3,791 Works

Additional file 1 of Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults

Binbin Su, Xiaoxuan Zhu, Kai Yang, Yunfan Xiao, Chunmei Li, Keai Shi, Jia Qu, Fan Lu, Ming Li & Lele Cui
Additional file 1: Figure S1. Vessel densities of the whole measured area, parafovea, and four quadrants (temporal, superior, nasal, and inferior) in the (a, c) SCP and (b, d) DCP measured with optical coherence tomography angiography stratified by age in males and females. Table S1. Baseline characteristics of male participants in the study. Table S2. Baseline characteristics of female participants in the study. Table S3. Vessel densities of the whole measured area, parafovea, and four...

5-Hydroxymethylation alterations in cell-free DNA reflect molecular distinctions of diffuse large B cell lymphoma at different primary sites

Ye Shen, Jinping Ou, Bo He, Jinmin Yang, Huihui Liu, Lihong Wang, Bingjie Wang, Liang Gao, Chengqi Yi, Jinying Peng & Xinan Cen
Abstract Background 5-Hydroxymethylcytosine (5hmC), an important DNA epigenetic modification, plays a vital role in tumorigenesis, progression and prognosis in many cancers. Diffuse large B cell lymphoma (DLBCL) can involve almost any organ, but the prognosis of patients with DLBCL at different primary sites varies greatly. Previous studies have shown that 5hmC displays a tissue-specific atlas, but its role in DLBCLs at different primary sites remains unknown. Results We found that primary gastric DLBCL (PG-DLBCL) and...

Table S4.xlsx from Transcriptome analysis and mining of genes related to shade tolerance in foxtail millet (Setaria italica (L.) P. Beauv.)

Dan Liu, Yanjiao Cui, Zilong Zhao, Jing Zhang, Suying Li & Zhengli Liu
A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

Additional file 1 of LARRPM restricts lung adenocarcinoma progression and M2 macrophage polarization through epigenetically regulating LINC00240 and CSF1

Yue Li, Chen Chen, Hai-lin Liu, Zhen-fa Zhang & Chang-li Wang
Additional file 1: Table S1. Relationships between LARRPM expression and clinicopathological features in LUAD.

Additional file 5 of LARRPM restricts lung adenocarcinoma progression and M2 macrophage polarization through epigenetically regulating LINC00240 and CSF1

Yue Li, Chen Chen, Hai-lin Liu, Zhen-fa Zhang & Chang-li Wang
Additional file 5: Figure S4. The correlation between LARRPM expression, 5hmC level at CSF1 promoter, CpG82 methylation level and CSF1 expression in LUAD tissues. A Correlation between CSF1 and LARRPM expression analysed using the TCGA LUAD data. r = − 0.3069, P < 0.0001 by Spearman correlation analysis. B Correlation between CSF1 and LARRPM expression analysed in our LUAD cohort. r = − 0.5774, P < 0.0001 by Spearman correlation analysis. C 5hmC levels of...

Additional file 7 of LARRPM restricts lung adenocarcinoma progression and M2 macrophage polarization through epigenetically regulating LINC00240 and CSF1

Yue Li, Chen Chen, Hai-lin Liu, Zhen-fa Zhang & Chang-li Wang
Additional file 7: Fig. S6. Depletion of LARRPM in LUAD cells enhanced the oncogenic roles of infiltrated M2 macrophages. A–F Conditioned medium (CM) was collected from co-culture of macrophages with HCC827 cells with LARRPM depletion or control HCC827 cells, or collected from only HCC827 cells with LARRPM depletion or control HCC827 cells. A Cell proliferation of HCC827 cells treated with the CM was detected using CCK-8 assays. B Cell proliferation of HCC827 cells treated with...

Additional file 6 of Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments

Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin & Yang Li
Additional file 6: Table S1. The mitochondria-related genes extracted from the uniprot database.

Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments

Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin & Yang Li
Abstract Background Glioblastoma (GBM) is the most common primary malignant brain tumor that leads to lethality. Several studies have demonstrated that mitochondria play an important role in GBM and that mitochondria-related genes (MRGs) are potential therapeutic targets. However, the role of MRGs in GBM remains unclear. Methods Differential expression and univariate Cox regression analyses were combined to screen for prognostic differentially-expressed (DE)-MRGs in GBM. Based on LASSO Cox analysis, 12 DE-MRGs were selected to construct...

Additional file 7 of Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments

Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin & Yang Li
Additional file 7: Table S2. The primer sequences used in the study.

Additional file 8 of Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments

Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin & Yang Li
Additional file 8: Table S3. The 201 DE-MRGs between neoplatstic and non-neoplastic cells.

