1,199,268 Works

Additional file 5: of Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells

Hyun Hwang, Min-Suk Oh, Dong Lee & Hyo-Jeong Kuh
Figure S5. Differential sensitivity to GEM in pancreatic cancer cell lines when cultured as monolayers in 96-well plates. Drug-response was measured after 72 h exposure using APH assay. Data represent the mean ± SD of three independent experiments. (TIF 50 kb)

Smoking-induced risk of future cardiovascular disease is partly mediated by cadmium in tobacco: Malmö Diet and Cancer Cohort Study

Huiqi Li, Björn Fagerberg, Gerd Sallsten, Yan Borné, Bo Hedblad, Gunnar Engström, Lars Barregard & Eva Andersson
Abstract Background Smoking is a strong risk factor for cardiovascular disease (CVD) and causes exposure to cadmium, which is a pro-atherosclerotic metal. Cadmium exposure has also been shown to increase the risk of CVD, even after adjustment for smoking. Our hypothesis was that part of the risk of CVD in smokers may be mediated by cadmium exposure from tobacco smoke. We examined this hypothesis in a mediation analysis, trying to assess how much of the...

Additional file 2: of Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells

Hyun Hwang, Min-Suk Oh, Dong Lee & Hyo-Jeong Kuh
Figure S2. Expression of vimentin (a) and MT1-MMP (b) in invadopodia of PANC-1 TSs. In-well staining was carried out for vimentin and MT1-MMP (green), F-actin (red) and DAPI (blue) in whole TSs. Optical sections were acquired at 0.5 μm intervals and stacked into a z-projection. Scale bars: 20 μm. (TIF 1254 kb)

Additional file 1: of Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells

Hyun Hwang, Min-Suk Oh, Dong Lee & Hyo-Jeong Kuh
Figure S1. Components of the minipillar array chip. The minipillar array chip consists of a pair of base chips (top and bottom chip) (a) and minipillars (b). (c) Assembly of pillars are shown as positioned at 9â mm distance or 3.2â mm distance. (US Patent Application No. 15/347,767, ROK Patent Registration No. 10â 1,860,502) (TIF 1236 kb)

USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer

Xiaojun Man, Chiyuan Piao, Xuyong Lin, Chuize Kong, Xiaolu Cui & Yuanjun Jiang
Abstract Background USP13 has been reported to be involved in the tumorigenesis of human cancers, however, its functional role and regulatory mechanisms in bladder cancer (BC) remain unclear. Methods q-RT-PCR was performed to examine the expression of miR-130b-3p, miR-301b-3p and USP13 in BC tissue samples. Western blot, q-RT-PCR, bioinformatic analysis and dual-luciferase reporter assay were conducted to identify the regulatory function of miR-130b-3p/301b-3p for USP13. Co-immunoprecipitation assay was performed to assess the interaction between USP13...

Smoking-induced risk of future cardiovascular disease is partly mediated by cadmium in tobacco: Malmö Diet and Cancer Cohort Study

Huiqi Li, Björn Fagerberg, Gerd Sallsten, Yan Borné, Bo Hedblad, Gunnar Engström, Lars Barregard & Eva Andersson
Abstract Background Smoking is a strong risk factor for cardiovascular disease (CVD) and causes exposure to cadmium, which is a pro-atherosclerotic metal. Cadmium exposure has also been shown to increase the risk of CVD, even after adjustment for smoking. Our hypothesis was that part of the risk of CVD in smokers may be mediated by cadmium exposure from tobacco smoke. We examined this hypothesis in a mediation analysis, trying to assess how much of the...

Additional file 2: of Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells

Hyun Hwang, Min-Suk Oh, Dong Lee & Hyo-Jeong Kuh
Figure S2. Expression of vimentin (a) and MT1-MMP (b) in invadopodia of PANC-1 TSs. In-well staining was carried out for vimentin and MT1-MMP (green), F-actin (red) and DAPI (blue) in whole TSs. Optical sections were acquired at 0.5 μm intervals and stacked into a z-projection. Scale bars: 20 μm. (TIF 1254 kb)

Additional file 3: of Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells

Hyun Hwang, Min-Suk Oh, Dong Lee & Hyo-Jeong Kuh
Figure S3. Differential sensitivity of PANC-1 TSs and PSCs to anticancer drugs. Dose-response curves of GEM and PTX for PANC-1 TSs (a) and PSCs (b) was determined under mono- or co-culture conditions after 72 h exposure by APH assay. Data represent the mean ± SD of three independent experiments. (TIF 146 kb)

