Additional file 4: Table s1. Difference in rCBFR measured as F (H2O) and R1 (FE-PE2I) between patients and healthy controls (T-test results). Legend Measures are averaged left and right hemisphere rCBFR values. rCBFR: relative regional cerebral blood flow. HC Healthy controls; rCBFR relative regional cerebral blood flow. F relative regional cerebral blood flow measured with [15O]H2O PET. R1 relative regional cerebral blood flow measured with [18F]FE-PE2I.

Abstract Background Dopamine transporter (DAT) imaging is used in the diagnostic work-up in suspected parkinsonian syndromes and dementia with Lewy bodies but cannot differentiate between these syndromes, and an extra brain imaging examination of the regional cerebral blood flow (rCBF) or glucose metabolism is often needed for differential diagnosis. The requirement of two different imaging examinations is resource-consuming and inconvenient for the patients. Therefore, imaging of both cortical blood flow and DAT imaging with the...

Abstract Background In order to reduce work-related upper limb disorders, the Swedish Work Environment Authority introduced an occupational health surveillance targeting hand-intensive work. A process model, aimed at supporting the employers as well as the occupational health service provider (i.e., ergonomist) in the work process with the occupational health surveillance, was developed. The objective of this qualitative study was to explore ergonomists’ experiences of the execution of occupational health surveillance for hand-intensive work when following...

Additional file 1. Interview guide _ English version.

Abstract Background Tuberculosis has remained a leading cause of death among people living with HIV (PLHIV) globally. Isoniazid preventive therapy (IPT) is the recommended strategy by the World Health Organization to prevent TB disease and related deaths among PLHIV. However, delivery and uptake of IPT has remained suboptimal particularly in countries where HIV and TB are endemic such as Tanzania. This study sought to assess contextual factors that shape delivery and uptake of IPT in...

Additional file 3: Summary of Zenodo view and download statistics, plus citations (CSV format) as of 28 April 2022 [235].

Additional file 5: Authorship contributions and acknowledgements mapped to NORMAN-SLE lists (XLSX format).

Additional file 2: Supplementary tables and figures. Figure S1. Pearson correlation between the 117 original metabolites. Figure S2. Sensitivity analyses of mutually adjusted ORs for the overall associations and cancer type-specific deviations. Figure S3. Sensitivity analysis of mutually adjusted ORs for the overall associations and cancer type-specific deviations with or without excluding hormone users. Figure S4. p-values of tests for departure from linearity and effect modification by BMI. Figure S5. ORs for the overall associations...

Low socioeconomic status based both on educational level and income has been associated with asthma and respiratory symptoms, but changes over time in these associations have rarely been studied. The aim was to study the associations between educational or income inequality and asthma and respiratory symptoms among women and men over a 20-year period in northern Sweden. The study was performed within the Obstructive Lung disease in Northern Sweden (OLIN) research program. Mailed questionnaire surveys...

Metabarcoding of environmental DNA constitutes a state-of-the-art tool for environmental studies. One fundamental principle implicit in most metabarcoding studies is that individual sample amplicons can still be identified after being pooled with others – based on their unique combinations of tags – during the so-called demultiplexing step that follows sequencing. Nevertheless, it has been recognized that tags can sometimes be changed (i.e. tag jumping), which ultimately leads to sample crosstalk. Here, using four DNA metabarcoding...

Additional file 2: Table S1. Proportion of repetitive elements in the genome. Table S2. Comparative analysis of repeat sequences in two species. Table S3. List of 41 TEs shared in the two species (copy number >500). Table S4. Annotations of Class I retrotransposon transcript (TPM>1). Table S5. Retrotransposon transcript quantification matrix (TPM normalization) of L. migratoria. Table S6. Retrotransposon transcript quantification matrix (TPM normalization) of A. rhodopa. Table S7. Abundance of piRNAs corresponding to 41...

Additional file 1: Table s3. Test of normally distributed differences between R1 and F. Legend R1 relative regional cerebral blood flow measured with [18F]FE-PE2I, F relative regional cerebral blood flow measured with [15O]H2O PET.

