23 Works

Evaluation of Early Tocilizumab Effect on Multiorgan Dysfunction in Critically Ill Patients With COVID-19: A Propensity Score-Matched Study

Ohoud Aljuhani, Ghazwa B. Korayem, Ali F. Altebainawi, Abdullah Al Harthi, Hisham A. Badreldin, Muath A. Alsalloum, Khalid Eljaaly, Aisha Alharbi, Rowina Aljehani, Ramesh Vishwakarma, Abeer A. Alenazi, Mai Alalawi, Abdulrahman Alissa, Kholoud Al Aamer, Huda Al Enazi, Mohammed Almusallam, Abdulaziz Alshehri, Rawan Bukhari, Ghaday Alasmari, Maha M. AlQahtani, Sultanah Al Shammari, Hatim O. Alsulaymi & Khalid Al Sulaiman
Background: Tocilizumab (TCZ) has been proposed as potential rescue therapy for severe COVID-19. No previous study has primarily assessed the role of TCZ in preventing severe COVID-19-related multiorgan dysfunction. Hence, this multicenter cohort study aimed to evaluate the effectiveness of TCZ early use versus standard of care in preventing severe COVID-19-related multiorgan dysfunction in COVID-19 critically ill patients during intensive care unit (ICU) stay. Methods: A multicenter, retrospective cohort study includes critically ill adult patients...

Sex-specific maternal programming of corticosteroid binding globulin by predator odour

Sameera Abuaish, Sophia Lavergne, Benjamin Hing, Sophie St-Cyr, Richard Spinieli, Rudy Boonstra & Patrick McGowan
Predation is a key organizing force in ecosystems. The threat of predation may act to program the endocrine hypothalamic-pituitary-adrenal axis during development to prepare offspring for the environment they are likely to encounter. Such effects are typically investigated through measurement of corticosteroids (Cort). Corticosteroid-binding globulin (CBG) plays a key role in regulating the bioavailability of Cort, with only free unbound Cort being biologically active. We investigated the effects of prenatal predator odour exposure (POE) in...

Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative, docking and MD simulation studies

Mohammed S. Taghour, Hazem Elkady, Wagdy M. Eldehna, Nehal El-Deeb, Ahmed M. Kenawy, Abeer E Abd El-Wahab, Eslam B. Elkaeed, Bshra A. Alsfouk, Ahmed M. Metwaly & Ibrahim H. Eissa
A new set of quinoline and isatine derivatives were synthesized as antiangiogenic VEGFR-2 inhibitors. On a biological level, the in vitro ability of the obtained candidates to inhibit VEGFR-2 was found to be strong with IC50 values in the range of 76.64–175.50 nM. To investigate the cytotoxicity and safety, all compounds were tested against a panel of four cancer cell lines (A549, Caco2, HepG2 and MDA) as well as two normal cell lines (Vero and...

Informing a cost-effectiveness threshold for Saudi Arabia

Ahmed Hamdan Al-Jedai, James Lomas, Hajer Yousef Almudaiheem, Yazed Sulaiman H. Al-Ruthia, Shabab Alghamdi, Nancy Awad, Ahlam Alghamdi, Mohammad A. Alowairdhi, Hana Alabdulkarim, Majid Almadi, Reem F. Bunyan & Jessica Ochalek
Saudi Arabia’s Vision 2030 aims to reform health care across the Kingdom, with health technology assessment being adopted as one tool promising to improve the efficiency with which resources are used. An understanding of the opportunity costs of reimbursement decisions is key to fulfilling this promise and can be used to inform a cost-effectiveness threshold. This paper is the first to provide a range of estimates of this using existing evidence extrapolated to the context...

