45 Works

Data from: Modeling site heterogeneity with posterior mean site frequency profiles accelerates accurate phylogenomic estimation

Huai-Chun Wang, Bui Quang Minh, Edward Susko & Andrew J. Roger
Proteins have distinct structural and functional constraints at different sites that lead to site-specific preferences for particular amino acid residues as the sequences evolve. Heterogeneity in the amino acid substitution process between sites is not modeled by commonly used empirical amino acid exchange matrices. Such model misspecification can lead to artefacts in phylogenetic estimation such as long-branch attraction. Although sophisticated site-heterogeneous mixture models have been developed to address this problem in both Bayesian and maximum...

Age, tissue, genotype and virus infection regulate Wolbachia levels in Drosophila

Rupinder Kaur, Julien Martinez, Omar Rota-Stabelli, Frank Jiggins & Wolfgang Miller
The bacterial symbiont Wolbachia can protect insects against viral pathogens, and the varying levels of antiviral protection are correlated with the endosymbiont load within the insects. To understand why Wolbachia strains differ in their antiviral effects, we investigated the factors controlling Wolbachia density in five closely related strains in their natural Drosophila hosts. We found that Wolbachia density varied greatly across different tissues and between flies of different ages, and these effects depended on the...

Trastuzumab: subkutan oder intravenös?

Anna Glechner & Miriam Van den Nest

Primärprävention: Statine bei Personen mit kardiovaskulären Risikofaktoren

Anna Glechner & Miriam Van den Nest

Additional file 1 of Resilience of people with chronic medical conditions during the COVID-19 pandemic: a 1-year longitudinal prospective survey

Lorenzo Tarsitani, Irene Pinucci, Federico Tedeschi, Martina Patanè, Davide Papola, Christina Palantza, Ceren Acarturk, Emma Björkenstam, Richard Bryant, Sebastian Burchert, Camille Davisse-Paturet, Amanda Díaz-García, Rachel Farrel, Daniela C. Fuhr, Brian J. Hall, Anja C. Huizink, Agnes Iok Fong Lam, Gülşah Kurt, Ingmar Leijen, Ellenor Mittendorfer-Rutz, Naser Morina, Catherine Panter-Brick, Fredrick Dermawan Purba, Soledad Quero, Soraya Seedat … & Corrado Barbui
Additional file 1: Procedures for model identification. Fig. S1. Flowchart of sample identification. Table S1. Descriptive statistics of resilience indicators across the survey waves (N = 1052)*. Table S2. Frequency of each chronic medical condition in the whole sample. Table S3. Comparison between participants with and without chronic medical conditions at baseline*. Table S4. Descriptive statistics at the first wave of socio-demographic and clinical characteristics of participants with a chronic condition included vs excluded (because...

Additional file 1 of Resilience of people with chronic medical conditions during the COVID-19 pandemic: a 1-year longitudinal prospective survey

Lorenzo Tarsitani, Irene Pinucci, Federico Tedeschi, Martina Patanè, Davide Papola, Christina Palantza, Ceren Acarturk, Emma Björkenstam, Richard Bryant, Sebastian Burchert, Camille Davisse-Paturet, Amanda Díaz-García, Rachel Farrel, Daniela C. Fuhr, Brian J. Hall, Anja C. Huizink, Agnes Iok Fong Lam, Gülşah Kurt, Ingmar Leijen, Ellenor Mittendorfer-Rutz, Naser Morina, Catherine Panter-Brick, Fredrick Dermawan Purba, Soledad Quero, Soraya Seedat … & Corrado Barbui
Additional file 1: Procedures for model identification. Fig. S1. Flowchart of sample identification. Table S1. Descriptive statistics of resilience indicators across the survey waves (N = 1052)*. Table S2. Frequency of each chronic medical condition in the whole sample. Table S3. Comparison between participants with and without chronic medical conditions at baseline*. Table S4. Descriptive statistics at the first wave of socio-demographic and clinical characteristics of participants with a chronic condition included vs excluded (because...

