66,184 Works

Jkarm041-04-09.pdf

Rodriguez Psychosom Med 2016_PMC.pdf

Freedberg, Gombrich and Warburg.pdf

Metabolic Stress Drives Keratinocyte Defenses against Staphylococcus aureus Infection

Matthew Wickersham, Sarah Wachtel, Tania Wong Fok Lung, Grace Soong, Rudy Jacquet, Anthony Richardson, Dane Parker & Alice S. Prince
Human skin is commonly colonized and infected by Staphylococcus aureus. Exactly how these organisms are sensed by keratinocytes has not been clearly delineated. Using a combination of metabolic and transcriptomic methodologies, we found that S. aureus infection is sensed as a metabolic stress by the hypoxic keratinocytes. This induces HIF1α signaling, which promotes IL-1β production and stimulates aerobic glycolysis to meet the metabolic requirements of infection. We demonstrate that staphylococci capable of glycolysis, including WT...

Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway

Niyo Kato, Yoshitaka Kawasoe, Hannah Williams, Elena Lauren Coates, Upasana Roy, Yuqian Shi, Lorena S. Beese, Orlando D. Scharer, Hong Yan, Maxwell E. Gottesman, Tatsuro S. Takahashi & Jean J. Gautier
DNA interstrand crosslinks (ICLs) that are repaired in non-dividing cells must be recognized independently of replication-associated DNA unwinding. Using cell-free extracts from Xenopus eggs that support neither replication nor transcription, we establish that ICLs are recognized and processed by the mismatch repair (MMR) machinery. We find that ICL repair requires MutSα (MSH2–MSH6) and the mismatch recognition FXE motif in MSH6, strongly suggesting that MutSα functions as an ICL sensor. MutSα recruits MutLα and EXO1 to...

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Page 2

Registration Year

  • 2018
    66,184

Resource Types

  • Text
    2,474
  • Dataset
    30
  • Software
    4
  • Audiovisual
    1
  • Interactive Resource
    1