211 Works

Raw mass-standardized ionomic data from seven fish species and raw transcriptome sequences for mosquitofish inhabiting the Tar Creek Superfund Site in OK, USA

John Coffin, Joanna Kelley, Punidan Jeyasingh & Michael Tobler
Our understanding of the mechanisms mediating the resilience of organisms to environmental change remains lacking. Heavy metals negatively affect processes at all biological scales, yet organisms inhabiting contaminated environments must maintain homeostasis to survive. Tar Creek in Oklahoma, USA, contains high concentrations of heavy metals and an abundance of Western mosquitofish (Gambusia affinis), though several fish species persist at lower frequency. To test hypotheses about the mechanisms mediating the persistence and abundance of mosquitofish in...

Data from: Applied phenomics and genomics for improving barley yellow dwarf resistance in winter wheat

Paula Silva, Byron Evers, Alexandria Kieffaber, Xu Wang, Allan Fritz, Jared Crain, Jesse Poland & Liangliang Gao
Barley yellow dwarf is one of the major viral diseases of cereals. Phenotyping barley yellow dwarf in wheat is extremely challenging due to similarities to other biotic and abiotic stresses. Breeding for resistance is additionally challenging as the wheat primary germplasm pool lacks genetic resistance, with most of the few resistance genes named to date originating from a wild relative species. The objectives of this study were to (1) evaluate the use of high-throughput phenotyping...

Kernel weight contribution to yield genetic gain of maize: A global dataset of maize yield, kernel number, and kernel weight over the last century

Javier Fernandez, Carlos Messina, Andrea Salinas, P.V. Vara Prasad, Jesse Nippert & Ignacio Ciampitti
Studies characterizing the effect of a century of plant breeding on physiological traits are highly needed to identify candidate traits for future improvement in maize (Zea mays L.). A global evaluation of kernel weight progress over time requires the assembly of large and reliable data documenting genetic improvements in this trait across commercial breeding programs in different regions. We compiled a global dataset of yield and yield components from 34 published and unpublished studies comparing...

Stachydrine is effective and selective against blast phase chronic myeloid leukaemia through inhibition of multiple receptor tyrosine kinases

Ruixin Gu, Wei Zhang & Dandan Xu
Resistance to BCR-ABL tyrosine kinase inhibitor (TKI) is the cause of treatment failure in blast phase chronic myeloid leukaemia (BP-CML). Agents that act synergistically with BCR-ABL TKI are required to improve response. This work investigated the effects of stachydrine in CML. CML cells were treated with control or stachydrine at 20, 40 and 80 µM. Proliferation and apoptosis were examined after 72 h treatment. Combination studies were performed in four groups: control, TKI, stachydrine and...

Long non-coding RNA-PCGEM1 contributes to prostate cancer progression by sponging microRNA miR-129-5p to enhance chromatin licensing and DNA replication factor 1 expression

Qiao Fu, Fangfang Wang, Jun Yang, Wei Sun, Zhi Hu, Lv Xu, Hao Chu, Xiao Wang & Wei Zhang
PCGEM1 facilitates prostate cancer (PCa) progression. This study aimed to elucidate the mechanism of action of PCGEM1 in PCa. The expression of PCGEM1, microRNA miR-129-5p, chromatin licensing, and DNA replication factor 1 (CDT1) was detected by quantitative reverse transcription-PCR (qRT-PCR). A series of function experiments including cell counting kit-8 (CCK-8), caspase-3 activity, and cell cycle assays were performed to evaluate the influence of PCGEM1, miR-129-5p, and CDT1 on the biological processes of PCa cells. CyclinD1,...

Compound glycyrrhiza oral solution alleviates oxidative stress and inflammation by regulating SRC/MAPK pathway in chronic obstructive pulmonary disease

Xiaolin Xu, Mulan Huang, Xiaofeng Duan, Hongyu Liu, Wei Zhang & Dan Li
Patients with chronic obstructive pulmonary disease (COPD) suffer from persistent cough and breathlessness, which can be ameliorated by the Chinese herbal medicine glycyrrhiza. Furthermore, the SRC/MAPK pathway is activated in the process of oxidative stress and inflammation, which afflict COPD progression. Thus, this research aimed at dissecting the mechanism of compound glycyrrhiza oral solution (CGOS) relieving oxidative stress and inflammation in COPD via the SRC/MAPK pathway. After a COPD rat model was established using lipopolysaccharide...

