Additional file 12: Fig. S5. Enrichment analysis of DEGs for B. gargarizans metamorphosis. The top 30 GO terms and pathways of significant enrichment for the (A and B) upregulated DEGs and (C and D) downregulated DEGs. The y-axis corresponds to the GO term or KEGG pathway, the x-axis corresponds to the EnrichmentScore, and the size of the point corresponds to the number of differential genes in the term or pathway.

Additional file 13: Fig. S6. Enrichment analysis of differential lipid-related DEGs. (A) showed the top 30 GO terms of significant enrichment of the differential lipid-related DEGs on GO;(B) showed the top 30 pathways of significant enrichment of the differential lipid-related DEGs on KEGG.

Background:Nivolumab has been approved in China as second-line treatment for advanced non-small-cell lung cancer (NSCLC) via weight-based infusion, based on the CheckMate 078 study. We investigated the safety and efficacy of 240 mg flat-dose nivolumab in patients with advanced NSCLC, including those with hepatitis B virus (HBV) and epidermal growth factor receptor (EGFR) mutation/ALK receptor tyrosine kinase (ALK) translocation due to high prevalence in China.Methods:CheckMate 870 was a single-arm, open-label, phase IIIb trial in Asian...

Abstract Background To investigate the correlation between the clinical and pathological characteristics and outcomes in patients with eyelid malignant tumors underwent wide local excision. Methods This retrospective study included 141 cases of eyelid malignant neoplasms from January 2010 to December 2015 in Shanxi eye hospital. Demographic and clinical information were collected. The Kaplan–Meier method was used to calculate survival curves, and the log-rank test method was used to compare survival between groups. Cox proportional regression...

Additional file 10 Table S9. Genome-wide detection and functional annotation of selective sweep regions in the deepwater rice (DW).

Additional file 17 Table S16. Genome-wide detection and functional annotation of selective sweep regions in the irrigated GJ rice.

Additional file 17 Table S16. Genome-wide detection and functional annotation of selective sweep regions in the irrigated GJ rice.

Additional file 19 Table S18. Genome-wide detection of highly differentiated loci between DW and UP-XI.

Additional file 1. Questionnaire.

Additional file 1.

Abstract Background 2-methyl-4-chlorophenoxy acetic acid-Na (MPCA-Na) is a phenoxy carboxylic acid selective hormone herbicide that is widely used in the crop fields. However, drift of MPCA-Na during application is highly damaging to cotton (Gossypium hirsutum) and other crop plants. This study was carried out from 2019 to 2020 to determine the effects of different concentrations of MPCA-Na on physiological and metabolic activities besides growth and yield of cotton plants at seedling, budding, flowering and boll...

Additional file 1: Fig. S1. Clustering and PCA of transcriptomes of CsL and CtW. Fig. S2. Venn diagram of the DEGs related to plant hormone signaling transduction identified in CsL, CtW and CsL vs CtW. Table S1. List of primers used for qRT-PCR. Table S3. Summary of mapping transcriptome reads to reference sequence.

Additional file 2: Table S2. The expression information of genes in the transcriptome of two apricot kernel cultivars.

Additional file 4: Table S5. The expression level of DEGs related to plant hormone signaling transduction in two apricot kernel cultivars under freezing stress.

Supplementary Material 2

Abstract Purpose This study aimed to analyse the genomic alteration profiles and immune characteristics of a cohort of Chinese cervical cancer patients to understand why certain patients benefited from molecular targeted therapies and immunotherapy as well as their prognostic significance. Methods PD-L1 expression and clinicopathological information were obtained from 98 cervical cancer patients. Differences in PD-L1 expression and gene mutations between squamous cell carcinoma (SCC) and adenocarcinoma (AC) were analysed by the chi-square test or...

Additional file 2. Search strategies for English and Chinese databases.

Additional file 2. Search strategies for English and Chinese databases.

Additional file 5. Risk of Bias analysis using ROBIS tool.

The geodynamic evolution of the Palaeotethyan Ocean is key for understanding the development of Pangaea. The main continents of Southeast Asia were welded together in response to the closure of the Palaeotethyan Ocean. However, the precise location of the sutures and timing of the collisions are poorly constrained, especially the southward continuation from Peninsular Malaysia into west Indonesia. This study presents new zircon U–Pb geochronological, petrologic, elemental and Sr–Nd–Pb–Hf–O isotopic data in order to investigate...

Supplemental material, sj-docx-1-tam-10.1177_17588359221130501 for Efficacy and safety of adding bevacizumab biosimilar or original drug to platinum-based chemotherapy as first-line treatment in patients with advanced NSCLC: a systematic review and meta-analysis by Liu Yang, Maobai Liu, Na Li, Bin Zheng, Jianhao Deng, Hongfu Cai and Xueqiong Cao in Therapeutic Advances in Medical Oncology

Introduction:The role of bevacizumab combined with paclitaxel and carboplatin in the first-line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) has been supported by a large number of data. However, whether bevacizumab biosimilars have the same efficacy and safety as the original drug is still controversial. This meta-analysis was designed to evaluate whether bevacizumab biosimilars have the same clinical efficacy and safety as the original drug in patients with advanced non-squamous NSCLC.Methods:Electronic databases (PubMed, Embase,...

Supplemental material, sj-docx-1-tam-10.1177_17588359221130502 for Reconsidering T component of cancer staging for T3/T4 non-small-cell lung cancer with additional nodule by Fang Wang, Hang Su, Haoran E, Likun Hou, Minglei Yang, Long Xu, Jiani Gao, Mengmeng Zhao, Junqi Wu, Jiajun Deng, Xiaofeng Xie, Yifan Zhong, Yingze Li, Tingting Wang, Dong Xie, Chunyan Wu and Chang Chen in Therapeutic Advances in Medical Oncology

Additional file 13: Table S8. The annotation and homologs in Arabidopsis of these genes showing strong correlation with the lncRNAs were summarized in sunflower.

Additional file 13: Table S8. The annotation and homologs in Arabidopsis of these genes showing strong correlation with the lncRNAs were summarized in sunflower.