A relationship between exposure to sexual violence and thyroid hormone alterations has been observed among women with posttraumatic stress disorder (PTSD). Women with borderline personality disorder (BPD) report a high estimate of childhood trauma. The aim of the present study was to assess relationships between thyroid hormone measures and exposure to violence in childhood in women with BPD. A total of 92 clinically euthyroid women with BPD (53% with comorbid PTSD) diagnosis and at least...

A relationship between exposure to sexual violence and thyroid hormone alterations has been observed among women with posttraumatic stress disorder (PTSD). Women with borderline personality disorder (BPD) report a high estimate of childhood trauma. The aim of the present study was to assess relationships between thyroid hormone measures and exposure to violence in childhood in women with BPD. A total of 92 clinically euthyroid women with BPD (53% with comorbid PTSD) diagnosis and at least...

As a valid metric of metric-measure spaces, Gromov-Wasserstein (GW) distance has shown the potential for matching problems of structured data like point clouds and graphs. However, its application in practice is limited due to the high computational complexity. To overcome this challenge, we propose a novel importance sparsification method, called Spar-GW, to approximate GW distance efficiently. In particular, instead of considering a dense coupling matrix, our method leverages a simple but effective sampling strategy to...

As a valid metric of metric-measure spaces, Gromov-Wasserstein (GW) distance has shown the potential for matching problems of structured data like point clouds and graphs. However, its application in practice is limited due to the high computational complexity. To overcome this challenge, we propose a novel importance sparsification method, called Spar-GW, to approximate GW distance efficiently. In particular, instead of considering a dense coupling matrix, our method leverages a simple but effective sampling strategy to...

The REMOTE Panel is a four wave longitudinal dataset collected from over 3500 Norwegian employees over the course of 2022 to capture their experiences with remote and hybrid work arrangements.
The dataset is licensed under CC BY-NC-ND 4.0 for non-commercial use only. Note that the data will not be shared as long as the REMOTE project is ongoing, and all use of the data until the project is completed must be through REMOTE with...

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the...

Supplemental material, sj-docx-1-sph-10.1177_19417381221147305 for A Longitudinal Case-Control Study of a Female Athlete Preinjury and After ACL Reconstruction: Hop Performance, Knee Muscle Strength, and Knee Landing Mechanics by Josefine E. Naili, Jonas L. Markström and Charlotte K. Häger in Sports Health: A Multidisciplinary Approach

ObjectivesAndrogen deprivation therapy (ADT) has long been a cornerstone in treatment of advanced prostate cancer (PCa), and is known to improve the results of radiotherapy (RT) for high-risk disease. The purpose of our study was to use a multiplexed immunohistochemical (mIHC) approach to investigate the infiltration of immune cells in PCa tissue after eight weeks of ADT and/or RT with 10 Gy.MethodsFrom a cohort of 48 patients divided into two treatment arms, we obtained biopsies...

Data file in Excel format, with clinical diabetes and neuropathy parameters in a Swedish cohort, taken at baseline and follow-up in 2014. The follow-up data corresponds to the same time point where in vivo corneal confocal microscopy data/images were taken (see other datasets in the collection).

Stress-related exhaustion is associated with cognitive deficits, measured subjectively using questionnaires targeting everyday slips and failures or more objectively as performance on cognitive tests. Yet, only weak associations between subjective and objective cognitive measures in this group has been presented, theorized to reflect recruitment of compensational resources during cognitive testing. This explorative study investigated how subjectively reported symptoms of cognitive functioning and burnout levels relate to performance as well as neural activation during a response...

Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated...

Athletes with an anterior cruciate ligament (ACL) injury followed by ACL reconstruction (ACLR) often perform various testing to guide return to sport, but preinjury data are rarely available for comparison. This longitudinal case-control study reports absolute value and between-leg symmetry data on maximal performances for single-leg hop height and distance, muscle strength, and side hop landing mechanics of an 18-year-old female soccer athlete collected 5 months before sustaining an ACL injury and again at 10,...

