Additional file 3: Supplementary Table S3. Comparison between the Gibbs Framework and the GRIPP-2(SF).

Abstract Background PrEP literacy is influenced by many factors including the types of information available and how it is interpreted. The level of PrEP literacy may influence acceptability and uptake. Methods We conducted 25 in-depth interviews in a HIV vaccine trial preparedness cohort study. We explored what participants knew about PrEP, sources of PrEP knowledge and how much they know about PrEP. We used the framework approach to generate themes for analysis guided by the...

Background: Rape is a common traumatic event which may result in the development of posttraumatic stress disorder (PTSD), yet few studies have investigated risk biomarkers in sexually traumatised individuals. Adiponectin is a novel cytokine within inflammatory and cardiometabolic pathways with evidence of involvement in PTSD. Objective: This prospective exploratory study in a sample of female rape survivors investigated the association of single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and posttraumatic stress symptom (PTSS)...

Abstract Background Interventions aimed at reducing risky sexual behavior are considered an important strategy for averting Human Immunodeficiency Virus (HIV) infection among youth (15–24 years) who continue to be at risk of the disease. Enhancing intervention success requires a comprehensive understanding of the barriers and facilitators to interventions targeting youth. However, there is lack of a systematic review of both quantitative and qualitative studies to comprehensively identify and synthesize barriers and facilitators to HIV prevention...

Abstract Background Interventions aimed at reducing risky sexual behavior are considered an important strategy for averting Human Immunodeficiency Virus (HIV) infection among youth (15–24 years) who continue to be at risk of the disease. Enhancing intervention success requires a comprehensive understanding of the barriers and facilitators to interventions targeting youth. However, there is lack of a systematic review of both quantitative and qualitative studies to comprehensively identify and synthesize barriers and facilitators to HIV prevention...

Additional file 5. COREQ checklist.

Additional file 4. Heatwave characteristics for period 2020 – 2039 using data simulated from RCP 8.5 projections.

Supplementary Material 3

Additional file 1. Description of the 14 CHAT interventions as provided to participants.

Additional file 2. IINDIAGO matrix: Expanded COM-B: TDF domains, theoretical constructs and relevance to GDM women (identified barriers & enablers): Self-care.

Additional file 3. Heatwave characteristics for period 2020 – 2039 using data simulated from RCP 4.5 projections.

Abstract Heatwaves can have severe impacts on human health extending from illness to mortality. These health effects are related to not only the physical phenomenon of heat itself but other characteristics such as frequency, intensity, and duration of heatwaves. Therefore, understanding heatwave characteristics is a crucial step in the development of heat-health warning systems (HHWS) that could prevent or reduce negative heat-related health outcomes. However, there are no South African studies that have quantified heatwaves...

PRISMA-ScR for the protocol for scoping review of work system design in healthcare

Mycobacterium tuberculosis (M.tb) causes tuberculosis (TB) and remains one of the leading causes of mortality due to an infectious pathogen. Host immune responses have been implicated in driving the progression from infection to severe lung disease. We analyzed longitudinal RNA sequencing (RNAseq) data from the whole blood of 74 TB progressors whose samples were grouped into four six-month intervals preceding diagnosis (the GC6-74 study). We additionally analyzed RNAseq data from an independent cohort of 90...

BackgroundThe COVID-19 pandemic had a global impact on health systems and the delivery of health services, including for chronic conditions such as HIV. In South Africa, impacts on HIV services have widely been quantitatively described. Across different health settings, patients have also qualitatively described numerous negative impacts to their HIV care. However, patient perspectives on COVID-19 impacts to HIV care in South Africa, the largest HIV care system in the world, have been little explored...

Background: Communication interventions for childhood vaccination are promising strategies to address vaccine hesitancy, but current research is limited by the outcomes measured. Most studies measure only vaccination-related outcomes, with minimal consideration of vaccine hesitancy-relevant intermediate outcomes. This impedes understanding of which interventions or elements are effective. It is also unknown which outcomes are important to the range of stakeholders affected by vaccine hesitancy. Outcome selection shapes the evidence base, informing future interventions and trials, and...

Additional file 2: Supplementary Material 2. Semi-structured interview guide.

Additional file 2: Supplementary Material 2. Semi-structured interview guide.

Additional file 3: Criteria for inclusion and exclusion of studies for screening.

Additional file 1: Supplemental Table 1. Health services by service type category in 10 countries. Supplemental Table 2. Definition of containment policies and dichotomous recoding. Supplemental Table 3. Results from multi-level linear regression model for the association between the OxCGRT stringency index and relative service volumes (median stringency index). Supplemental Table 4. Results from multi-level linear regression model for the association between the OxCGRT stringency index and relative service volumes (max stringency index).

Additional file 1: Supplemental Table 1. Health services by service type category in 10 countries. Supplemental Table 2. Definition of containment policies and dichotomous recoding. Supplemental Table 3. Results from multi-level linear regression model for the association between the OxCGRT stringency index and relative service volumes (median stringency index). Supplemental Table 4. Results from multi-level linear regression model for the association between the OxCGRT stringency index and relative service volumes (max stringency index).

Additional file 5: Table:CERQual assessments for seven main findings of the PHC Integration rapid review.

Abstract Background Integrated delivery of primary health care (PHC) services is a health reform recommended for achieving ambitious targets of the Sustainable Development Goals and Universal Health Coverage, responding to growing challenges of managing non-communicable and multimorbidity. However, more evidence is needed on effective implementation of PHC integration in different country settings. Objective This rapid review synthesized qualitative evidence on implementation factors affecting integration of non-communicable disease (NCD) into PHC, from the perspective of implementers....

Additional file 2: Supplementary File 2. PRISMA-ScR Checklist.

Abstract Background Behavioral interventions are often complex, operate at multiple levels, across settings, and employ a range of behavior change techniques. Collecting and reporting key indicators of initial trial and intervention feasibility is essential to decisions for progressing to larger-scale trials. The extent of reporting on feasibility indicators and how this may have changed over time is unknown. The aims of this study were to (1) conduct a historical scoping review of the reporting of...