1,179 Works

Genomic characteristics of two breast malignant phyllodes tumors during pregnancy and lactation identified through whole-exome sequencing

Tinge Lei, Mengjia Shen, Xu Deng, Yongqiang Shi, Yan Peng, Hui Wang & Tongbing Chen
Abstract Background The genomic landscape of breast malignant phyllodes tumors (PTs) is not well defined, especially pregnancy-related malignant PTs. To clarify this topic, whole-exome next-generation sequencing (NGS) was performed on tumor samples and paired normal breast tissues from two pregnancy-related malignant PTs, followed by a functional analysis of the genetic alterations. Methods DNA from malignant PT samples and matched normal breast tissues of both patients were subjected to molecular profiling. NGS of the whole-exome was...

Optimization of the vancomycin administration regimen by clinical pharmacists based on a population pharmacokinetics model: a prospective interventional study

Haodi Lu, Lufen Duan, Yanxia Yu, Jingjing Li, Lu Shi, Sudong Xue, Qian Zhang, Qin Zhou, Chenqi Zhu, Erning Shang, Xinxin Yan & Lian Tang
In vancomycin treatment, the rates of correct blood sampling and initial trough concentrations within the target range are very low. Studies of interventions by clinical pharmacists based on population pharmacokinetics (PPK) models are limited. This study aimed to evaluate the intervention effect of clinical pharmacist-mediated optimization of the vancomycin administration regimen based on a PPK model. Retrospectively enrolled patients constituted the control group, and prospectively enrolled patients constituted the intervention group. The vancomycin administration regimen,...

Additional file 1 of Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies

Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao & Wei Zhang
Additional file 1: Table S1. Clinical improvements in rituximab cohort and control cohort

sj-pdf-4-cix-10.1177_11769351221126285 – Supplemental material for Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer

Yu Sun & Jun Zhao
Supplemental material, sj-pdf-4-cix-10.1177_11769351221126285 for Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer by Yu Sun and Jun Zhao in Cancer Informatics

sj-pdf-5-cix-10.1177_11769351221126285 – Supplemental material for Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer

Yu Sun & Jun Zhao
Supplemental material, sj-pdf-5-cix-10.1177_11769351221126285 for Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer by Yu Sun and Jun Zhao in Cancer Informatics

sj-pdf-5-cix-10.1177_11769351221126285 – Supplemental material for Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer

Yu Sun & Jun Zhao
Supplemental material, sj-pdf-5-cix-10.1177_11769351221126285 for Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer by Yu Sun and Jun Zhao in Cancer Informatics

Additional file 3 of Facilitators, barriers and strategies for health-system guidance implementation: a critical interpretive synthesis protocol

Qi Wang, Ying Zhu, Shitong Xie, Mohammad Golam Kibria, Qiangqiang Guo, Ahmed Atef Belal, Yanfei Li, Jingyi Zhang, Yaolong Chen, Holger J. Schünemann, Michael G. Wilson, Kehu Yang & John N. Lavis
Additional file 3. Data extraction form.

Additional file 2 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 2: Table S2. Plasmids used in this study.

Additional file 3 of Construction and yield optimization of a cinnamylamine biosynthesis route in Escherichia coli

Qi Wang, Linlin Ma, Zhiguo Wang, Quan Chen, Qian Wang & Qingsheng Qi
Additional file 3: Table S3. Oligonucleotides used in this study.

sj-docx-1-cll-10.1177_09636897221124485 – Supplemental material for Identification of Immune Infiltration and Effective Immune Biomarkers in Acute Lung Injury by Bioinformatics Analysis

Dandan Ling, Xiang Zhang, Jiamin Wu, Qianyun Xu, Zhiyong He & Jun Zhang
Supplemental material, sj-docx-1-cll-10.1177_09636897221124485 for Identification of Immune Infiltration and Effective Immune Biomarkers in Acute Lung Injury by Bioinformatics Analysis by Dandan Ling, Xiang Zhang, Jiamin Wu, Qianyun Xu, Zhiyong He and Jun Zhang in Cell Transplantation

sj-docx-1-cll-10.1177_09636897221124485 – Supplemental material for Identification of Immune Infiltration and Effective Immune Biomarkers in Acute Lung Injury by Bioinformatics Analysis

Dandan Ling, Xiang Zhang, Jiamin Wu, Qianyun Xu, Zhiyong He & Jun Zhang
Supplemental material, sj-docx-1-cll-10.1177_09636897221124485 for Identification of Immune Infiltration and Effective Immune Biomarkers in Acute Lung Injury by Bioinformatics Analysis by Dandan Ling, Xiang Zhang, Jiamin Wu, Qianyun Xu, Zhiyong He and Jun Zhang in Cell Transplantation

Additional file 2 of Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Tine De Coster, Heleen Masset, Olga Tšuiko, Maaike Catteeuw, Yan Zhao, Nicolas Dierckxsens, Ainhoa Larreategui Aparicio, Eftychia Dimitriadou, Sophie Debrock, Karen Peeraer, Marta de Ruijter-Villani, Katrien Smits, Ann Van Soom & Joris Robert Vermeesch
Additional file 2: Figure S2. Analysis of blastomeres following multipolar zygotic division. A) Interpretation of haplarithm plots. Overview of chromosome-wise haplarithm patterns for distinct genomic constitutions (i.e. biparental disomy, paternal monosomy and paternal meiotic/dispermic uniparental heterodisomy). Corresponding whole-genome errors (i.e. biparental diploid or androgenetic) are characterized by the manifestation of those patterns throughout the (majority of the) genome. Defined single-cell BAF values of the segmented P1, P2, M1 and M2, form haplotype blocks, demarcated by...

