629,518 Works

Orthostatic Tremor Responds to Bilateral Thalamic Deep Brain Stimulation

Mark K Lyons, Mandana Behbahani, Orland K. Boucher, John N. Caviness & Virgilio Gerald H Evidente
Background: Orthostatic tremor (OT) is a disabling movement disorder manifested by postural and gait disturbance. Primarily a condition of elderly people, it can be progressive in up to 15% of patients. The primary treatments are medications that are often ineffective. Case Report: A 75-year-old male presented with a 10-year history of progressive and disabling OT. He had tried various medications without significant benefits. He underwent bilateral thalamic Vim deep brain stimulation (DBS). At 30-month follow-up,...

White Matter Hyperintensity Burden on Magnetic Resonance Imaging in Essential Tremor

Andre P. Oliveira, Adam M. Brickman, Frank A. Provenzano, Jordan Muraskin & Elan D. Louis
Background: Whereas structural abnormalities in the cerebellum have been associated with essential tremor (ET), the contribution of vascular disease via white matter hyperintensities (WMHs) and strokes has not been examined. In this study, we explored these potential associations and hypothesized that ET would be associated with greater overall WMH volume, greater cerebellar WMH volume and greater infarct presence. Methods: In a cross-sectional magnetic resonance imaging (MRI) study of 540 community-dwelling elderly persons in northern Manhattan,...

Intermediate CAG repeats in Huntington’s Disease: Analysis of COHORT

Ainhi Duy Ha, Christopher A Beck & Joseph Jankovic
Background: There is emerging evidence that clinical and neuro-pathological manifestations of Huntington's disease (HD) may occur in individuals with intermediate length cytosine-adenine-guanine (CAG) repeats (27–35 CAG repeats) in the Huntingtin (HTT) gene. We aim to further define the clinical characteristics of individuals who possess CAG repeat lengths in this range. Methods: Data from the Cooperative Huntington's Observational Research Trial (COHORT) were analyzed. Participants were categorized according to the number of CAG repeats into normal (≤26),...

Update on the Non-Huntington’s Disease Choreas with Comments on the Current Nomenclature

Ruth Helen Walker
Chorea can be caused by a multitude of etiologies: neurodegenerative, pharmacological, structural, metabolic, and others. In absence of other apparent causes, exclusion of Huntington's disease is often a first step in the diagnostic process. There are a number of neurodegenerative disorders whose genetic etiology has been identified in the past decade. Molecular diagnosis has enabled genetic identification of disorder subtypes which were previously grouped together, such as the neurodegeneration with brain iron accumulation disorders and...

Paroxysmal Kinesigenic Dyskinesia-like Symptoms in a Patient with Tourette Syndrome

Genko Oyama, Michael S. Okun, Tetsuo Ashizawa & Irene A. Malaty
Background: Paroxysmal kinesigenic dyskinesia (PKD) is characterized by episodic dystonia or choreiform movements provoked by sudden voluntary movement. PKD is not commonly reported in Tourette syndrome (TS). We describe a unique case of TS with PKD-like episodic dyskinesia that responded to carbamazepine. Case Report: A 36-year-old male with long-standing TS developed paroxysmal “cramping”. Attacks were provoked by quick, sudden arm movements, which induced dystonic cramping, or by reaching overhead, which caused painful contraction of truncal...

Thalamic Deep Brain Stimulation for Orthostatic Tremor

Toby C. Yaltho & William G. Ondo
Background: Orthostatic tremor is an uncommon disorder manifest by high frequency, low amplitude leg tremor upon weight bearing. Treatment with oral tremor agents is inconsistent and usually not satisfactory. Methods: We implanted bilateral ventralis intermedius nuclei deep brain stimulators into an 82-year-old male with refractory orthostatic tremor. Results: The patient had a marked subjective and objective improvement in leg and arm tremor, mainly manifested by an improved ability to stand. Discussion: Bilateral thalamic deep brain...

