Purpose: Around 9% of children have difficulty acquiring intelligible speech despite typical sensory, neuro-motor and cognitive function. Speech-language pathologists (SLPs) rely on descriptions of children’s speech errors to identify speech sound disorder (SSD) and determine intervention targets and goals. Existing normative data, however, need re-evaluation to reflect changes in populations and the language learning environment. This research evaluates whether developmental phonological patterns widely accepted as describing typical acquisition predict speech errors in a recent sample...

Abstract Background Esophageal adenocarcinoma is a lethal disease. For locally advanced patients, neoadjuvant chemoradiotherapy followed by surgery is the standard of care. Risk stratification relies heavily on clinicopathologic features, particularly pathologic response, which is inadequate, therefore establishing the need for new and reliable biomarkers for risk stratification. Methods Thirty four patients with locally advanced esophageal adenocarcinoma were analyzed, of which 21 received a CROSS regimen with carboplatin, paclitaxel, and radiation. Capture-based targeted sequencing was performed...

Abstract Background According to current guidelines, more than 70% of patients with invasive submucosal colorectal cancer (T1 CRC) undergo a radical operation with lymph node dissection, even though only ~ 10% have lymph node metastasis (LNM). Hence, there is imperative to develop biomarkers that can help robustly identify LNM-positive patients to prevent such overtreatments. Given the emerging interest in exosomal cargo as a source for biomarker development in cancer, we examined the potential of exosomal...

Additional file 5: Supplemental Figure 2. Validation of novel combination panel in predicting lymph node metastasis from high-risk T1 CRC patients. Left chart) A receiver operating characteristic curve analysis to evaluate the performance of exosomal and cell-free miRNAs combination panel in a validation cohort. Right chart) Waterfall plot for modified risk score distribution in a validation cohort. LNN: lymph node metastasis negative, LNP: lymph node metastasis positive, AUC: area under the curve.

Additional file 5: Supplemental Figure 2. Validation of novel combination panel in predicting lymph node metastasis from high-risk T1 CRC patients. Left chart) A receiver operating characteristic curve analysis to evaluate the performance of exosomal and cell-free miRNAs combination panel in a validation cohort. Right chart) Waterfall plot for modified risk score distribution in a validation cohort. LNN: lymph node metastasis negative, LNP: lymph node metastasis positive, AUC: area under the curve.

Additional file 1.

Abstract Background Little research is available regarding vaccination attitudes among those recently diagnosed with COVID-19. This is important to investigate, particularly among those experiencing mild-to-moderate illness, given the ongoing need to improve uptake of both initial vaccine series and booster doses, and the divergent ways such an experience could impact attitudes. Methods From September 3 – November 12, 2021, all patients enrolled in Baylor Scott & White’s “COVID-19 Digital Care Journey for Home Monitoring” were...

Additional file 3: Supplemental Table 2. Univariate and multivariate analysis for lymph node metastasis detection in the validation cohort.

Additional file 4: Supplemental Figure 1. Comparison of diagnostic ability of four cell-free miRNAs and four exosomal miRNAs in lymph node metastasis detection. A) A receiver operating characteristic (ROC) curve analysis to evaluate the performance of four cell-free miRNAs. B) ROC curve analysis to evaluate the performance of four exosomal miRNAs. Cf-: cell-free, exo: exosomal, AUC: area under the curve.

Additional file 6: Supplemental Figure 3. A nomogram illustrates the probability of lymph node metastasis risk.

Additional files from A microRNA signature for risk-stratification and response prediction to FOLFOX-based adjuvant therapy in stage II and III colorectal cancer

Additional files from A microRNA signature for risk-stratification and response prediction to FOLFOX-based adjuvant therapy in stage II and III colorectal cancer

Abstract Background It is increasingly recognized that policies have played a role in both alleviating and exacerbating the health and economic consequences of the COVID-19 pandemic. There has been limited systematic evaluation of variation in U.S. local COVID-19-related policies. This study introduces the U.S. COVID-19 County Policy (UCCP) Database, whose objective is to systematically gather, characterize, and assess variation in U.S. county-level COVID-19-related policies. Methods In January-March 2021, we collected an initial wave of cross-sectional...

Additional file 1.

Additional file 1.

Purpose: Around 9% of children have difficulty acquiring intelligible speech despite typical sensory, neuro-motor and cognitive function. Speech-language pathologists (SLPs) rely on descriptions of children’s speech errors to identify speech sound disorder (SSD) and determine intervention targets and goals. Existing normative data, however, need re-evaluation to reflect changes in populations and the language learning environment. This research evaluates whether developmental phonological patterns widely accepted as describing typical acquisition predict speech errors in a recent sample...

Abstract Background Esophageal adenocarcinoma is a lethal disease. For locally advanced patients, neoadjuvant chemoradiotherapy followed by surgery is the standard of care. Risk stratification relies heavily on clinicopathologic features, particularly pathologic response, which is inadequate, therefore establishing the need for new and reliable biomarkers for risk stratification. Methods Thirty four patients with locally advanced esophageal adenocarcinoma were analyzed, of which 21 received a CROSS regimen with carboplatin, paclitaxel, and radiation. Capture-based targeted sequencing was performed...

Additional file 1.

Abstract Background It is increasingly recognized that policies have played a role in both alleviating and exacerbating the health and economic consequences of the COVID-19 pandemic. There has been limited systematic evaluation of variation in U.S. local COVID-19-related policies. This study introduces the U.S. COVID-19 County Policy (UCCP) Database, whose objective is to systematically gather, characterize, and assess variation in U.S. county-level COVID-19-related policies. Methods In January-March 2021, we collected an initial wave of cross-sectional...

Abstract Background Little research is available regarding vaccination attitudes among those recently diagnosed with COVID-19. This is important to investigate, particularly among those experiencing mild-to-moderate illness, given the ongoing need to improve uptake of both initial vaccine series and booster doses, and the divergent ways such an experience could impact attitudes. Methods From September 3 – November 12, 2021, all patients enrolled in Baylor Scott & White’s “COVID-19 Digital Care Journey for Home Monitoring” were...

Supplementary Material 1

Additional file 1. Materials and methods.

Additional file 2: Supplemental Table 1. Clinicopathological factors of clinical cohorts.

Additional file 1. Materials and methods.

Additional file 2: Supplemental Table 1. Clinicopathological factors of clinical cohorts.