In silico, in vitro VEGFR-2 inhibition, and anticancer activity of a 3-(hydrazonomethyl)naphthalene-2-ol derivative

Eslam B. Elkaeed, Reda G. Yousef, Hazem Elkady, Ahmed B. M. Mehany, Bshra A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa
In agreement with the general features of VEGFR-2 inhibitors, a new naphthalene analog (compound 7) has been designed and synthesized. The inhibitory potential of compound 7 was indicated by the proper binding and the perfect energy of −21.10 kcal/mol compared to sorafenib (−21.22) in the molecular docking studies. Next, six MD simulation studies over 100 ns (RMSD, RMSF, SASA, RoG, hydrogen bonding, and distance between the center of mass) confirmed the accurate interaction of compound...

Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative, docking and MD simulation studies

Mohammed S. Taghour, Hazem Elkady, Wagdy M. Eldehna, Nehal El-Deeb, Ahmed M. Kenawy, Abeer E Abd El-Wahab, Eslam B. Elkaeed, Bshra A. Alsfouk, Ahmed M. Metwaly & Ibrahim H. Eissa
A new set of quinoline and isatine derivatives were synthesized as antiangiogenic VEGFR-2 inhibitors. On a biological level, the in vitro ability of the obtained candidates to inhibit VEGFR-2 was found to be strong with IC50 values in the range of 76.64–175.50 nM. To investigate the cytotoxicity and safety, all compounds were tested against a panel of four cancer cell lines (A549, Caco2, HepG2 and MDA) as well as two normal cell lines (Vero and...

sj-docx-1-jic-10.1177_08850666221150886 - Supplemental material for Evaluation of Early Tocilizumab Effect on Multiorgan Dysfunction in Critically Ill Patients With COVID-19: A Propensity Score-Matched Study

Ohoud Aljuhani, Ghazwa B. Korayem, Ali F. Altebainawi, Abdullah Al Harthi, Hisham A. Badreldin, Muath A. Alsalloum, Khalid Eljaaly, Aisha Alharbi, Rowina Aljehani, Ramesh Vishwakarma, Abeer A. Alenazi, Mai Alalawi, Abdulrahman Alissa, Kholoud Al Aamer, Huda Al Enazi, Mohammed Almusallam, Abdulaziz Alshehri, Rawan Bukhari, Ghaday Alasmari, Maha M. AlQahtani, Sultanah Al Shammari, Hatim O. Alsulaymi & Khalid Al Sulaiman
Supplemental material, sj-docx-1-jic-10.1177_08850666221150886 for Evaluation of Early Tocilizumab Effect on Multiorgan Dysfunction in Critically Ill Patients With COVID-19: A Propensity Score-Matched Study by Ohoud Aljuhani, Ghazwa B. Korayem, Ali F. Altebainawi, Abdullah Al Harthi, Hisham A. Badreldin, Muath A. Alsalloum, Khalid Eljaaly, Aisha Alharbi, Rowina Aljehani, Ramesh Vishwakarma, Abeer A. Alenazi, Mai Alalawi, Abdulrahman Alissa, Kholoud Al Aamer, Huda Al Enazi, Mohammed Almusallam, Abdulaziz Alshehri, Rawan Bukhari, Ghaday Alasmari, Maha M. AlQahtani, Sultanah Al Shammari,...

sj-docx-1-jic-10.1177_08850666221150886 - Supplemental material for Evaluation of Early Tocilizumab Effect on Multiorgan Dysfunction in Critically Ill Patients With COVID-19: A Propensity Score-Matched Study

