561 Works

Additional file 2 of Comparative study of excretory–secretory proteins released by Schistosoma mansoni-resistant, susceptible and naïve Biomphalaria glabrata

Conor E. Fogarty, Min Zhao, Donald P. McManus, Mary G. Duke, Scott F. Cummins & Tianfang Wang
Additional file 2: Table S1. Statistical analysis of behavioural bioassays. Two-way ANONA method was used to evaluate the significance of the behavioural modifications.

MOESM2 of Comparative study of excretoryâ secretory proteins released by Schistosoma mansoni-resistant, susceptible and naĂŻve Biomphalaria glabrata

Conor Fogarty, Min Zhao, Donald McManus, Mary Duke, Scott Cummins & Tianfang Wang
Additional file 2: Table S1. Statistical analysis of behavioural bioassays. Two-way ANONA method was used to evaluate the significance of the behavioural modifications.

MOESM4 of Comparative study of excretoryâ secretory proteins released by Schistosoma mansoni-resistant, susceptible and naĂŻve Biomphalaria glabrata

Conor Fogarty, Min Zhao, Donald McManus, Mary Duke, Scott Cummins & Tianfang Wang
Additional file 4: Table S3. A list of the total proteins, unique proteins and corresponding peptides identified resistant B. glabrata with reference to the B. glabrata proteome.

MOESM8 of Comparative study of excretoryâ secretory proteins released by Schistosoma mansoni-resistant, susceptible and naĂŻve Biomphalaria glabrata

Conor Fogarty, Min Zhao, Donald McManus, Mary Duke, Scott Cummins & Tianfang Wang
Additional file 8: Table S5. A list of the total proteins, unique proteins and corresponding peptides identified in susceptible B. glabrata SCW with reference to the S. mansoni proteome, and enriched GO terms related to the proteins.

Development of an automatic integrated gene detection system for novel severe acute respiratory syndrome-related coronavirus (SARS-CoV2)

Yuchang Li, Jing Li, Ying Zhang, Lizhong Dai, Lin Li, Juan Liu, Sen Zhang, Xiaoyan Wu, Yi Hu, Chengfeng Qin, Tao Jiang & Xiaoping Kang
In December 2019, Wuhan, China suffered a serious outbreak of a novel coronavirus infectious disease (COVID) caused by novel severe acute respiratory syndrome-related coronavirus (SARS-CoV 2). To quickly identify the pathogen, we designed and screened primer sets, and established a sensitive and specific qRT-PCR assay for SARS-CoV 2; the lower limit of detection (LOD) was 15 (95% CI: 9.8–21) copies per reaction. We combined this qRT-PCR assay with an automatic integration system for nucleic acid...

Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

Huan Han, Qingfeng Ma, Cong Li, Rui Liu, Li Zhao, Wei Wang, Pingan Zhang, Xinghui Liu, Guosheng Gao, Fang Liu, Yingan Jiang, Xiaoming Cheng, Chengliang Zhu & Yuchen Xia
Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While the majority of patients were considered mild, critically ill patients involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm is associated with severe outcome. We enrolled 102 COVID-19 patients who were admitted to Renmin Hospital (Wuhan, China). All patients were classified into moderate, severe...

Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population

Qian Xin, Gang Xin, Li Li, Wenjuan Sun, Wen Jiang, Jue Wang, Yun Luan, Ying Zhang, Ling Cheng, Shuhong Duan, Fanzhen Hong, Qinghong Ji & Weihong Ma
Preeclampsia (PE) is a disorder that occurs during the pregnancy and could affect the maternal and perinatal mortality as well as morbidity. The aim of our study is to investigate the associations between the hypertension susceptibility genes ITGA9, MOV10 and CACNB2 with PE in Chinese Han population. A case–control study including 178 PE patients and 202 healthy controls was conducted to assess the associations between three loci (ITGA9 rs155524, MOV10 rs2932538 and CACNB2 rs4373814) and...

