1,153,485 Works

High-fat diet withdrawal modifies alcohol preference and transcription of dopaminergic and GABAergic receptors

Luana Martins De Carvalho, Juliana Lauar Gonçalves, Agatha Sondertoft Braga Pedersen, Samara Damasceno, Renato Elias Moreira Júnior, Tatiani Uceli Maioli, Ana Maria Caetano De Faria & Ana Lúcia Brunialti Godard
The bidirectional and positive relation between the ingestion of fat and alcohol has become the subject of extensive discussion. However, this relation is more studied in animal models of binge eating with intermittent access of high-fat diet or in a model of short period of this diet consumption. Here, we developed a model to elucidate how chronic high-fat diet and its withdrawal influence alcohol intake (two-bottle choice) and anxiety behavior (marble burying test). In the...

FOXO regulates cell fate specification of Drosophila ventral olfactory projection neurons

Jia-Yi Wei, Pei-Chi Chung, Sao-Yu Chu & Hung–Hsiang Yu
Diverse types of neurons must be specified in the developing brain to form the functional neural circuits that are necessary for the execution of daily tasks. Here, we describe the participation of Forkhead box class O (FOXO) in cell fate specification of a small subset of Drosophila ventral olfactory projection neurons (vPNs). Using the two-color labeling system, twin-spot MARCM, we determined the temporal birth order of each vPN type, and this characterization served as a...

High-fat diet withdrawal modifies alcohol preference and transcription of dopaminergic and GABAergic receptors

Luana Martins De Carvalho, Juliana Lauar Gonçalves, Agatha Sondertoft Braga Pedersen, Samara Damasceno, Renato Elias Moreira Júnior, Tatiani Uceli Maioli, Ana Maria Caetano De Faria & Ana Lúcia Brunialti Godard
The bidirectional and positive relation between the ingestion of fat and alcohol has become the subject of extensive discussion. However, this relation is more studied in animal models of binge eating with intermittent access of high-fat diet or in a model of short period of this diet consumption. Here, we developed a model to elucidate how chronic high-fat diet and its withdrawal influence alcohol intake (two-bottle choice) and anxiety behavior (marble burying test). In the...

FOXO regulates cell fate specification of Drosophila ventral olfactory projection neurons

Jia-Yi Wei, Pei-Chi Chung, Sao-Yu Chu & Hung–Hsiang Yu
Diverse types of neurons must be specified in the developing brain to form the functional neural circuits that are necessary for the execution of daily tasks. Here, we describe the participation of Forkhead box class O (FOXO) in cell fate specification of a small subset of Drosophila ventral olfactory projection neurons (vPNs). Using the two-color labeling system, twin-spot MARCM, we determined the temporal birth order of each vPN type, and this characterization served as a...

High diagnostic yield and novel variants in very late-onset spasticity

Momen Almomen, Kristina Martens, Asfia Quadir, Carly Sabine Pontifex, Alexandra Hanson, Lawrence Korngut & Gerald Pfeffer
Hereditary spastic paraplegias (HSPs) are a diverse group of genetic conditions with variable severity and onset age. From a neurogenetic clinic, we identified 14 patients with very late-onset HSP, with symptoms starting after the age of 35. In this cohort, sequencing of known genetic causes was performed using clinically available HSP sequencing panels. We identified 4 patients with mutations in SPG7 and 3 patients with SPAST mutations, representing 50% of the cohort and indicating a...

FOXO regulates cell fate specification of Drosophila ventral olfactory projection neurons

Jia-Yi Wei, Pei-Chi Chung, Sao-Yu Chu & Hung–Hsiang Yu
Diverse types of neurons must be specified in the developing brain to form the functional neural circuits that are necessary for the execution of daily tasks. Here, we describe the participation of Forkhead box class O (FOXO) in cell fate specification of a small subset of Drosophila ventral olfactory projection neurons (vPNs). Using the two-color labeling system, twin-spot MARCM, we determined the temporal birth order of each vPN type, and this characterization served as a...

High-fat diet withdrawal modifies alcohol preference and transcription of dopaminergic and GABAergic receptors

Luana Martins De Carvalho, Juliana Lauar Gonçalves, Agatha Sondertoft Braga Pedersen, Samara Damasceno, Renato Elias Moreira Júnior, Tatiani Uceli Maioli, Ana Maria Caetano De Faria & Ana Lúcia Brunialti Godard
The bidirectional and positive relation between the ingestion of fat and alcohol has become the subject of extensive discussion. However, this relation is more studied in animal models of binge eating with intermittent access of high-fat diet or in a model of short period of this diet consumption. Here, we developed a model to elucidate how chronic high-fat diet and its withdrawal influence alcohol intake (two-bottle choice) and anxiety behavior (marble burying test). In the...

High diagnostic yield and novel variants in very late-onset spasticity

Momen Almomen, Kristina Martens, Asfia Quadir, Carly Sabine Pontifex, Alexandra Hanson, Lawrence Korngut & Gerald Pfeffer
Hereditary spastic paraplegias (HSPs) are a diverse group of genetic conditions with variable severity and onset age. From a neurogenetic clinic, we identified 14 patients with very late-onset HSP, with symptoms starting after the age of 35. In this cohort, sequencing of known genetic causes was performed using clinically available HSP sequencing panels. We identified 4 patients with mutations in SPG7 and 3 patients with SPAST mutations, representing 50% of the cohort and indicating a...

