The blue light hazard (BLH) and luminous efficacy of a source (ηV) are associated with the photobiological safety and energy saving of light-emitting diodes (LEDs), respectively. In this study, we used genetic algorithm (GA) to optimize the BLH, ηV, and color rendering parameters of five-chip hybrid white LEDs. Based on the optimal results, we used five-chip LEDs to obtain the hybrid white light. Their peak wavelengths were 461.5 (blue), 523.9 (green), 588.2 (orange), 643.3 (red),...

The blue light hazard (BLH) and luminous efficacy of a source (ηV) are associated with the photobiological safety and energy saving of light-emitting diodes (LEDs), respectively. In this study, we used genetic algorithm (GA) to optimize the BLH, ηV, and color rendering parameters of five-chip hybrid white LEDs. Based on the optimal results, we used five-chip LEDs to obtain the hybrid white light. Their peak wavelengths were 461.5 (blue), 523.9 (green), 588.2 (orange), 643.3 (red),...

Idiopathic pulmonary fibrosis (IPF) is characterized by lung scarring and has no effective treatment. Fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and migration are major clinical manifestations of this disease; hence, blocking these processes is a practical treatment strategy. Here, highly upregulated LINC00941/lncIAPF was found to accelerate pulmonary fibrosis by promoting fibroblast-to-myofibroblast differentiation and myofibroblast proliferation and migration. Assay for transposase-accessible chromatin using sequencing and chromatin immunoprecipitation experiments elucidated that histone 3 lysine 27 acetylation (H3K27ac) activated...

This study reviewed all published valproic acid (VPA) population pharmacokinetic (PPK) models in adult patients and assessed them using external validation methods to determine predictive performance. Thirteen published PPK models (labeled with letters A to M) not restricted to children were identified in PubMed, Embase, and Web of Science databases. They were evaluated in a sample totaling 411 serum concentrations from 146 adult inpatients diagnosed with bipolar disorder in a Chinese hospital. Serum concentrations of...

Primary ovarian insufficiency (POI), also known as premature ovarian failure, is an ovarian defect in humans characterized by the premature depletion of ovarian follicles before the age of 40. However, the mechanisms underlying POI remain largely unknown. Here, we show that knockout of Epg5 (ectopic P-granules autophagy protein 5 homolog (C. elegans)) results in subfertility in female mice, which exhibit a POI-like phenotype. Single-cell RNA sequencing analysis revealed that the knockout of Epg5 affected the...

Here, we report significant pressure-modulate optoelectronic properties of NiPS3. Upon compression, NiPS3 exhibited a photocurrent increase of five orders of magnitude over the initial value. Interestingly, when NiPS3 was finally decompressed to ambient conditions, the photocurrent could maintain a two-order-of-magnitude enhancement. In addition, the spectral response range was extended to the near-infrared spectral range (up to 1650 nm) under high pressure. Raman and XRD measurements and theoretical calculations revealed significant enhancement in both interlayer and...

Additional file 14. Functional enrichment of genes differentially expressed in the medial preoptic area (MPOA), the nucleus accumbens (NAc), or the lateral septum (LS). For each pairwise comparison, the functional enrichments in gene ontologies of the biological processes (BP), cellular components (CC), and molecular functions (MF) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) were tested for the differentially expressed genes up- or down-regulated (UP, and DOWN, respectively)....

Additional file 15. Functional enrichment of overlapping and distinct sets of differentially expressed genes in the medial preoptic area (MPOA). In (A), the number of differentially expressed genes overlapping or distinct between all sets of sexually biased comparisons in the MPOA is depicted. For each set, the functional enrichments in gene ontologies of the biological processes (B), cellular components (C), and molecular functions (D) categories are displayed. ***p < 0.001, hypergeometric test for overlaps between...

Additional file 16. Representation of the number of genes differentially expressed in the medial preoptic area (MPOA, top), nucleus accumbens (NAc, middle), and lateral septum (LS, bottom) across all chromosomes and linkage groups in the prairie vole assembly. Only cases with at least one differentially expressed gene are depicted.

Additional file 1: Figure S1. Vessel densities of the whole measured area, parafovea, and four quadrants (temporal, superior, nasal, and inferior) in the (a, c) SCP and (b, d) DCP measured with optical coherence tomography angiography stratified by age in males and females. Table S1. Baseline characteristics of male participants in the study. Table S2. Baseline characteristics of female participants in the study. Table S3. Vessel densities of the whole measured area, parafovea, and four...

