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Envejecimiento del cerebro y proteinopatías

Jorge Ivan Castillo-Quan
Teleconferencia entre el servicio neurología del CMNO, IMSS, Guadalajara y NeuroMéxico con el tema ENVEJECIMIENTO DEL CEREBRO Y PROTEINOPATíAS, del día 7 de Mayo de! 2019

Envejecimiento del cerebro y proteinopatías

Jorge Ivan Castillo-Quan
Teleconferencia entre el servicio neurología del CMNO, IMSS, Guadalajara y NeuroMéxico con el tema ENVEJECIMIENTO DEL CEREBRO Y PROTEINOPATíAS, del día 7 de Mayo de! 2019

Gradient fluid shear stress regulates migration of osteoclast precursors

Yan Gao, Taiyang Li, Qing Sun & Bo Huo
Cell migration is highly sensitive to fluid shear stress (FSS) in blood flow or interstitial fluid flow. However, whether the FSS gradient can regulate the migration of cells remains unclear. In this work, we constructed a parallel-plate flow chamber with different FSS gradients and verified the gradient flow field by particle image velocimetry measurements and finite element analyses. We then investigated the effect of FSS magnitudes and gradients on the migration of osteoclast precursor RAW264.7...

Gradient fluid shear stress regulates migration of osteoclast precursors

Yan Gao, Taiyang Li, Qing Sun & Bo Huo
Cell migration is highly sensitive to fluid shear stress (FSS) in blood flow or interstitial fluid flow. However, whether the FSS gradient can regulate the migration of cells remains unclear. In this work, we constructed a parallel-plate flow chamber with different FSS gradients and verified the gradient flow field by particle image velocimetry measurements and finite element analyses. We then investigated the effect of FSS magnitudes and gradients on the migration of osteoclast precursor RAW264.7...

T lymphocytes migrate upstream after completing the leukocyte adhesion cascade

Nicholas R. Anderson, Alexander Buffone & Daniel A. Hammer
The leukocyte adhesion cascade is of critical importance for both the maintenance of immune homeostasis and the ability of immune cells to perform effector functions. Here, we present data showing CD4+ T cells migrate upstream (against the direction of flow) after completing the leukocyte adhesion cascade on surfaces displaying either ICAM-1 or ICAM-1 and VCAM-1, but migrate downstream on surfaces displaying only VCAM-1. Cells completing the cascade on HUVECs initially migrate upstream before reverting to...

T lymphocytes migrate upstream after completing the leukocyte adhesion cascade

Nicholas R. Anderson, Alexander Buffone & Daniel A. Hammer
The leukocyte adhesion cascade is of critical importance for both the maintenance of immune homeostasis and the ability of immune cells to perform effector functions. Here, we present data showing CD4+ T cells migrate upstream (against the direction of flow) after completing the leukocyte adhesion cascade on surfaces displaying either ICAM-1 or ICAM-1 and VCAM-1, but migrate downstream on surfaces displaying only VCAM-1. Cells completing the cascade on HUVECs initially migrate upstream before reverting to...

Hyaluronan-CD44 interactions mediate contractility and migration in periodontal ligament cells

Zeinab Al-Rekabi, Adriane M. Fura, Ilsa Juhlin, Alaa Yassin, Tracy E. Popowics & Nathan J. Sniadecki
The role of hyaluronan (HA) in periodontal healing has been speculated via its interaction with the CD44 receptor. While HA-CD44 interactions have previously been implicated in numerous cell types; effect and mechanism of exogenous HA on periodontal ligament (PDL) cells is less clear. Herein, we examine the effect of exogenous HA on contractility and migration in human and murine PDL cells using arrays of microposts and time-lapse microscopy. Our findings observed HA-treated human PDL cells...

