197,290 Works

Oxaliplatin induces immunogenic cells death and enhances therapeutic efficacy of checkpoint inhibitor in a model of murine lung carcinoma

Fengfei Sun, Lijuan Cui, Tingting Li, Silin Chen, Junmei Song & Dezhi Li
Background: Platinum compounds are commonly used for lung cancer treatment. However, the severe side effects and relatively poor prognosis limit their therapeutic effect. Therefore, developing novel platinum derivative and treatment strategy are critical for current lung cancer therapy. Methods: Flow cytometry, HMGB1 and ATP release, and immunoblotting were performed to evaluate the Oxaliplatin-induced immunogenic cell death (ICD) in two lung carcinoma cells. Vaccination approach and subcutaneous tumor models were created to analyze the tumor regression...

Oxaliplatin induces immunogenic cells death and enhances therapeutic efficacy of checkpoint inhibitor in a model of murine lung carcinoma

Fengfei Sun, Lijuan Cui, Tingting Li, Silin Chen, Junmei Song & Dezhi Li
Background: Platinum compounds are commonly used for lung cancer treatment. However, the severe side effects and relatively poor prognosis limit their therapeutic effect. Therefore, developing novel platinum derivative and treatment strategy are critical for current lung cancer therapy. Methods: Flow cytometry, HMGB1 and ATP release, and immunoblotting were performed to evaluate the Oxaliplatin-induced immunogenic cell death (ICD) in two lung carcinoma cells. Vaccination approach and subcutaneous tumor models were created to analyze the tumor regression...

Plantas Nativas del Campus Universidad Nacional de Colombia Sede Bogotá

Diego Aguilera & Juan Camilo Ríos-Orjuela
Plantas Nativas del Campus (Ilustración científica), es una revista de arte y ciencia de la Universidad Nacional de Colombia y del Grupo Estudiantil de dibujo e ilustración científica (GEDIC). Reúne las plantas nativas mas representativas del campus de la Universidad Nacional de Colombia, sede Bogotá, acompañadas de una ilustración y su respectiva diagnosis.

Plantas Nativas del Campus Universidad Nacional de Colombia Sede Bogotá

Diego Aguilera & Juan Camilo Ríos-Orjuela
Plantas Nativas del Campus (Ilustración científica), es una revista de arte y ciencia de la Universidad Nacional de Colombia y del Grupo Estudiantil de dibujo e ilustración científica (GEDIC). Reúne las plantas nativas mas representativas del campus de la Universidad Nacional de Colombia, sede Bogotá, acompañadas de una ilustración y su respectiva diagnosis.

The Pleiotropic Effects of Sodium–Glucose Cotransporter-2 Inhibitors: Beyond the Glycemic Benefit

Dhiren K. Patel & Jodi Strong
Article full text
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The Pleiotropic Effects of Sodium–Glucose Cotransporter-2 Inhibitors: Beyond the Glycemic Benefit

Dhiren K. Patel & Jodi Strong
Article full text
The article associated with this page has been accepted for online publication and is in the final stages of production. The link to the full text will be made available on this page in the next few days
Provide enhanced digital features for this article
If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact adisrapidplus@springer.com.

...

Effects of Research Disturbance on Nest Survival in a Mixed Colony of Waterbirds

Champagnon, Lisa Gili & Hugo Carré
Script and data of the manuscript untitled "Effects of Research Disturbance on Nest Survival in a Mixed Colony of Waterbirds" submitted to PeerJ journal

Effects of Research Disturbance on Nest Survival in a Mixed Colony of Waterbirds

Champagnon, Lisa Gili & Hugo Carré
Script and data of the manuscript untitled "Effects of Research Disturbance on Nest Survival in a Mixed Colony of Waterbirds" submitted to PeerJ journal

Chemotaxonomy and cytotoxicity of the liverwort Porella Viridissima

Benjamin Métoyer, Nicolas Lebouvier, Edouard Hnawia, Louis Thouvenot, Fengrui Wang, Liva Harinantenaina Rakotondraibe, Phila Raharivelomanana, Yoshinori Asakawa & Mohammed Nour
The first chemotaxonomic study based on volatile components of Porella viridissima (Mitt.) Grolle is reported. The GC-MS analysis of ether extract was performed; ten santalane and five pinguisane-type sesquiterpenes were identified together with perrottetianal A as major diterpene. Most of detected santalane-type sesquiterpenes are reported for the first time in liverwort. P. viridissima was found to belong to the chemotype III (pinguisane/sacculatane) and shared chemical similarities with P. navicularis. Perrotettianal A was isolated and has...