Additional file 1: of Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells

Hyun Hwang, Min-Suk Oh, Dong Lee & Hyo-Jeong Kuh
Figure S1. Components of the minipillar array chip. The minipillar array chip consists of a pair of base chips (top and bottom chip) (a) and minipillars (b). (c) Assembly of pillars are shown as positioned at 9â mm distance or 3.2â mm distance. (US Patent Application No. 15/347,767, ROK Patent Registration No. 10â 1,860,502) (TIF 1236 kb)

Additional file 8: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Appendix 1. The reasons for exclusion studies. (DOC 175 kb)

USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer

Xiaojun Man, Chiyuan Piao, Xuyong Lin, Chuize Kong, Xiaolu Cui & Yuanjun Jiang
Abstract Background USP13 has been reported to be involved in the tumorigenesis of human cancers, however, its functional role and regulatory mechanisms in bladder cancer (BC) remain unclear. Methods q-RT-PCR was performed to examine the expression of miR-130b-3p, miR-301b-3p and USP13 in BC tissue samples. Western blot, q-RT-PCR, bioinformatic analysis and dual-luciferase reporter assay were conducted to identify the regulatory function of miR-130b-3p/301b-3p for USP13. Co-immunoprecipitation assay was performed to assess the interaction between USP13...

Additional file 6: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Table S3. The results of meta-regression subgroup analyses stratified by control type. (DOC 84 kb)

Acceptance and commitment therapy for chronic pain: protocol of a systematic review and individual participant data meta-analysis

Jiaxi Lin, Whitney Scott, Lewis Carpenter, Sam Norton, Matthias Domhardt, Harald Baumeister & Lance McCracken
Abstract Background Acceptance and commitment therapy (ACT) can be effective in treating chronic pain. Despite evidence supporting the effectiveness of ACT, uncertainties remain regarding which subgroups in the chronic pain population are likely to benefit most and least. This protocol describes the application for two meta-analytic approaches, one at the level of individual participant data and the other at the level of aggregated data, from randomized controlled trials of ACT for chronic pain (ACT-CP-MA). Methods...

Additional file 7: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Table S4. The results of meta-regression subgroup analyses according to â risk of biasâ for primary outcomes. (DOC 73 kb)

Additional file 7: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Table S4. The results of meta-regression subgroup analyses according to â risk of biasâ for primary outcomes. (DOC 73 kb)

Additional file 1: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Figure S1. Study selection PRISMA flow diagram. (TIF 5172 kb)

Additional file 4: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Table S1. Search strategy for the MEDLINE Database. (DOC 50 kb)

Acceptance and commitment therapy for chronic pain: protocol of a systematic review and individual participant data meta-analysis

Jiaxi Lin, Whitney Scott, Lewis Carpenter, Sam Norton, Matthias Domhardt, Harald Baumeister & Lance McCracken
Abstract Background Acceptance and commitment therapy (ACT) can be effective in treating chronic pain. Despite evidence supporting the effectiveness of ACT, uncertainties remain regarding which subgroups in the chronic pain population are likely to benefit most and least. This protocol describes the application for two meta-analytic approaches, one at the level of individual participant data and the other at the level of aggregated data, from randomized controlled trials of ACT for chronic pain (ACT-CP-MA). Methods...

Additional file 6: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Table S3. The results of meta-regression subgroup analyses stratified by control type. (DOC 84 kb)

Additional file 8: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Appendix 1. The reasons for exclusion studies. (DOC 175 kb)

Additional file 5: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Table S2. The results of meta-regression subgroup analyses for the 15 studies which reported LBR. (DOC 61 kb)

Additional file 5: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Table S2. The results of meta-regression subgroup analyses for the 15 studies which reported LBR. (DOC 61 kb)

Additional file 4: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Table S1. Search strategy for the MEDLINE Database. (DOC 50 kb)

Additional file 2: of The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis

Zheng-Yun Xie, Zhi-Hang Peng, Bing Yao, Li Chen, Yan-Yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-Yan Yang & You-Bing Xia
Figure S2. Effects of acupuncture on spontaneous abortion outcome. (TIF 1233 kb)

Infection against infection: parasite antagonism against parasites, viruses and bacteria

Shi-Shi Shen, Xiao-Yan Qu, Wei-Zhe Zhang, Jian Li & Zhi-Yue Lv
Abstract Background Infectious diseases encompass a large spectrum of diseases that threaten human health, and coinfection is of particular importance because pathogen species can interact within the host. Currently, the antagonistic relationship between different pathogens during concurrent coinfections is defined as one in which one pathogen either manages to inhibit the invasion, development and reproduction of the other pathogen or biologically modulates the vector density. In this review, we provide an overview of the phenomenon...

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