27 Works

Parcours « résidentiels » d’entreprises : de la décentralisation industrielle au desserrement rapproché

Philippe Thiard

Additional file 2 of Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude & Johanna Lepeule
Additional file 2: Supplementary tables ST1-ST12. ST1 – Participants’ characteristics; ST2 - Global methylation analyses; ST3 - Inflation Factors; ST4 - Top 100 DMPs; ST5 - Replication Analysis; ST6 - DMRs; ST7 - Trait Enrichment; ST8 - Gene enrichment; ST9 - Sensitivity analyses of DMRs; ST10 - Association between blood pressure and cell-type composition; ST11 – Compositional mediation analysis; ST12 - Mediation analysis: role of the ratio Stromal/Syncytiotrophoblasts.

Additional file 1 of Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude & Johanna Lepeule
Additional file 1: Supplementary methods and figures S1-S7. S1 - Workflow of DNA methylation data pre-processing; S2 - Overview of blood pressure data; S3 - Reference placental cell-type composition observed in the EDEN cohort; S4 - Pearson correlation between DMR effect sizes; S5.A - Sensitivity analyses for DMRs found in our main analysis; S5.B - Sensitivity analysis excluding preeclampsia cases for the DMRs found in our main analysis; S6.A - Magnitude and 95% confidence intervals...

Assessing real-world effectiveness of therapies: what is the impact of incretin-based treatments on hospital use for patients with type 2 diabetes?

Clémence Bussiere, Pauline Chauvin, Jean-Michel Josselin & Christine Sevilla-Dedieu
Abstract Background Managing type 2 diabetes represents a major public health concern due to its important and increasing prevalence. Our study investigates the impact of taking incretin-based medication on the risk of being hospitalized and the length of hospital stay for individuals with type 2 diabetes. Method We use claim panel data from 2011 to 2015 and provide difference-in-differences (DID) estimations combined with matching techniques to better ensure the treatment and control groups’ comparability. Our...

Clinical outcome of wild-type AmpC-producing Enterobacterales infection in critically ill patients treated with β-lactams: a prospective multicenter study

Roman Mounier, Ronan Le Guen, Paul-Louis Woerther, Mathieu Nacher, Clément Bonnefon, Nicolas Mongardon, Olivier Langeron, Eric Levesque, Séverine Couffin, Stéphanie Houcke, Michel Wolff, Ariane Roujansky, Caroline Schimpf, Armand Mekontso Dessap, Fabrice Cook, Keyvan Razazi & Hatem Kallel
Abstract Background β-lactams are the main antibiotics used against wild-type AmpC-producing Enterobacterales (wtAE). However, they may fail or select AmpC-overproducing mutants. Our aim was to assess factors associated with clinical failure of β-lactams in the treatment of wtAE infection. Methods From September 2017 to December 2020, we prospectively included all consecutive patients treated by definitive β-lactams therapy for wtAE infection in four university ICUs. Clinical failure was defined as inadequate response to antimicrobial therapy leading...

Additional file 1 of Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude & Johanna Lepeule
Additional file 1: Supplementary methods and figures S1-S7. S1 - Workflow of DNA methylation data pre-processing; S2 - Overview of blood pressure data; S3 - Reference placental cell-type composition observed in the EDEN cohort; S4 - Pearson correlation between DMR effect sizes; S5.A - Sensitivity analyses for DMRs found in our main analysis; S5.B - Sensitivity analysis excluding preeclampsia cases for the DMRs found in our main analysis; S6.A - Magnitude and 95% confidence intervals...

Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude & Johanna Lepeule
Abstract Background Maternal blood pressure levels reflect cardiovascular adaptation to pregnancy and proper maternal-fetal exchanges through the placenta and are very sensitive to numerous environmental stressors. Maternal hypertension during pregnancy has been associated with impaired placental functions and with an increased risk for children to suffer from cardiovascular and respiratory diseases later on. Investigating changes in placental DNA methylation levels and cell-type composition in association with maternal blood pressure could help elucidate its relationships with...

Psychotherapeutic interventions for burns patients and the potential use with Stevens-Johnson syndrome and toxic epidermal necrolysis patients: A systematic integrative review

Pauline O'Reilly, PAULINE MESKELL, Barbara Whelan, CATRIONA KENNEDY, Bart Ramsay, ALICE COFFEY, DONAL FORTUNE, Sarah Walsh, Saskia Ingen-Housz-Oro, Christopher Bunker, Donna M. Wilson, Isabelle Delaunois, Liz Dore, Siobhan Howard & Sheila Ryan
Background The existing evidence demonstrates that survivors of SJS/TEN have reported long-lasting psychological effects of their condition. Burns patients experience similar psychological effects. It is important to look at ways to help allay the psychological complications of SJS/ TEN. As there is an absence of evidence on SJS/TEN psychotherapeutic interventions, it was judged to be beneficial to determine the evidence underpinning psychotherapeutic interventions used with burns patients.
Aims and objectives The aim of this...