Data from: Systematic review and network meta-analysis comparing antithrombotic agents for the prevention of stroke and major bleeding in patients with atrial fibrillation

Chris Cameron, Douglas Coyle, Trevor Richter, Shannon Kelly, Kasandra Gauthier, Sabine Steiner, Marc Carrier, Kathryn Coyle, Annie Bai, Kristen Moulton, Tammy Clifford & George Wells
Objective: To examine the comparative efficacy and safety of antithrombotic treatments (apixaban, dabigatran, edoxaban, rivaroxaban and vitamin K antagonists (VKA) at a standard adjusted dose (target international normalised ratio 2.0–3.0), acetylsalicylic acid (ASA), ASA and clopidogrel) for non-valvular atrial fibrillation and among subpopulations. Design: Systematic review and network meta-analysis. Data sources: A systematic literature search strategy was designed and carried out using MEDLINE, EMBASE, the Cochrane Register of Controlled Trials and the grey literature including...

Data from: Phylogenomics resolves the timing and pattern of insect evolution

Bernhard Misof, Shanlin Liu, Karen Meusemann, Ralph S. Peters, Alexander Donath, Christoph Mayer, Paul B. Frandsen, Jessica Ware, Tomas Flouri, Rolf G. Beutel, Oliver Niehuis, Malte Petersen, Fernando Izquierdo-Carrasco, Torsten Wappler, Jes Rust, Andre J. Aberer, Ulrike Aspöck, Horst Aspöck, Daniela Bartel, Alexander Blanke, Simon Berger, Alexander Böhm, Thomas Buckley, Brett Calcott, Junqing Chen … & Xin Zhou
Insects are the most speciose group of animals, but the phylogenetic relationships of many major lineages remain unresolved. We inferred the phylogeny of insects from 1478 protein-coding genes. Phylogenomic analyses of nucleotide and amino acid sequences, with site-specific nucleotide or domain-specific amino acid substitution models, produced statistically robust and congruent results resolving previously controversial phylogenetic relations hips. We dated the origin of insects to the Early Ordovician [~479 million years ago (Ma)], of insect flight...

Data from: Hierarchical decision-making balances current and future reproductive success

Eva Ringler, Georgine Szipl, Ryan J. Harrigan, Petra Bartl-Binder, Rosanna Mangione, Max Ringler & Perta Bartl-Binder
Parental decisions in animals are often context-dependent and shaped by fitness trade-offs between parents and offspring. For example, the selection of breeding habitats can considerably impact the fitness of both offspring and parents, and therefore parents should carefully weigh the costs and benefits of available options for their current and future reproductive success. Here we show that resource-use preferences are shaped by a trade-off between parental effort and offspring safety in a tadpole-transporting frog. In...

Supplement to: Hippocampal neurochemical profile and glucose transport kinetics in patients with type 1 diabetes

Petr Bednařík, Pierre Gilles Henry, Ameer Khowaja, Nathan Rubin, Anjali Kumar, Dinesh Deelchand, Lynn Eberly, Elizabeth Seaquist, Gülin Öz & Moheet Amir
Context Longstanding type 1 diabetes (T1D) may lead to alterations in hippocampal neurochemical profile. Upregulation of hippocampal glucose transport as a result of recurrent exposure to hypoglycemia may preserve cognitive function during future hypoglycemia in subjects with T1D and impaired awareness of hypoglycemia (IAH). The effect of T1D on hippocampal neurochemical profile and glucose transport is unknown. Objective To test the hypothesis that hippocampal neurochemical composition is altered in T1D and glucose transport is upregulated...

