248 Works

Whole blood DNA methylomes of 958 healthy adults from the Milieu Intérieur cohort

Jacob Bergstedt, Sadoune Ait Kaci Azzou, Kristin Tsuo, Anthony Jaquaniello, Alejandra Urrutia, Maxime Rotival, David T. S. Lin, Julia MacIsaac, Michael Kobor, Matthew Albert, Darragh Duffy, Etienne Patin & Lluis Quintana-Murci
Dataset description: DNA methylation, one of the most studied epigenetic marks in humans, is associated with several non-communicable diseases, including multiple sclerosis, type 2 diabetes and cardiovascular disease, and may thus serve as a valuable biomarker of disease status. Yet, the factors that drive epigenetic variation in humans, particularly those relating to the immune system, remain to be fully characterized. To investigate factors impacting population variation in DNA methylation, we generated whole blood-derived DNA methylation...

Les métiers du grand âge, métiers à risque ? (LIEPP Policy Brief, n°56)

Thomas Rapp, Jérôme Ronchetti & Jonathan SICSIC
Les métiers du grand âge sont au cœur des politiques du bien-vieillir des pays Européens. Les travailleurs du secteur apportent des soins en établissement et au domicile des personnes. Ces métiers sont pénibles et ont souvent un impact négatif sur la santé (fonctionnelle et mentale) des travailleurs. Si cet effet délétère des métiers du grand âge est souvent cité comme un frein à la rétention des travailleurs dans le secteur, il est encore mal documenté....

Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning

Thomas Jaylet, Roel Quintens, Mohamed Abderrafi Benotmane, Jukka Luukkonen, Ignacia Braga Tanaka, Chrystelle Ibanez, Christelle Durand, Magdalini Sachana, Omid Azimzadeh, Christelle Adam-Guillermin, Knut Erik Tollefsen, Olivier Laurent, Karine Audouze & Olivier Armant
Brain development during embryogenesis and in early postnatal life is particularly complex and involves the interplay of many cellular processes and molecular mechanisms, making it extremely vulnerable to exogenous insults, including ionizing radiation (IR). Microcephaly is one of the most frequent neurodevelopmental abnormalities that is characterized by small brain size, and is often associated with intellectual deficiency. Decades of research span from epidemiological data on in utero exposure of the A-bomb survivors, to studies on...

Radiation adverse outcome pathways (AOPs) are on the horizon: advancing radiation protection through an international Horizon-Style exercise

Julie J. Burtt, Julie Leblanc, Kristi Randhawa, Addie Ivanova, Murray A. Rudd, Ruth Wilkins, Edouard I. Azzam, Markus Hecker, Nele Horemans, Hildegarde Vandenhove, Christelle Adam-Guillermin, Olivier Armant, Dmitry Klokov, Karine Audouze, Jan Christian Kaiser, Simone Moertl, Katalin Lumniczky, Ignacia B. Tanaka, Yutaka Yamada, Nobuyuki Hamada, Isaf Al-Nabulsi, R. Julian Preston, Simon Bouffler, Kimberly Applegate, Donald Cool … & Vinita Chauhan
The Adverse Outcome Pathway (AOP) framework, a systematic tool that can link available mechanistic data with phenotypic outcomes of relevance to regulatory decision-making, is being explored in areas related to radiation risk assessment. To examine the challenges including the use of AOPs to support the radiation protection community, an international horizon-style exercise was initiated through the Organisation for Economic Co-operation and Development Nuclear Energy Agency High-Level Group on Low Dose Research Radiation/Chemical AOP Joint Topical...

Additional file 2 of EEG resting-state functional connectivity: evidence for an imbalance of external/internal information integration in autism

Prany Wantzen, Patrice Clochon, Franck Doidy, Fabrice Wallois, Mahdi Mahmoudzadeh, Pierre Desaunay, Mille Christian, Jean-Marc Guilé, Fabian Guénolé, Francis Eustache, Jean-Marc Baleyte & Bérengère Guillery-Girard
Additional file 2. Backward stepwise regression analyses with age and ASD symptomatology (AQ) as individual predictors on connectivity values (within and between-RSN functional connectivity) that were significantly different between groups. Significant results were obtained only for the TD group. SMN: sensorimotor network; DAN: dorsal attention network; DMN: default mode network; L: left, R: right. RSNs: Resting State Networks.

