2,743 Works

Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway

Bin Wang, Jing Zhang, Xin Liu, Qingqing Chai, Xiaoran Lu, Xiaoyu Yao, Zhichang Yang, Liangliang Sun, Silas F. Johnson, Richard C Schwartz & Yong-Hui Zheng
Zaire ebolavirus (EBOV) causes a severe hemorrhagic fever in humans and non-human primates with high morbidity and mortality. EBOV infection is dependent on its structural glycoprotein (GP), but high levels of GP expression also trigger cell rounding, detachment, and downregulation of many surface molecules that is thought to contribute to its high pathogenicity. Thus, EBOV has evolved an RNA editing mechanism to reduce its GP expression and increase its fitness. We now report that the...

A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence

Hui-Li Yang, Zhen-Zhen Lai, Jia-Wei Shi, Wen-Jie Zhou, Jie Mei, Jiang-Feng Ye, Tao Zhang, Jian Wang, Jian-Yuan Zhao, Da-Jin Li & Ming-Qing Li
Massive infiltrated and enriched decidual macrophages (dMφ) have been widely regarded as important regulators of maternal-fetal immune tolerance and trophoblast invasion, contributing to normal pregnancy. However, the characteristics of metabolic profile and the underlying mechanism of dMφ residence remain largely unknown. Here, we observe that dMφ display an active glycerophospholipid metabolism. The activation of ENPP2-lysophosphatidic acid (LPA) facilitates the adhesion and retention, and M2 differentiation of dMφ during normal pregnancy. Mechanistically, this process is mediated...

A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence

Hui-Li Yang, Zhen-Zhen Lai, Jia-Wei Shi, Wen-Jie Zhou, Jie Mei, Jiang-Feng Ye, Tao Zhang, Jian Wang, Jian-Yuan Zhao, Da-Jin Li & Ming-Qing Li
Massive infiltrated and enriched decidual macrophages (dMφ) have been widely regarded as important regulators of maternal-fetal immune tolerance and trophoblast invasion, contributing to normal pregnancy. However, the characteristics of metabolic profile and the underlying mechanism of dMφ residence remain largely unknown. Here, we observe that dMφ display an active glycerophospholipid metabolism. The activation of ENPP2-lysophosphatidic acid (LPA) facilitates the adhesion and retention, and M2 differentiation of dMφ during normal pregnancy. Mechanistically, this process is mediated...

Data of RSPB-2022-1850 from Tree-ring evidence of ecological stress memory

Yumei Mu, Lixin Lyu, Yan Li & Ouya Fang
A dataset including decline and recovery rate of 499 paried past tree-growth depressions from 368 juniper trees.

Data of RSPB-2022-1850 from Tree-ring evidence of ecological stress memory

Yumei Mu, Lixin Lyu, Yan Li & Ouya Fang
A dataset including decline and recovery rate of 499 paried past tree-growth depressions from 368 juniper trees.

Autism-like behaviors regulated by the serotonin receptor 5-HT2B in the dorsal fan-shaped body neurons of Drosophila melanogaster

Haowei Cao, Junbo Tang, Qisha Liu, Juan Huang & Rui Xu
Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and repetitive stereotyped behaviors. Previous studies have reported an association of serotonin or 5-hydroxytryptamine (5-HT) with ASD, but the specific receptors and neurons by which serotonin modulates autistic behaviors have not been fully elucidated. Methods RNAi-mediated knockdown was done to destroy the function of tryptophan hydroxylase (Trh) and all the five serotonin receptors. Given that ubiquitous knockdown of 5-HT2B...

Additional file 3 of Autism-like behaviors regulated by the serotonin receptor 5-HT2B in the dorsal fan-shaped body neurons of Drosophila melanogaster

Haowei Cao, Junbo Tang, Qisha Liu, Juan Huang & Rui Xu
Additional file 3: Fig. S3. Verification of 5-HT2B knockout flies. (A) Molecular verification of 5-HT2B knockout flies by PCR analysis. Only one band was seen in w1118 controls, but a lower band could exist when a fragment of approximately 233 bp was deleted from the 5-HT2B locus. (B) The PCR-Sanger sequencing results of two reserved homozygous 5-HT2B knockout lines. The results show that the 5-HT2BKO_5-1 line has a 224 bp deletion in the first exon...

Additional file 1 of Using machine learning to identify gene interaction networks associated with breast cancer

Liyuan Liu, Wenli Zhai, Fei Wang, Lixiang Yu, Fei Zhou, Yujuan Xiang, Shuya Huang, Chao Zheng, Zhongshang Yuan, Yong He, Zhigang Yu & Jiadong Ji
Additional file 1: Figure S1. The differential interaction network inferred by JDINAC after adjusting for BMI and menopause status.

Additional file 1 of Using machine learning to identify gene interaction networks associated with breast cancer

Liyuan Liu, Wenli Zhai, Fei Wang, Lixiang Yu, Fei Zhou, Yujuan Xiang, Shuya Huang, Chao Zheng, Zhongshang Yuan, Yong He, Zhigang Yu & Jiadong Ji
Additional file 1: Figure S1. The differential interaction network inferred by JDINAC after adjusting for BMI and menopause status.

Additional file 3 of Using machine learning to identify gene interaction networks associated with breast cancer

Liyuan Liu, Wenli Zhai, Fei Wang, Lixiang Yu, Fei Zhou, Yujuan Xiang, Shuya Huang, Chao Zheng, Zhongshang Yuan, Yong He, Zhigang Yu & Jiadong Ji
Additional file 3: Table S2. Top 10 gene interaction pairs identified by JDINAC after adjusting for menopausal status.