Relationship between body composition and bone mineral density in postmenopausal women with type 2 diabetes mellitus

Lei Gao, Ping Zhang, Yan Wang, Wei Zhang, Jian Zhao, Ying Liu, Jing Liu & Shaoqiang He
Abstract Background The aim of the study were to analyze the lumbar volumetric bone mineral density (BMD), fat distribution and changes of skeletal muscle with quantitative computed tomography (QCT) in postmenopausal women with type 2 diabetes mellitus (T2DM), and to evaluate the relationship between body composition and BMD. Methods One hundred seventy-seven postmenopausal women with T2DM and 136 postmenopausal women without diabetes were included in the study and were divided into two groups according to...

Additional file 5 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 5. Figure S2: Mutational profile of plasma samples. Gene mutations detected in tissue and plasma samples in each patient. Colors denote different variant types. Horizontal and vertical bars denote the detection of tissue mutations in presurgical and postsurgical plasma samples, respectively. Twenty most prevalent gene mutations in tissue samples were shown.

Additional file 5 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 5. Figure S2: Mutational profile of plasma samples. Gene mutations detected in tissue and plasma samples in each patient. Colors denote different variant types. Horizontal and vertical bars denote the detection of tissue mutations in presurgical and postsurgical plasma samples, respectively. Twenty most prevalent gene mutations in tissue samples were shown.

Additional file 3 of Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments

Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin & Yang Li
Additional file 3: Fig. S3. The time dependent ROC curves for other three prognostic models. A Time dependent ROC curves for immune-related gene signature in the TCGA GBM cohort. B Time dependent ROC curves for pyroptosis-related gene signature in the TCGA GBM cohort. C Time dependent ROC curves for autophagy-related gene signature in the TCGA GBM cohort.

Additional file 4 of Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments

Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin & Yang Li
Additional file 4: Fig. S4. Validation of independence of our risk score as a prognostic factor. A The forest plot showed the univariate cox analysis using risk score, age, radiotherapy, TMZ chemotherapy, and gender as variates in the GSE16011 GBM cohort. B The forest plot showed the multivariate cox analysis using risk score, age, radiotherapy, and TMZ chemotherapy as variates in the GSE16011 GBM cohort. C Stratified OS analysis in GSE16011 GBM patients with different...

Additional file 3 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 3. Table S3: Performance of three strategies.

Additional file 1 of Association between frequency of dairy product consumption and hypertension: a cross-sectional study in Zhejiang Province, China

Hao Wang, Lingli Chen, Yuan Cao, Kaixu Xie, Chunmei Wang, Pei Pei, Yu Guo, Fiona Bragg, Min Yu, Zhengming Chen & Liming Li
Additional file 1. Table S1. Unadjusted and adjusted β coefficients for SBP and DBP associated with frequency of dairy product consumption among adults without self-reported physician-diagnosed hypertension in Zhejiang. Table S2. Unadjusted and adjusted prevalence ratios for hypertension associated with frequency of dairy product consumption among adults in Zhejiang. Table S3. Adjusted odds ratios for hypertension associated with consuming dairy products weekly vs. never according to participant characteristics.

Additional file 2 of Construction of a ferroptosis-related five-lncRNA signature for predicting prognosis and immune response in thyroid carcinoma

Yuan Qin, Dai Zhang, Huan Zhang, Lan Hou, Zhe Wang, Liu Yang, Mingkun Zhang, Ge Zhao, Qing Yao, Rui Ling & Juliang Zhang
Additional file 2: Table S2. Akaike information criterion for the prognostic signature.

Additional file 1 of Boosting cisplatin chemotherapy by nanomotor-enhanced tumor penetration and DNA adducts formation

Lihua Xu, Kaixiang Zhang, Xing Ma, Yingying Li, Yajie Jin, Chenglin Liang, Yong Wang, Wendi Duan, Hongling Zhang, Zhenzhong Zhang, Jinjin Shi, Junjie Liu, Yunlong Wang & Wentao Li
Additional file 1: Figure S1. DLS analysis of F68@TA prepared by different mass ratio of F68 and TA. (n=3). Figure S2. TEM images of F68@TA@Ag NPs prepared with different content of AgNO3. Figure S3. (A) Size distributions and (B) zeta potentials of F68@TA, F68@TA/CDDP, and AINR solutions. Figure S4. Tyndall Effects of F68@TA/CDDP solution at different pHs for 1 h. Figure S5. DLS analysis of F68@TA/CDDP treated with PBS at different pHs for 48 h....

