52 Works

Questioning to Resolve Transduction Problems

Eric Meinhardt, Anna Mai, Eric Bakovic & Adam McCollum

Photoelectrochemical Immunosensor Based on ZnIn2S4/Bi2Se3 Nanocomposite for the Determination of Cardiac Troponin I

Wanxin Dong, Xinxin Mo, Yu Wang, Qin Lei & He Li
In this work, a novel flexible photoelectrochemical immunosensor is developed to determine cardiac troponin I (cTnI) in serum. The flower-like ZnIn2S4 nanospheres (ZIS), as signal amplification material, were successfully synthesized by a solvothermal method. The ZIS and Bi2Se3 were modified on the indium tin oxide- polyethylene terephthalate (ITO-PET) electrode, which effectively accelerates the electronic transition and improved the photocurrent conversion efficiency (signal on). However, the binding of antigen–antibody proteins blocks the electron transfer, resulting in...

SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation

Patricia Richard, Shuang Feng, Yueh-Lin Tsai, Wencheng Li, Paola Rinchetti, Ubayed Muhith, Juan Irizarry-Cole, Katharine Stolz, Lionel A. Sanz, Stella Hartono, Mainul Hoque, Saba Tadesse, Hervé Seitz, Francesco Lotti, Michio Hirano, Frédéric Chédin, Bin Tian & James L. Manley
SETX (senataxin) is an RNA/DNA helicase that has been implicated in transcriptional regulation and the DNA damage response through resolution of R-loop structures. Mutations in SETX result in either of two distinct neurodegenerative disorders. SETX dominant mutations result in a juvenile form of amyotrophic lateral sclerosis (ALS) called ALS4, whereas recessive mutations are responsible for ataxia called ataxia with oculomotor apraxia type 2 (AOA2). How mutations in the same protein can lead to different phenotypes...

Ribosomal stalk proteins RPLP1 and RPLP2 promote biogenesis of flaviviral and cellular multi-pass transmembrane proteins

Premal Shah, Rafael Campos, H.R. Sagara Wijeratne, Mariano Garcia-Blanco & Shelton Bradrick
The ribosomal stalk proteins, RPLP1 and RPLP2 (RPLP1/2), which form the ancient ribosomal stalk, were discovered decades ago but their functions remain mysterious. We had previously shown that RPLP1/2 are exquisitely required for replication of dengue virus (DENV) and other mosquito-borne flaviviruses. Here, we show that RPLP1/2 function to relieve ribosome pausing within the DENV envelope coding sequence, leading to enhanced protein stability. We evaluated viral and cellular translation in RPLP1/2-depleted cells using ribosome profiling...

Ecological divergence and the history of gene flow in the Nearctic milksnakes (Lampropeltis triangulum complex)

Frank Burbrink, Justin Bernstein, Arianna Kuhn, Marcelo Gehara & Sara Ruane
Many phylogeographic studies on species with large ranges have found genetic-geographic structure associated with changes in habitat and physical barriers to gene flow. These studies may conclude absence of population structure, lineage structure that indicates unique species have been discovered, or suggest more research is needed prior to delimitation. Comparative risks of delimiting species incorrectly or failing to delimit species are usually not weighed and a more detailed return to these problems with more data...

Quantifier-free tree transductions

Shiori Ikawa, Akane Ohtaka & Adam Jardine

Potential causes and consequences of rapid mitochondrial genome evolution in thermoacidophilic Galdieria (Rhodophyta)

Chung Hyun Cho, Seung In Park, Claudia Ciniglia, Eun Chan Yang, Louis Graf, Debashish Bhattacharya & Hwan Su Yoon
The Cyanidiophyceae is an early-diverged red algal class that thrives in extreme conditions around acidic hot springs. Although this lineage has been highlighted as a model for understanding the biology of extremophilic eukaryotes, little is known about the molecular evolution of their mitochondrial genomes (mitogenomes). To fill this knowledge gap, we sequenced five mitogenomes from representative clades of Cyanidiophyceae and identified two major groups, here referred to as Galdieria-type (G-type) and Cyanidium-type (C-type). G-type mitogenomes...

