1,417,611 Works

Reduction of conditioned avoidance via contingency reversal

Angelos-Miltiadis Krypotos, Johanna M. P. Baas & Iris M. Engelhard
There is an increased interest in how excessive avoidance can diminish. Avoidance reduction is typically tested by using Extinction with Response Prevention (ExRP) protocols, where feared stimuli are presented without any aversive outcome while avoidance is prevented. These effects, however, often do not persist. Here, we tested whether pairing an avoidance response with the presence of an aversive event would reduce avoidance more than ExRP. Participants (N = 58) first saw a picture of a...

Reduction of conditioned avoidance via contingency reversal

Angelos-Miltiadis Krypotos, Johanna M. P. Baas & Iris M. Engelhard
There is an increased interest in how excessive avoidance can diminish. Avoidance reduction is typically tested by using Extinction with Response Prevention (ExRP) protocols, where feared stimuli are presented without any aversive outcome while avoidance is prevented. These effects, however, often do not persist. Here, we tested whether pairing an avoidance response with the presence of an aversive event would reduce avoidance more than ExRP. Participants (N = 58) first saw a picture of a...

Genotype x Environment Interaction and Stability for Grain Yield of Buckwheat (Fagopyrum Tataricum Geartn)

Manoj Kandel & Jiban Shrestha
Stability analysis is an important step in developing cultivars. Seven buckwheat genotypes were evaluated at hilly regions of Nepal namely Dolakha, Ramechhap, Solukhumbu, Kaski, Dailekh, Surkhet, Jumla and Doti districts during winter seasons of 2017 and 2018 using randomized complete block design with three replications to identify stable and high yielding genotypes. The genotype × environment interaction for grain yield was significant (P≤0.05). The genotypes ACC#2227-1 (1.62 t/ha) and ACC#2223-1 (1.52 t/ha) were found higher...

Genotype x Environment Interaction and Stability for Grain Yield of Buckwheat (Fagopyrum Tataricum Geartn)

Manoj Kandel & Jiban Shrestha
Stability analysis is an important step in developing cultivars. Seven buckwheat genotypes were evaluated at hilly regions of Nepal namely Dolakha, Ramechhap, Solukhumbu, Kaski, Dailekh, Surkhet, Jumla and Doti districts during winter seasons of 2017 and 2018 using randomized complete block design with three replications to identify stable and high yielding genotypes. The genotype × environment interaction for grain yield was significant (P≤0.05). The genotypes ACC#2227-1 (1.62 t/ha) and ACC#2223-1 (1.52 t/ha) were found higher...

Effects of micronutrients on growth and productivity of maize in acidic soil

Bishnu Hari Adhikary, Jiban Shrestha & Bandhu Raj Baral
Micronutrients are trace elements which are needed by the maize crop in small amounts and play an active role in the plant metabolic functions in shortage of which show deficiency symptoms and crop yields are reduced, they are therefore to be added into the soil before crop planting or applied directly to the crop to increase maize productivity. In order to evaluate the effects of micronutrients (B, Zn, Mo, S and Mn) on the grain...

Effects of micronutrients on growth and productivity of maize in acidic soil

Bishnu Hari Adhikary, Jiban Shrestha & Bandhu Raj Baral
Micronutrients are trace elements which are needed by the maize crop in small amounts and play an active role in the plant metabolic functions in shortage of which show deficiency symptoms and crop yields are reduced, they are therefore to be added into the soil before crop planting or applied directly to the crop to increase maize productivity. In order to evaluate the effects of micronutrients (B, Zn, Mo, S and Mn) on the grain...

Body Mass Index and Polycystic Ovary Syndrome: A Two-sample Bidirectional Mendelian Randomization Study

Zhiqiang Li
Observational studies have shown a link between elevated body mass index (BMI) and the risk of polycystic ovary syndrome (PCOS). While Mendelian randomization (MR) studies in Europeans have suggested a causal role of increased BMI in PCOS, whether the same role is suggested in Asians has yet to be investigated. We used MR studies to infer causal effects using genetic data from East Asian populations.