The REMOTE Panel is a four wave longitudinal dataset collected from over 3500 Norwegian employees over the course of 2022 to capture their experiences with remote and hybrid work arrangements.
The dataset is licensed under CC BY-NC-ND 4.0 for non-commercial use only. Note that the data will not be shared as long as the REMOTE project is ongoing, and all use of the data until the project is completed must be through REMOTE with...

In males, aging is accompanied by decline in serum testosterone levels due to impairment of testicular Leydig cells. The polycomb protein BMI1 has recently been identified as an anti-aging factor. In our previous study, BMI1 null mice showed decreased serum testosterone and Leydig cell population, excessive oxidative stress and p16/p19 signaling activation. However, a cause-and-effect relationship between phenotypes and pathways was not investigated. Here, we used the rescue approach to study the role of oxidative...

Supplemental material, sj-docx-1-tpp-10.1177_20451253231151514 for Incidence of hyperthyroidism in patients with bipolar or schizoaffective disorder with or without lithium: 21-year follow-up from the LiSIE retrospective cohort study by Ingrid Lieber, Michael Ott, Robert Lundqvist, Mats Eliasson and Ursula Werneke in Therapeutic Advances in Psychopharmacology

We tested interactive effects of warming (+2°C) and browning on periphyton accrual and pigment composition when grown on a synthetic substrate (plastic strips) in the euphotic zone of sixteen experimental ponds. We found that increased DOC alone, or in combination with warming, resulted in a substantially enhanced biomass accrual of periphyton, illustrating that periphyton is capable of using nutrients associated with DOC, and by this may affect nutrient availability for phytoplankton. However, warming weakened the...

Supplemental Material for Infiltrating immune cells in prostate cancer tissue after androgen deprivation and radiotherapy by Ann Erlandsson, Marie Lundholm, Johan Watz, Anders Bergh, Elitsa Petrova, Farhood Alamdari, Thomas Helleday, Sabina Davidsson, Ove Andren and Firas Tarish in International Journal of Immunopathology and Pharmacology.

The REMOTE Panel is a four wave longitudinal dataset collected from over 3500 Norwegian employees over the course of 2022 to capture their experiences with remote and hybrid work arrangements.

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the...

Athletes with an anterior cruciate ligament (ACL) injury followed by ACL reconstruction (ACLR) often perform various testing to guide return to sport, but preinjury data are rarely available for comparison. This longitudinal case-control study reports absolute value and between-leg symmetry data on maximal performances for single-leg hop height and distance, muscle strength, and side hop landing mechanics of an 18-year-old female soccer athlete collected 5 months before sustaining an ACL injury and again at 10,...

Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning...

Supplemental Material for Infiltrating immune cells in prostate cancer tissue after androgen deprivation and radiotherapy by Ann Erlandsson, Marie Lundholm, Johan Watz, Anders Bergh, Elitsa Petrova, Farhood Alamdari, Thomas Helleday, Sabina Davidsson, Ove Andren and Firas Tarish in International Journal of Immunopathology and Pharmacology.

Background:Lithium-associated hyperthyroidism is much rarer than lithium-associated hypothyroidism. Yet, it may be of substantial clinical significance for affected individuals. For instance, lithium-associated hyperthyroidism could destabilise mood, mimic manic episodes and impact physical health. Only few studies have explored incidence rates of lithium-associated hyperthyroidism. Even fewer studies have compared incidence rates according to lithium exposure history.Objectives:To determine the impact of lithium treatment on the incidence rate of hyperthyroidism in patients with bipolar or schizoaffective disorder and...

Social sustainability has increasingly become a goal for urban policy and planning, and for local and regional developmental strategies. Neighbourhoods are a common spatial scale for studying social sustainability and there is a growing focus on social sustainability in urban neighbourhoods for both researchers and policymakers. This paper is based on a qualitative case study of a neighbourhood defined by the municipality as at-risk of negative social development in a municipality in northern Sweden. The...

We consider the model-free feature screening problem that aims to discard non-informative features before downstream analysis. Most of the existing feature screening approaches have at least quadratic computational cost with respect to the sample size n, thus may suffer from a huge computational burden when n is large. To alleviate the computational burden, we propose a scalable model-free sure independence screening approach. This approach is based on the so-called sliced-Wasserstein dependency, a novel metric that...