Identification and validation of a novel signature as a diagnostic and prognostic biomarker in colorectal cancerDi Wang, Junye Liufu, Qiyuan Yang, Shengqun Dai, Jiaqi Wang & Biao Xie
Abstract Background Colorectal cancer (CRC) is one of the most common malignant neoplasms worldwide. Although marker genes associated with CRC have been identified previously, only a few have fulfilled the therapeutic demand. Therefore, based on differentially expressed genes (DEGs), this study aimed to establish a promising and valuable signature model to diagnose CRC and predict patient’s prognosis. Methods The key genes were screened from DEGs to establish a multiscale embedded gene co-expression network, protein-protein interaction...
Prophylactic antibiotic use during labor and delivery in China: a nationwide, multicenter, hospital-based, cross-sectional studyQiguo Lian, Tao Zheng, Xiaona Huo, Jun Zhang & Lin Zhang
Abstract Background Prophylactic antibiotic use during delivery is common in routine obstetric practice to prevent infection globally, especially in low- and middle-income countries. In China, however, little is currently known about the national estimates for prophylactic antibiotic use during delivery. Therefore, we aimed to describe the prevalence of prophylactic antibiotic use and guideline adherence using national data in China. Methods This cross-sectional study analyzed a national dataset from the China Labor and Delivery Survey in...
Deep reinforcement learning proves its success in solving complicated combinatorial problems. This work studies essential issues of DRL and its applications in the disassembly planning problem for 4D-printed products and energy-aware task planning problems. From the aspect of the methodology, this work utilizes experimental results and theoretical analysis to prove the existence of compatible issues in the deep deterministic policy gradient algorithm. This work is the first to estimate the compatibility in quantity with the...
Understanding intergenerational relations in China has become increasingly important against a backdrop of rapid social and demographic transitions and an ongoing urban-rural divide. From the parental perspective, this research investigates patterns and determinants of intergenerational relations between middle-aged and older parents and their non-coresident children in urban and rural China using data from the China Health and Retirement Longitudinal Study (2018) (N = 14,616). Latent class analysis revealed three typologies of intergenerational relations found across...
Abies kawakamii (Hay.) Ito is an endemic species mainly distributed in Taiwan’s subalpine region with an elevation of 3,000–3,600 m above sea level. It is a significant ecological indicator species in high subtropical mountains regarding plant geography and climate change. Taiwan is an island in the Asian-Pacific region. Typhoons cause forest gaps belonging to small-scale disturbances in the forest ecosystem, which is critical in maintaining species diversity and forest regeneration. We set up seven long-term...
Additional file 2 of Potential contribution of early endothelial progenitor cell (eEPC)-to-macrophage switching in the development of pulmonary plexogenic lesionFeng-Jin Shao, Xiao-Ling Guo, Jia-Xue Xu, Rui Liu, Dan-Yue Li, Qing-Hao Li, Ting Zhou, Cun Fang & Xun Tan
Additional file 2: Fig. S1. Effect of TNFα on eEPC viability.
Additional file 1 of Prediction and prognosis of adverse maternal and foetal/neonatal outcomes in pulmonary hypertension: an observational study and nomogram constructionYuqin Chen, Dansha Zhou, Mingmei Xiong, Xin Xi, Wenni Zhang, Ruifeng Zhang, Lishi Chen, Qian Jiang, Ning Lai, Xiang Li, Jieer Luo, Xuanyi Li, Weici Feng, Chuhui Gao, Jiyuan Chen, Xin Fu, Wei Hong, Mei Jiang, Kai Yang, Wenju Lu, Yiping Luo, Jun Zhang, Zhe Cheng, Chunli Liu & Jian Wang
Additional file 1. Supplementary materials for the prediction and prognosis of adverse maternal and foetal/neonatal outcomes in pulmonary hypertension.
