409 Works

A Model Theoretic Perspective on Phonological Feature Systems

Scott Nelson

Data from: Integrating 3D models with morphometric measurements to improve volumetric estimates in marine mammals

Nathan Hirtle, Julia Stepanuk, Eleanor Heywood, Fredrik Christiansen & Lesley Thorne
1. Studies of body condition are key to understanding the health, bioenergetics, and ecological roles of marine mammals. Due to challenges in studying marine mammals at sea, body condition is often approximated using metrics representing the size of the dorsal surface visible from aerial imagery, but quantifying variability in body volume would enable a more holistic understanding of bioenergetics. Further, the number and location of measurements needed to accurately quantify body condition has received little...

EcoPhyloMapper: an R package for integrating geographic ranges, phylogeny, and morphology

Pascal Title, Donald Swiderski & Miriam Zelditch
1. Spatial patterns of species richness, phylogenetic and morphological diversity are key to answering many questions in ecology and evolution. Across spatial scales, geographic and environmental features, as well as evolutionary history and phenotypic traits, are thought to play roles in shaping both local species communities and regional assemblages. By examining these geographic patterns, it is possible to infer how different axes of biodiversity influence one another, and how their interaction with abiotic factors has...

Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer

Fei Yu, Weidan Tan, Zhiquan Chen, Xiaoju Shen, Xiaoxiang Mo, Xiaocheng Mo, Jingchuan He, Zhihua Deng, Jie Wang, Zhuo Luo & Jie Yang
Abstract Background As the increasing mortality and incidence of lung cancer (LC), there is an urgent need to discover novel treatment agent. In this study, we aimed to investigate the anti-LC effects of nitidine chloride (NC), a small molecular compound extracted from Chinese herbal medicine, while detailing its underlying mechanisms. Methods Cell viability was detected by MTT assays and five cell death inhibitors, including ferrostatin-1 (Fer-1), Z-VAD-FMK, necrostatin-1 (Nec-1), disulfiram (DSF) and IM-54 were used...

Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer

Fei Yu, Weidan Tan, Zhiquan Chen, Xiaoju Shen, Xiaoxiang Mo, Xiaocheng Mo, Jingchuan He, Zhihua Deng, Jie Wang, Zhuo Luo & Jie Yang
Abstract Background As the increasing mortality and incidence of lung cancer (LC), there is an urgent need to discover novel treatment agent. In this study, we aimed to investigate the anti-LC effects of nitidine chloride (NC), a small molecular compound extracted from Chinese herbal medicine, while detailing its underlying mechanisms. Methods Cell viability was detected by MTT assays and five cell death inhibitors, including ferrostatin-1 (Fer-1), Z-VAD-FMK, necrostatin-1 (Nec-1), disulfiram (DSF) and IM-54 were used...

Additional file 1 of The role of proteoglycan form of DMP1 in cranial repair

Yang Liu, Pingping Niu, Mengqi Zhou & Hui Xue
Additional file 1: SupplementaryTable 1.

Additional file 3 of The role of proteoglycan form of DMP1 in cranial repair

Yang Liu, Pingping Niu, Mengqi Zhou & Hui Xue
Additional file 3.

Additional file 9 of Novel trends of genome evolution in highly complex tropical sponge microbiomes

Joseph B. Kelly, David E. Carlson, Jun Siong Low & Robert W. Thacker
Additional file 9: Table S4. The top BLASTn hits for representative CSGs.

Additional file 1 of Novel trends of genome evolution in highly complex tropical sponge microbiomes

Joseph B. Kelly, David E. Carlson, Jun Siong Low & Robert W. Thacker
Additional file 1: Fig. S1. Phylogenetic depiction of MAG distributions across Caribbean Ircinia species and redundancy in primary metabolic modes. The heatmap immediately to the right of the tree indicates the ln-transformed relative abundances of each MAG by host specimen. Species abbreviations accompanying specimen labels at the bottom of the heatmap are as follows: ICam (I. campana), IcfR (I. cf. reteplana), IRad (I. radix), ILae (I. laeviconulosa), IBoc (I. bocatorensis B), ILow (I. lowi), IVan...