Ohoud Aljuhani, Ghazwa B. Korayem, Ali F. Altebainawi, Abdullah Al Harthi, Hisham A. Badreldin, Muath A. Alsalloum, Khalid Eljaaly, Aisha Alharbi, Rowina Aljehani, Ramesh Vishwakarma, Abeer A. Alenazi, Mai Alalawi, Abdulrahman Alissa, Kholoud Al Aamer, Huda Al Enazi, Mohammed Almusallam, Abdulaziz Alshehri, Rawan Bukhari, Ghaday Alasmari, Maha M. AlQahtani, Sultanah Al Shammari, Hatim O. Alsulaymi & Khalid Al Sulaiman
Supplemental material, sj-docx-1-jic-10.1177_08850666221150886 for Evaluation of Early Tocilizumab Effect on Multiorgan Dysfunction in Critically Ill Patients With COVID-19: A Propensity Score-Matched Study by Ohoud Aljuhani, Ghazwa B. Korayem, Ali F. Altebainawi, Abdullah Al Harthi, Hisham A. Badreldin, Muath A. Alsalloum, Khalid Eljaaly, Aisha Alharbi, Rowina Aljehani, Ramesh Vishwakarma, Abeer A. Alenazi, Mai Alalawi, Abdulrahman Alissa, Kholoud Al Aamer, Huda Al Enazi, Mohammed Almusallam, Abdulaziz Alshehri, Rawan Bukhari, Ghaday Alasmari, Maha M. AlQahtani, Sultanah Al Shammari,...

Evaluation of Early Tocilizumab Effect on Multiorgan Dysfunction in Critically Ill Patients With COVID-19: A Propensity Score-Matched Study

Ohoud Aljuhani, Ghazwa B. Korayem, Ali F. Altebainawi, Abdullah Al Harthi, Hisham A. Badreldin, Muath A. Alsalloum, Khalid Eljaaly, Aisha Alharbi, Rowina Aljehani, Ramesh Vishwakarma, Abeer A. Alenazi, Mai Alalawi, Abdulrahman Alissa, Kholoud Al Aamer, Huda Al Enazi, Mohammed Almusallam, Abdulaziz Alshehri, Rawan Bukhari, Ghaday Alasmari, Maha M. AlQahtani, Sultanah Al Shammari, Hatim O. Alsulaymi & Khalid Al Sulaiman
Background: Tocilizumab (TCZ) has been proposed as potential rescue therapy for severe COVID-19. No previous study has primarily assessed the role of TCZ in preventing severe COVID-19-related multiorgan dysfunction. Hence, this multicenter cohort study aimed to evaluate the effectiveness of TCZ early use versus standard of care in preventing severe COVID-19-related multiorgan dysfunction in COVID-19 critically ill patients during intensive care unit (ICU) stay. Methods: A multicenter, retrospective cohort study includes critically ill adult patients...

Additional file 1 of Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: a multicenter cohort study

Khalid Al Sulaiman, Ghazwa B. Korayem, Ali F. Altebainawi, Shmeylan Al Harbi, Abdulrahman Alissa, Abdullah Alharthi, Raed Kensara, Amjaad Alfahed, Ramesh Vishwakarma, Hussain Al Haji, Naif Almohaimid, Omar Al Zumai, Fahad Alrubayan, Abdulmajid Asiri, Nasser Alkahtani, Abdulaziz Alolayan, Samiah Alsohimi, Nawal Melibari, Alaa Almagthali, Seba Aljahdali, Abeer A. Alenazi, Alawi S. Alsaeedi, Ghassan Al Ghamdi, Omar Al Faris, Joud Alqahtani … & Ohoud Aljuhani
Additional file 1. Outcomes definition(s).

Additional file 1 of Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: a multicenter cohort study

Khalid Al Sulaiman, Ghazwa B. Korayem, Ali F. Altebainawi, Shmeylan Al Harbi, Abdulrahman Alissa, Abdullah Alharthi, Raed Kensara, Amjaad Alfahed, Ramesh Vishwakarma, Hussain Al Haji, Naif Almohaimid, Omar Al Zumai, Fahad Alrubayan, Abdulmajid Asiri, Nasser Alkahtani, Abdulaziz Alolayan, Samiah Alsohimi, Nawal Melibari, Alaa Almagthali, Seba Aljahdali, Abeer A. Alenazi, Alawi S. Alsaeedi, Ghassan Al Ghamdi, Omar Al Faris, Joud Alqahtani … & Ohoud Aljuhani
Additional file 1. Outcomes definition(s).

