7 Works

Data from: Evaluating population receptive field estimation frameworks in terms of robustness and reproducibility

Mario Senden, Joel Reithler, Sven Gijsen & Rainer Goebel
Within vision research retinotopic mapping and the more general receptive field estimation approach constitute not only an active field of research in itself but also underlie a plethora of interesting applications. This necessitates not only good estimation of population receptive fields (pRFs) but also that these receptive fields are consistent across time rather than dynamically changing. It is therefore of interest to maximize the accuracy with which population receptive fields can be estimated in a...

Data from: Comparison of T2*-weighted and QSM contrasts in Parkinson's disease to visualize the STN with MRI

Anneke Alkemade, Gilles De Hollander, Max C. Keuken, Andreas Schäfer, Derek V.M. Ott, David Weise, Sonja A. Kotz, Birte U. Forstmann & Derek V. M. Ott
The subthalamic nucleus (STN) plays a crucial role in the surgical treatment of Parkinson's disease (PD). Studies investigating optimal protocols for STN visualization using state of the art magnetic resonance imaging (MRI) techniques have shown that susceptibility weighted images, which display the magnetic susceptibility distribution, yield better results than T1-weighted, T2-weighted, and T2*-weighted contrasts. However, these findings are based on young healthy individuals, and require validation in elderly individuals and persons suffering from PD. Using...

Data from: Task-related effective connectivity reveals that the cortical rich club gates cortex-wide communication

Mario Senden, Niels Reuter, Martijn P. Van Den Heuvel, Rainer Goebel, Gustavo Deco & Matthieu Gilson
Higher cognition may require the globally coordinated integration of specialized brain regions into functional networks. A collection of structural cortical hubs—referred to as the rich club—has been hypothesized to support task-specific functional integration. In the present paper, we use a whole-cortex model to estimate directed interactions between 68 cortical regions from functional magnetic resonance imaging activity for four different tasks (reflecting different cognitive domains) and resting state. We analyze the state-dependent input and output effective...

ZETA benchmarking neuropixels data

Jorrit Montijn
Pre-processed matlab data files containing clustered spiking data of cells recorded across various visually-responsive regions with Neuropixels. The data can be accessed using the files provided at https://github.com/JorritMontijn/ZETA_analysis_repository. Neurophysiological studies depend on a reliable quantification of whether and when a neuron responds to stimulation. Current methods to determine responsiveness require arbitrary parameter choices, such as binning size. These choices can change the results, which invites bad statistical practice and reduces the replicability. Moreover, many methods...

Data from: Whole-cell properties of cerebellar nuclei neurons in vivo

Cathrin B. Canto, Laurens Witter & Chris I. De Zeeuw
Cerebellar nuclei neurons integrate sensorimotor information and form the final output of the cerebellum, projecting to premotor brainstem targets. This implies that, in contrast to specialized neurons and interneurons in cortical regions, neurons within the nuclei encode and integrate complex information that is most likely reflected in a large variation of intrinsic membrane properties and integrative capacities of individual neurons. Yet, whether this large variation in properties is reflected in a heterogeneous physiological cell population...

Data from: Cortical thickness, surface area and subcortical volume differentially contribute to cognitive heterogeneity in Parkinson's disease

Niels Gerrits, Anita Van Loenhoud, Stan Van Den Berg, Henk Berendse, Elisabeth Foncke, Martin Klein, Diederick Stoffers, Ysbrand Van Der Werf & Odile Van Den Heuvel
Parkinson's disease (PD) is often associated with cognitive deficits, although their severity varies considerably between patients. Recently, we used voxel-based morphometry (VBM) to show that individual differences in gray matter (GM) volume relate to cognitive heterogeneity in PD. VBM does, however, not differentiate between cortical thickness (CTh) and surface area (SA), which might be independently affected in PD. We therefore re-analyzed our cohort using the surface-based method FreeSurfer, and investigated (i) CTh, SA, and (sub)cortical...

Data from: High bandwidth synaptic communication and frequency tracking in human neocortex

Guilherme Testa-Silva, Matthijs B. Verhoog, Daniele Linaro, Christiaan P. J. De Kock, Johannes C. Baayen, Rhiannon M. Meredith, Chris I. De Zeeuw, Michele Giugliano & Huibert D. Mansvelder
Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than rodent synapses. To test this, we recorded from connected pairs of pyramidal neurons in acute brain slices of adult human and mouse temporal cortex and probed the dynamical properties of use-dependent plasticity. We found that human synaptic connections were...

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Affiliations

  • Netherlands Institute for Neuroscience
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  • Royal Netherlands Academy of Arts and Sciences
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  • VU University Amsterdam
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