5 Works

Antitumor activity of the protein kinase inhibitor 1-(β-D-2′-deoxyribofuranosyl)-4,5,6,7-tetrabromo- 1H-benzimidazole in breast cancer cell lines

Mirosława Koronkiewicz, Zygmunt Kazimierczuk & Andrzej Orzeszko
Abstract Background The protein kinases CK2 and PIM-1 are involved in cell proliferation and survival, the cell cycle, and drug resistance, and they are found overexpressed in virtually all types of human cancer, including breast cancer. In this study, we investigated the antitumor activity of a deoxynucleoside derivative, the protein kinase inhibitor compound 1-(β-D-2′-deoxyribofuranosyl)-4,5,6,7-tetrabromo-1H-benzimidazole (K164, also termed TDB), inter alia CK2 and PIM-1, on breast cancer cell lines (MDA-MB-231, MCF-7, and SK-BR-3). Methods An evaluation...

Additional file 1 of Antitumor activity of the protein kinase inhibitor 1-(β-D-2′-deoxyribofuranosyl)-4,5,6,7-tetrabromo- 1H-benzimidazole in breast cancer cell lines

Mirosława Koronkiewicz, Zygmunt Kazimierczuk & Andrzej Orzeszko
Additional file 1.

Antitumor activity of the protein kinase inhibitor 1-(β-D-2′-deoxyribofuranosyl)-4,5,6,7-tetrabromo- 1H-benzimidazole in breast cancer cell lines

Mirosława Koronkiewicz, Zygmunt Kazimierczuk & Andrzej Orzeszko
Abstract Background The protein kinases CK2 and PIM-1 are involved in cell proliferation and survival, the cell cycle, and drug resistance, and they are found overexpressed in virtually all types of human cancer, including breast cancer. In this study, we investigated the antitumor activity of a deoxynucleoside derivative, the protein kinase inhibitor compound 1-(β-D-2′-deoxyribofuranosyl)-4,5,6,7-tetrabromo-1H-benzimidazole (K164, also termed TDB), inter alia CK2 and PIM-1, on breast cancer cell lines (MDA-MB-231, MCF-7, and SK-BR-3). Methods An evaluation...

Legal issues in marketing of anabolic-androgenic steroids

Adam Mazurek & Krzysztof Jop
This article provides an insight into the issue of illicit marketing of anabolic-androgenic steroids (AAS) in Poland. This risk attached to this phenomenon is particularly reflected in forensic opinions elaborated by the National Medicines Institute for the Police, prosecutor’s offices, Border Guard and other agencies. The casework opinions concern AAS preparations not admitted to trading in Poland for various reasons, raw materials used in the production process, preparations admitted to trading, yet marketed in breach...

Additional file 1 of Antitumor activity of the protein kinase inhibitor 1-(β-D-2′-deoxyribofuranosyl)-4,5,6,7-tetrabromo- 1H-benzimidazole in breast cancer cell lines

Mirosława Koronkiewicz, Zygmunt Kazimierczuk & Andrzej Orzeszko
Additional file 1.

Registration Year

  • 2022
    4
  • 2020
    1

Resource Types

  • Collection
    2
  • Text
    2
  • Data Paper
    1

Affiliations

  • Narodowy Instytut Leków
    5
  • Warsaw University of Life Sciences
    4