Additional file 2 of Novel trends of genome evolution in highly complex tropical sponge microbiomes

Joseph B. Kelly, David E. Carlson, Jun Siong Low & Robert W. Thacker
Additional file 2: Fig. S2. Plots depicting prevalence of MAGs associated with Caribbean Ircinia by source and region, inferred using the relative abundance matrix produced by CoverM. A. Bar chart depicting the percent of MAGs that are found across multiple host species. B. Bar chart depicting the regional specificity of MAGs. C. PCA of taxonomic community compositions of each host species’ microbiome.

Additional file 6 of Novel trends of genome evolution in highly complex tropical sponge microbiomes

Joseph B. Kelly, David E. Carlson, Jun Siong Low & Robert W. Thacker
Additional file 6: Table S1. Taxonomy, statistics, source metadata, and CSG occurrence in MAGs that passed QC and dereplication steps and were used in the final analyses. The archaeal MAGs and the Trichodesmium MAG that did not meet the completeness threshold are included.

Novel trends of genome evolution in highly complex tropical sponge microbiomes

Joseph B. Kelly, David E. Carlson, Jun Siong Low & Robert W. Thacker
Abstract Background Tropical members of the sponge genus Ircinia possess highly complex microbiomes that perform a broad spectrum of chemical processes that influence host fitness. Despite the pervasive role of microbiomes in Ircinia biology, it is still unknown how they remain in stable association across tropical species. To address this question, we performed a comparative analysis of the microbiomes of 11 Ircinia species using whole-metagenomic shotgun sequencing data to investigate three aspects of bacterial symbiont...

Supplementary document for Broadband behavior of quadratic metalenses with a wide field of view - 6011078.pdf

Yang Liu, Jianhao Zhang, Xavier Le Roux, Eric Cassan, Delphine Marris-Morini, Laurent Vivien, Carlos Alonso Ramos & Daniele Melati
Supplemental document with additional data, simulation results, and figures.

Supplementary document for Double exceptional points in grating coupled Metal-Insulator-Metal heterostructure - 5996704.pdf

Jianming Mai, Yu Chen, Guixin Li & Kok Cheah
Supplementary information

LncRNA SNHG16 promotes development of oesophageal squamous cell carcinoma by interacting with EIF4A3 and modulating RhoU mRNA stability

Lihua Ren, Xin Fang, Sachin Mulmi Shrestha, Qinghua Ji, Hui Ye, Yan Liang, Yang Liu, Yadong Feng, Jingwu Dong & Ruihua Shi
Abstract Background Numerous studies have revealed that long noncoding RNAs (lncRNAs) are closely related to the development of many diseases and carcinogenesis. However, their specific biological function and molecular mechanism in oesophageal squamous cell carcinoma (ESCC) remains unclear. Methods RNA-Seq was performed to determine the differential expressions of lncRNAs in ESCC, and the level of SNHG16 expression was detected in ESCC and intraepithelial neoplasia (IEN) samples. In vitro and in vivo experiments were performed to...

Additional file 1 of Development and validation of an extended Cox prognostic model for patients with ER/PR+ and HER2− breast cancer: a retrospective cohort study

Yiqun Xie, Xizhou Li, Ying Wu, Wenting Cui & Yang Liu
Additional file 1: Appendix 1. Clinicopathologic characteristics of 28 deaths.

Additional file 4 of The FUS/circEZH2/KLF5/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition

Peng Liu, Zehao Wang, Xueqi Ou, Peng Wu, Yue Zhang, Song Wu, Xiangsheng Xiao, Yuehua Li, Feng Ye & Hailin Tang
Additional file 4. Supplemental Method

Development and validation of an extended Cox prognostic model for patients with ER/PR+ and HER2− breast cancer: a retrospective cohort study

Yiqun Xie, Xizhou Li, Ying Wu, Wenting Cui & Yang Liu
Abstract Background The purpose of this study was to explore a new estrogen receptor (ER) and/or progesterone receptor (PR)+ and human epidermal growth factor receptor 2 (HER2)− breast cancer prognostic model, called the extended Cox prognostic model, for determining the cutoff values for multiple continuous prognostic factors and their interaction via the new model concept and variable selection method. Methods A total of 335 patients with ER/PR+ and HER2− breast cancer were enrolled for the...