Additional file 1 of Assessing real-world effectiveness of therapies: what is the impact of incretin-based treatments on hospital use for patients with type 2 diabetes?

Clémence Bussiere, Pauline Chauvin, Jean-Michel Josselin & Christine Sevilla-Dedieu
Supplementary Material 1

De la diachronie à la synchronie et vice versa

Julie Glikman, Hava Bat Zeev Shyldkrot, Sabine Lehmann, Frédérique Sitri & Thomas Verjans

Telomere length and mitochondrial DNA copy number in bipolar disorder: A sibling study

Luana Spano, Bruno Etain, Jean-Louis Laplanche, Marion Leboyer, Sébastien Gard, Frank Bellivier & Cynthia Marie-Claire
An accelerated cellular ageing has been observed in bipolar disorder (BD) using biomarkers such as telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). Several risk factors might drive premature ageing in individuals with BD, including a familial predisposition. This study compared TL and mtDNAcn between individuals with BD and their (un)-affected siblings, and explored factors that may explain proband-sibling differences. Sixty individuals with BD and seventy-four siblings (34 affected with BD or mood disorders...

Outsourcing recruitment as a solution to prevent discrimination : A correspondence study (LIEPP Working Paper, n°104)

Clémence Berson, Morgane Laouenan & Emmanuel Valat
In this work, we assess how organization of recruitment in large companies affects ethnic discrimination. We consider large multi-establishment companies and distinguish two types of organization of recruitment: hiring made through a human resources (HR) department at a centralized level of the company and hiring made only at the level of the establishment concerned by the position, generally by managers in charge of recruitment. Our results indicate that access to a centralized HR department in...

The Value of Rotavirus Vaccination in Europe: A Call for Action

Adis journals on behalf of, Robert Cohen, Federico Martinón-Torres, Inga Posiuniene, Bernd Benninghoff, Kyu-Bin Oh & Dirk Poelaert
The above graphical abstracts represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-reviewed publication” opposite).

Clinical outcome of wild-type AmpC-producing Enterobacterales infection in critically ill patients treated with β-lactams: a prospective multicenter study

Roman Mounier, Ronan Le Guen, Paul-Louis Woerther, Mathieu Nacher, Clément Bonnefon, Nicolas Mongardon, Olivier Langeron, Eric Levesque, Séverine Couffin, Stéphanie Houcke, Michel Wolff, Ariane Roujansky, Caroline Schimpf, Armand Mekontso Dessap, Fabrice Cook, Keyvan Razazi & Hatem Kallel
Abstract Background β-lactams are the main antibiotics used against wild-type AmpC-producing Enterobacterales (wtAE). However, they may fail or select AmpC-overproducing mutants. Our aim was to assess factors associated with clinical failure of β-lactams in the treatment of wtAE infection. Methods From September 2017 to December 2020, we prospectively included all consecutive patients treated by definitive β-lactams therapy for wtAE infection in four university ICUs. Clinical failure was defined as inadequate response to antimicrobial therapy leading...

Additional file 1 of Clinical outcome of wild-type AmpC-producing Enterobacterales infection in critically ill patients treated with β-lactams: a prospective multicenter study

Roman Mounier, Ronan Le Guen, Paul-Louis Woerther, Mathieu Nacher, Clément Bonnefon, Nicolas Mongardon, Olivier Langeron, Eric Levesque, Séverine Couffin, Stéphanie Houcke, Michel Wolff, Ariane Roujansky, Caroline Schimpf, Armand Mekontso Dessap, Fabrice Cook, Keyvan Razazi & Hatem Kallel
Additional file 1. supplementary data on the methods and outcomes of the secondary objectives of the study.

The Value of Rotavirus Vaccination in Europe: A Call for Action

Adis journals on behalf of, Robert Cohen, Federico Martinón-Torres, Inga Posiuniene, Bernd Benninghoff, Kyu-Bin Oh & Dirk Poelaert
The above graphical abstracts represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-reviewed publication” opposite).

Additional file 1 of Assessing real-world effectiveness of therapies: what is the impact of incretin-based treatments on hospital use for patients with type 2 diabetes?