Additional file 1 of Gene Identification, expression analysis and molecular docking of ATP sulfurylase in the selenization pathway of Cardamine hupingshanensis

Zhijing Xiao, Yanke Lu, Yi Zou, Chi Zhang, Li Ding, Kai Luo, Qiaoyu Tang & Yifeng Zhou
Supplementary Figure S1: Multiple sequence alignment of all the ChATPS proteins; Supplementary Table S1: Physicochemical properties of ATPS proteins in C. hupingshanensis. Supplementary Table S2: The gene coding sequences and protein sequences of ChATPS. Supplementary Table S3: Secondary structure analysis of the nine proteins. Supplementary Table S4: Primers used in qRT-PCR analysis for ChATPS. Table S5: The binding energy of each ligand to each protein at the catalytic site (unit: kcal mol-1). Table S6: At...

Additional file 1 of Breastfeeding by a mother taking cyclosporine for nephrotic syndrome

Ruizhe Li, Chuan Zhang, Hongjing Wang & Yunfei An
Supplementary Material 1

Additional file 1 of Breastfeeding by a mother taking cyclosporine for nephrotic syndrome

Ruizhe Li, Chuan Zhang, Hongjing Wang & Yunfei An
Supplementary Material 1

Additional file 1 of MiR-493-5p inhibits Th9 cell differentiation in allergic asthma by targeting FOXO1

Xingyu Rao, Heting Dong, Weili Zhang, Huiming Sun, Wenjing Gu, Xinxing Zhang, Li Huang, Yongdong Yan, Chuangli Hao, Wei Ji, Canhong Zhu & Zhengrong Chen
Additional file 1: Figure S1. mRNA changes of miR-493-5p and partial cytokines related to Th9 cell differentiation in mouse asthma model. **P < 0.01, compared to control. Figure S2. Validation of overexpression/knockout efficiency. (A) The overexpression/knockout efficiency of miR-493-5p mimic/inhibitor. (B) The overexpression efficiency of FOXO1.

MiR-493-5p inhibits Th9 cell differentiation in allergic asthma by targeting FOXO1

Xingyu Rao, Heting Dong, Weili Zhang, Huiming Sun, Wenjing Gu, Xinxing Zhang, Li Huang, Yongdong Yan, Chuangli Hao, Wei Ji, Canhong Zhu & Zhengrong Chen
Abstract The role of micro RNAs (miRNAs) in asthma remains unclear. In this study, we examined the role of miRNA in targeting FOXO1 in asthma. Results showed that miR-493-5p was one of the differentially expressed miRNAs in the PBMCs of asthmatic children, and was also associated with Th cell differentiation. The miR-493-5p expression decreased significantly in the OVA-induced asthma mice than the control groups. The miR-493-5p mimic inhibited the expression of the IL-9, IRF4 and...

Genetic diversity in the transmission-blocking vaccine candidate Plasmodium vivax gametocyte protein Pvs230 from the China–Myanmar border area and central Myanmar

Xin Zhao, Yubing Hu, Yan Zhao, Lin Wang, Zifang Wu, Myat Thu Soe, Myat Phone Kyaw, Liwang Cui, Xiaotong Zhu & Yaming Cao
Abstract Background Sexual stage surface antigens are potential targets of transmission-blocking vaccines (TBVs). The gametocyte and gamete surface antigen P230, a leading TBV candidate, is critical for red blood cell binding during exflagellation and subsequent oocyst development. Here, the genetic diversity of Pvs230 was studied in Plasmodium vivax parasite isolates from the China–Myanmar border (CMB) and central Myanmar. Methods Plasmodium vivax isolates were collected in clinics from malaria-endemic areas of the CMB (143 samples) and...

sj-jpg-14-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-jpg-14-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-jpg-15-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-jpg-15-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-jpg-15-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-jpg-15-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-jpg-13-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-jpg-13-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-jpg-16-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-jpg-16-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-tif-8-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-tif-8-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-tif-1-npx-10.1177_1934578X221130874 - Supplemental material for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu & Qi Zhang
Supplemental material, sj-tif-1-npx-10.1177_1934578X221130874 for Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model by Wenkai Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, Fuhai Zhou, Haiwei Liu and Qi Zhang in Natural Product Communications

sj-pdf-1-trj-10.1177_00405175221130771 - Supplemental material for Influence of the graft-copolymerized hydrophilic lignin content on the structure and mechanical properties of gel-spun poly(vinyl alcohol) composite fibers

Yu Cheng, Jiaxian Lin, Xiaorui Sun, Lianjie Duan, Yuanyuan Zheng, Xiaoxia Sun, Xian Li & Chunhong Lu
Supplemental material, sj-pdf-1-trj-10.1177_00405175221130771 for Influence of the graft-copolymerized hydrophilic lignin content on the structure and mechanical properties of gel-spun poly(vinyl alcohol) composite fibers by Yu Cheng, Jiaxian Lin, Xiaorui Sun, Lianjie Duan, Yuanyuan Zheng, Xiaoxia Sun, Xian Li and Chunhong Lu in Textile Research Journal

Additional file 2 of A centenary tale: population genetic insights into the introduction history of the oriental fire-bellied toad (Bombina orientalis) in Beijing

Shan Zhang, Meixi Lin, Jiawei Liu, Jiangce Chen, Dong Liu, Jindong Zhao & Meng Yao
Additional file 2: Data S1. Individual mitochondrial DNA haplotypes and microsatellite genotype data.

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