Additional file 1 of Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Inemesit A. Udofia, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Additional file 1. HPLC chromatogram of ethanolic leaf extract of cannabis.

Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Udofia A. Inemesit, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Abstract Background Data available support that ninety percent of male infertility cases are due to low sperm counts. There is a scarcity of data on the medicinal effects of cannabis on fertility. This study evaluated testicular function and sperm quality modulation with cannabis in rats. Methodology Twenty-five male Wistar rats were randomly grouped into five: A, B, C, and D, each group have 5 rats. A (control): 0.2 ml 2% DMSO, B (vitamin C): 90...

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies

Reda G. Yousef, Alaa Elwan, Ibraheem M. M. Gobaara, Ahmed B. M. Mehany, Wagdy M. Eldehna, Souad A. El-Metwally, Bshra A. Alsfouk, Eslam B. Elkaeed, Ahmed M. Metwaly & Ibrahim H. Eissa
New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the highest anti-proliferative activities with IC50 values of 15.4 and 9.8 µM against HCT-116 and HepG2, respectively compared to sorafenib (IC50 = 9.30 and 7.40 µM). Compound 7 owned promising cytotoxic activities with IC50 values of 15.7 and 15.5 µM against the same cell lines, respectively. Subsequently, the VEGFR-2 inhibitory activities...

Additional file 1 of Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Inemesit A. Udofia, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Additional file 1. HPLC chromatogram of ethanolic leaf extract of cannabis.

Additional file 1 of Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Udofia A. Inemesit, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Additional file 1. HPLC chromatogram of ethanolic leaf extract of cannabis.

Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Inemesit A. Udofia, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Abstract Background Data available support that ninety percent of male infertility cases are due to low sperm counts. There is a scarcity of data on the medicinal effects of cannabis on fertility. This study evaluated testicular function and sperm quality modulation with cannabis in rats. Methodology Twenty-five male Wistar rats were randomly grouped into five: A, B, C, and D, each group have 5 rats. A (control): 0.2 ml 2% DMSO, B (vitamin C): 90...

Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: a multicenter cohort study

Khalid Al Sulaiman, Ghazwa B. Korayem, Ali F. Altebainawi, Shmeylan Al Harbi, Abdulrahman Alissa, Abdullah Alharthi, Raed Kensara, Amjaad Alfahed, Ramesh Vishwakarma, Hussain Al Haji, Naif Almohaimid, Omar Al Zumai, Fahad Alrubayan, Abdulmajid Asiri, Nasser Alkahtani, Abdulaziz Alolayan, Samiah Alsohimi, Nawal Melibari, Alaa Almagthali, Seba Aljahdali, Abeer A. Alenazi, Alawi S. Alsaeedi, Ghassan Al Ghamdi, Omar Al Faris, Joud Alqahtani … & Ohoud Aljuhani
Abstract Background Inhaled nitric oxide (iNO) is used as rescue therapy in patients with refractory hypoxemia due to severe COVID-19 acute respiratory distress syndrome (ARDS) despite the recommendation against the use of this treatment. To date, the effect of iNO on the clinical outcomes of critically ill COVID-19 patients with moderate-to-severe ARDS remains arguable. Therefore, this study aimed to evaluate the use of iNO in critically ill COVID-19 patients with moderate-to-severe ARDS. Methods This multicenter,...

Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: a multicenter cohort study

Khalid Al Sulaiman, Ghazwa B. Korayem, Ali F. Altebainawi, Shmeylan Al Harbi, Abdulrahman Alissa, Abdullah Alharthi, Raed Kensara, Amjaad Alfahed, Ramesh Vishwakarma, Hussain Al Haji, Naif Almohaimid, Omar Al Zumai, Fahad Alrubayan, Abdulmajid Asiri, Nasser Alkahtani, Abdulaziz Alolayan, Samiah Alsohimi, Nawal Melibari, Alaa Almagthali, Seba Aljahdali, Abeer A. Alenazi, Alawi S. Alsaeedi, Ghassan Al Ghamdi, Omar Al Faris, Joud Alqahtani … & Ohoud Aljuhani
Abstract Background Inhaled nitric oxide (iNO) is used as rescue therapy in patients with refractory hypoxemia due to severe COVID-19 acute respiratory distress syndrome (ARDS) despite the recommendation against the use of this treatment. To date, the effect of iNO on the clinical outcomes of critically ill COVID-19 patients with moderate-to-severe ARDS remains arguable. Therefore, this study aimed to evaluate the use of iNO in critically ill COVID-19 patients with moderate-to-severe ARDS. Methods This multicenter,...

In silico, in vitro VEGFR-2 inhibition, and anticancer activity of a 3-(hydrazonomethyl)naphthalene-2-ol derivative

Eslam B. Elkaeed, Reda G. Yousef, Hazem Elkady, Ahmed B. M. Mehany, Bshra A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa
In agreement with the general features of VEGFR-2 inhibitors, a new naphthalene analog (compound 7) has been designed and synthesized. The inhibitory potential of compound 7 was indicated by the proper binding and the perfect energy of −21.10 kcal/mol compared to sorafenib (−21.22) in the molecular docking studies. Next, six MD simulation studies over 100 ns (RMSD, RMSF, SASA, RoG, hydrogen bonding, and distance between the center of mass) confirmed the accurate interaction of compound...

Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Inemesit A. Udofia, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Abstract Background Data available support that ninety percent of male infertility cases are due to low sperm counts. There is a scarcity of data on the medicinal effects of cannabis on fertility. This study evaluated testicular function and sperm quality modulation with cannabis in rats. Methodology Twenty-five male Wistar rats were randomly grouped into five: A, B, C, and D, each group have 5 rats. A (control): 0.2 ml 2% DMSO, B (vitamin C): 90...

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies

Reda G. Yousef, Alaa Elwan, Ibraheem M. M. Gobaara, Ahmed B. M. Mehany, Wagdy M. Eldehna, Souad A. El-Metwally, Bshra A. Alsfouk, Eslam B. Elkaeed, Ahmed M. Metwaly & Ibrahim H. Eissa
New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the highest anti-proliferative activities with IC50 values of 15.4 and 9.8 µM against HCT-116 and HepG2, respectively compared to sorafenib (IC50 = 9.30 and 7.40 µM). Compound 7 owned promising cytotoxic activities with IC50 values of 15.7 and 15.5 µM against the same cell lines, respectively. Subsequently, the VEGFR-2 inhibitory activities...

Informing a cost-effectiveness threshold for Saudi Arabia

Ahmed Hamdan Al-Jedai, James Lomas, Hajer Yousef Almudaiheem, Yazed Sulaiman H. Al-Ruthia, Shabab Alghamdi, Nancy Awad, Ahlam Alghamdi, Mohammad A. Alowairdhi, Hana Alabdulkarim, Majid Almadi, Reem F. Bunyan & Jessica Ochalek
Saudi Arabia’s Vision 2030 aims to reform health care across the Kingdom, with health technology assessment being adopted as one tool promising to improve the efficiency with which resources are used. An understanding of the opportunity costs of reimbursement decisions is key to fulfilling this promise and can be used to inform a cost-effectiveness threshold. This paper is the first to provide a range of estimates of this using existing evidence extrapolated to the context...

Registration Year

  • 2023
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  • 2021
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Affiliations

  • Princess Nourah bint Abdulrahman University
    23
  • King Abdulaziz Medical City
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  • King Abdullah International Medical Research Center
    8
  • Riyadh Armed Forces Hospital
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  • King Saud bin Abdulaziz University for Health Sciences
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  • King Abdul Aziz University Hospital
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  • King Abdulaziz University
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  • European Organisation for Research and Treatment of Cancer
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