Additional file 8 of Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Tine De Coster, Heleen Masset, Olga Tšuiko, Maaike Catteeuw, Yan Zhao, Nicolas Dierckxsens, Ainhoa Larreategui Aparicio, Eftychia Dimitriadou, Sophie Debrock, Karen Peeraer, Marta de Ruijter-Villani, Katrien Smits, Ann Van Soom & Joris Robert Vermeesch
Additional file 8: Figure S8. Anuclear blastomeres and fragments. A) Phylogenetic tree based on reassembled mitochondrial genomes of 11 anuclear blastomeres and two anuclear fragments, showing a common ancestor for sequenced blastomeres and fragments retrieved from the same embryo. One anuclear blastomere was not included. B) Box plots and median values of the number of raw reads per 10 Mb bin (y-axis) per chromosome (chr1 - chrX) and for the mitochondrial DNA (chrM) (x-axis) as...

Correlation analysis between the static and the changed neutrophil-to-lymphocyte ratio and in-hospital mortality in critical patients with acute heart failure

Tao Liu, Bing Wang, Shengjue Xiao, Lifang Sun, Zhijian Zhu, Shasha Wang, Baoyin Li, Jianhui Yao, Conggang Huang, Wei Ge, Lei Qian, Zhigang Lu & Yesheng Pan
Association between neutrophil-to-lymphocyte ratio (NLR) on admission and poor prognosis in patients with acute heart failure (AHF) has been well established. However, the relationship between dynamic changes in NLR and in-hospital mortality in AHF patients has not been studied. Our purpose was to determine if an early change in NLR within the first week after AHF patients was admitted to intensive care unit (ICU) was associated with in-hospital mortality. Data from the medical information mart...

Additional file 1 of Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Additional file 1: Supplementary Fig. S1. qRT-PCRassessmentsoftransfectionefficiencies The transfection efficiencies of miR-200a-3p mimics (A), sh-miR-200a-3p (B), and YAP(C)wereperformedinC33A,SihaandHelacells.*p<0.05, **p<0.01,***p<0.001,ns:notsignificant. The authors declare that they have no competing interests. Supplementary Fig. S2. themRNAandproteinlevelsofYAPinHelacells Significant decreases in levels of YAP mRNA (A) and YAP protein (B) following up-regulations of miR-200a-3p, or significant increases in levels of YAP mRNA (C) and protein (D) following down-regulations of miR-200a-3p were not observed in Helacells.*p<0.05,**p<0.01,***p<0.001,ns:notsignificant.

Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Abstract Background Although evidence has revealed that miR-200a-3p is involved in the malignant progression of various tumors, the regulatory mechanism of miR-200a-3p in the development of cervical cancer (CC) cells with different HPV statuses remains unknown. The present study was to investigate the differential effects of either miR-200a-3p or YAP on tumorous cells’ fate in vitro in HPV-negative and HPV-positive cervical cancer cell models, and to explore if the changes in proliferation, migration, and invasion...

Additional file 5 of System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma

Cheng Yan, Yandie Niu, Feng Li, Wei Zhao & Liukai Ma
Additional file 5: Figure S5. GSEA enrichment analysis identifies KEGG pathways associated with high-risk and low-risk groups in the training set (A) and test set (B).

Additional file 7 of System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma

Cheng Yan, Yandie Niu, Feng Li, Wei Zhao & Liukai Ma
Additional file 7: Figure S7. Kaplan-Meier curves of the prognostic pyroptosis-related genes in the training set. The survival curves of NLRP1 (A), NLRP2 (B), GSDMC (C), IL18 (D), CASP4 (E).

Additional file 1 of System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma

Cheng Yan, Yandie Niu, Feng Li, Wei Zhao & Liukai Ma
Additional file 1: Figure S1. Functional enrichment analyses of gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). (A) Bubble graph for GO enrichment (the bigger bubble means the more genes enriched, and the increasing depth of red means the differences were more obvious; q-value: the adjusted p-value). (B) KEGG enrichment analysis of differentially expressed genes.

Additional file 10 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 10. 1430 genes that are significantly regulated between EBP and Ctrl but not between EB and Ctrl.

Additional file 2 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 2. 1261 Differentially expressed genes between the WT and AF1_FFF uterus on GD3.

Additional file 1 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 1: Fig. S1. Genotyping, PGR levels fertility of AF1 mutant mice. Fig. S2. AF1_FFF mutation did not affect nuclear localization of PGR. Fig. S3. Serum concentrations of progesterone on GD3 and GD4.5 between the genotypes are not significantly different. Fig. S4. AF1 mediates progesterone suppression of estrogen regulated cell proliferation genes. Fig. S5. AF1 mediates progesterone suppression of estrogen regulated Mtorc1 signaling, interferon gamma response, and hypoxia Hallmark gene sets. Fig. S6. The...

Additional file 9 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 9. 386 EB-regulated genes also regulated by progesterone compared between EB and EBP.

Additional file 4 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 4. 1341 Differentially expressed genes between the WT and AF1_FFF uterus on GD4.5.

Additional file 5 of Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li & Valerie C. L. Lin
Additional file 5. 901 Common genes between estrogen-regulated in the OVX WT and dysregulated in the AF_FFF GD4.5.

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