CCNE1 is a potential target of Metformin for tumor suppression of ovarian high-grade serous carcinoma

Jie Mei, Huixiang Tian, Hsuan-Shun Huang, Nayiyuan Wu, Yu-Ligh Liou, Tang-Yuan Chu, Jing Wang & Wei Zhang
High-grade serous ovarian cancer (HGSOC) is the most common and malignant type of ovarian cancer, accounting for 70%–80% of mortality. However, the treatment of HGSOC has improved little in the past few decades. Metformin is the first-line medication for the treatment of type 2 diabetes and has now gained more attention in cancer treatment. In this study, we sought to identify potential hub genes that metformin could target in the treatment of HGSOC. We downloaded...

A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner

Qiankun Yang, Jianguo Zhang, Feixue Liu, Huizhen Chen, Wei Zhang, Haitao Yang, Nana He, Jingquan Dong & Panpan Zhao
Aeromonas caviae, an important food-borne pathogen, induces serious invasive infections and inflammation. The pro-inflammatory IL-1β functions against pathogenic infections and is elevated in various Aeromonas infection cases. However, the molecular mechanism of A. caviae-mediated IL-1β secretion remains unknown. In this study, mouse macrophages (PMs) were used to establish A. caviae infection model and multiple strategies were utilized to explore the mechanism of IL-1β secretion. IL-1β was elevated in A. caviae infected murine serum, PMs lysates...

The Cauchy Combination Test under Arbitrary Dependence Structures

Mingya Long, Zhengbang Li, Wei Zhang & Qizhai Li
Combining individual p-values to perform an overall test is often encountered in statistical applications. The Cauchy combination test (CCT) (Journal of the American Statistical Association, 2020, 115, 393–402) is a powerful and computationally efficient approach to integrate individual p-values under arbitrary dependence structures for sparse signals. We revisit this test to additionally show that (i) the tail probability of the CCT can be approximated just as well when more relaxed assumptions are imposed on individual...

Emergency versus delayed hepatectomy following transarterial embolization in spontaneously ruptured hepatocellular carcinoma survivors: a systematic review and meta-analysis

Wei Zhang, Zhangkan Huang & Xu Che
Abstract Background Spontaneous rupture is a life-threatening complication of hepatocellular carcinoma (HCC). Recent trends in surgical treatments avoid emergency hepatectomy (EH) and favor emergency transarterial embolization (TAE) followed by delayed hepatectomy (DH). Still, there is debate on which is the better treatment option and whether delaying hepatectomy increases peritoneal metastasis. Aim To provide evidence-based references for the optimal management of patients with spontaneously ruptured HCC by comparing the outcomes of EH and DH. Methods Literature...

Supplemental Material - Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review

Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen & Wei Zhang
Supplemental Material for Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review by Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen, and Wei Zhang in International Journal of Immunopathology and Pharmacology

Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review

Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen & Wei Zhang
Objective: With the global epidemic of coronavirus disease 2019 (COVID-19), vaccination rates are increasing globally. This study evaluated the relevant clinical manifestations of vaccinated COVID-19 patients. Methods: We searched carefully in 11 databases such as PubMed, Embase, Scopus, Cochrane Library, Web of Science, Ovid, China National Knowledge Infrastructure Database, Wan Fang Data, Sinomed, VIP Database, and Reading Showing Database up to 26 March 2022. To search for articles that have described the characteristics of vaccinated...

Additional file 3 of Microbiome insights into pediatric familial adenomatous polyposis

Thomas M. Attard, Seth Septer, Caitlin E. Lawson, Mark I. Attard, Sonny T. M. Lee & Shahid Umar
Additional file 3. The training and validation sets used in machine learning methods.

Additional file 1 of SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal

Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Xiaoping Tu, Liang Peng, Sijin Liu, Xing Bai, Yongping Song, Zhongxing Jiang, Ruliang Zhang & Wenzhi Tian
Additional file 1. Supplement figures (Figs. S1–S15), materials and methods.

Additional file 3 of Emergency versus delayed hepatectomy following transarterial embolization in spontaneously ruptured hepatocellular carcinoma survivors: a systematic review and meta-analysis

Wei Zhang, Zhangkan Huang & Xu Che
Additional file 3: Supplemental file 3. Begg’s test and Egger's test for each outcome.

Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review

Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen & Wei Zhang
Objective: With the global epidemic of coronavirus disease 2019 (COVID-19), vaccination rates are increasing globally. This study evaluated the relevant clinical manifestations of vaccinated COVID-19 patients. Methods: We searched carefully in 11 databases such as PubMed, Embase, Scopus, Cochrane Library, Web of Science, Ovid, China National Knowledge Infrastructure Database, Wan Fang Data, Sinomed, VIP Database, and Reading Showing Database up to 26 March 2022. To search for articles that have described the characteristics of vaccinated...