Genetic analysis of KillerRed in C. elegans identifies a shared role of calcium genes in ROS-mediated neurodegeneration

Lyndsay E. A. Young, Chelsea Shoben, Kyra Ricci & Daniel C. Williams
In C. elegans, neurodegeneration induced by excitotoxicity or aggregation of misfolded proteins is dependent on genes involved in calcium release from the endoplasmic reticulum. Reactive oxygen species (ROS) can also induce neurodegeneration, but the relationship between ROS-mediated neurodegeneration and calcium has not been established. We activated KillerRed in the GABA neurons of C. elegans to produce ROS that leads to functional loss and structural degeneration of these neurons and demonstrated that the severity of neurodegeneration...

High diagnostic yield and novel variants in very late-onset spasticity

Momen Almomen, Kristina Martens, Asfia Quadir, Carly Sabine Pontifex, Alexandra Hanson, Lawrence Korngut & Gerald Pfeffer
Hereditary spastic paraplegias (HSPs) are a diverse group of genetic conditions with variable severity and onset age. From a neurogenetic clinic, we identified 14 patients with very late-onset HSP, with symptoms starting after the age of 35. In this cohort, sequencing of known genetic causes was performed using clinically available HSP sequencing panels. We identified 4 patients with mutations in SPG7 and 3 patients with SPAST mutations, representing 50% of the cohort and indicating a...

Genetic analysis of KillerRed in C. elegans identifies a shared role of calcium genes in ROS-mediated neurodegeneration

Lyndsay E. A. Young, Chelsea Shoben, Kyra Ricci & Daniel C. Williams
In C. elegans, neurodegeneration induced by excitotoxicity or aggregation of misfolded proteins is dependent on genes involved in calcium release from the endoplasmic reticulum. Reactive oxygen species (ROS) can also induce neurodegeneration, but the relationship between ROS-mediated neurodegeneration and calcium has not been established. We activated KillerRed in the GABA neurons of C. elegans to produce ROS that leads to functional loss and structural degeneration of these neurons and demonstrated that the severity of neurodegeneration...

A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer

Yanan Wang, Tianyu Han, Mingxi Gan, Meng Guo, Caifeng Xie, Jiangbo Jin, Song Zhang, Pengcheng Wang, Jiaqing Cao & Jian-Bin Wang
The anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase, is responsible for the transition from metaphase to anaphase and the exit from mitosis. The anaphase promoting complex subunit 10 (APC10), a subunit of the APC/C, executes a vital function in substrate recognition. However, no research has reported the connection between APC10 and cancer until now. In this study, we uncovered a novel, unprecedented role of APC10 in tumor progression, which is independent of...

A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer

Yanan Wang, Tianyu Han, Mingxi Gan, Meng Guo, Caifeng Xie, Jiangbo Jin, Song Zhang, Pengcheng Wang, Jiaqing Cao & Jian-Bin Wang
The anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase, is responsible for the transition from metaphase to anaphase and the exit from mitosis. The anaphase promoting complex subunit 10 (APC10), a subunit of the APC/C, executes a vital function in substrate recognition. However, no research has reported the connection between APC10 and cancer until now. In this study, we uncovered a novel, unprecedented role of APC10 in tumor progression, which is independent of...

The negative effect of lipid challenge on autophagy inhibits T cell responses

Ignacio Guerrero-Ros, Cristina C Clement, Cara A Reynolds, Bindi Patel, Laura Santambrogio, Ana M Cuervo & Fernando Macian
Obesity is associated with changes in the immune system that significantly hinder its ability to mount efficient immune responses. Previous studies have reported a dysregulation of immune responses caused by lipid challenge; however, the mechanisms underlying that dysregulation are still not completely understood. Autophagy is an essential catabolic process through which cellular components are degraded by the lysosomal machinery. In T cells, autophagy is an actively regulated process necessary to sustain homeostasis and activation. Here,...

The negative effect of lipid challenge on autophagy inhibits T cell responses

Ignacio Guerrero-Ros, Cristina C. Clement, Cara A. Reynolds, Bindi Patel, Laura Santambrogio, Ana M. Cuervo & Fernando Macian
Obesity is associated with changes in the immune system that significantly hinder its ability to mount efficient immune responses. Previous studies have reported a dysregulation of immune responses caused by lipid challenge; however, the mechanisms underlying that dysregulation are still not completely understood. Autophagy is an essential catabolic process through which cellular components are degraded by the lysosomal machinery. In T cells, autophagy is an actively regulated process necessary to sustain homeostasis and activation. Here,...

The negative effect of lipid challenge on autophagy inhibits T cell responses

Ignacio Guerrero-Ros, Cristina C. Clement, Cara A. Reynolds, Bindi Patel, Laura Santambrogio, Ana M. Cuervo & Fernando Macian
Obesity is associated with changes in the immune system that significantly hinder its ability to mount efficient immune responses. Previous studies have reported a dysregulation of immune responses caused by lipid challenge; however, the mechanisms underlying that dysregulation are still not completely understood. Autophagy is an essential catabolic process through which cellular components are degraded by the lysosomal machinery. In T cells, autophagy is an actively regulated process necessary to sustain homeostasis and activation. Here,...

The effects of perceived stress on hope in women with breast cancer and the role of psychological hardiness.

Abbas Abdollahi
The data is in format of SPSS. It is about the moderating role of hardiness in the link between perceived stress and hope in breast cancer patients

The effects of perceived stress on hope in women with breast cancer and the role of psychological hardiness.

Abbas Abdollahi
The data is in format of SPSS. It is about the moderating role of hardiness in the link between perceived stress and hope in breast cancer patients

The effects of perceived stress on hope in women with breast cancer and the role of psychological hardiness.

Abbas Abdollahi
The data is in format of SPSS. It is about the moderating role of hardiness in the link between perceived stress and hope in breast cancer patients

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