271,658 Works

Effects of Light Quality on Pod Elongation in Soybean (Glycine max (L.) Merr.) and Cowpea (Vigna unguiculata (L.) Walp.)

Seiya Tanaka, Nobuyuki Ario, Andressa Camila Seiko Nakagawa, Yuki Tomita, Naoki Murayama, Takatoshi Taniguchi, Norimitsu Hamaoka, Mari Iwaya-Inoue & Yushi Ishibashi
Soybean pods are located at the nodes, where they are in the shadow, whereas cowpea pods are located outside of the leaves and are exposed to sunlight. To compare the effects of light quality on pod growth in soybean and cowpea, we measured the length of pods treated with white, blue, red or far-red light. In both species, pods elongated faster during the dark period than during the light period in all light treatments except...

RUG3 is a negative regulator of plant responses to ABA in Arabidopsis thaliana

Chao Su, Jinhong Yuan, Hongtao Zhao, Yankun Zhao, Hongtao Ji, Youning Wang & Xia Li
Mitochondria is a main target of various stressors. Dysfunction of mitochondria stimulates overproduction of reactive oxygen species (ROS), which can cause oxidative damage to mitochondria and DNA. Recently, we demonstrated that RCC1/UVR8/GEF-like 3 (RUG3), a member of the Regulator of Chromatin Condensation 1 (RCC1) protein family, can directly interact with ataxia telangiectasia mutated (ATM), a key regulator of the DNA damage response (DDR), and synergistically regulates the alternative splicing of mitochondrial nad2. Aberrant ROS accumulation...

Effects of light quality on pod elongation in soybean (Glycine max (L.) Merr.) and cowpea (Vigna unguiculata (L.) Walp.)

Seiya Tanaka, Nobuyuki Ario, Andressa Camila Seiko Nakagawa, Yuki Tomita, Naoki Murayama, Takatoshi Taniguchi, Norimitsu Hamaoka, Mari Iwaya-Inoue & Yushi Ishibashi
Soybean pods are located at the nodes, where they are in the shadow, whereas cowpea pods are located outside of the leaves and are exposed to sunlight. To compare the effects of light quality on pod growth in soybean and cowpea, we measured the length of pods treated with white, blue, red or far-red light. In both species, pods elongated faster during the dark period than during the light period in all light treatments except...

Effects of light quality on pod elongation in soybean (Glycine max (L.) Merr.) and cowpea (Vigna unguiculata (L.) Walp.)

Seiya Tanaka, Nobuyuki Ario, Andressa Camila Seiko Nakagawa, Yuki Tomita, Naoki Murayama, Takatoshi Taniguchi, Norimitsu Hamaoka, Mari Iwaya-Inoue & Yushi Ishibashi
Soybean pods are located at the nodes, where they are in the shadow, whereas cowpea pods are located outside of the leaves and are exposed to sunlight. To compare the effects of light quality on pod growth in soybean and cowpea, we measured the length of pods treated with white, blue, red or far-red light. In both species, pods elongated faster during the dark period than during the light period in all light treatments except...

RUG3 is a negative regulator of plant responses to ABA in Arabidopsis thaliana

Chao Su, Jinhong Yuan, Hongtao Zhao, Yankun Zhao, Hongtao Ji, Youning Wang & Xia Li
Mitochondria is a main target of various stressors. Dysfunction of mitochondria stimulates overproduction of reactive oxygen species (ROS), which can cause oxidative damage to mitochondria and DNA. Recently, we demonstrated that RCC1/UVR8/GEF-like 3 (RUG3), a member of the Regulator of Chromatin Condensation 1 (RCC1) protein family, can directly interact with ataxia telangiectasia mutated (ATM), a key regulator of the DNA damage response (DDR), and synergistically regulates the alternative splicing of mitochondrial nad2. Aberrant ROS accumulation...

Differentiation of conjunctiva mesenchymal stem cells into secreting islet beta cells on plasma treated electrospun nanofibrous scaffold

Samad Nadri, Ghasem Barati, Hossein Mostafavi, Abdolreza Esmaeilzadeh & Seyed Ehsan Enderami
Transplantation of stem cells using biocompatible nanofibrous scaffolds is a promising therapeutic method for treating Diabetic Mellitus. The aim of this study was to derive insulin-producing cells (IPCs) from conjunctiva-derived mesenchymal stem cell (CJMSCs) and to compare the functionality of differentiated IPCs in a three-dimensional (3D) culture with 2D. Furthermore, the effects of hydrophobicity of scaffold on IPCs differentiation were examined. Scanning electron microscopy (SEM), quantitative real times PCR (qPCR), Immunostaining and flow cytometry were...