Hyaluronan-CD44 interactions mediate contractility and migration in periodontal ligament cells

Zeinab Al-Rekabi, Adriane M. Fura, Ilsa Juhlin, Alaa Yassin, Tracy E. Popowics & Nathan J. Sniadecki
The role of hyaluronan (HA) in periodontal healing has been speculated via its interaction with the CD44 receptor. While HA-CD44 interactions have previously been implicated in numerous cell types; effect and mechanism of exogenous HA on periodontal ligament (PDL) cells is less clear. Herein, we examine the effect of exogenous HA on contractility and migration in human and murine PDL cells using arrays of microposts and time-lapse microscopy. Our findings observed HA-treated human PDL cells...

Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin

Juo-Han Lin, Wen-Jui Lee, Han-Chung Wu, Chih-Hsiung Wu, Li-Ching Chen, Chi-Cheng Huang, Hang-Lung Chang, Tzu-Chun Cheng, Hui-Wen Chang, Chi-Tang Ho, Shih-Hsin Tu & Yuan-Soon Ho
The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/β-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, β-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to...

Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin

Juo-Han Lin, Wen-Jui Lee, Han-Chung Wu, Chih-Hsiung Wu, Li-Ching Chen, Chi-Cheng Huang, Hang-Lung Chang, Tzu-Chun Cheng, Hui-Wen Chang, Chi-Tang Ho, Shih-Hsin Tu & Yuan-Soon Ho
The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/β-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, β-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to...

Power Point Presentation Learning Speeds for Mouse and Trackpad in Elementary School Students with Developmental Delays

Jeanne E Stork
This is the Power Point presentation that accompanies the paper Learning Speeds for Mouse and Trackpad in Elementary School Students with Developmental Delays. This study compared student improvement in trackpad skills versus mouse skills. While the research focused on elementary school students with developmental delays, the information may be helpful to any school that is deciding whether to invest in mice, trackpads, or both. Improvement data was analyzed from thirty-six students ages five through ten,...

Does enhanced nutrient availability increase volatile emissions in cranberry?

Elvira S. De Lange & Cesar Rodriguez-Saona
Nutrient availability impacts plant indirect defenses, such as emissions of herbivore-induced plant volatiles (HIPVs) that attract natural enemies of herbivores. However, the effects are variable depending on the cropping system, and emissions may increase, decrease, or be not affected by nutrient availability. Here, we evaluated the effects of different fertilizer regimes, which varied nitrogen (N), phosphorus (P), and potassium (K) availability, on HIPV emissions in cranberry, Vaccinium macrocarpon Ait. Plants included six cranberry varieties that...

Does enhanced nutrient availability increase volatile emissions in cranberry?

Elvira S. De Lange & Cesar Rodriguez-Saona
Nutrient availability impacts plant indirect defenses, such as emissions of herbivore-induced plant volatiles (HIPVs) that attract natural enemies of herbivores. However, the effects are variable depending on the cropping system, and emissions may increase, decrease, or be not affected by nutrient availability. Here, we evaluated the effects of different fertilizer regimes, which varied nitrogen (N), phosphorus (P), and potassium (K) availability, on HIPV emissions in cranberry, Vaccinium macrocarpon Ait. Plants included six cranberry varieties that...

TCam-2 Cells Deficient for SOX2 and FOXA2 are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo

Daniel Nettersheim, Saskia Vadder, Sina Jostes, Alena Heimsoeth & Hubert Schorle
Testicular germ cell tumors (GCTs) are very common in young men and can be stratified into seminomas and non-seminomas. While seminomas share a similar gene expression and epigenetic profile with primordial germ cells, the stem cell population of the non-seminomas, the embryonal carcinoma (EC), resembles malignant embryonic stem cells. Thus, ECs are able to differentiate into cells of all three germ layers (teratomas) and even extra-embryonic-tissue-like cells (yolk-sac tumor, choriocarcinoma). In the last years, we...