Epidemiology and clinical course of COVID-19 in Shanghai, China

Yinzhong Shen, Fang Zheng, Danfeng Sun, Yun Ling, Jun Chen, Feng Li, Tao Li, Zhiping Qian, Yuyi Zhang, Qingnian Xu, Li Liu, Qin Huang, Fei Shan, Lie Xu, Jun Wu, Zhaoqin Zhu, Zhigang Song, Shenyang Li, Yuxin Shi, Jianliang Zhang, Xueyun Wu, Joshua B. Mendelsohn, Tongyu Zhu & Hongzhou Lu
Background: Novel coronavirus pneumonia (COVID-19) is prevalent around the world. We aimed to describe epidemiological features and clinical course in Shanghai. Methods: We retrospectively analysed 325 cases admitted at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020. Results: 47.4% (154/325) had visited Wuhan within 2 weeks of illness onset. 57.2% occurred in 67 clusters; 40% were situated within 53 family clusters. 83.7% developed fever during the disease course. Median times from...

Participatory Variety Selection of Three African Leafy Vegetables in Western Kenya

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Editorial

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Data from: Antibiotics in hives and their effects on honey bee physiology and behavioral development

Yarira Ortiz-Alvarado, David Clark, Carlos Vega-Melendez, Zomary Flores-Cruz, Maria Dominguez-Bello & Tugrul Giray
Recurrent honey bee losses make it critical to understand the impact of human interventions, such as antibiotics use in apiculture. Antibiotics are used to prevent or treat bacterial infections in colonies. However, little is known about their effects on honey bee development. We studied the effect of two commercial beekeeping antibiotics on the bee physiology and behavior throughout development. Our results show that antibiotic treatments have an effect on amount of lipids and rate of...

Data from: Evolutionary and phylogenetic insights from a nuclear genome sequence of the extinct, giant subfossil koala lemur Megaladapis edwardsi

Stephanie Marciniak, Mehreen R. Mughal, Laurie R. Godfrey, Richard J. Bankoff, Heritiana Randrianatoandro, Brooke E. Crowley, Christina M. Bergey, Kathleen M. Muldoon, Jeannot Randrianasy, Brigitte M. Raharivololona, Stephan C. Schuster, Ripan S. Malhi, Anne D. Yoder, , Logan Kistler & George H. Perry
No endemic Madagascar animal with body mass >10 kg survived a relatively recent wave of extinction on the island. From morphological and isotopic analyses of skeletal ‘subfossil’ remains we can reconstruct some of the biology and behavioral ecology of giant lemurs (primates; up to ~160 kg), elephant birds (up to ~860 kg), and other extraordinary Malagasy megafauna that survived well into the past millennium. Yet much about the evolutionary biology of these now extinct species...

Selective extinctions resulting from random habitat destruction lead to under‐estimates of local and regional biodiversity loss in a manipulative field experiment

Ryan Almeida, Kevin Smith, Alexander Berro, Alston Lippert, Jake Clary, Sam McKlin & Erin Scott
Land-use change is a significant cause of anthropogenic extinctions, which are likely to continue and accelerate as habitat conversion proceeds in most biomes. One way to understand the effects of habitat loss on biodiversity is through improved tools for predicting the number and identity of species losses in response to habitat loss. There are relatively few methods for predicting extinctions and even fewer opportunities for rigorously assessing the quality of these predictions. In this paper...

New England Seismic Transect

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A planned linear array of broadband seismometers across New England (New Hampshire and Vermont) aimed at understanding the crust and upper mantle structure. The experiment targets the so-called Northern Appalachian Anomaly (NAA) in the upper mantle, which may represent a recently formed mantle upwelling.