Untitled ItemBody Mass Index and Polycystic Ovary Syndrome: A Two-sample Bidirectional Mendelian Randomization Study

Zhiqiang Li
Observational studies have shown a link between elevated body mass index (BMI) and the risk of polycystic ovary syndrome (PCOS). While Mendelian randomization (MR) studies in Europeans have suggested a causal role of increased BMI in PCOS, whether the same role is suggested in Asians has yet to be investigated. We used MR studies to infer causal effects using genetic data from East Asian populations.

Body Mass Index and Polycystic Ovary Syndrome: A Two-sample Bidirectional Mendelian Randomization Study

Zhiqiang Li
Observational studies have shown a link between elevated body mass index (BMI) and the risk of polycystic ovary syndrome (PCOS). While Mendelian randomization (MR) studies in Europeans have suggested a causal role of increased BMI in PCOS, whether the same role is suggested in Asians has yet to be investigated. We used MR studies to infer causal effects using genetic data from East Asian populations.

Kondisi Hak Cipta dan Lisensi di kalangan penerbit Indonesia

Muhamad Ratodi
Paper ini merupakan draft makalah yang memotret kondisi penggunaan lisensi terbuka di kalangan penerbit Indonesia

Kondisi Hak Cipta dan Lisensi di kalangan penerbit Indonesia

Muhamad Ratodi
Paper ini merupakan draft makalah yang memotret kondisi penggunaan lisensi terbuka di kalangan penerbit Indonesia

Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure)

Susan Stienen, João Pedro Ferreira, Masatake Kobayashi, Gregoire Preud’homme, Daniela Dobre, Jean-Loup Machu, Kevin Duarte, Emmanuel Bresso, Marie-Dominique Devignes, Natalia López, Nicolas Girerd, Svend Aakhus, Giuseppe Ambrosio, Hans-Peter Brunner-La Rocca, Ricardo Fontes-Carvalho, Alan G. Fraser, Loek Van Heerebeek, Stephane Heymans, Gilles De Keulenaer, Paolo Marino, Kenneth McDonald, Alexandre Mebazaa, Zoltàn Papp, Riccardo Raddino, Carsten Tschöpe … & Patrick Rossignol
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome for which clear evidence of effective therapies is lacking. Understanding which factors determine this heterogeneity may be helped by better phenotyping. An unsupervised statistical approach applied to a large set of biomarkers may identify distinct HFpEF phenotypes. Methods: Relevant proteomic biomarkers were analyzed in 392 HFpEF patients included in Metabolic Road to Diastolic HF (MEDIA-DHF). We performed an unsupervised cluster analysis to define...

Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure)

Susan Stienen, João Pedro Ferreira, Masatake Kobayashi, Gregoire Preud’homme, Daniela Dobre, Jean-Loup Machu, Kevin Duarte, Emmanuel Bresso, Marie-Dominique Devignes, Natalia López, Nicolas Girerd, Svend Aakhus, Giuseppe Ambrosio, Hans-Peter Brunner-La Rocca, Ricardo Fontes-Carvalho, Alan G. Fraser, Loek Van Heerebeek, Stephane Heymans, Gilles De Keulenaer, Paolo Marino, Kenneth McDonald, Alexandre Mebazaa, Zoltàn Papp, Riccardo Raddino, Carsten Tschöpe … & Patrick Rossignol
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome for which clear evidence of effective therapies is lacking. Understanding which factors determine this heterogeneity may be helped by better phenotyping. An unsupervised statistical approach applied to a large set of biomarkers may identify distinct HFpEF phenotypes. Methods: Relevant proteomic biomarkers were analyzed in 392 HFpEF patients included in Metabolic Road to Diastolic HF (MEDIA-DHF). We performed an unsupervised cluster analysis to define...

Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation

Zhen Wang, Hong Zhou, Huaping Zheng, Xikun Zhou, Guobo Shen, Xiu Teng, Xiao Liu, Jun Zhang, Xiaoqiong Wei, Zhonglan Hu, Fanlian Zeng, Yawen Hu, Jing Hu, Xiaoyan Wang, Shuwen Chen, Juan Cheng, Chen Zhang, Yiyue Gui, Song Zou, Yan Hao, Qixiang Zhao, Wenling Wu, Yifan Zhou, Kaijun Cui, Nongyu Huang … & Jiong Li
The precise mechanism through which macroautophagy/autophagy affects psoriasis is poorly understood. Here, we found that keratinocyte (KC) autophagy, which was positively correlated with psoriatic severity in patients and mouse models and could be inhibited by mitogen-activated protein kinase (MAPK) family inactivation. The impairment of autophagic flux alleviated psoriasisform inflammation. We also found that an autophagy-based unconventional secretory pathway (autosecretion) dependent on ATG5 (autophagy related 5) and GORASP2 (golgi reassembly stacking protein 2) promoted psoriasiform KC...

Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation

Zhen Wang, Hong Zhou, Huaping Zheng, Xikun Zhou, Guobo Shen, Xiu Teng, Xiao Liu, Jun Zhang, Xiaoqiong Wei, Zhonglan Hu, Fanlian Zeng, Yawen Hu, Jing Hu, Xiaoyan Wang, Shuwen Chen, Juan Cheng, Chen Zhang, Yiyue Gui, Song Zou, Yan Hao, Qixiang Zhao, Wenling Wu, Yifan Zhou, Kaijun Cui, Nongyu Huang … & Jiong Li
The precise mechanism through which macroautophagy/autophagy affects psoriasis is poorly understood. Here, we found that keratinocyte (KC) autophagy, which was positively correlated with psoriatic severity in patients and mouse models and could be inhibited by mitogen-activated protein kinase (MAPK) family inactivation. The impairment of autophagic flux alleviated psoriasisform inflammation. We also found that an autophagy-based unconventional secretory pathway (autosecretion) dependent on ATG5 (autophagy related 5) and GORASP2 (golgi reassembly stacking protein 2) promoted psoriasiform KC...

Facile fabrication of superhydrophobic brass surface for excellent corrosion resistance

J. Dominic, G. Perumal, H. S. Grewal & H. S. Arora
In this study, superhydrophobic surfaces were fabricated using 1H,1H,2H,2H-perfluorooctyltriethoxysilane monolayer deposition on thermally oxidized brass. The superhydrophobic surface showed a contact angle (CA) of 155° with a CA hysteresis of 3.5°. The corrosion behaviour of developed superhydrophobic surface was evaluated using potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) studies in 3.5% NaCl solution. The superhydrophobic surface showed exceptional corrosion behaviour with nearly 21 times higher corrosion resistance compared to as-received (AS) brass. The EIS analysis...

Facile fabrication of superhydrophobic brass surface for excellent corrosion resistance

J. Dominic, G. Perumal, H. S. Grewal & H. S. Arora
In this study, superhydrophobic surfaces were fabricated using 1H,1H,2H,2H-perfluorooctyltriethoxysilane monolayer deposition on thermally oxidized brass. The superhydrophobic surface showed a contact angle (CA) of 155° with a CA hysteresis of 3.5°. The corrosion behaviour of developed superhydrophobic surface was evaluated using potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) studies in 3.5% NaCl solution. The superhydrophobic surface showed exceptional corrosion behaviour with nearly 21 times higher corrosion resistance compared to as-received (AS) brass. The EIS analysis...

Simulated spectrum peak wave period (3-hourly, 150a) from FIO-ESM v2.0 abrupt-4xCO2 experiment r1i1p1f1

Zhenya Song, Ying Bao, Qi Shu, Yajuan Song, Xiaodan Yang & Fangli Qiao
Simulated spectrum peak wave period (3-hourly, 150a) from FIO-ESM v2.0 abrupt-4xCO2 experiment (CO2 abruptly quadrupled and then held constant) r1i1p1f1, which is branch from Jan 1, 301 of piControl experiment. The grid, named gx1v6, is the displaced pole (the North Pole displaced to the Greenland) grid with 1.1 degree in longitude and 0.27-0.54 degree in latitude.

Simulated spectrum peak wave period (3-hourly, 150a) from FIO-ESM v2.0 abrupt-4xCO2 experiment r1i1p1f1

Zhenya Song, Ying Bao, Qi Shu, Yajuan Song, Xiaodan Yang & Fangli Qiao
Simulated spectrum peak wave period (3-hourly, 150a) from FIO-ESM v2.0 abrupt-4xCO2 experiment (CO2 abruptly quadrupled and then held constant) r1i1p1f1, which is branch from Jan 1, 301 of piControl experiment. The grid, named gx1v6, is the displaced pole (the North Pole displaced to the Greenland) grid with 1.1 degree in longitude and 0.27-0.54 degree in latitude.