Comprehensive analysis of lncRNA expression profiles in cytopathic biotype BVDV-infected MDBK cells provides an insight into biological contexts of host–BVDV interactions

Xuwen Gao, Chao Niu, Zhuo Wang, Shuo Jia, Meijing Han, Yingying Ma, Xueting Guan, Li Wang, Xinyuan Qiao & Yigang Xu
Bovine viral diarrhea virus (BVDV) is the causative agent of bovine viral diarrhea-mucosal disease, which significantly affects the production performance of cattle, causing serious economic losses to the cattle industries worldwide. Up to now, some mechanisms involved in host–BVDV interaction are still not fully understood. The discovery of long non-coding RNAs (lncRNAs) has provided a new perspective on gene regulation in diverse biological contexts, particularly in viral infection and host immune responses. However, little is...

Additional file 8 of Temporal expression study of miRNAs in the crown tissues of winter wheat grown under natural growth conditions

Menglei Wang, Chenhui Yang, Kangning Wei, Miao Zhao, Liqiang Shen, Jie Ji, Li Wang, Daijing Zhang, Junqiang Guo, Yun Zheng, Juanjuan Yu, Mo Zhu, Haiying Liu & Yong-Fang Li
Additional file 8: Table S5. Sequence of primers used in this study.

Circular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells

Yuefu Han, Xingqiao Wen, Xiaojuan Li, Dong Chen, Lian Peng, Bin Lai & Hongcai Huang
Numerous differentially expressed circular RNAs (circRNAs) have been identified; however, their roles have not been fully elucidated. Since dysregulated circRNAs may have clinical applications, it is vital to study their expression characteristics, function, and mechanism in prostate cancer cells. The role, regulatory mechanism, and expression of hsa_circ_0075542 were analyzed using quantitative reverse transcription polymerase chain reaction. The results indicated that the expression of hsa_circ_0075542 was downregulated in prostate tumor tissues. The functions of prostate cancer...

Long non-coding RNA TRPM2 antisense RNA as a potential therapeutic target promotes tumorigenesis and metastasis in esophageal cancer

Wei Wang, Yukai Dai, Xin Yang & Xinming Xiong
Esophageal cancer (EC) is one type of aggressive gastrointestinal cancers. The treatment of EC is challenging. Effective therapeutic targets require development. Long non-coding RNA TRPM2 antisense RNA (LncRNA TRPM2-AS) is considering a novel biomarker and therapeutic target for various types of cancer. However, the role of lncRNA TRPM2-AS in EC remains unknown. This study aimed to illustrate effects of LncRNA TRPM2-AS on EC growth and metastasis and potential underlying molecular mechanisms. LncRNA TRPM2-AS expression was...

Circular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells

Yuefu Han, Xingqiao Wen, Xiaojuan Li, Dong Chen, Lian Peng, Bin Lai & Hongcai Huang
Numerous differentially expressed circular RNAs (circRNAs) have been identified; however, their roles have not been fully elucidated. Since dysregulated circRNAs may have clinical applications, it is vital to study their expression characteristics, function, and mechanism in prostate cancer cells. The role, regulatory mechanism, and expression of hsa_circ_0075542 were analyzed using quantitative reverse transcription polymerase chain reaction. The results indicated that the expression of hsa_circ_0075542 was downregulated in prostate tumor tissues. The functions of prostate cancer...

Foliar nutrient diagnosis norms for litchi (Litchi chinensis Sonn. cv. Feizixiao) in South China

Donglin Luo, Wei Wang, Cuihua Bai, Luwei Zhu, Huan Li, Changmin Zhou, Quanmin Qiu & Lixian Yao
Foliar nutrient diagnosis is a potent tool for nutrient management in crops. Litchi (Litchi chinensis Sonn.) plantation in China dominates the worldwide litchi cultivation, and Feizixiao is the most widely cultivated species in China. Herein, 538 leaf samples were collected at fruit swelling stage and the terminal shoot maturing stage during 2016–2017, and the fruit yields of all the sampled trees were recorded. The suitability of four nutrient diagnosis methods including critical value approach (CVA),...

