secretome, and induced the release of Atg8 orthologs and autophagy receptors. Atg8-family proteins, in particular, were secreted inside small extracellular vesicles (sEVs) in a lipidation-dependent manner. CQ treatment enhanced the release of Atg8-family proteins inside sEVs. Using full-length ATG16L1 and...

Additional file 5 of Cross-watershed distribution pattern challenging the elimination of Oncomelania hupensis, the intermediate host of Schistosoma japonicum, in Sichuan province, China

Shen Chen, Ding Lu, Lei Duan, Ben Ma, Chao Lv, Yin-long Li, Shen-ning Lu, Lan-hua Li, Liang Xu, Zi-song Wu, Shang Xia, Jing Xu, Yang Liu & Shan Lv
Additional file 5: Figure S4. A Kruskal-Wallis comparison analysis of median distances among different groups.

Cross-watershed distribution pattern challenging the elimination of Oncomelania hupensis, the intermediate host of Schistosoma japonicum, in Sichuan province, China

Shen Chen, Ding Lu, Lei Duan, Ben Ma, Chao Lv, Yin-long Li, Shen-ning Lu, Lan-hua Li, Liang Xu, Zi-song Wu, Shang Xia, Jing Xu, Yang Liu & Shan Lv
Abstract Background Snail control is critical to schistosomiasis control efforts in China. However, re-emergence of Oncomelania hupensis is challenging the achievements of schistosomiasis control. The present study aimed to test whether the amphibious snails can spread across watersheds using a combination of population genetics and geographic statistics. Methods The digital maps and attributes of snail habitats were obtained from the national survey on O. hupensis. Snail sampling was performed in 45 counties of Sichuan Province....

Tumour-associated macrophages enhance breast cancer malignancy via inducing ZEB1-mediated DNMT1 transcriptional activation

Zhongwei Li, Pengfei Wang, Wenjie Cui, Hongmei Yong, Diandian Wang, Tiesuo Zhao, Wenwen Wang, Ming Shi, Junnian Zheng & Jin Bai
Abstract Background DNMT1 has been shown to be highly expressed in a variety of cancers, including breast cancer. However, the mechanism is not very clear. Therefore, we aim to reveal the mechanism of DNMT1 highly express in breast cancer. And we also want to explore the role of DNMT1 in tumour microenvironment promoting breast cancer progression. Results In this study, we demonstrate that DNMT1 is overexpressed in breast cancer and that DNMT1 promotes breast cancer...

Supplementary document for An enhanced self-powered ion-modulated photodetector based on asymmetric composite structure of superionic conductor RbAg4I5 and graphene - 6021357.pdf

Pengfei Wang, Duanhao Huang, Hao Liu, Yu Liu, Jun Yin, feng huang & Jia-Lin Sun
Supplement 1

Enhanced self-powered ion-modulated photodetector based on an asymmetric composite structure of superionic conductor RbAg4I5 and graphene

Pengfei Wang, Duanhao Huang, Hao Liu, Yu Liu, Jun Yin, feng huang & Jia-Lin Sun
Traditional strategies for self-powered devices face limitations in the performance improvement due to trade-off relationship between different parameters. Here, a new kind of ion-modulation self-powered photodetector is first proposed and fabricated by depositing superionic conductor RbAg4I5 on one side of monolayer graphene. The graphene homojunction is successfully formed at the boundary of asymmetric structure due to the formation of bound states of ions and electrons at the contact interface. This kind of homojunction avoids trade...

Registration Year

  • 2022
    69

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Affiliations

  • Huangshan University
    69
  • Shandong University
    45
  • First Affiliated Hospital of Xi'an Jiaotong University
    39
  • Northeast Forestry University
    39
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    37
  • Shanghai First People's Hospital
    34
  • Soochow University
    34
  • Shanghai University of Traditional Chinese Medicine
    33
  • Sun Yat-sen Memorial Hospital
    33
  • Qingdao University
    33