Labeled motor neurons following single and double nerve reinnervation of the long head of the biceps

Matthias Luft
We developed a novel rat model to investigate the neurophysiological effects of peripheral double nerve transfers to a single target muscle. In 62 male Sprague-Dawley rats the ulnar nerve of the antebrachium alone (n=30) or together with the anterior interosseus nerve (n=32) was transferred to reinnervate the long head of the biceps brachii. To further assess reinnervation, retrograde labeling was performed. Twelve weeks following surgery retrograde tracer dyes were injected in the long head of...

Statine bei PatientInnen mit Artherosklerose

Anna Glechner & Miriam Van den Nest

Die Interessensvertretungen österreichischer Bibliothekar*innen in der Ersten Republik

Walter Mentzel
75 Jahre VÖB. 1946–2021, Hg. v. Alker-Windbichler, Bauer und Köstner-Pemsel, 2021, S. 93–124

sj-pdf-1-smm-10.1177_09622802221129051 - Supplemental material for Online control of the False Discovery Rate in group-sequential platform trials

Sonja Zehetmayer, Martin Posch & Franz Koenig
Supplemental material, sj-pdf-1-smm-10.1177_09622802221129051 for Online control of the False Discovery Rate in group-sequential platform trials by Sonja Zehetmayer, Martin Posch and Franz Koenig in Statistical Methods in Medical Research

Data from: Outcome after reconstruction of the proximal tibia – complications and competing risk analysis

Stephan Puchner, Paul Kutscha-Lissberg, Alexandra Kaider, Joannis Panotopoulos, Rudolf Puchner, Christoph Böhler, Gerhard Hobusch, Reinhard Windhager, Philipp T. Funovics & Stephan E. Puchner
Background and Objectives: The proximal tibia (pT) is a common site for bone tumors. Improvements in imaging, chemotherapy and surgical technique made limb salvage surgery the treatment of choice. Yet, reconstructions of the pT have been associated with less favorable outcome compared to other parts of the extremities. The aim of this study was to evaluate the outcome of patients with a modular endoprosthetic reconstruction of the pT. Methods: Eighty-one consecutive patients with an average...

Data from: Do pet dogs (Canis familiaris) follow ostensive and non-ostensive human gaze to distant space and to objects?

Charlotte Duranton, Friederike Range & Zsófia Virányi
Dogs are renowned for being skilful at using human-given communicative cues such as pointing. Results are contradictory, however, when it comes to dogs' following human gaze, probably due to methodological discrepancies. Here we investigated whether dogs follow human gaze to one of two food locations better than into distant space even after comparable pre-training. In Experiments 1 and 2, the gazing direction of dogs was recorded in a gaze-following into distant space and in an...

Universitätsbibliotheken der öffentlichen Universitäten in Österreich – unverzichtbare Partner für Forschung und Lehre? Ergebnisse einer Analyse von Entwicklungsplänen, Leistungsvereinbarungen und Wissensbilanzen 2004 bis 2019

Bruno Bauer
Mit 1. Jänner 2004 ist das Bundesgesetz über die Organisation der Universitäten und ihre Studien (Universitätsgesetz – UG 2002) in Kraft getreten, das die öffentlichen Universitäten in Österreich in die Vollrechtsfähigkeit entlassen hat. Damit einher ging die Etablierung von Rahmenbedingungen für ein strategisches Management an den Universitäten. An die Stelle der bisher vom zuständigen Bundesministerium gepflegten Verordnungskultur ist eine Vereinbarungskultur zwischen Universitäten und Bundesministerium getreten. Eine wesentliche Rolle kommt hierbei Entwicklungsplänen, Leistungsvereinbarungen und Wissensbilanzen zu....

Data from: The genetic landscape of axonal neuropathies in the middle aged and elderly: focus on MME (supplementary information)

Michaela Auer-Grumbach
OBJECTIVE: To test the hypothesis that monogenic neuropathies such as Charcot-Marie-Tooth disease (CMT) contribute to frequent but often unexplained neuropathies in the elderly, we performed genetic analysis of 230 patients with unexplained axonal neuropathies and disease onset >35 years. METHODS: We recruited patients, collected clinical data and conducted whole-exome sequencing (WES, n=126) and MME single-gene sequencing (n=104). We further queried WES repositories for MME variants and measured blood levels of the MME-encoded protein neprilysin. RESULTS:...

