Objective: To investigate the longitudinal dose-effect relationship between dopamine replacement therapy and impulse control disorders (ICDs) in Parkinson’s disease (PD). Methods: We used data from a multicentre longitudinal cohort of consecutive PD patients with ≤5y disease duration at baseline followed annually up to 5y. ICDs were evaluated during face-to-face semi-structured interviews with movement disorder specialists. Generalized estimating equations Poisson models with robust variance were used to study the association between several time-dependent definitions of dopamine...