Additional file 1 of Modelling the effects of antimicrobial metaphylaxis and pen size on bovine respiratory disease in high and low risk fattening cattle

Sébastien Picault, Pauline Ezanno, Kristen Smith, David Amrine, Brad White & Sébastien Assié
Additional file 1. Additional information on the processes involved in the model (section 1) and the whole content of the model (section 2).

Modelling the effects of antimicrobial metaphylaxis and pen size on bovine respiratory disease in high and low risk fattening cattle

Sébastien Picault, Pauline Ezanno, Kristen Smith, David Amrine, Brad White & Sébastien Assié
Abstract Bovine respiratory disease (BRD) dramatically affects young calves, especially in fattening facilities, and is difficult to understand, anticipate and control due to the multiplicity of factors involved in the onset and impact of this disease. In this study we aimed to compare the impact of farming practices on BRD severity and on antimicrobial usage. We designed a stochastic individual-based mechanistic BRD model which incorporates not only the infectious process, but also clinical signs, detection...

Additional file 2 of Modelling the effects of antimicrobial metaphylaxis and pen size on bovine respiratory disease in high and low risk fattening cattle

Sébastien Picault, Pauline Ezanno, Kristen Smith, David Amrine, Brad White & Sébastien Assié
Additional file 2. BRD model in EMULSION format. BRD model expressed within the modelling language used by the EMULSION simulation engine (based on YAML format).

Supplementary document for Activity Enhancement of Photo-generated Carrier in CsPbBr3 Nanocrystals Improved by Cd Element - 6060264.pdf

Lianfei Yao, Xue Lou, Ning Sui, Wei Zhang, Hongwei Xiao, Xiaochun Chi, Hanzhuang Zhang & Yinghui Wang
Fitting methods and supplementary data

Deep brain stimulation of the nucleus basalis of Meynert modulates hippocampal–frontoparietal networks in patients with advanced Alzheimer’s disease

Yin Jiang, Tian-Shuo Yuan, Ying-Chuan Chen, Peng Guo, Teng-Hong Lian, Yu-Ye Liu, Wei Liu, Yu-Tong Bai, Quan Zhang, Wei Zhang & Jian-Guo Zhang
Abstract Background Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has shown potential for the treatment of mild-to-moderate Alzheimer’s disease (AD). However, there is little evidence of whether NBM-DBS can improve cognitive functioning in patients with advanced AD. In addition, the mechanisms underlying the modulation of brain networks remain unclear. This study was aimed to assess the cognitive function and the resting-state connectivity following NBM-DBS in patients with advanced AD. Methods Eight...

Additional file 4 of Effects of mitochondrial dysfunction on bone metabolism and related diseases: a scientometric study from 2003 to 2022

Wei Zhang, Chang-Liang Xia, Jun-Nan Ma, Jia-Xuan Li, Qi Chen, Shuan-Ji Ou, Yang Yang, Yong Qi & Chang-Peng Xu
Additional file 4: SupplementaryTable 2. The top 10 co-cited references related to this field

Additional file 6 of Effects of mitochondrial dysfunction on bone metabolism and related diseases: a scientometric study from 2003 to 2022

Wei Zhang, Chang-Liang Xia, Jun-Nan Ma, Jia-Xuan Li, Qi Chen, Shuan-Ji Ou, Yang Yang, Yong Qi & Chang-Peng Xu
Additional file 6: Supplementary Table 4. The top 10 institutions and cited institutions related to this field.

Effects of mitochondrial dysfunction on bone metabolism and related diseases: a scientometric study from 2003 to 2022

Wei Zhang, Chang-Liang Xia, Jun-Nan Ma, Jia-Xuan Li, Qi Chen, Shuan-Ji Ou, Yang Yang, Yong Qi & Chang-Peng Xu
Abstract Background In recent years, mitochondrial dysfunction has been extensively studied and published, but research on the effects of mitochondrial dysfunction on bone metabolism and related diseases is only just beginning. Furthermore, no studies have been carried out to systematically illustrate this area from a scientometric point of view. The goal of this research is to review existing knowledge and identify new trends and possible hotspots in this area. Methods All publications related to the...

Additional file 2 of Satisfactory breeding potential is transiently eliminated in beef bulls with clinical anaplasmosis

Anne C. Lovett, Emily J. Reppert, John R. Jaeger, Qing Kang, Macy R. Flowers, Naemi P. Bickmeier, Tippawan Anantatat, Shannon C. O’Day, Chance L. Armstrong & Kathryn E. Reif
Supplementary Material 2

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Affiliations

  • Kansas State University
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  • Shanghai Jiao Tong University
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  • Capital Medical University
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  • North West Agriculture and Forestry University
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  • Huazhong University of Science and Technology
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