Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated...

ObjectiveTo conduct a systematic review and meta-analysis to compare the effects of statins and placebo on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with hypertension.MethodsWe used different databases such as MEDLINE and the Cochrane Library Central Register of Controlled Trials (CENTRAL) to search for randomized controlled trials published from 1 January 2000 to 1 January 2022 to retrieve relevant studies and full-text articles evaluating statins versus placebo in patients with hypertension....

Supplemental material, sj-docx-1-car-10.1177_19476035221144748 for Pain Intensity and Trajectory Following Intra-Articular Injection of Mono-Iodoacetate in Experimental Osteoarthritis: A Meta-Analysis of In Vivo Studies by Hongyu Jin, Yuanheng Yang, Guanghua Lei, Chao Zeng, Ke He, Yilun Wang, Caifeng Deng, Jie Wei, Xiaoxiao Li and Hui Li in CARTILAGE

Supplemental material, sj-docx-1-car-10.1177_19476035221144748 for Pain Intensity and Trajectory Following Intra-Articular Injection of Mono-Iodoacetate in Experimental Osteoarthritis: A Meta-Analysis of In Vivo Studies by Hongyu Jin, Yuanheng Yang, Guanghua Lei, Chao Zeng, Ke He, Yilun Wang, Caifeng Deng, Jie Wei, Xiaoxiao Li and Hui Li in CARTILAGE

Supplemental material, sj-pptx-1-cpa-10.1177_07067437231154993 for A Meta-Research of Randomized Controlled Trials in the Field of Mental Health: Comparing Pharmacological to Non-Pharmacological Interventions from 1955 to 2020 by Sheng Chen, PhD, Alina Lee, MSc, and Wei Wang, PhD in The Canadian Journal of Psychiatry

ObjectiveThis study aimed to provide a general overview of mental health randomized controlled trials (RCTs) and summarize the temporal trends in terms of the number of studies, median sample sizes, and median effect sizes using data collected from the Cochrane Database of Systematic Reviews (CDSR).MethodsUsing data collected from the CDSR, the temporal trends are compared in terms of the number of studies, median sample sizes, and median effect sizes between two broad categories of interventions:...

A fully mechanized mining face is characterized by serious dust pollution and dust is a major cause of pneumoconiosis that haunts numerous miners. For a fully mechanized face having large mining heights, the main dust source in the pavement area is produced by the moving support frame. To reduce the amount of dust during support's movement, the distribution and dissipation of dust in this process were studied by combining numerical simulations with underground measurements. The...

Supplemental material, sj-docx-1-pie-10.1177_09544089211031116 for Investigation on dust dispersion during support movement in a fully mechanized mining face and the technology with support frame enclosure dust control by Jinming Mo, Wei Ma, Dandan Li and Sheji Zhang in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering

Asini Corii Colla (ACC) and Taurus Corii Colla (TCC) are well-known for their high nutritional value, especially for medicinal purposes. However, the aforementioned are also potential candidates for adulteration because of their low yield and high price. A UPLC-MS/MS approach based on the specific peptide was proposed to detect adulterated gelatin with possible mixed animal species. To explore the antioxidant activity, the peptides were separated to evaluate their effect on ·OH radical and DPPH· scavenging...

Supplemental material, sj-tif-4-cll-10.1177_09636897221149444 for CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response by Lu Cao, Xiaoqian Ma, Juan Zhang, Min Yang, Zhenhu He, Cejun Yang, Sang Li, Pengfei Rong and Wei Wang in Cell Transplantation

Supplementary Material

Supplemental material, sj-docx-3-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch,...

Fringe skeletons extraction method maybe the most straightforward method for electronic speckle pattern interferometry (ESPI) phase extraction. Due to the ESPI fringe patterns have the characteristics of high noise, low contrast and different fringe shapes, it is very difficult to extract skeletons from ESPI fringe patterns with high accuracy. To deal with this problem, we propose a skeletons extraction method based on deep learning, called channel transformer U-Net, for directly extracting skeletons from the noisy...

In this supplemental document, we present details of secret key rate calculation of CV-QKD.