A Vision for Talca's Future: Post-Earthquake Reconstruction Redevelopment Studio

Alejandro De Castro Mazarro, Clara E. Irazabal Zurita, Ellis Calvin, Patricia Argueta, Jordan Salinger, Colin Anderson, Juan Pablo Azares, Yizhuo Feng, Norabelle Greenberger, Jinny Khanduja, Julia B. Lewis, Madeeha Merchant, Lucrecia Montemayor Solano, Carolina Montilla, Max B. Podemski, Lucy E. M. Robson & Allison Schwartz
In September 2012, SERVIU, the regional arm of the Chilean Ministry of Hotusing and Urban Development (MINVU), tasked our program with evaluating and reassessing housing reconstruction efforts in Talca, the capital city of the Maule region, in the wake of the 2010 earthquake that affected the region. To carry out this task, we focused on a case study neighborhood in Talca’s historic center, Barrio Las Heras. This document provides the synthesis of fourteen weeks working...

Lightning talk on MARC records for the Contemporary Composers Web Archive presented at #saa14 (Society of American Archivists 2014)

Anna L. Perricci
These slides supported a lightning talk on MARC records for the Contemporary Composers Web Archive presented in session 703 at #saa14 (Society of American Archivists 2014)

Biogeochemical Evidence for Hydrologic Changes during the Holocene in a Lake Sediment Record from Southeast Greenland

Nicholas L. Balascio, William Joseph D'Andrea, Raymond S. Bradley & Bianca B. Perren
Holocene paleoclimate records from Greenland help us understand the response of the Greenland Ice Sheet and regional oceanic and atmospheric circulation systems to natural climate variability in order to place recent changes in a longer-term perspective. Here biogeochemical analysis of a lake sediment core from southeast Greenland is used to define changes in moisture balance and runoff during the Holocene in a catchment near the margin of the Greenland Ice Sheet. A 1.6 m sediment...

Restless “lower back” in a patient with Parkinson’s disease

Keisuke Suzuki, Masayuki Miyamoto, Tomoyuki Miyamoto & Koichi Hirata
Background: In restless legs syndrome (RLS), the isolated involvement of other body parts in the absence of leg involvement is rare. Case report: We report an 82‐year‐old male with a 1‐year history of Parkinson’s disease (PD) who developed an abnormal sensation limited to his “lower back.” He fulfilled the four essential RLS criteria, with the major caveat that the criteria were applied in a modified manner to his lower back rather than his legs. The...

Does Pramipexole Treatment Improve Headache in Patients with Concomitant Migraine and Restless Legs Syndrome?

Keisuke Suzuki, Shiho Suzuki, Masayuki Miyamoto, Tomoyuki Miyamoto, Ayaka Numao, Yuka Watanabe, Ryotaro Takashima & Koichi Hirata
Background: Recent studies have suggested a strong link between migraines and restless legs syndrome (RLS). It is possible that these disorders share a dopaminergic dysfunction in the hypothalamic A11 nucleus that contributes to this association. However, there have been no clinical studies to evaluate the effect of dopaminergic treatment on migraine symptoms in patients with concomitant migraines and RLS. Methods: We present an illustrative patient with concomitant RLS and migraine who showed improvement in her...

Research Without Borders Twitter Archive, #rwob, December 4, 2014

Brian Luna Lucero
The dataset includes all tweets using the hashtag #rwob made between December 1 and December 8th, 2014. The hashtag was associated with the Research Without Borders event held at Columbia University on April 29, 2014. This panel discussion, explored “big open data” from three perspectives: the humanities, journalism, and the social web. Presentations covered how large amounts of data are managed, made sense of, and made accessible. The panelists also addressed the challenges of working...