Molecular evidence to the day length in regulating the short shoot phenomenon during summer in roses (Rosa sp.)

Li Wang, Wan Jiang, Wuhua Zhang, Weitong Chen, Yu Mo, Tong Zhou, Jinzhu Zhang & Daidi Che
The short shoot phenomenon is an important phenotype underlying the economic value of roses – node number can directly affect shoot length. To elucidate the molecular mechanism of how day length affects shoot length, the effect of 8, 10, and 12 h day lengths on node number were studied. The number of nodes between the 8 and 12 h treatment groups significantly differed. Node development in the 12 h treatment group occurred significantly earlier than...

Preparation of hollow Aux-Cu2O nanospheres by galvanic replacement to enhance the selective electrocatalytic CO2 reduction to ethanol

Lijie Zhang, Ying Zhang, Hongtao Wang, Jianbing Chen & Zhongqi Cao
Electrocatalytic CO2 reduction to fuel is one of the important ways to solve energy and environmental problems. In this work, the preparation of hollow Aux-Cu2O electrocatalyst and the performance of electrocatalytic CO2 reduction to ethanol were studied. Hollow Cu2O nanospheres were prepared by a soft template method, and Aux-Cu2O composites were prepared by galvanic replacement. The characterization results of XRD and XPS reveal that Cu+ is the main chemical state of Cu in the catalysts....

Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups

Qi Wang, Jie Liu, Zi-Dan Zhou, Ke-Xin Zhou, Fei Li, Qi-Wen Zhang, Shou-Kai Wang, Wei Wang, Zhen Jin & You-Zhi Tang
A series of pleuromutilin derivatives containing alkylamine and nitrogen heterocycle groups were designed and synthesised under mild conditions. The in vitro antibacterial activity of these semisynthetic derivatives against four strains of Staphylococcus aureus (MRSA ATCC 43300, S.aureus ATCC 29213, S.aureus AD3, and S.aureus 144) were evaluated by the broth dilution method. Compound 13 was found to have excellent antibacterial activity against MRSA (MIC = 0.0625 μg/mL). Furthermore, compound 13 was further studied by the time-killing...

Additional file 1 of Comparative clinical outcome following individualized follitropin delta dosing in Chinese women undergoing ovarian stimulation for in vitro fertilization /intracytoplasmic sperm injection

Rui Yang, Yunshan Zhang, Xiaoyan Liang, Xueru Song, Zhaolian Wei, Jianqiao Liu, Yezhou Yang, Jichun Tan, Qingxue Zhang, Yingpu Sun, Wei Wang, Weiping Qian, Lei Jin, Shuyu Wang, Yang Xu, Jing Yang, Marie Goethberg, Bernadette Mannaerts, Wen Wu, Zugeng Zheng & Jie Qiao
Additional file 1: Additional Figure 1. Study design and study timeline. AE, adverse event; OHSS, ovarian hyperstimulation syndrome; GnRH, gonadotropin-releasing hormone

Additional file 1 of Systematic comparation of the biological and transcriptomic landscapes of human amniotic mesenchymal stem cells under serum-containing and serum-free conditions

Yunyan Sun, Ti-er Wang, Qianwen Hu, Wenxia Zhang, Yun Zeng, Xun Lai, Leisheng Zhang & Mingxia Shi
Additional file 1: Figure S1. Cell vitality assay of hAMSCs with PI3K-AKT-mTOR signal reactivation and tumorigenicity assay.

Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Their Dynamic Changes with Type 2 Diabetes Mellitus: A Cohort Study in China

Canjia Zhang, Huan Chen, Shangxin Cui, Yeli Lin, Yongqiang Liang, Ping Zhao, Changyi Wang, Shan Xu, Xiaolin Peng, Hongen Chen, Li Wang, Dan Zhao, Ming Zhang, Dongsheng Hu, Yanmei Lou & Fulan Hu
This study aimed at investigating the relationships between Platelet-Lymphocyte ratio (PLR) and Neutrophil–Lymphocyte ratio (NLR) and their dynamic changes (∆PLR, ∆NLR) with type 2 diabetes mellitus (T2DM) in a Chinese cohort study. This study recruited 41,439 individuals who were diagnosed without T2DM at first health examination and completed at least one follow-up. The relationships between NLR, PLR, ∆PLR, ∆NLR and T2DM risk were analyzed using the Cox regression model with corresponding Hazard Ratios (HRs) and...