Clémence Bussiere, Pauline Chauvin, Jean-Michel Josselin & Christine Sevilla-Dedieu
Supplementary Material 1

Telomere length and mitochondrial DNA copy number in bipolar disorder: A sibling study

Luana Spano, Bruno Etain, Jean-Louis Laplanche, Marion Leboyer, Sébastien Gard, Frank Bellivier & Cynthia Marie-Claire
An accelerated cellular ageing has been observed in bipolar disorder (BD) using biomarkers such as telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). Several risk factors might drive premature ageing in individuals with BD, including a familial predisposition. This study compared TL and mtDNAcn between individuals with BD and their (un)-affected siblings, and explored factors that may explain proband-sibling differences. Sixty individuals with BD and seventy-four siblings (34 affected with BD or mood disorders...

Additional file 1 of Clinical outcome of wild-type AmpC-producing Enterobacterales infection in critically ill patients treated with β-lactams: a prospective multicenter study

Roman Mounier, Ronan Le Guen, Paul-Louis Woerther, Mathieu Nacher, Clément Bonnefon, Nicolas Mongardon, Olivier Langeron, Eric Levesque, Séverine Couffin, Stéphanie Houcke, Michel Wolff, Ariane Roujansky, Caroline Schimpf, Armand Mekontso Dessap, Fabrice Cook, Keyvan Razazi & Hatem Kallel
Additional file 1. supplementary data on the methods and outcomes of the secondary objectives of the study.

Placebo response in moderate-to-severe psoriasis: prevalence meta-analysis of randomised controlled trials

Sivem Afach, Laurence Le Cleach & Emilie Sbidian
The study supplemental includes the flow chart of included studies, the table of characteristics of included studies and their populations and the table of excluded studies with their reasons.

Placebo response in moderate-to-severe psoriasis: prevalence meta-analysis of randomised controlled trials

Sivem Afach, Laurence Le Cleach & Emilie Sbidian
The study supplemental includes the flow chart of included studies, the table of characteristics of included studies and their populations and the table of excluded studies with their reasons.

Additional file 2 of Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude & Johanna Lepeule
Additional file 2: Supplementary tables ST1-ST12. ST1 – Participants’ characteristics; ST2 - Global methylation analyses; ST3 - Inflation Factors; ST4 - Top 100 DMPs; ST5 - Replication Analysis; ST6 - DMRs; ST7 - Trait Enrichment; ST8 - Gene enrichment; ST9 - Sensitivity analyses of DMRs; ST10 - Association between blood pressure and cell-type composition; ST11 – Compositional mediation analysis; ST12 - Mediation analysis: role of the ratio Stromal/Syncytiotrophoblasts.

Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude & Johanna Lepeule
Abstract Background Maternal blood pressure levels reflect cardiovascular adaptation to pregnancy and proper maternal-fetal exchanges through the placenta and are very sensitive to numerous environmental stressors. Maternal hypertension during pregnancy has been associated with impaired placental functions and with an increased risk for children to suffer from cardiovascular and respiratory diseases later on. Investigating changes in placental DNA methylation levels and cell-type composition in association with maternal blood pressure could help elucidate its relationships with...

La retraite : un évènement protecteur pour la santé de tous (LIEPP Policy Brief, n°59)

Thomas Barnay & Eric Defebvre
À partir de données françaises issues de l’enquête Santé et Itinéraire Professionnel (Sip), nous montrons que la retraite joue un rôle positif sur la santé, tout particulièrement chez les personnes ayant été exposées à des conditions de travail pénibles. Cette relation est tout particulièrement forte pour les hommes non­ diplômés ayant été confrontés à des facteurs de risques physiques avec une diminution de 21,2 points de pourcentage (pp) de déclarer une santé perçue dégradée, de...

Assessing real-world effectiveness of therapies: what is the impact of incretin-based treatments on hospital use for patients with type 2 diabetes?

Clémence Bussiere, Pauline Chauvin, Jean-Michel Josselin & Christine Sevilla-Dedieu
Abstract Background Managing type 2 diabetes represents a major public health concern due to its important and increasing prevalence. Our study investigates the impact of taking incretin-based medication on the risk of being hospitalized and the length of hospital stay for individuals with type 2 diabetes. Method We use claim panel data from 2011 to 2015 and provide difference-in-differences (DID) estimations combined with matching techniques to better ensure the treatment and control groups’ comparability. Our...

Registration Year

  • 2022
    27

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Affiliations

  • Paris-Est Créteil University
    27
  • University of Paris
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  • University of Rennes 1
    10
  • Inserm
    9
  • Hôpitaux Universitaires Henri-Mondor
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  • Assistance Publique - Hôpitaux de Paris
    6
  • French National Centre for Scientific Research
    6
  • Harvard University
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  • University of Paris-Saclay
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  • Mondor Institute of Biomedical Research
    6