Differentiation of conjunctiva mesenchymal stem cells into secreting islet beta cells on plasma treated electrospun nanofibrous scaffold

Samad Nadri, Ghasem Barati, Hossein Mostafavi, Abdolreza Esmaeilzadeh & Seyed Ehsan Enderami
Transplantation of stem cells using biocompatible nanofibrous scaffolds is a promising therapeutic method for treating Diabetic Mellitus. The aim of this study was to derive insulin-producing cells (IPCs) from conjunctiva-derived mesenchymal stem cell (CJMSCs) and to compare the functionality of differentiated IPCs in a three-dimensional (3D) culture with 2D. Furthermore, the effects of hydrophobicity of scaffold on IPCs differentiation were examined. Scanning electron microscopy (SEM), quantitative real times PCR (qPCR), Immunostaining and flow cytometry were...

miR-124 inhibits progression of hepatocarcinoma by targeting KLF4 and promises a novel diagnostic marker

Li-Pei Wu, Jian Wu, Anquan Shang, Man Yang, Ling-Ling Li, Jing Yu, Lei-Rong Xu, Chun-Bing Wang, Wei-Wei Wang, Jian-Jun Zhu & Wen-Ying Lu
Hepatocarcinoma is one of the most lethal malignancy haunting the Chinese population, which is partially due to the difficulties in diagnosis at an early stage. The search for a biomarker that could signify the presence and progress of hepatocarcinoma is never ended. MicroRNAs are 22-nt RNAs that could bind to 3′ UTR of target mRNAs, mediating degradation of mRNAs or inhibiting the translation. Although much has been investigated, the role of miR-124 in hepatocarcinoma remained...

miR-124 inhibits progression of hepatocarcinoma by targeting KLF4 and promises a novel diagnostic marker

Li-Pei Wu, Jian Wu, Anquan Shang, Man Yang, Ling-Ling Li, Jing Yu, Lei-Rong Xu, Chun-Bing Wang, Wei-Wei Wang, Jian-Jun Zhu & Wen-Ying Lu
Hepatocarcinoma is one of the most lethal malignancy haunting the Chinese population, which is partially due to the difficulties in diagnosis at an early stage. The search for a biomarker that could signify the presence and progress of hepatocarcinoma is never ended. MicroRNAs are 22-nt RNAs that could bind to 3′ UTR of target mRNAs, mediating degradation of mRNAs or inhibiting the translation. Although much has been investigated, the role of miR-124 in hepatocarcinoma remained...

Efaverinz and nano-gold-loaded mannosylated niosomes: a host cell-targeted topical HIV-1 prophylaxis via thermogel system

Tanushree Malik, Gaurav Chauhan, Goutam Rath, Rohan N. Kesarkar, Abhay S. Chowdhary & Amit K. Goyal
Sexual dissemination of Human Immunodeficiency Virus-1 (HIV-1) is the prime mode of its spread. Topical microbicidal approach has gained much attention, but no real success is observed till date, either due to toxicity or resistance of active moieties and the lack of efficient drug delivery approaches. In this research protocol, a unique combination approach of a standard drug moiety, that is, Efaverinz (EFV) and a nanometal, that is, gold nanoparticles (GNPs) was tried. Both these...

Efaverinz and nano-gold-loaded mannosylated niosomes: a host cell-targeted topical HIV-1 prophylaxis via thermogel system

Tanushree Malik, Gaurav Chauhan, Goutam Rath, Rohan N. Kesarkar, Abhay S. Chowdhary & Amit K. Goyal
Sexual dissemination of Human Immunodeficiency Virus-1 (HIV-1) is the prime mode of its spread. Topical microbicidal approach has gained much attention, but no real success is observed till date, either due to toxicity or resistance of active moieties and the lack of efficient drug delivery approaches. In this research protocol, a unique combination approach of a standard drug moiety, that is, Efaverinz (EFV) and a nanometal, that is, gold nanoparticles (GNPs) was tried. Both these...