TCam-2 Cells Deficient for SOX2 and FOXA2 are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo

Daniel Nettersheim, Saskia Vadder, Sina Jostes, Alena Heimsoeth & Hubert Schorle
Testicular germ cell tumors (GCTs) are very common in young men and can be stratified into seminomas and non-seminomas. While seminomas share a similar gene expression and epigenetic profile with primordial germ cells, the stem cell population of the non-seminomas, the embryonal carcinoma (EC), resembles malignant embryonic stem cells. Thus, ECs are able to differentiate into cells of all three germ layers (teratomas) and even extra-embryonic-tissue-like cells (yolk-sac tumor, choriocarcinoma). In the last years, we...

PDF of Presentation Learning Speeds for Mouse and Trackpad in Elementary School Students with Developmental Delays

Jeanne E Stork
Here is the PDF of the presentation for the paper Learning Speeds for Mouse and Trackpad in Elementary School Students with Developmental Delays. The internal links (Table of Contents and Return to Beginning) do not work in this PDF.

Power Point Presentation Learning Speeds for Mouse and Trackpad in Elementary School Students with Developmental Delays

Jeanne E Stork
This is the Power Point presentation that accompanies the paper Learning Speeds for Mouse and Trackpad in Elementary School Students with Developmental Delays. This study compared student improvement in trackpad skills versus mouse skills. While the research focused on elementary school students with developmental delays, the information may be helpful to any school that is deciding whether to invest in mice, trackpads, or both. Improvement data was analyzed from thirty-six students ages five through ten,...

PDF of Presentation Learning Speeds for Mouse and Trackpad in Elementary School Students with Developmental Delays

Jeanne E Stork
Here is the PDF of the presentation for the paper Learning Speeds for Mouse and Trackpad in Elementary School Students with Developmental Delays. The internal links (Table of Contents and Return to Beginning) do not work in this PDF.

Wavy leaf design

Florence Hawkins
Design inspired by a 'Modernist linen sample in green' by Herbert J.Croft, 1934 and a Japanese katagami ' Waves', both from MoDA's archive collection.
This project is part of Ceres Artists in Residence at MoDA, which aims to use objects from MoDA's collections as a starting point for exploration of resist printing using natural dyes.
Wavy leaf design is a repeat textile pattern composed of two main layers: the slylised shape of a leaf as a block...

Wavy leaf design

Florence Hawkins
Design inspired by a 'Modernist linen sample in green' by Herbert J.Croft, 1934 and a Japanese katagami ' Waves', both from MoDA's archive collection.
This project is part of Ceres Artists in Residence at MoDA, which aims to use objects from MoDA's collections as a starting point for exploration of resist printing using natural dyes.
Wavy leaf design is a repeat textile pattern composed of two main layers: the slylised shape of a leaf as a block...

Learning Speeds for Mouse and Trackpad in Elementary School Students with Developmental Delays Summary Presentation

Jeanne E Stork
This is the Power Point presentation that accompanies the paper Learning Speeds for Mouse and Trackpad in Elementary School Students with Developmental Delays. This study compared student improvement in trackpad skills versus mouse skills. While the research focused on elementary school students with developmental delays, the information may be helpful to any school that is deciding whether to invest in mice, trackpads, or both. Improvement data was analyzed from thirty-six students ages five through ten,...

data.sharing.xlsx

Lili Xie
any question about this data can contact with me.

Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi

Ana Camila Oliveira Souza, Qusai Al Abdallah, Kaci DeJarnette, Adela Martin-Vicente, Ashley V. Nywening, Christian DeJarnette, Emily A. Sansevere, Wenbo Ge, Glen E. Palmer & Jarrod R Fortwendel
Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique β-subunit. GGTase-I enzymes are validated drug targets that contribute to virulence in Cryptococcus neoformans and to the yeast-to-hyphal transition in Candida albicans. Therefore, we sought to investigate the importance of the α-subunit, RamB, and the β-subunit, Cdc43, of the A. fumigatus GGTase-I complex to hyphal growth and...

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