In this supplemental document, we present details of secret key rate calculation of CV-QKD.

Learning-based computer-generated holography (CGH) algorithms appear as novel alternatives to generate phase-only holograms. However, most existing learning-based approaches underperform their iterative peers in terms of display quality. Here, we propose an unsupervised Fourier-inspired neural network that could generate phase-only holograms in real time and obtain high-fidelity reconstructed images. Both simulation and experiment were performed to showcase its capability. By explicitly leveraging Fourier transforms within the neural network architecture, global features of the holograms are more...

Bright γ-ray sources are of great significance for fundamental research, medicine and industry. However, γ-ray production by bremsstrahlung, Compton scattering, and synchrotron radiation is often subjected to large divergence, wide size and/or low efficiency, making it difficult to achieve high-brightness γ-ray sources. Here we have found an efficient mechanism to generate γ-rays with unprecedented brilliance by use of an ultrarelativistic electron beam with nC charge incident onto a solid surface at grazing incidence. With this...

Bright γ-ray sources are of great significance for fundamental research, medicine and industry. However, γ-ray production by bremsstrahlung, Compton scattering, and synchrotron radiation is often subjected to large divergence, wide size and/or low efficiency, making it difficult to achieve high-brightness γ-ray sources. Here we have found an efficient mechanism to generate γ-rays with unprecedented brilliance by use of an ultrarelativistic electron beam with nC charge incident onto a solid surface at grazing incidence. With this...

Four prenylated indole alkaloids (1−4) were targeted isolated from the mangrove rhizosphere soil-derived fungus Penicillium janthinellum HK1-6 by using molecular networking strategies. Among them, the planar structure and relative configuration of notoamide X (1) were elucidated by detailed analysis of the spectroscopic data especially the NOESY spectrum for the first time and its absolute configuration was determined by ECD spectrum. Furthermore, curated molecular networks of MS/MS data were generated with GNPS which allowed highlighting six...

Supplemental material, sj-xlsx-1-tct-10.1177_15330338221150069 for The Application of Morphogo in the Detection of Megakaryocytes from Bone Marrow Digital Images with Convolutional Neural Networks by Xiaofen Wang, Ying Wang, Chao Qi, Sai Qiao, Suwen Yang, Rongrong Wang, Hong Jin and Jun Zhang in Technology in Cancer Research & Treatment

Supplemental material, sj-xlsx-1-tct-10.1177_15330338221150069 for The Application of Morphogo in the Detection of Megakaryocytes from Bone Marrow Digital Images with Convolutional Neural Networks by Xiaofen Wang, Ying Wang, Chao Qi, Sai Qiao, Suwen Yang, Rongrong Wang, Hong Jin and Jun Zhang in Technology in Cancer Research & Treatment

The systemic review and meta-analysis aimed to identify the predictors for short-term successful weaning from CRRT in severe AKI patients. PubMed, Embase, the Cochrane Library, and grey literature were searched for relevant studies investigating variables for short-term successful weaning from CRRT to August 2022. Our criteria included patients with AKI who required CRRT but excluded patients with kidney failure. The pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using fixed-effect (I2≤50% and...

The Chinese Industrial Emissions Database (CIED) provides inventory of particulate matter (PM), SO2 and NOX from Chinese industries from 2015 to 2018, based on direct measurements from China’s continuous emission monitoring systems (CEMS) network. This document provides stack gas concentrations for China’s different industrial emission sources.

Supplemental material, sj-docx-1-jis-10.1177_01655515221151140 for Implementation of a conversational virtual assistant for open government data portal: Effects on citizens by Di Wang, Deborah Richards, Ayse Aysin Bilgin and Chuanfu Chen in Journal of Information Science

Insufficient support services are one of the barriers for citizen’s open government data (OGD) utilisation. Considering the strengths and effectiveness of virtual assistants (VAs) in providing instant and user-friendly support services, this study focuses primarily on its implementation for OGD portals. A conversational VA prototype is specifically developed. A between-subjects experiment with one factor (VA/text-based support services) was carried out. Results show citizens’ positive attitudes towards VAs providing support services on OGD portals. No significant...