Examining the Link Between Pledging, Hazing, and Organizational Commitment Among Members of a Black Greek Fraternity

Sean Rogers, Carmen Rogers & Treshawn Anderson

Data from: Chronotropic incompetence limits aerobic exercise capacity in patients taking beta-blockers

Krzysztof Smarz, Maciej Tysarowski, Beata Zaborska, Ewa Pilichowska-Paszkiet, Malgorzata Sikora-Frac, Andrzej Budaj & Tomasz Jaxa-Chamiec
Background: Chronotropic incompetence in patients taking beta-blockers is associated with poor prognosis; however, its impact on exercise capacity (EC) remains unclear. Hypothesis: Chronotropic incompetence in patients taking beta-blockers is associated with lower EC. Methods: We retrospectively analyzed data from consecutive patients taking beta-blockers referred for cardiopulmonary exercise testing. EC was expressed as peak oxygen uptake (VO2peak; mL/kg/min). Chronotropic incompetence was defined as chronotropic index (CI) ≤ 62%. CI was calculated as [(HR at peak–resting HR)...

Photoelectrochemical Immunosensor Based on ZnIn2S4/Bi2Se3 Nanocomposite for the Determination of Cardiac Troponin I

Wanxin Dong, Xinxin Mo, Yu Wang, Qin Lei & He Li
In this work, a novel flexible photoelectrochemical immunosensor is developed to determine cardiac troponin I (cTnI) in serum. The flower-like ZnIn2S4 nanospheres (ZIS), as signal amplification material, were successfully synthesized by a solvothermal method. The ZIS and Bi2Se3 were modified on the indium tin oxide- polyethylene terephthalate (ITO-PET) electrode, which effectively accelerates the electronic transition and improved the photocurrent conversion efficiency (signal on). However, the binding of antigen–antibody proteins blocks the electron transfer, resulting in...

Information-theoretic Characterization of the Sub-regular Hierarchy

Huteng Dai & Richard Futrell

Developing New Natural Plant Products from the Spice Xylopia aethiopica from Ghana and Liberia

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Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicentre, proof-of-concept, observational study

Yang Li, Xian Zhou, Tao Li, Shiji Chan, Yiqi Yu, Jing-Wen Ai, Haocheng Zhang, Feng Sun, Qiran Zhang, Lei Zhu, Lingyun Shao, Bin Xu & Wenhong Zhang
Critically ill patients with coronavirus diseases 2019 (COVID-19) are of grave concern. Those patients usually underwent a stage of excessive inflammation before developing acute respiratory distress syndrome. In this study, we test the hypothesis that short-term, low-to-moderate-dose corticosteroids would benefit patients when used in the early phase of excessive inflammation, namely, the therapeutic window. Among a Shanghai cohort and a validation cohort, we enrolled COVID-19 patients showing marked radiographic progression. Short-term, low-to-moderate-dose corticosteroids were considered...

Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicenter, proof-of-concept, observational study.

Yang Li, Xian Zhou, Tao Li, Shiji Chan, Yiqi Yu, Jing-Wen Ai, Haocheng Zhang, Feng Sun, Qiran Zhang, Lei Zhu, Lingyun Shao, Bin Xu & Wenhong Zhang
Background: Critically ill patients with COVID-19 are of grave concern. Those patients usually underwent a stage of excessive inflammation before developing acute respiratory distress syndrome. In this study, we test the hypothesis that short-term, low-to-moderate-dose corticosteroids would benefit patients when used in the early phase of excessive inflammation namely, the therapeutic window. Methods: Among a Shanghai cohort and a validation cohort, we enrolled COVID-19 patients showing marked radiographic progression. Short-term, low-to-moderate-dose corticosteroids were considered for...

Registration Year

  • 2020
    52

Resource Types

  • Dataset
    26
  • Text
    25
  • Other
    1

Affiliations

  • Rutgers, The State University of New Jersey
    36
  • Rutgers University
    14
  • Zhejiang University
    11
  • West China Hospital of Sichuan University
    9
  • Huazhong University of Science and Technology
    9
  • Chinese Academy of Sciences
    8
  • Fudan University
    7
  • Capital Medical University
    7
  • Central South University
    6
  • Shanghai Jiao Tong University
    6