14 Works

Additional file 1 of Playing a musical instrument and the risk of dementia among older adults: a systematic review and meta-analysis of prospective cohort studies

Ahmed Arafa, Masayuki Teramoto, Saori Maeda, Yukie Sakai, Saya Nosaka, Qi Gao, Haruna Kawachi, Rena Kashima, Chisa Matsumoto & Yoshihiro Kokubo
Additional File 1.

Playing a musical instrument and the risk of dementia among older adults: a systematic review and meta-analysis of prospective cohort studies

Ahmed Arafa, Masayuki Teramoto, Saori Maeda, Yukie Sakai, Saya Nosaka, Qi Gao, Haruna Kawachi, Rena Kashima, Chisa Matsumoto & Yoshihiro Kokubo
Abstract Background Engaging in leisure activities was suggested to protect older adults from dementia. However, the association between playing a musical instrument and the risk of dementia is not well-established. This study aimed to investigate this association in older adults using a systematic review and meta-analysis of prospective cohort studies. Methods Pooled hazard ratio (HR) and 95% confidence interval (CI) of having dementia for older adults playing a musical instrument were calculated using the random-effects...

Data from: Temporal variation in genetic diversity and effective population size of Mediterranean and subalpine Arabidopsis thaliana populations

Nasr H. Gomaa, Alicia Montesinos-Navarro, Carlos Alonso-Blanco & F. Xavier Picó
Currently there exists a limited knowledge on the extent of temporal variation in population genetic parameters of natural populations. Here we study the extent of temporal variation in population genetics by genotyping 151 genome-wide SNP markers polymorphic in 466 individuals collected from nine populations of the annual plant Arabidopsis thaliana during four years. Populations are located along an altitudinal climatic gradient from Mediterranean to subalpine environments in NE Spain, which has been shown to influence...

Biomarkers of caspofungin resistance in Candida albicans isolates: A proteomic approach

Giuseppe Buda De Cesare, Ahmed Hafez, David Stead, Carlos Llorens & Carol A. Munro
Candida albicans is a clinically important polymorphic fungal pathogen that causes life-threatening invasive infections in immunocompromised patients. Antifungal therapy failure is a substantial clinical problem, due to the emergence of an increasing number of drug-resistant isolates. Caspofungin is a common antifungal drug, often used as first-line therapy that inhibits cell wall β-(1,3)-glucan synthesis. In this work, the cell surface of different echinocandin-resistant C. albicans clinical isolates was compared with sensitive isolates and their responses to...

Additional file 1 of Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Inemesit A. Udofia, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Additional file 1. HPLC chromatogram of ethanolic leaf extract of cannabis.

Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Udofia A. Inemesit, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Abstract Background Data available support that ninety percent of male infertility cases are due to low sperm counts. There is a scarcity of data on the medicinal effects of cannabis on fertility. This study evaluated testicular function and sperm quality modulation with cannabis in rats. Methodology Twenty-five male Wistar rats were randomly grouped into five: A, B, C, and D, each group have 5 rats. A (control): 0.2 ml 2% DMSO, B (vitamin C): 90...

Additional file 1 of Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Inemesit A. Udofia, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Additional file 1. HPLC chromatogram of ethanolic leaf extract of cannabis.

Data from: Among- and within-population variation in flowering time of Iberian Arabidopsis thaliana estimated in field and glasshouse conditions

Belén Méndez-Vigo, Nasr H. Gomaa, Carlos Alonso-Blanco & F. Xavier Picó
The study of the evolutionary and population genetics of quantitative traits requires the assessment of within- and among-population patterns of variation. We carried out experiments including eight Iberian Arabidopsis thaliana populations (10 individuals per population) in glasshouse and field conditions. We quantified among- and within-population variation for flowering time and for several field life-history traits. Individuals were genotyped with microsatellites, single nucleotide polymorphisms and four well-known flowering genes (FRI, FLC, CRY2 and PHYC). Phenotypic and...

Additional file 1 of Playing a musical instrument and the risk of dementia among older adults: a systematic review and meta-analysis of prospective cohort studies

Ahmed Arafa, Masayuki Teramoto, Saori Maeda, Yukie Sakai, Saya Nosaka, Qi Gao, Haruna Kawachi, Rena Kashima, Chisa Matsumoto & Yoshihiro Kokubo
Additional File 1.

Playing a musical instrument and the risk of dementia among older adults: a systematic review and meta-analysis of prospective cohort studies

Ahmed Arafa, Masayuki Teramoto, Saori Maeda, Yukie Sakai, Saya Nosaka, Qi Gao, Haruna Kawachi, Rena Kashima, Chisa Matsumoto & Yoshihiro Kokubo
Abstract Background Engaging in leisure activities was suggested to protect older adults from dementia. However, the association between playing a musical instrument and the risk of dementia is not well-established. This study aimed to investigate this association in older adults using a systematic review and meta-analysis of prospective cohort studies. Methods Pooled hazard ratio (HR) and 95% confidence interval (CI) of having dementia for older adults playing a musical instrument were calculated using the random-effects...

Additional file 1 of Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Udofia A. Inemesit, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Additional file 1. HPLC chromatogram of ethanolic leaf extract of cannabis.

Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Inemesit A. Udofia, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Abstract Background Data available support that ninety percent of male infertility cases are due to low sperm counts. There is a scarcity of data on the medicinal effects of cannabis on fertility. This study evaluated testicular function and sperm quality modulation with cannabis in rats. Methodology Twenty-five male Wistar rats were randomly grouped into five: A, B, C, and D, each group have 5 rats. A (control): 0.2 ml 2% DMSO, B (vitamin C): 90...

Biomarkers of caspofungin resistance in Candida albicans isolates: A proteomic approach

Giuseppe Buda De Cesare, Ahmed Hafez, David Stead, Carlos Llorens & Carol A. Munro
Candida albicans is a clinically important polymorphic fungal pathogen that causes life-threatening invasive infections in immunocompromised patients. Antifungal therapy failure is a substantial clinical problem, due to the emergence of an increasing number of drug-resistant isolates. Caspofungin is a common antifungal drug, often used as first-line therapy that inhibits cell wall β-(1,3)-glucan synthesis. In this work, the cell surface of different echinocandin-resistant C. albicans clinical isolates was compared with sensitive isolates and their responses to...

Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats

Charles O. Nwonuma, Victoria C. Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S. Adeyemi, Omokolade O. Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A. Adah, Oluwakemi J. Awakan, Charles E. Okolie, Nnaemeka Tobechukwu Asogwa, Inemesit A. Udofia, Godshelp O. Egharevba, Nada H. Aljarba, Saad Alkahtani & Gaber El-Saber Batiha
Abstract Background Data available support that ninety percent of male infertility cases are due to low sperm counts. There is a scarcity of data on the medicinal effects of cannabis on fertility. This study evaluated testicular function and sperm quality modulation with cannabis in rats. Methodology Twenty-five male Wistar rats were randomly grouped into five: A, B, C, and D, each group have 5 rats. A (control): 0.2 ml 2% DMSO, B (vitamin C): 90...

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