Prediction and prognosis of adverse maternal and foetal/neonatal outcomes in pulmonary hypertension: an observational study and nomogram constructionYuqin Chen, Dansha Zhou, Mingmei Xiong, Xin Xi, Wenni Zhang, Ruifeng Zhang, Lishi Chen, Qian Jiang, Ning Lai, Xiang Li, Jieer Luo, Xuanyi Li, Weici Feng, Chuhui Gao, Jiyuan Chen, Xin Fu, Wei Hong, Mei Jiang, Kai Yang, Wenju Lu, Yiping Luo, Jun Zhang, Zhe Cheng, Chunli Liu & Jian Wang
Abstract Background Pregnant women with pulmonary hypertension (PH) have higher mortality rates and poor foetal/neonatal outcomes. Tools to assess these risk factors are not well established. Methods Predictive and prognostic nomograms were constructed using data from a “Development” cohort of 420 pregnant patients with PH, recorded between January 2009 and December 2018. Logistic regression analysis established models to predict the probability of adverse maternal and foetal/neonatal events and overall survival by Cox analysis. An independent...
Additional file 4 of Prognostic value of creatinine-to-cystatin c ratio in patients with type 2 diabetes mellitus: a cohort studyWen Wei, Shanggang Li, Jin Liu, Yong Liu, Kaihong Chen, Shiqun Chen, Mei Tu & Hong Chen
Additional file 4: Figure S2. Hazard ratios for long-term all-cause mortality in different subgroups.
A global phase diagram of bound states in the continuum (BICs) in photonic-crystal slabs is obtained based on a universal classification of BICs by their different Friedrich-Wintgen origins. Previously, BICs in photonic-crystal slabs are classified into three types: single-resonance parametric, symmetry-protected and Friedrich-Wintgen BICs. Here, we show that the single-resonance parametric BICs come from the coupling between the guided resonance (GR) and Fabry-Pérot (FP) modes, and the symmetry-protected BICs from the coupling between two degenerate...
Prognostic value of creatinine-to-cystatin c ratio in patients with type 2 diabetes mellitus: a cohort studyWen Wei, Shanggang Li, Jin Liu, Yong Liu, Kaihong Chen, Shiqun Chen, Mei Tu & Hong Chen
Abstract Background The serum creatinine-to-cystatin C ratio (Scr/Scys) has been suggested as a surrogate marker of muscle mass and a predictor of adverse outcomes in many diseases. However, the prognostic value of Scr/Scys in patients with type 2 diabetes mellitus (T2DM) is unknown. The aim of this study is to assess the prognostic value of Scr/Scys in patients with T2DM. Methods In this retrospective observational study, we enrolled 3668 T2DM patients undergoing coronary angiography (CAG)....
Additional file 1 of Self-assembly of DNA nanostructure containing cell-specific aptamer as a precise drug delivery system for cancer therapy in non-small cell lung cancerNing Wang, Chang Yu, Tingting Xu, Dan Yao, Lingye Zhu, Zhifa Shen & Xiaoying Huang
Additional file 1: Scheme S1. The self-assembly process from single-strand DNA to a structural unit. The detail base sequences of three single-strand DNA, including S6 (aptamer), PP (palindrome probe), and Linker, are displayed in the pattern diagram. Figure S1. 8% PAGE image showing the influence of palindrome sequences on the synthesis of DNA nanostructure. CP (common probe) was instead of PP (palindrome probe). C-NS represented the synthetic products from self-assembly system in the absence of...
Additional file 4 of MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancerZhenhao Zeng, Wenrui He, Yi Jiang, Hao Jiang, Xiaofeng Cheng, Wen Deng, Xiaochen Zhou, Cheng Zhang & Gongxian Wang
Additional file 4 Figure S4. Differentially expressed genes associated with MAPK8IP2 or MAPK8IP3 in PCa. (A) The correlation between MAPK8IP2 and differentially expressed genes. (B-C) Heat map showing genes positively or negatively correlated with MAPK8IP2 (the top 50 genes). (D) The correlation between MAPK8IP3 and differentially expressed genes. (E-F) Heat map showing genes positively or negatively correlated with MAPK8IP3 (the top 50 genes). (G) The Venn results displayed that only PDIA2 was positively associated with...
