6 Works

Data from: Activation recovery interval imaging of premature ventricular contraction

Ting Yang, Long Yu, Qi Jin, Liqun Wu & Bin He
Dispersion of ventricular repolarization due to abnormal activation contributes to the susceptibility to cardiac arrhythmias. However, the global pattern of repolarization is difficult to assess clinically. Activation recovery interval (ARI) has been used to understand the properties of ventricular repolarization. In this study, we developed an ARI imaging technique to noninvasively reconstruct three-dimensional (3D) ARI maps in 10 premature ventricular contraction (PVC) patients and evaluated the results with the endocardial ARI maps recorded by a...

Data from: Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data

Pengcheng Zhou, Shanna L. Resendez, Jose Rodriguez-Romaguera, Jessica C. Jimenez, Shay Q. Neufeld, Andrea Giovannucci, Johannes Friedrich, Eftychios A Pnevmatikakis, Garret D. Stuber, Rene Hen, Mazen A. Kheirbek, Bernardo L. Sabatini, Robert E. Kass & Liam Paninski
In vivo calcium imaging through microendoscopic lenses enables imaging of previously inaccessible neuronal populations deep within the brains of freely moving animals. However, it is computationally challenging to extract single-neuronal activity from microendoscopic data, because of the very large background fluctuations and high spatial overlaps intrinsic to this recording modality. Here, we describe a new constrained matrix factorization approach to accurately separate the background and then demix and denoise the neuronal signals of interest. We...

Data from: Selection, periodicity and potential function for highly iterative Palindrome-1 (HIP1) in cyanobacterial genomes

Minli Xu, Jeffrey G. Lawrence & Dannie Durand
Highly Iterated Palindrome 1 (HIP1, GCGATCGC) is hyper-abundant in most cyanobacterial genomes. In some cyanobacteria, average HIP1 abundance exceeds one motif per gene. Such high abundance suggests a significant role in cyanobacterial biology. However, 20 years of study have not revealed whether HIP1 has a function, much less what that function might be. We show that HIP1 is 15-300 fold over-represented in genomes analysed. More importantly, HIP1 sites are conserved both within and between open...

Data from: The distribution of income is worse than you think: including pollution impacts into measures of income inequality

Nicholas Z. Muller, Peter Hans Matthews & Virginia Wiltshire-Gordon
This paper calculates the distribution of an adjusted measure of income that deducts damages due to exposure to air pollution from reported market income in the United States from 2011 to 2014. The Gini coefficient for this measure of adjusted income is 0.682 in 2011, as compared to 0.482 for market income. By 2014, we estimate that the Gini for adjusted income fell to 0.646, while the market income Gini did not appreciably change. The...

Data from: Beyond novelty effect: a mixed-methods exploration into the motivation for long-term activity tracker use

Grace Shin, Yuanyuan Feng, Mohammad Hossein Jarrahi & Nicci Gafinowitz
Objectives: Activity trackers hold the promise to support people in managing their health through quantified measurements about their daily physical activities. Monitoring personal health with quantified activity tracker-generated data provides patients with an opportunity to self-manage their health. Many activity tracker user studies have been conducted within short time frames, however, which makes it difficult to discover the impact of the activity tracker’s novelty effect or the reasons for the device’s long-term use. This study...

Data from: Transcriptome profiles of sunflower reveal the potential role of microsatellites in gene expression divergence

Chathurani Ranathunge, Gregory L. Wheeler, Melody E. Chimahusky, Meaghan M. Kennedy, Jesse I. Morrison, Brian S. Baldwin, Andy D. Perkins & Mark E. Welch
The mechanisms by which natural populations generate adaptive genetic variation are not well understood. Some studies propose that microsatellites can function as drivers of adaptive variation. Here we tested a potentially adaptive role for transcribed microsatellites with natural populations of the common sunflower (Helianthus annuus L.) by assessing the enrichment of microsatellites in genes that show expression divergence across latitudes. Seeds collected from six populations at two distinct latitudes in Kansas and Oklahoma were planted...

Registration Year

  • 2018

Resource Types

  • Dataset


  • Carnegie Mellon University
  • University of North Carolina
  • Howard Hughes Medical Institute
  • Columbia University
  • The Ohio State University
  • University of Minnesota
  • University of Pittsburgh
  • Simons Foundation
  • Middlebury College
  • Mississippi State University