Simulated spectrum peak wave period (3-hourly, 150a) from FIO-ESM v2.0 abrupt-4xCO2 experiment r1i1p1f1

Zhenya Song, Ying Bao, Qi Shu, Yajuan Song, Xiaodan Yang & Fangli Qiao
Simulated spectrum peak wave period (3-hourly, 150a) from FIO-ESM v2.0 abrupt-4xCO2 experiment (CO2 abruptly quadrupled and then held constant) r1i1p1f1, which is branch from Jan 1, 301 of piControl experiment. The grid, named gx1v6, is the displaced pole (the North Pole displaced to the Greenland) grid with 1.1 degree in longitude and 0.27-0.54 degree in latitude.

Genesis and structure of eusperm and parasperm of Plicopurpura patula in relation to phylogeny of Neogastropoda: proteomics of parasperm suggests role in paternity assurance

John A. Buckland-Nicks & Angela H. Fields
Eusperm and parasperm ultrastructure have been studied for the first time in the neogastropod Plicopurpura patula. Eusperm structure is typical of many Neogastropoda, in which an apical bleb characterizes the conical acrosome with subacrosomal granule; the nucleus is tubular and penetrated to its tip by basal body and axoneme; the mid-piece comprises spiral mitochondria that ensheath the axoneme but terminate at the annulus, defining the junction with the end-piece. In the proximal portion of the...

Genesis and structure of eusperm and parasperm of Plicopurpura patula in relation to phylogeny of Neogastropoda: proteomics of parasperm suggests role in paternity assurance

John A. Buckland-Nicks & Angela H. Fields
Eusperm and parasperm ultrastructure have been studied for the first time in the neogastropod Plicopurpura patula. Eusperm structure is typical of many Neogastropoda, in which an apical bleb characterizes the conical acrosome with subacrosomal granule; the nucleus is tubular and penetrated to its tip by basal body and axoneme; the mid-piece comprises spiral mitochondria that ensheath the axoneme but terminate at the annulus, defining the junction with the end-piece. In the proximal portion of the...

Genome-wide DNA sampling by Ago nuclease from the cyanobacterium Synechococcus elongatus

Anna Olina, Anton Kuzmenko, Maria Ninova, Alexei A. Aravin, Andrey Kulbachinskiy & Daria Esyunina
Members of the conserved Argonaute (Ago) protein family provide defence against invading nucleic acids in eukaryotes in the process of RNA interference. Many prokaryotes also contain Ago proteins that are predicted to be active nucleases; however, their functional activities in host cells remain poorly understood. Here, we characterize the in vitro and in vivo properties of the SeAgo protein from the mesophilic cyanobacterium Synechococcus elongatus. We show that SeAgo is a DNA-guided nuclease preferentially acting...

Genome-wide DNA sampling by Ago nuclease from the cyanobacterium Synechococcus elongatus

Anna Olina, Anton Kuzmenko, Maria Ninova, Alexei A. Aravin, Andrey Kulbachinskiy & Daria Esyunina
Members of the conserved Argonaute (Ago) protein family provide defence against invading nucleic acids in eukaryotes in the process of RNA interference. Many prokaryotes also contain Ago proteins that are predicted to be active nucleases; however, their functional activities in host cells remain poorly understood. Here, we characterize the in vitro and in vivo properties of the SeAgo protein from the mesophilic cyanobacterium Synechococcus elongatus. We show that SeAgo is a DNA-guided nuclease preferentially acting...

Exponential approximation of multivariate bandlimited functions from average oversampling

Wenjian Chen & Haizhang Zhang
Instead of sampling a function at a single point, average sampling takes the weighted sum of function values around the point. Such a sampling strategy is more practical and more stable. In this note, we present an explicit method with an exponentially-decaying approximation error to reconstruct a multivariate bandlimited function from its finite average oversampling data. The key problem in our analysis is how to extend a function so that its inverse Fourier transform decays...

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