Data from: An integrative phylogenomic approach to elucidate the evolutionary history and divergence times of Neuropterida (Insecta: Holometabola)

Alexandros Vasilikopoulos, Bernhard Misof, Karen Meusemann, Doria Lieberz, Tomáš Flouri, Rolf G. Beutel, Oliver Niehuis, Torsten Wappler, Jes Rust, Ralph S. Peters, Alexander Donath, Lars Podsiadlowski, Christoph Mayer, Daniela Bartel, Alexander Böhm, Shanlin Liu, Paschalia Kapli, Carola Greve, James E. Jepson, Xingyue Liu, Xin Zhou, Horst Aspöck & Ulrike Aspöck
Background The latest advancements in DNA sequencing technologies have facilitated the resolution of the phylogeny of insects, yet parts of the tree of Holometabola remain unresolved. The phylogeny of Neuropterida has been extensively studied, but no strong consensus exists concerning the phylogenetic relationships within the order Neuroptera, and the timeline of diversification of thelineages of Neuropterida. Here, we assembled a novel transcriptomic dataset to address previously unresolved issues in the phylogeny of Neuropterida and to...

Substrate induced currents through the monoamine transporters and single cell uptake of the fluorescent substrate APP+

Walter Sandtner
The concentrative power of the transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT) is thought to be fueled by the transmembrane Na+ gradient, but it is conceivable that they can also tap other energy sources, e.g. membrane voltage and/or the transmembrane K+ gradient. We address this by recording uptake of endogenous substrates or the fluorescent substrate APP+ ((4-(4-dimethylamino)phenyl-1-methylpyridinium) under voltage control in cells expressing DAT, NET or SERT. We show that DAT and NET...

Intraartikuläre Injektionen mit Corticosteroiden bei Knie-Arthrose

Anna Glechner & Miriam Van den Nest

Online control of the False Discovery Rate in group-sequential platform trials

Sonja Zehetmayer, Martin Posch & Franz Koenig
When testing multiple hypotheses, a suitable error rate should be controlled even in exploratory trials. Conventional methods to control the False Discovery Rate assume that all p-values are available at the time point of test decision. In platform trials, however, treatment arms enter and leave the trial at different times during its conduct. Therefore, the actual number of treatments and hypothesis tests is not fixed in advance and hypotheses are not tested at once, but...

sj-R-2-smm-10.1177_09622802221129051 - Supplemental material for Online control of the False Discovery Rate in group-sequential platform trials

Sonja Zehetmayer, Martin Posch & Franz Koenig
Supplemental material, sj-R-2-smm-10.1177_09622802221129051 for Online control of the False Discovery Rate in group-sequential platform trials by Sonja Zehetmayer, Martin Posch and Franz Koenig in Statistical Methods in Medical Research

Data from: Genetic architecture and functional characterization of genes underlying the rapid diversification of male external genitalia between Drosophila simulans and Drosophila mauritiana

Kentaro M. Tanaka, Corinna Hopfen, Matthew R. Herbert, Christian Schlötterer, David L. Stern, John P. Masly, Alistair P. McGregor & Maria D. S. Nunes
Male sexual characters are often among the first traits to diverge between closely related species and identifying the genetic basis of such changes can contribute to our understanding of their evolutionary history. However, little is known about the genetic architecture or the specific genes underlying the evolution of male genitalia. The morphology of the claspers, posterior lobes and anal plates exhibit striking differences between Drosophila mauritiana and Drosophila simulans. Using QTL and introgression-based high-resolution mapping,...

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Affiliations

  • Medical University of Vienna
    45
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  • Koç University
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