Green synthesis of silver nanoparticles using Thymbra spicata L. var. spicata (zahter) aqueous leaf extract and evaluation of their morphology-dependent antibacterial and cytotoxic activity

Fatih Erci, Rabia Cakir-Koc & Ibrahim Isildak
Silver (Ag) nanoparticles (NPs) were green synthesized at room temperature using different concentrations of the Thymbra spicata L. var. spicata (Zahter) aqueous leaf extracts for the first time. With the synthesis of AgNPs using the leaf extract of Cynara scolymus (Artichoke) and Mentha piperita (Peppermint), the biological activities of the nanoparticles synthesized using leaf extract of three economically significant plants have been studied comparatively. Nanoparticles were characterized by different spectroscopic and microscopic analysis. TEM analysis...

Green synthesis of silver nanoparticles using Thymbra spicata L. var. spicata (zahter) aqueous leaf extract and evaluation of their morphology-dependent antibacterial and cytotoxic activity

Fatih Erci, Rabia Cakir-Koc & Ibrahim Isildak
Silver (Ag) nanoparticles (NPs) were green synthesized at room temperature using different concentrations of the Thymbra spicata L. var. spicata (Zahter) aqueous leaf extracts for the first time. With the synthesis of AgNPs using the leaf extract of Cynara scolymus (Artichoke) and Mentha piperita (Peppermint), the biological activities of the nanoparticles synthesized using leaf extract of three economically significant plants have been studied comparatively. Nanoparticles were characterized by different spectroscopic and microscopic analysis. TEM analysis...

Biodegradable composite porous poly(dl-lactide-co-glycolide) scaffold supports mesenchymal stem cell differentiation and calcium phosphate deposition

Serena Casagrande, Roberto Tiribuzi, Emanuele Cassetti, Francesca Selmin, Gian Luca Gervasi, Lanfranco Barberini, Marco Freddolini, Maurizio Ricci, Aurélie Schoubben, Giuliano G. Cerulli & Paolo Blasi
In recent decades, tissue engineering strategies have been proposed for the treatment of musculoskeletal diseases and bone fractures to overcome the limitations of the traditional surgical approaches based on allografts and autografts. In this work we report the development of a composite porous poly(dl-lactide-co-glycolide) scaffold suitable for bone regeneration. Scaffolds were produced by thermal sintering of porous microparticles. Next, in order to improve cell adhesion to the scaffold and subsequent proliferation, the scaffolds were coated...

Biodegradable composite porous poly(dl-lactide-co-glycolide) scaffold supports mesenchymal stem cell differentiation and calcium phosphate deposition

Serena Casagrande, Roberto Tiribuzi, Emanuele Cassetti, Francesca Selmin, Gian Luca Gervasi, Lanfranco Barberini, Marco Freddolini, Maurizio Ricci, Aurélie Schoubben, Giuliano G. Cerulli & Paolo Blasi
In recent decades, tissue engineering strategies have been proposed for the treatment of musculoskeletal diseases and bone fractures to overcome the limitations of the traditional surgical approaches based on allografts and autografts. In this work we report the development of a composite porous poly(dl-lactide-co-glycolide) scaffold suitable for bone regeneration. Scaffolds were produced by thermal sintering of porous microparticles. Next, in order to improve cell adhesion to the scaffold and subsequent proliferation, the scaffolds were coated...

The Answer to Riemann is Giant..pdf

Nicholas R. Wright
We prove the Riemann Hypothesis, by means of the Extended Riemann Hypothesis, the Generalized Riemann Hypothesis, and the Grand Riemann Hypothesis. Quasicrystals are the answer to the Riemann Hypothesis. A solution could be found using Russell’s Paradox. Measurement is possible through nominative determinism. Deuring–Heilbronn repulsion phenomenon was useful in regression analysis. An index method of forecasting was overlooked for centuries. In summary, the Grand Riemann Hypothesis should be seen as the standard. Grand Riemann Hypothesis...

The Answer to Riemann is Giant..pdf

Nicholas R. Wright
We prove the Riemann Hypothesis, by means of the Extended Riemann Hypothesis, the Generalized Riemann Hypothesis, and the Grand Riemann Hypothesis. Quasicrystals are the answer to the Riemann Hypothesis, however, a semantic prime. A solution could be found using Russell’s Paradox. Measurement is possible through nominative determinism. Deuring–Heilbronn repulsion phenomenon was useful in regression analysis. An index method of forecasting was overlooked for centuries. In summary, the Grand Riemann Hypothesis should be seen as the...