Leukocyte telomere length, allelic variations in related genes and risk of coronary heart disease in people with long-standing type 1 diabetes

Manuel Sanchez, Caroline Kannengiesser, Sophie Hoang, Louis Potier, Frédéric Fumeron, Nicolas Venteclef, André Scheen, Jean-François Gautier, Samy Hadjadj, Michel Marre, Ronan Roussel, Kamel Mohammedi & Gilberto Velho
Abstract Background Type 1 diabetes is associated with accelerated vascular aging and advanced atherosclerosis resulting in increased rates of cardiovascular disease and premature death. We evaluated associations between Leukocyte telomere length (LTL), allelic variations (SNPs) in LTL-related genes and the incidence of coronary heart disease (CHD) in adults with long-standing type 1 diabetes. Methods We assessed associations of LTL, measured at baseline by RT–PCR, and of SNPs in 11 LTL-related genes with the risk of...

Additional file 1 of Assessing real-world effectiveness of therapies: what is the impact of incretin-based treatments on hospital use for patients with type 2 diabetes?

Clémence Bussiere, Pauline Chauvin, Jean-Michel Josselin & Christine Sevilla-Dedieu
Supplementary Material 1

Accuracy of clinicians’ ability to predict the need for renal replacement therapy: a prospective multicenter study

Alexandre Sitbon, Michael Darmon, Guillaume Geri, Paul Jaubert, Pauline Lamouche-Wilquin, Clément Monet, Lucie Le Fèvre, Marie Baron, Marie-Line Harlay, Côme Bureau, Olivier Joannes-Boyau, Claire Dupuis, Damien Contou, Virginie Lemiale, Marie Simon, Christophe Vinsonneau, Clarisse Blayau, Frederic Jacobs & Lara Zafrani
Abstract Purpose Identifying patients who will receive renal replacement therapy (RRT) during intensive care unit (ICU) stay is a major challenge for intensivists. The objective of this study was to evaluate the performance of physicians in predicting the need for RRT at ICU admission and at acute kidney injury (AKI) diagnosis. Methods Prospective, multicenter study including all adult patients hospitalized in 16 ICUs in October 2020. Physician prediction was estimated at ICU admission and at...

Additional file 1 of Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude & Johanna Lepeule
Additional file 1: Supplementary methods and figures S1-S7. S1 - Workflow of DNA methylation data pre-processing; S2 - Overview of blood pressure data; S3 - Reference placental cell-type composition observed in the EDEN cohort; S4 - Pearson correlation between DMR effect sizes; S5.A - Sensitivity analyses for DMRs found in our main analysis; S5.B - Sensitivity analysis excluding preeclampsia cases for the DMRs found in our main analysis; S6.A - Magnitude and 95% confidence intervals...

Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude & Johanna Lepeule
Abstract Background Maternal blood pressure levels reflect cardiovascular adaptation to pregnancy and proper maternal-fetal exchanges through the placenta and are very sensitive to numerous environmental stressors. Maternal hypertension during pregnancy has been associated with impaired placental functions and with an increased risk for children to suffer from cardiovascular and respiratory diseases later on. Investigating changes in placental DNA methylation levels and cell-type composition in association with maternal blood pressure could help elucidate its relationships with...

Phenotypic variability in 446 CADASIL patients: Impact of NOTCH3 gene mutation location in addition to the effects of age, sex and vascular risk factors

Charlotte Dupé, Stéphanie Guey, Lucie Biard, Sokhna Dieng, Jessica Lebenberg, Lina Grosset, Nassira Alili, Dominique Hervé, Elisabeth Tournier-Lasserve, Eric Jouvent, Sylvie Chevret & Hugues Chabriat
The recent discovery that the prevalence of cysteine mutations in the NOTCH3 gene responsible for CADASIL was more than 100 times higher in the general population than that estimated in patients highlighted that the mutation location in EGFr-like-domains of the NOTCH3 receptor could have a major effect on the phenotype of the disease. The exact impact of such mutations locations on the multiple facets of the disease has not been fully evaluated. We aimed to...

Additional file 4 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Additional file 4 Supplementary Table 4. List of 21 relevant functional networks identified by performing a network analysis in IPA on 335 differentially expressed mRNAs.

Additional file 8 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Additional file 8 Supplementary Table 8. List of 2027 significant mature miRNA-mRNA interactions with p-value ≤0.05 and Pearson correlation index ρ ≤ − 0.5.

Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Abstract Background Bipolar Disorder (BD) is a complex mental disease characterized by recurrent episodes of mania and depression. Lithium (Li) represents the mainstay of BD pharmacotherapy, despite the narrow therapeutic index and the high variability in treatment response. However, although several studies have been conducted, the molecular mechanisms underlying Li therapeutic effects remain unclear. Methods In order to identify molecular signatures and biological pathways associated with Li treatment response, we conducted transcriptome and miRNome microarray...