Boosting cisplatin chemotherapy by nanomotor-enhanced tumor penetration and DNA adducts formation

Lihua Xu, Kaixiang Zhang, Xing Ma, Yingying Li, Yajie Jin, Chenglin Liang, Yong Wang, Wendi Duan, Hongling Zhang, Zhenzhong Zhang, Jinjin Shi, Junjie Liu, Yunlong Wang & Wentao Li
Abstract Despite many nano-based strategies devoted to delivering cisplatin for tumor therapy, its clinical benefits are compromised by poor tissue penetration and limited DNA adducts formation of the drug. Herein, a cisplatin loading nanomotor based janus structured Ag-polymer is developed for cisplatin delivery of deeper tissue and increased DNA adducts formation. The nanomotor displayed a self‐propelled tumor penetration fueled by hydrogen peroxide (H2O2) in tumor tissues, which is catalytically decomposed into a large amount of...

Prevalence of reproductive tract infections among women preparing to conceive in Chongqing, China: trends and risk factors

Jun Liu, Mengyao Zeng, Liu Yang, Yanyan Mao, Yang He, Min Li, Qing Chen, Weijin Zhou, Liang Chen & Qianxi Zhu
Abstract Background Reproductive tract infection has become a major public health issue all over the world for its high and growing prevalence. It can cause adverse pregnancy outcomes in pregnant women and their foetuses. This study aimed to investigate the trends and risk factors of the prevalence of reproductive tract infections among women who prepared to conceive in the Chongqing Municipality (China) from 2012 to 2016. Methods A multi-center cross-sectional study was conducted between January...

Additional file 1 of Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass

Jiang-Wei Xia, Lin Zhang, Jin Li, Cheng-Da Yuan, Xiao-Wei Zhu, Yu Qian, Saber Khederzadeh, Jia-Xuan Gu, Lin Xu, Jian-Hua Gao, Ke-Qi Liu, David Karasik, Shu-Yang Xie, Guo-Bo Chen & Hou-Feng Zheng
Additional file 1: Fig. S1. Restricted cubic spline analysis to show the relationship between birth weight and Lumbar spine bone parameters. Fig. S2. Restricted cubic spline analysis to show the relationship between birth weight and Lateral spine bone parameters. Fig. S3. Restricted cubic spline analysis to show the relationship between birth weight and heel BMD. Table S1. Characteristics of the single nucleotide polymorphisms associated with the birth weight. Table S2. Detailed information on the GWAS...

Additional file 1 of Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass

Jiang-Wei Xia, Lin Zhang, Jin Li, Cheng-Da Yuan, Xiao-Wei Zhu, Yu Qian, Saber Khederzadeh, Jia-Xuan Gu, Lin Xu, Jian-Hua Gao, Ke-Qi Liu, David Karasik, Shu-Yang Xie, Guo-Bo Chen & Hou-Feng Zheng
Additional file 1: Fig. S1. Restricted cubic spline analysis to show the relationship between birth weight and Lumbar spine bone parameters. Fig. S2. Restricted cubic spline analysis to show the relationship between birth weight and Lateral spine bone parameters. Fig. S3. Restricted cubic spline analysis to show the relationship between birth weight and heel BMD. Table S1. Characteristics of the single nucleotide polymorphisms associated with the birth weight. Table S2. Detailed information on the GWAS...

NLRC5 Restricts Dengue Virus Infection by Promoting the Autophagic Degradation of Viral NS3 through E3 Ligase CUL2 (cullin 2)

Jiawei Hao, Jinqian Li, Zhenzhen Zhang, Yang Yang, Qing Zhou, Tiantian Wu, Tongling Chen, Zhongdao Wu, Ping Zhang, Jun Cui & Yi-Ping Li
NLRC5 has been reported to be involved in antiviral immunity; however, the underlying mechanism remains poorly understood. Here, we investigated the functional role of NLRC5 in the infection of a flavivirus, dengue virus (DENV). We found that expression of NLRC5 was strongly induced by virus infection and IFNB or IFNG stimulation in different cell lines. Overexpression of NLRC5 remarkably suppressed DENV infection, whereas knockout of NLRC5 led to a significant increase in DENV infection. Mechanistic...

YAP1 protects against septic liver injury via ferroptosis resistance

Jin Wang, Qian Zhu, Rui Li, Jing Zhang, Xujun Ye & Xinyi Li
Abstract Background The liver plays crucial roles in sepsis and is one of the major targets for sepsis-related injuries. Ferroptosis, a newly emerged form of lytic cell death, has been implicated in sepsis related organ failure. Yes-associated protein1 (YAP1), a key regulator of the Hippo signaling pathway, may be involved in ferroptosis development. This study aimed to elucidate the role of YAP1 in septic liver injury through regulating ferroptosis, especially ferritinophagy-mediated ferroptosis. Results Cecal ligation...

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