NanoSIMS results from olivine-hosted melt embayments: Magma ascent rate during explosive basaltic eruptions

Alexander S. Lloyd, Philipp Ruprecht, Erik H. Hauri, William Rose, Helge M. Gonnermann & Terry A. Plank
The explosivity of volcanic eruptions is governed in part by the rate at which magma ascends and degasses. Because the time scales of eruptive processes can be exceptionally fast relative to standard geochronometers, magma ascent rate remains difficult to quantify. Here we use as a chronometer concentration gradients of volatile species along open melt embayments within olivine crystals. Continuous degassing of the external melt during magma ascent results in diffusion of volatile species from embayment...

James Neal on the Challenges of Leadership: An LA and M Exclusive Interview

"Jim Neal is currently the vice president for Information Services and University Librarian at Columbia University, providing leadership for university academic computing and network services and a system of twenty-five libraries. He also works with the Electronic Publishing Initiative at Columbia (EPIC) and the Columbia Center for New Media Teaching and Learning (CCNMTL). Previously, he served as the dean of University Libraries at Indiana University and Johns Hopkins University and held administrative positions in the...

Scholarly E-Book Use across Disciplines: Content Analysis of Usage Reports and Search Terms

Nisa Bakkalbasi & Melissa J. Goertzen
Data collected through COUNTER usage statistics and the LibQUAL+ service quality assessment survey tell us that faculty and students value access to the growing e-book collection at Columbia University Libraries (CUL). While the aggregate results indicate that e-book use continues to increase, usage rates are not uniform across disciplines. Given the highly diverse research needs of the university community, CUL is keen to understand scholarly e-book usage in various disciplines. In this study, we sought...

Circumpolar View of the Southern Ocean from 1962 to 1992

Arnold L. Gordon
The 1962-1992 period spanning the Eltanin/Islas Orcadas expeditions to the Ice Station Weddell, and the following World Ocean Circulation Experiment, may be viewed as the closing phase of an era of broad based, circumpolar surveys of the Southern Ocean. Today, investigating the spatial and temporal dimensions of such complex ocean and it’s coupling to the climate system, requires the integration of observations from ships, aircrafts, satellites, tethered instrumentation and autonomous vehicles with numerical models. However,...

A paleointensity technique for multidomain igneous rocks

Huapei Wang & Dennis V. Kent
We developed a paleointensity technique to account for concave-up Arai diagrams due to multidomain (MD) contributions to determine unbiased paleointensities for 24 trial samples from site GA-X in Pleistocene lavas from Floreana Island, Galapagos Archipelago. The main magnetization carrier is fine-grained low-titanium magnetite of variable grain size. We used a comprehensive back-zero-forth (BZF) heating technique by adding an additional zero-field heating between the Thellier two opposite in- field heating steps in order to estimate paleointensities...

Opening of the Neo-Tethys Ocean and the Pangea B to Pangea A transformation during the Permian

Giovanni Muttoni, Maurizio Gaetani, Dennis V. Kent, Dario Sciunnach, Lucia Angiolini, Fabrizio Berra, Eduardo Garzanti, Massimo Mattei & Andrea Zanchi
We studied the stratigraphy, composition, and paleomagnetic properties of lateritic weathering profiles of Permian age from northern Iran and western Karakoram, Pakistan. A limited set of samples deemed representative yielded stable low-inclination paleomagnetic components carried essentially by hematite of chemical origin isolated in massive, fine-grained, and homogeneous ferricrete facies. These laterites originated at equatorial paleolatitudes characterized by intense weathering processes under warm and humid climatic conditions. Paleomagnetic estimates of paleolatitude from Iran, Karakoram, and north...

Migration of Hominins With Megaherbivores into Europe via the Danube-Po Gateway in the Late Matuyama Climate Revolution

Giovanni Muttoni, Dennis V. Kent, Giancarlo Scardia & Edoardo Monesi
We update critical reviews of sites bearing hominin remains and/or tools from Europe (including the Balkans and Greece) and conclude that the only compelling evidence of hominin presence in these regions was after -0.9 Ma (million-years-ago), bracketed by the end of the Jaramillo subchron (0.99 Ma) and the Brunhes/Matuyama boundary (0.78 Ma) and straddling the climatic late Early Pleistocene revolution (EPR) at the onset of enhanced glacialrmterglacial activity that reverberated worldwide. Europe may have become...