Additional file 2: Figure s1. Correlation plots of R1 (FE-PE2I) and F (H2O): cingulate, putamen and caudate. Legend Right: Cingulate cortex, Middle: Putamen, Left: Caudate. Values are averaged over the left and right hemispheres. HC Healthy controls (open squares), Pat Patients (filled red dots).

Additional file 3: Figure s2. Bland–Altman plots. Legend Bland–Altman plots illustrating the relationship between the difference between R1 (FE-PE2I) and F (H2O) relative regional cerebral blood flow (on the y-axis), and the mean of R1 and F (on the x-axis) in the frontal, parietal and temporal lobes and the cingulate cortex, the putamen and the caudate, respectively. The mean of the difference is indicated by the bold black line. The upper and lower limits of...

Additional file 4: Table s1. Difference in rCBFR measured as F (H2O) and R1 (FE-PE2I) between patients and healthy controls (T-test results). Legend Measures are averaged left and right hemisphere rCBFR values. rCBFR: relative regional cerebral blood flow. HC Healthy controls; rCBFR relative regional cerebral blood flow. F relative regional cerebral blood flow measured with [15O]H2O PET. R1 relative regional cerebral blood flow measured with [18F]FE-PE2I.

Fast-adapting type 1 (FA-1) and slow-adapting type 1 (SA-1) first-order neurons in the human tactile system have distal axons that branch in the skin and form many transduction sites, yielding receptive fields with many highly sensitive zones or ‘subfields’. We previously demonstrated that this arrangement allows FA-1 and SA-1 neurons to signal the geometric features of touched objects, specifically the orientation of raised edges scanned with the fingertips. Here we show that such signaling operates...

Abstract Background The importance of stroma for tumor progression is recognized for many cancer types. In this study, we aim to evaluate the expression of types I (Col1) and IV (Col4) collagens, alpha-smooth muscle actin (a-SMA), and matrix metallopeptidase 9 (MMP-9) in the tumor stroma of small papillary thyroid carcinoma (PTC). Material and methods Twenty-five non-metastatic small PTCs (pT1N0) and nineteen metastatic small PTCs (pT1N1b) including corresponding metastatic lateral lymph nodes were selected and paraffinized...

Abstract Background The importance of stroma for tumor progression is recognized for many cancer types. In this study, we aim to evaluate the expression of types I (Col1) and IV (Col4) collagens, alpha-smooth muscle actin (a-SMA), and matrix metallopeptidase 9 (MMP-9) in the tumor stroma of small papillary thyroid carcinoma (PTC). Material and methods Twenty-five non-metastatic small PTCs (pT1N0) and nineteen metastatic small PTCs (pT1N1b) including corresponding metastatic lateral lymph nodes were selected and paraffinized...

Additional file 1: Supplementary Table 1. Gender comparison of the mean values of the distribution and total scores of the different stromal biomarkers (Col1, Col4, a-SMA and MMP-9) regarding the different tumour groups (N0T and N1T). No significant differences were found between males and females regarding the expression of stromal biomarkers.

Additional file 1. Gene expression data retrieved from the Sequence Read Archive, https://www.ncbi.nlm.nih.gov/sra .

Abstract Correlation networks derived from multivariate data appear in many applications across the sciences. These networks are usually dense and require sparsification to detect meaningful structure. However, current methods for sparsifying correlation networks struggle with balancing overfitting and underfitting. We propose a module-based cross-validation procedure to threshold these networks, making modular structure an integral part of the thresholding. We illustrate our approach using synthetic and real data and find that its ability to recover a...

Additional file 2. Data base searches.

Additional file 3. Guidelines for data charting

Additional file 5. Table of included articles (author(s), year of publication, reference, country, aims and research questions, methodology, type of data material, length of data collection period, number of participants)

The Permo-Triassic vertebrate assemblage zones (AZs) of South Africa’s Karoo Basin are a standard for local and global correlations. However, temporal, geographical, and methodological limitations challenge the AZs reliability. We analyze a unique fossil dataset comprising 1408 occurrences of 115 species grouped into 19 stratigraphic bin intervals from the Cistecephalus, Daptocephalus, Lystrosaurus declivis, and Cynognathus AZs. Using network science tools we compare six frameworks: Broom, Rubidge, Viglietti, Member, Formation, including a framework suggesting diachroneity of...