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Low-Dose Fractionated Irradiation Promotes Axonal Regeneration Beyond Reactive Gliosis and Facilitates Locomotor Function Recovery After Spinal Cord Injury in Beagle Dogs

Qiang Zhang, Ying Xiong, Bo Zhu, Bifeng Zhu, Daishi Tian & Wei Wang

Injury to the adult central nervous system (CNS) results in the formation of glial scar tissues. Glial scar-induced failure of regenerative axon pathfinding may limit axon regrowth beyond the lesion site and cause incorrect reinnervation and dystrophic appearance of stalled growth after CNS trauma. Glial scars also upregulate chondroitin sulfate proteoglycans (CSPGs) and expression of proinflammatory factor(s) that form a barrier to axonal regeneration. Therefore, interventions for glial scarring are an attractive strategy for augmenting...

In vitro human colonic fermentation of indigestible fraction isolated from lunch menus: impact on the gut metabolites and antioxidant capacity

Victor Manuel Zamora-Gasga, Alicia Paulina Cárdenas-Castro, Efigenia Montalvo-González, María Guadalupe Flavia Loarca-Piña, Vázquez-Landaverde Pedro Alberto, Juscelino Tovar & Sonia Guadalupe Sáyago-Ayerdi
The indigestible fraction (IF) isolated from three lunch menus: Modified Mexican Lunch (MM-L), Traditional Mexican Lunch (TM-L) and Alternative Mexican Lunch (AM-L), was studied in terms of antioxidant capacity (AOX) and metabolites produced through fermentation by human intestinal microbiota. IFs were isolated after withstanding in vitro gastrointestinal digestion and total soluble polyphenols (TSP), condensed tannins (CT), hydrolysable polyphenols (HP) and AOX (DPPH, FRAP) were evaluated. AOX, pH and bacterial metabolites profile changes were also monitored...

The effect of fish oil supplementation on brain DHA and EPA content and fatty acid profile in mice

Kelly J. Valentini, C. Austin Pickens, Jason A. Wiesinger & Jenifer I. Fenton
Supplementation with omega-3 (n-3) fatty acids may improve cognitive performance and protect against cognitive decline. However, changes in brain phospholipid fatty acid composition after supplementation with n-3 fatty acids are poorly described. The purpose of this study was to feed increasing n-3 fatty acids and characterise the changes in brain phospholipid fatty acid composition and correlate the changes with red blood cells (RBCs) and plasma in mice. Increasing dietary docosahexaenoic (DHA) and eicosapentaenoic acid (EPA)...

The effect of fish oil supplementation on brain DHA and EPA content and fatty acid profile in mice

Kelly J. Valentini, C. Austin Pickens, Jason A. Wiesinger & Jenifer I. Fenton
Supplementation with omega-3 (n-3) fatty acids may improve cognitive performance and protect against cognitive decline. However, changes in brain phospholipid fatty acid composition after supplementation with n-3 fatty acids are poorly described. The purpose of this study was to feed increasing n-3 fatty acids and characterise the changes in brain phospholipid fatty acid composition and correlate the changes with red blood cells (RBCs) and plasma in mice. Increasing dietary docosahexaenoic (DHA) and eicosapentaenoic acid (EPA)...

Influence of low versus moderate glycemic index of diet on substrate oxidation and energy expenditure during incremental exercise in endurance athletes: a randomized counterbalanced cross-over trial

Krzysztof Durkalec-Michalski, Emilia Ewa Zawieja, Bogna Ewa Zawieja, Tomasz Podgórski, Dominika Jurkowska & Jan Jeszka
The study was aimed at assessing the influence of 3-week low glycemic index (LGI) versus moderate glycemic index (MGI) diet on substrate oxidation during incremental exercise. 17 runners completed two 3-week trials of either LGI or MGI diet in a randomised counterbalanced manner. Before and after each trial the incremental cycling test was performed. Metabolic alternations were observed only within tested diets and no significant differences in fat and carbohydrate (CHO) oxidation were found between...

Influence of low versus moderate glycemic index of diet on substrate oxidation and energy expenditure during incremental exercise in endurance athletes: a randomized counterbalanced cross-over trial

Krzysztof Durkalec-Michalski, Emilia Ewa Zawieja, Bogna Ewa Zawieja, Tomasz Podgórski, Dominika Jurkowska & Jan Jeszka
The study was aimed at assessing the influence of 3-week low glycemic index (LGI) versus moderate glycemic index (MGI) diet on substrate oxidation during incremental exercise. 17 runners completed two 3-week trials of either LGI or MGI diet in a randomised counterbalanced manner. Before and after each trial the incremental cycling test was performed. Metabolic alternations were observed only within tested diets and no significant differences in fat and carbohydrate (CHO) oxidation were found between...

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