We designed this study to examine performance under stress and quantify individual differences in subjective stress and performance outcomes. There will be three manipulations of time pressure, one primary measure of subjective stress, and three primary performance outcomes. Time pressure manipulations involve time constraints, waiting periods, and urgency messaging. Performance outcomes pertain to the spatial domain, specifically wayfinding (non-locomotive navigation). The first confirmatory analyses will test main effects and interactions of the time pressure manipulations...

Dollar stores are increasingly becoming a major source for grocery purchases for many American households. Especially, households participating in the Supplemental Nutrition Assistance Program (SNAP), who experience a monthly cycle of having abundant and healthier foods at the beginning of the month, but insufficient and less nutritious foods at the end of the month, may rely on the dollar store more at the end of monthly cycle. Besides, the role of dollar stores can be...

Abstract Developing multifunctional composites has received widespread attention for cancer treatment. Herein, a metal–phenolic network (MPN)-based composite loading with chemotherapy agents (TAFP) exhibits high anti-tumor therapeutic efficacy via photothermal therapy (PTT), chemo-dynamic therapy (CDT), and chemotherapy. The nanocomposite was formed by mixing the chemotherapeutic drugs (cisplatin, DDP) into the tannic acid (TA) and Fe3+ network (TAFe) to integrate the synergistic effect of PTT, CDT, and chemotherapy. Due to the acidic tumor microenvironment, the active substances...

Extremes in environmental conditions can limit growth and reproduction of animals. Sedentary marine animals are particularly susceptible to winter food limitation since they cannot relocate to more favorable conditions. Winter conditions have been linked to tissue mass declines as high as 70% in several temperate-zone suspension-feeding bivalve species; however, no comparable studies have been conducted on intertidal gastropods. Here, we investigate whether the suspension-feeding intertidal marine gastropod Crepidula fornicata also loses substantial tissue mass during...

Abstract Background A major hand-foot-and-mouth disease (HFMD) pathogen, coxsackievirus A16 (CVA16), has predominated in several of the last 10 years and caused the largest number of HFMD outbreaks between 2011 and 2018 in China. We evaluated the efficacy of maternal anti-CVA16 antibody transfer via the placenta and explored the dynamics of maternal and natural infection-induced neutralizing antibodies in children. Methods Two population-based longitudinal cohorts in southern China were studied during 2013–2018. Participants were enrolled in...

Abstract Background A major hand-foot-and-mouth disease (HFMD) pathogen, coxsackievirus A16 (CVA16), has predominated in several of the last 10 years and caused the largest number of HFMD outbreaks between 2011 and 2018 in China. We evaluated the efficacy of maternal anti-CVA16 antibody transfer via the placenta and explored the dynamics of maternal and natural infection-induced neutralizing antibodies in children. Methods Two population-based longitudinal cohorts in southern China were studied during 2013–2018. Participants were enrolled in...

Additional file 1. Table S1. COVID-Specific Items and Scales. Table S2. Descriptive Statistics of Person-Reported Outcomes. Table S3. Unadjusted Group Comparisons on Person-Reported Outcomes. Table S4. Representativeness Checks. Table S5. Distribution of Covariates in the Matched Samples. Table S6. Comparison of Explained Variance by Demographics and COVID-specific Variables in Whole-Sample vs. Matched Cohort Analyses.

Additional file 2: Figures S1, S2. Figure S1. Ranking with the 12 most significant metabolites derived from the O-PLS DA model. Figure S2. Adjusted Cox for the analysis of the patient risk scored grouped in ascending tertiles of glycated haemoglobin.

Additional file 2: Figures S1, S2. Figure S1. Ranking with the 12 most significant metabolites derived from the O-PLS DA model. Figure S2. Adjusted Cox for the analysis of the patient risk scored grouped in ascending tertiles of glycated haemoglobin.

Abstract Multiple computational approaches have been developed to improve our understanding of genetic variants. However, their ability to identify rare pathogenic variants from rare benign ones is still lacking. Using context annotations and deep learning methods, we present pathogenicity prediction models, MetaRNN and MetaRNN-indel, to help identify and prioritize rare nonsynonymous single nucleotide variants (nsSNVs) and non-frameshift insertion/deletions (nfINDELs). We use independent test sets to demonstrate that these new models outperform state-of-the-art competitors and achieve...

Additional file 1. Online Supplementary Appendix: Clinical Research Diagnostic Criteria for BipolarDisorder.

While political protest and labor unions are seen as important elements in democratic societies, systematic research on the relationship between the two is scarce. Past research finds that union members are more likely to engage in protest, but it is unclear whether unions increase protest among non-members. This study draws on two waves of data from the Cooperative Congressional Election Study and examines two mechanisms through which labor unions facilitate political protest among non-members: social...

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Influenza A viruses (IAV) circulate endemically among many wild aquatic bird populations that seasonally migrate between wintering grounds in southern latitudes to breeding ranges along the perimeter of the circumpolar arctic. Arctic and subarctic zones are hypothesized to serve as ecologic drivers of the intercontinental movement and reassortment of IAVs due to high densities of disparate populations of long distance migratory and native bird species present during breeding seasons. Iceland is a staging ground that...

The DNA methyltransferases (DNMTs) were found in mammals to maintain DNA methylation. Among them, DNMT1 was the first identified, and it is an attractive target for tumour chemotherapy. DC_05 and DC_517 have been reported in our previous work, which is non-nucleoside DNMT1 inhibitor with low micromolar IC50 values and significant selectivity towards other S-adenosyl-L-methionine (SAM)-dependent protein methyltransferases. In this study, through a process of similarity-based analog searching, a series of DNMT1 inhibitors were designed, synthesized,...

The DNA methyltransferases (DNMTs) were found in mammals to maintain DNA methylation. Among them, DNMT1 was the first identified, and it is an attractive target for tumour chemotherapy. DC_05 and DC_517 have been reported in our previous work, which is non-nucleoside DNMT1 inhibitor with low micromolar IC50 values and significant selectivity towards other S-adenosyl-L-methionine (SAM)-dependent protein methyltransferases. In this study, through a process of similarity-based analog searching, a series of DNMT1 inhibitors were designed, synthesized,...

Additional file 1: Table S1. Baseline characteristics of the study population.

Supplementary Material for The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery by Mingke Li, Yawei Dai, Shuai Hu, Yansong Li, Dasheng Lu, Rui Zheng, and Kai Wang in Perfusion.

Supplementary Material for The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery by Mingke Li, Yawei Dai, Shuai Hu, Yansong Li, Dasheng Lu, Rui Zheng, and Kai Wang in Perfusion.

Non-small-cell lung cancer patients harboring TP53/KRAS co-mutation could benefit from a PD-L1 inhibitor Supplementary Figure 2

Additional file 1: Figure S1. SEM image of TAFP. Figure S2. Elements mapping of TAFP including C, N, O, Pt elements. Figure S3. XPS spectrum of Pt 4f in TAFP indicating the existence of Pt element. Figure S4. Standard curve of DDP determined by HPLC at 254 nm. Figure S5. Zeta potential of TAFP dispersed in DI water. Figure S6. Fluorescence images of the uptake of TAFP by SKOV3 cells after co-incubation with TAFP for...