Associations of RPEL1 and miR-1307 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in Chinese systemic lupus erythematosus patients

Zi-Ye Yan, Wan-Qin Hu, Qi-Qun Zong, Guang-Hui Yu, Chun-Xia Zhai, Lin-Lin Wang, Yu-Hua Wang, Ting-Yu Zhang, Zhen Li, Ying Teng, Jing Cai, Yang-Fan Chen, Mu Li, Zhou-Zhou Xu, Fa-Ming Pan, Hai-Feng Pan, Hong Su & Yan-Feng Zou
ObjectiveOur present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients.MethodsInitially, 1000 participants (500 SLE cases and 500 controls) were recruited for the case–control study. Then, 429 cases who received GCs were followed through 12 weeks to explore GCs efficacy, depression, anxiety, and HRQoL. We selected the iMLDR technique...

Associations of RPEL1 and miR-1307 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in Chinese systemic lupus erythematosus patients

Zi-Ye Yan, Wan-Qin Hu, Qi-Qun Zong, Guang-Hui Yu, Chun-Xia Zhai, Lin-Lin Wang, Yu-Hua Wang, Ting-Yu Zhang, Zhen Li, Ying Teng, Jing Cai, Yang-Fan Chen, Mu Li, Zhou-Zhou Xu, Fa-Ming Pan, Hai-Feng Pan, Hong Su & Yan-Feng Zou
ObjectiveOur present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients.MethodsInitially, 1000 participants (500 SLE cases and 500 controls) were recruited for the case–control study. Then, 429 cases who received GCs were followed through 12 weeks to explore GCs efficacy, depression, anxiety, and HRQoL. We selected the iMLDR technique...

Additional file 1 of Artificial intelligence for quantifying immune infiltrates interacting with stroma in colorectal cancer

Jing Yang, Huifen Ye, Xinjuan Fan, Yajun Li, Xiaomei Wu, Minning Zhao, Qingru Hu, Yunrui Ye, Lin Wu, Zhenhui Li, Xueli Zhang, Changhong Liang, Yingyi Wang, Yao Xu, Qian Li, Su Yao, Dingyun You, Ke Zhao & Zaiyi Liu
Additional file 1.

Additional file 1 of Dietary vitamin A intakes of chinese children with adequate liver stores as assessed by the retinol isotope dilution technique

Jing Zeng, Yanming Li, Yan Ren, Weiwei Gu, Zhaolin Li, Mei Yang & Bing Xiang
Supplementary Material 1

Improving winter wheat yield estimation under complex irrigation conditions through coupling APSIM crop growth model and the machine learning approach

Quandi Niu, Jianxi Huang, Xuecao Li, Hai Huang, Haixiang Guan, Wei Wang, Wei Su, Li Li, Shuangxi Miao & Dongqin Yin
The annual dynamics of winter wheat yield in Henan, China from 2018 to 2021 are provided, with the resolution of 20m and GeoTiff format.

sj-docx-1-npx-10.1177_1934578X221127960 - Supplemental material for The Effect of Coumestrol on Hub Genes in Lung Squamous Cell Carcinoma Based on Bioinformatic Strategy

Qingqing Shan, Yifan Zhang, Xu Zhang, Wei Wang & Zongan Liang
Supplemental material, sj-docx-1-npx-10.1177_1934578X221127960 for The Effect of Coumestrol on Hub Genes in Lung Squamous Cell Carcinoma Based on Bioinformatic Strategy by Qingqing Shan, Yifan Zhang, Xu Zhang, Wei Wang and Zongan Liang in Natural Product Communications

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