Additional file 3 of Residential proximity to croplands at birth and childhood leukaemia

Sophie Bamouni, Denis Hémon, Laure Faure, Jacqueline Clavel & Stéphanie Goujon
Additional file 3: Additional Table 1. Association between the incidence rate of childhood acute lymphoblastic leukaemia and three potential ecological confounders characterising the municipality of residence at birth: size of urban unit, residential UV radiation exposure, and a socioeconomic deprivation index (RNCE, 1990–2015).

Additional file 4 of Residential proximity to croplands at birth and childhood leukaemia

Sophie Bamouni, Denis Hémon, Laure Faure, Jacqueline Clavel & Stéphanie Goujon
Additional file 4: Additional Table 2. Distribution of the at-risk population a over 1990-2015 by category of crop density and potential confounding factor stratum (size of urban unit, residential UV radiation exposure, and a French deprivation index), children born in 1990-2015, mainland France.

Additional file 4 of Residential proximity to croplands at birth and childhood leukaemia

Sophie Bamouni, Denis Hémon, Laure Faure, Jacqueline Clavel & Stéphanie Goujon
Additional file 4: Additional Table 2. Distribution of the at-risk population a over 1990-2015 by category of crop density and potential confounding factor stratum (size of urban unit, residential UV radiation exposure, and a French deprivation index), children born in 1990-2015, mainland France.

Residential proximity to croplands at birth and childhood leukaemia

Sophie Bamouni, Denis Hémon, Laure Faure, Jacqueline Clavel & Stéphanie Goujon
Abstract Background Domestic and parental occupational pesticide exposures are suspected of involvement in the occurrence of childhood acute leukaemia (AL), but the role of exposure to agricultural activities is little known. In a previous ecological study conducted in France, we observed an increase in acute lymphoblastic leukaemia (ALL) incidence rate with increasing viticulture density in the municipalities of residence at diagnosis. Objectives This study aimed to test the hypothesis that residential proximity to croplands at...

Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa.

Kesego Tapela, Fatima O Oyawoye, Charles Ochieng' Olwal, Precious C Opurum, Jones Amo Amponsah, Kekeli Aku Lumor Segbedzi, Becky Tetteh, Frederick Kumi-Ansah, Joe K Mutungi, Evangeline Obodai, Emmanuella Amoako, Seth Agyemang, Nicaise Tuikue Ndam, William Kwabena Ampofo, Julian C Rayner, Gordon A Awandare, Lily Paemka, Yaw Bediako & Peter Kojo Quashie
BACKGROUND: West Africa has recorded a relatively higher proportion of asymptomatic coronavirus disease 2019 (COVID-19) cases than the rest of the world, and West Africa-specific host factors could play a role in this discrepancy. Here, we assessed the association between COVID-19 severity among Ghanaians with their immune profiles and ABO blood groups. METHODS: Plasma samples were obtained from Ghanaians PCR-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive individuals. The participants were categorized into symptomatic and...

Additional file 4 of Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa

Kesego Tapela, Fatima O. Oyawoye, Charles Ochieng’ Olwal, Precious C. Opurum, Jones Amo Amponsah, Kekeli Aku Lumor Segbedzi, Becky Tetteh, Frederick Kumi-Ansah, Joe K. Mutungi, Evangeline Obodai, Emmanuella Amoako, Seth Agyemang, Nicaise Tuikue Ndam, William Kwabena Ampofo, Julian C. Rayner, Gordon A. Awandare, Lily Paemka, Yaw Bediako & Peter Kojo Quashie
Additional file 4. Cytokine concentration levels in COVID-19 patients. Comparison of cytokine concentration levels between COVID-19 symptomatic, asymptomatic patients, pre-COVID-19 health participants, COVID-19 pandemic health individuals and COVID-19 non-survivors. The cytokine concentration levels were measured from plasma of COVID-19 symptomatic (n = 29) and asymptomatic (n = 29), individuals, pre-COVID-19 health participants (100), COVID-19 pandemic health individuals (33) and COVID-19 non-survivors (2). The median quantity of the cytokines is shown by a horizontal line across...