Additional file 1 of The FUS/circEZH2/KLF5/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition

Peng Liu, Zehao Wang, Xueqi Ou, Peng Wu, Yue Zhang, Song Wu, Xiangsheng Xiao, Yuehua Li, Feng Ye & Hailin Tang
Additional file 1. Supplemental Figure 1

From Black Box to Shining Spotlight: Using Random Forest Prediction Intervals to Illuminate the Impact of Assumptions in Linear Regression

Andrew J. Sage, Yang Liu & Joe Sato
We introduce a pair of Shiny web applications that allow users to visualize random forest prediction intervals alongside those produced by linear regression models. The apps are designed to help undergraduate students deepen their understanding of the role that assumptions play in statistical modeling by comparing and contrasting intervals produced by regression models with those produced by more flexible algorithmic techniques. We describe the mechanics of each approach, illustrate the features of the apps, provide...

Nonparametric prediction distribution from resolution-wise regression with heterogeneous data

Jialu Li, Wan Zhang, Peiyao Wang, Qizhai Li, Kai Zhang & Yufeng Liu
Modeling and inference for heterogeneous data have gained great interest recently due to rapid developments in personalized marketing. Most existing regression approaches are based on the conditional mean and may require additional cluster information to accommodate data heterogeneity. In this paper, we propose a novel nonparametric resolution-wise regression procedure to provide an estimated distribution of the response instead of one single value. We achieve this by decomposing the information of the response and the predictors...

Constructing new acid-activated anticancer peptide by attaching a desirable anionic binding partner peptide

Yun Zhang, Linlin Chang, Hexin Bao, Xiaoyan Wu, Hui Liu, Sanhu Gou, Jingying Zhang & Jingman Ni
Improving the cell selectivity of anticancer peptides (ACPs) is a major hurdle in their clinical utilisation. In this study, a new acid-activated ACP was designed by conjugating a cationic ACP LK to its anionic binding partner peptide (LEH) via a disulphide linker to trigger antitumor activity at acidic pH while masking its killing activity at normal pH. Three anionic binding peptides containing different numbers of glutamic acid (Glu) and histidine were engineered to obtain an...

Additional file 1 of β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression

Yang Liu, Nanshan Song, Hang Yao, Siyuan Jiang, Yueping Wang, Ying Zheng, Yuanzhang Zhou, Jianhua Ding, Gang Hu & Ming Lu
Additional file 1: Fig. S1. CUMS depression model induces astrocyte dysfunction in the hippocampus of mice. (A) Astrocyte dysfunction induced by CUMS. Representative images of astrocyte immunostaining for GFAP in mice hippocampus, Scale bar: 200 μm (upper panel); Scale bar: 40 μm (lower panel). (B) Immunofluorescence staining of NeuN in mice hippocampus. NeuN: Red; DAPI: Blue; Scale bar: 100 μm. (C) Microglial activation induced in CUMS model. Representative images of microglial immunostaining for Iba-1 in...

Additional file 1 of YAP1 protects against septic liver injury via ferroptosis resistance

Jin Wang, Qian Zhu, Rui Li, Jing Zhang, Xujun Ye & Xinyi Li
Additional file 1. Supplementary figures.

Additional file 1 of Enhancement of linalool production in Saccharomyces cerevisiae by utilizing isopentenol utilization pathway

Yaoyao Zhang, Xianshuang Cao, Jin Wang & Feng Tang
Additional file 1: Fig. S1. Inhibitory effects of linalool on strain BY4742-MC-02. Strain BY4742-MC-02 was grown in SS-URA medium with 0.5 % Tween 80 (v v-1) and cultured at 30°C, 200 rpm for 72 h. Then different concentrations of linalool were added to the culture and recorded the cell growth curve. All values represent the mean ± standard deviation from three biological replicates. Fig. S2. Effects of different combinations of isoprenol and prenol on S....

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Affiliations

  • Stony Brook University
    409
  • Shanghai Jiao Tong University
    310
  • Zhejiang University
    291
  • Fudan University
    290
  • Capital Medical University
    289
  • Sun Yat-sen University
    284
  • University of Chinese Academy of Sciences
    264
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    263
  • Sun Yat-sen University Cancer Center
    261
  • Shandong University
    244