Focal Task-specific Dystonia among Professional Musicians in Latin America

Emilia Mabel Gatto, Anabel Chade, Gabriel Persi, Virginia Parisi, Ana Ayarza, Miguel Campuzzano & Silvia Garcia
This letter was written in response to: Frucht SJ. Focal task-specific dystonia—from early descriptions to a new, modern formulation. Tremor Other Hyperkinet Mov. 2014; 4. doi: 10.7916/D8VD6WHP

Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses

Diego Iacono, Maria Geraci-Erck, Hui Peng, Marcie L. Rabin & Roger Kurlan
Background: Dystonias (Dys) represent the third most common movement disorder after essential tremor (ET) and Parkinson's disease (PD). While some pathogenetic mechanisms and genetic causes of Dys have been identified, little is known about their neuropathologic features. Previous neuropathologic studies have reported generically defined neuronal loss in various cerebral regions of Dys brains, mostly in the basal ganglia (BG), and specifically in the substantia nigra (SN). Enlarged pigmented neurons in the SN of Dys patients...

A statistical assessment of tropical cyclone activity in atmospheric general circulation models

Suzana J. Camargo, Anthony G. Barnston & Stephen E. Zebiak
The properties of tropical cyclones in three low-resolution atmospheric general circulation models (AGCMs) in seven ocean basins are discussed. The models are forced by prescribed, observed sea surface temperatures over a period of 40 yr, and their simulations of tropical cyclone activity are compared with observations. The model cyclone characteristics considered include genesis position, number of cyclones per year, seasonality, accumulated cyclone energy, track locations, and number of storm days. Correlations between model and observed...

Association of U.S. tornado occurrence with monthly environmental parameters

Michael K. Tippett, Adam H. Sobel & Suzana J. Camargo
Monthly U.S. tornado numbers are here related to observation-based monthly averaged atmospheric parameters. Poisson regression is used to form an index which captures the climatological spatial distribution and seasonal variation of tornado occurrence, as well as year-to-year variability, and provides a framework for extended range forecasts of tornado activity. Computing the same index with predicted atmospheric parameters from a comprehensive forecast model gives some evidence of the predictability of monthly tornado activity.

Climate change in the Fertile Crescent and implications of the recent Syrian drought

Shahrzad Zarrin Mohtadi, Colin Patrick Kelley, Mark A. Cane, Yochanan Kushnir & Richard Seager
Significance: There is evidence that the 2007−2010 drought contributed to the conflict in Syria. It was the worst drought in the instrumental record, causing widespread crop failure and a mass migration of farming families to urban centers. Century-long observed trends in precipitation, temperature, and sea-level pressure, supported by climate model results, strongly suggest that anthropogenic forcing has increased the probability of severe and persistent droughts in this region, and made the occurrence of a 3-year...

Fluorescence, pigment and microscopic characterization of Bering Sea phytoplankton community structure and photosynthetic competency in the presence of a Cold Pool during summer

Joaquim I. Goes, Maria Fatima Helga D. Gomes, Elin M. Haugen, Kali T. McKee, Eurico J. D'Sa, Alexander M. Chekalyuk, Diane K. Stoecker, Phyllis J. Stabeno, Sei-Ichi Saitoh & Raymond N. Sambrotto
Spectral fluorescence measurements of phytoplankton chlorophyll a (Chl a), phytoplankton phycobilipigments and variable fluorescence (Fv/Fm), are utilized with High Performance Liquid Chromatography (HPLC) estimates of phytoplankton pigments and microscopic cells counts to construct a comprehensive picture of summer-time phytoplankton communities and their photosynthetic competency in the eastern Bering Sea shelf. Although the Bering Sea was ice-free during our study, the exceptionally cold winter that preceded the summer of 2008 when our cruise took place, facilitated...

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