Additional file 5 of MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancerZhenhao Zeng, Wenrui He, Yi Jiang, Hao Jiang, Xiaofeng Cheng, Wen Deng, Xiaochen Zhou, Cheng Zhang & Gongxian Wang
Additional file 5 Figure S5. (A) the expression level of MAPK8IP2 was significantly downregulated in the siMAPK8IP2 group compared with the siNC group and the blank group after transfection. (B-D) proliferation migration and invasion of PC3 cells were significantly inhibitor in the siMAPK8IP2 group compared with the siNC group and the blank group.
Additional file 8 of MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancerZhenhao Zeng, Wenrui He, Yi Jiang, Hao Jiang, Xiaofeng Cheng, Wen Deng, Xiaochen Zhou, Cheng Zhang & Gongxian Wang
Additional file 8 Table S3. KEGG enrichment analysis of the MAPK8IP2 gene and its partner genes.
Abstract Background MAPK8IP2 is one of the JNK-interacting proteins (JIPs) family members, and is involved in the regulation of the JNK and P38 MAPK signaling pathways. MAPK8IP2 has been reported to be closely associated with several cancers. However, the biological function of MAPK8IP2 in prostate cancer (PCa) remains unclear. Methods MAPK8IP2 expression in PCa and subgroups of PCa was analyzed by public databases. The prognostic role of MAPK8IP2 in prostate cancer was analyzed using the...
New ages of Early Cretaceous magmatic rocks in the Yanbian area (NE China): implications for the subduction and slab rollback of the Paleo-Pacific Plate beneath eastern China during Early CretaceousQingxiang Du, Guangsu Li, Zuozhen Han & Xiaoli Shen
The precise age of slab rollback of the Paleo-Pacific Plate during Early Cretaceous has been contentious. In this study, we have conducted LA-ICP-MS zircon U-Pb dating, major and trace elements, and Sr-Nd isotopes analyses on the late Early Cretaceous diabase porphyries, andesitic basalts and basanites in the Yanbian area (NE China). Zircon U-Pb dating of basanites, andesitic basalts, and diabase porphyries yielded weighted average ages of 104 ± 1.9 Ma (MSWD = 0.55, n =...
Payments for Ecosystem Services (PES) programs have been implemented globally to protect ecosystems while securing the well-being of affected people. Reasonable payment standards are key to successful PES programs. Although some approaches are available for determining payment standards, few studies have applied them for grassland conservation with location indicators and socioeconomic contexts properly considered. Using China’s first pilot Grassland Ecological Compensation Policy (GECP) as an example, we analyzed the effects of payment levels, other natural...
Additional file 1 of Gene expression profiles provide insights into the survival strategies in deep-sea mussel (Bathymodiolus platifrons) of different developmental stagesJunrou Huang, Peilin Huang, Jianguo Lu, Nengyou Wu, Genmei Lin, Xilin Zhang, Hong Cao, Wei Geng, Bin Zhai, Cuiling Xu & Zhilei Sun
Additional file 1: Fig. S1. Length distribution of the unigenes. Fig. S2. Expression level distribution of the unigenes. Fig. S3. Correlations between samples. Fig. S4. Clustering of samples. Fig. S5. Venn plot of the expressed genes in each tissues. The overlapping regions represent common expressed genes in the same tissue of different individuals. Fig. S6. Number of DEGs in each COG category. Fig. S7. Number of DEGs in the corresponding GO terms. Fig. S8. Significantly...
Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cellsWenwen Liu, Min Chen, Chao Liu, Liying Wang, Huafang Wei, Ruidan Zhang, Zhengxing Ren, Yinghong Chen, Mengcheng Luo, Jianguo Zhao, Hongwei Jiang, Fei Gao & Wei Li
Primary ovarian insufficiency (POI), also known as premature ovarian failure, is an ovarian defect in humans characterized by the premature depletion of ovarian follicles before the age of 40. However, the mechanisms underlying POI remain largely unknown. Here, we show that knockout of Epg5 (ectopic P-granules autophagy protein 5 homolog (C. elegans)) results in subfertility in female mice, which exhibit a POI-like phenotype. Single-cell RNA sequencing analysis revealed that the knockout of Epg5 affected the...
Knockdown of GSG2 inhibits the development and progression of non-small cell lung cancer in vitro and in vivoFan Zhang, Bin Qiu, Ying Ji, Hao Zhang, Peng Song, Nan Sun, Liang Zhao, Fang Lv, Lixia Yin, Yibo Gao, Qi Xue, Shugeng Gao & Jie He
Lung cancer has been recognized as the most common malignant neoplasm of the respiratory system with extremely high morbidity, among which non-small cell lung cancer (NSCLC) accounts for the majority. Many published literatures have revealed the roles of GSG2 in the progression of ovarian cancer, bladder cancer and breast cancer. However, there were no reports on the relationship between GSG2 and NSCLC. Herein, GSG2 was identified as a potential tumor promoter in NSCLC development, whose...
CircRIMKLB promotes myoblast proliferation and inhibits differentiation by sponging miR-29c to release KCNJ12Jian Wang, Yifan Wen, Jiawei Xu, Binglin Yue, Jialin Zhong, Li Zheng, Chuzhao Lei, Hong Chen & Yongzhen Huang
Muscle development is a complex process that was regulated by many factors, among which non-coding RNAs (ncRNAs) play a vital role in regulating multiple life activities of muscle cells. Circular RNA (circRNA), a type of non-coding RNA with closed-loop structure, has been reported to affect multiple life processes. However, the roles of circRNAs on muscle development have not been fully elucidated. The present study aimed to determine whether and how circRIMKLB affects muscle development. Our...
Buffalo holds an excellent potential for beef production, and circRNA plays an important role in regulating myogenesis. However, the regulatory mechanism of circRNAs during buffalo skeletal muscle development has not been fully explored. In this study, circRNA expression profiles during the proliferation and differentiation stages of buffalo myoblasts were analysed by RNA-seq. Here, a total of 3,142 circRNAs candidates were identified, and 110 of them were found to be differentially expressed in the proliferation and...
The clinical burden of extremely preterm birth in a large medical records database in the United States: complications, medication use, and healthcare resource utilizationCsaba Siffel, Andrew K. Hirst, Sujata P. Sarda, Hong Chen, Jeannette Ferber, Michael W. Kuzniewicz & De-Kun Li
Approximately 5% of global preterm births are extremely premature (EP), defined as occurring at less than 28 weeks gestational age. Advances in care have led to an increase in the survival of EP infants during the neonatal period. However, EP infants have a higher risk of developing complications such as bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and retinopathy of prematurity (ROP). BPD and other respiratory morbidities are particularly prevalent among this population. To understand the...
Additional file 4 of Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammationDongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding & Zhiwei Liu
Additional file 4: Figure S4. Enrichment of differentially expressed genes in Serpine1-overexpressing MLE-12 cells. A, B GO and KEGG enrichment of the upregulated genes. C, D GO and KEGG enrichment of the downregulated genes. Q-value ≤ 0.05 and fold-change ≥ 2 were used as the thresholds for screening the differentially expressed genes.
Institute of Botany683
Shanghai Jiao Tong University566
Chinese Academy of Medical Sciences & Peking Union Medical College499
University of Chinese Academy of Sciences463
Nanjing Medical University405
Huazhong University of Science and Technology382
West China Hospital of Sichuan University371
Central South University366