Additional file 19. Estimated cell type proportions. The proportions of various cell types were estimated in our dataset using a publicly-available single-cell RNA sequencing dataset. While panel (A) shows the estimated proportions for all genes detected in our study, panels (B) and (C) depict the estimated proportion of the “Astrocytes” and “Neurons” cell types, or only “Neurons”, respectively, in genes differentially expressed in the given structure.

Additional file 21. Number of immediate early genes (IEG) in the genes differentially expressed in the medial preoptic area (MPOA), nucleus accumbens (NAc), and lateral septum (LS).

Additional file 22. Structure-specific associations of gene coexpression modules with parental behaviors. The correlation of each co-expression module from the weighted gene coexpression network analysis with behavioral traits (behaviors scored during parental behavior test and phenotype status) is depicted for each structure. The correlation value is detailed alongside its corresponding p-value in parentheses. Note that within each structure, only modules with at least one significant association are depicted. MPOA: medial preoptic area, NAc: nucleus accumbens,...

Additional file 23. Functional enrichment for modules and groups of modules derived from the weighted gene co-expression analysis (WGCNA). For each pairwise group of modules, the functional enrichments in gene ontologies (GO) of the biological processes (BP), cellular components (CC), and molecular functions (MF) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG).

Additional file 23. Functional enrichment for modules and groups of modules derived from the weighted gene co-expression analysis (WGCNA). For each pairwise group of modules, the functional enrichments in gene ontologies (GO) of the biological processes (BP), cellular components (CC), and molecular functions (MF) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG).

Additional file 24. Functional enrichment of gene ontologies of the biological processes category in gene co-expression modules derived from the weighted gene coexpression network analysis (WGCNA).

Additional file 26. Functional enrichment of gene ontologies of the molecular functions category in gene co-expression modules derived from the weighted gene coexpression network analysis (WGCNA).

Additional file 28. Representative location of tissue punches collection. As no atlas in stereotaxic coordinates exists for the prairie vole brain, representative plates from the rat brain atlas [95] are depicted. Tissue punches were taken from sections ranging from plates 12–18 for the nucleus accumbens (NAc, A), plates 19–27 for the lateral septum (LS, B), and plates 32–40 for the medial preoptic area (MPOA, C).

Additional file 10. Figure S7: Prognostic value of presurgical ctDNA detection. A). The recurrence-free survival analysis of patients stratified by presurgical ctDNA detection. B). The multi-variant Cox regression for presurgical ctDNA detection. Abbreviations: RFS – recurrence-free survival, LNM – lymph node metastasis, LUAD – lung adenocarcinoma, LUSC - lung squamous-cell carcinoma.

Additional file 13. Supplementary results.

Additional file 1. Table S1: Patient demography.

Additional file 6. Figure S3: Prognostic values of postsurgical ctDNA detection at 3 months and 6 months. A-B) The recurrence-free survival analysis (top panel) and multi-variant Cox regression (bottom panel) of postsurgical ctDNA detection at 3 months (A) and 6 months (B). For the analysis at 6 months after surgeries, only patients with plasma samples available at this scheduled point and followed-up for more than 6 months were included. Abbreviations: RFS – recurrence-free survival, LNM...

Background:The first-line clinical strategy for small cartilage/osteochondral defects is microfracture (MF). However, its repair efficacy needs improvement.Hypothesis:Appropriate energy radial shockwave stimulation in MF holes would greatly improve repair efficacy in the porcine osteochondral defect model, and it may obtain comparable performance with common tissue engineering techniques.Study Design:Controlled laboratory study.Methods:Osteochondral defect models (8-mm diameter, 3-mm depth) were established in the weightbearing area of Bama pigs’ medial femoral condyles. In total, 25 minipigs were randomly divided into...

Background:The first-line clinical strategy for small cartilage/osteochondral defects is microfracture (MF). However, its repair efficacy needs improvement.Hypothesis:Appropriate energy radial shockwave stimulation in MF holes would greatly improve repair efficacy in the porcine osteochondral defect model, and it may obtain comparable performance with common tissue engineering techniques.Study Design:Controlled laboratory study.Methods:Osteochondral defect models (8-mm diameter, 3-mm depth) were established in the weightbearing area of Bama pigs’ medial femoral condyles. In total, 25 minipigs were randomly divided into...

Additional file 1: Supplementary figures Fig. S1-5 and legends.