The oldest unvaccinated Covid-19 survivors in South America

Mateus V. de Castro, Monize V. R. Silva, Michel S. Naslavsky, Marilia O. Scliar, Kelly Nunes, Maria Rita Passos-Bueno, Erick C. Castelli, Jhosiene Y. Magawa, Flávia L. Adami, Ana I. S. Moretti, Vivian L. de Oliveira, Silvia B. Boscardin, Edecio Cunha-Neto, Jorge Kalil, Emmanuelle Jouanguy, Paul Bastard, Jean-Laurent Casanova, Mauricio Quiñones-Vega, Patricia Sosa-Acosta, Jéssica S. de Guedes, Natália P. de Almeida, Fábio C. S. Nogueira, Gilberto B. Domont, Keity S. Santos & Mayana Zatz
Abstract Background Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2....

Supplemental Material from Interhemispheric communication during haptic self-perception

Gaiqing Kong, Antonio Cataldo, Miruna Nitu, Lucile Dupin, Hiroaki Gomi & Patrick Haggard
During the haptic exploration of a planar surface, slight resistances against to the hand's movement are illusorily perceived as asperities (bumps) in the surface. If the surface being touched is one's own skin, an actual bump would also produce increased tactile pressure from the moving finger onto the skin. We investigated how kinaesthetic and tactile signals combine to produce haptic perceptions during self-touch. Participants performed two successive movements with the right hand. A haptic force-control...

The current role of local treatment in metastatic prostate cancer: systematic review and meta-analysis

Willy Baccaglini, Antonio F. Rodrigues, Saulo B. Teles, Nicolle M. Christofe, Felipe P. A. Glina, Gustavo C. Lemos, Rafael Sanchez-Salas, Rubén Olivares & Arie Carneiro
The aim of this study was to evaluate the current role of local treatment in prostate cancer with a low metastatic burden (or oligometastatic) in relation to survival and safety. We performed a meta-analysis of studies published in the MEDLINE, EMBASE, and Cochrane databases until December 2021. Studies comparing local and nonlocal treatment in patients with metastatic prostate cancer were included. The risk of bias within studies was assessed using the Newcastle–Ottawa and Cochrane risk...

Additional file 2 of EEG resting-state functional connectivity: evidence for an imbalance of external/internal information integration in autism

Prany Wantzen, Patrice Clochon, Franck Doidy, Fabrice Wallois, Mahdi Mahmoudzadeh, Pierre Desaunay, Mille Christian, Jean-Marc Guilé, Fabian Guénolé, Francis Eustache, Jean-Marc Baleyte & Bérengère Guillery-Girard
Additional file 2. Backward stepwise regression analyses with age and ASD symptomatology (AQ) as individual predictors on connectivity values (within and between-RSN functional connectivity) that were significantly different between groups. Significant results were obtained only for the TD group. SMN: sensorimotor network; DAN: dorsal attention network; DMN: default mode network; L: left, R: right. RSNs: Resting State Networks.

Additional file 1 of A universal predictive and mechanistic urinary peptide signature in acute kidney injury

Alexis Piedrafita, Justyna Siwy, Julie Klein, Amal Akkari, Ana Amaya-garrido, Alexandre Mebazaa, Anna Belen Sanz, Benjamin Breuil, Laura Montero Herrero, Bertrand Marcheix, François Depret, Lucie Fernandez, Elsa Tardif, Vincent Minville, Melinda Alves, Jochen Metzger, Julia Grossac, Harald Mischak, Alberto Ortiz, Stéphane Gazut, Joost P. Schanstra, Stanislas Faguer, Nicolas Mayeur, Audrey Casemayou & François Labaste
Additional file 1: Supplementary Figure S1: S100A9 expression after epithelial injury. A. Urinary calprotectin (S100A8/A9) abundance 4 hours after cardiac bypass-surgery. B–F. Blood urea nitrogen (B), mRNA S100a9 (C), S100A9 immunostaining (D-E) and mRNA Kim1 (F) in sham mice and after bilateral renal ischemia/reperfusion (hours 6, 24 and 48). G–J. mRNA expression of S100a9 and Kim1 in MCT cells submitted to interleukin-1b (IL1β, 10 ng/mL) or tumor necrosis factor-1a (TNFa, 10 ng/mL) (G-H) or hypoxia...

Registration Year

  • 2022
    248

Resource Types

  • Text
    141
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    63
  • Dataset
    36
  • Other
    3
  • Image
    2
  • Journal Article
    2
  • Data Paper
    1

Affiliations

  • University of Paris
    243
  • Inserm
    92
  • Assistance Publique - Hôpitaux de Paris
    56
  • University of Paris-Saclay
    44
  • Centre Hospitalier Universitaire d'Angers
    30
  • Hôpital Bichat-Claude-Bernard
    28
  • University of Angers
    28
  • The Francis Crick Institute
    23
  • University of Cambridge
    21
  • University of Milan
    20