Chemotaxonomy and cytotoxicity of the liverwort Porella Viridissima

Benjamin Métoyer, Nicolas Lebouvier, Edouard Hnawia, Louis Thouvenot, Fengrui Wang, Liva Harinantenaina Rakotondraibe, Phila Raharivelomanana, Yoshinori Asakawa & Mohammed Nour
The first chemotaxonomic study based on volatile components of Porella viridissima (Mitt.) Grolle is reported. The GC-MS analysis of ether extract was performed; ten santalane and five pinguisane-type sesquiterpenes were identified together with perrottetianal A as major diterpene. Most of detected santalane-type sesquiterpenes are reported for the first time in liverwort. P. viridissima was found to belong to the chemotype III (pinguisane/sacculatane) and shared chemical similarities with P. navicularis. Perrotettianal A was isolated and has...

Adaptive market hypothesis and momentum effect: Evidence from Dhaka Stock Exchange

Tahmina Akhter & Othman Yong
This paper examines time-varying behavior of momentum and contrarian profits to identify the existence of adaptive market hypothesis (AMH), and whether AMH can provide justification for the presence of such anomalous behavior in the Dhaka Stock Exchange (DSE) of Bangladesh. To investigate the time-varying pattern of momentum/contrarian anomaly, the study uses stock prices of all listed companies on the DSE and values of DSE general index from January 1995 to December 2018. To construct the...

Adaptive market hypothesis and momentum effect: Evidence from Dhaka Stock Exchange

Tahmina Akhter & Othman Yong
This paper examines time-varying behavior of momentum and contrarian profits to identify the existence of adaptive market hypothesis (AMH), and whether AMH can provide justification for the presence of such anomalous behavior in the Dhaka Stock Exchange (DSE) of Bangladesh. To investigate the time-varying pattern of momentum/contrarian anomaly, the study uses stock prices of all listed companies on the DSE and values of DSE general index from January 1995 to December 2018. To construct the...

Fusarium and Alternaria mycotoxins present in Canadian wheat and durum harvest samples

Sheryl A. Tittlemier, Richard Blagden, Jason Chan, Don Gaba, Twylla McKendry, Kerri Pleskach & Mike Roscoe
The objectives of this work were to investigate the presence of a variety of mycotoxins in Canadian wheat and durum and to characterize the relationship between concentrations of the Fusarium-produced deoxynivalenol (DON) and the presence of visible Fusarium damage. There is a lack of reported mycotoxin surveillance data for Canadian wheat and durum; this work addresses this information gap. Wheat and durum harvest samples from the 2010, 2011 and 2013–2016 growing seasons were analysed for...

Differential sensitivity among Puccinia striiformis f. sp. tritici isolates to propiconazole and pyraclostrobin fungicides

Zhanhai Kang, ZHANHAI KANG, Xing Li, XING LI, Anmin Wan, ANMIN WAN, Meinan Wang, MEINAN WANG, Xianming Chen & XIANMING CHEN
Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a destructive disease of wheat in the USA and fungicides have been used to manage the disease. However, it is not clear whether Pst has developed resistance to the commonly used fungicides. In this study, historical and recent Pst isolates were tested for sensitivity to Tilt, a propiconazole demethylation inhibitor fungicide, and Headline, a pyraclostrobin quinone outside inhibitor fungicide. Both Tilt and Headline at...

Differential sensitivity among Puccinia striiformis f. sp. tritici isolates to propiconazole and pyraclostrobin fungicides

Zhanhai Kang, Xing Li, Anmin Wan, Meinan Wang & Xianming Chen
Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a destructive disease of wheat in the USA and fungicides have been used to manage the disease. However, it is not clear whether Pst has developed resistance to the commonly used fungicides. In this study, historical and recent Pst isolates were tested for sensitivity to Tilt, a propiconazole demethylation inhibitor fungicide, and Headline, a pyraclostrobin quinone outside inhibitor fungicide. Both Tilt and Headline at...

Fusarium and Alternaria mycotoxins present in Canadian wheat and durum harvest samples

Sheryl A. Tittlemier, Richard Blagden, Jason Chan, Don Gaba, Twylla Mckendry, Kerri Pleskach & Mike Roscoe
The objectives of this work were to investigate the presence of a variety of mycotoxins in Canadian wheat and durum and to characterize the relationship between concentrations of the Fusarium-produced deoxynivalenol (DON) and the presence of visible Fusarium damage. There is a lack of reported mycotoxin surveillance data for Canadian wheat and durum; this work addresses this information gap. Wheat and durum harvest samples from the 2010, 2011 and 2013–2016 growing seasons were analysed for...

Differential sensitivity among Puccinia striiformis f. sp. tritici isolates to propiconazole and pyraclostrobin fungicides

Zhanhai Kang, ZHANHAI KANG, Xing Li, XING LI, Anmin Wan, ANMIN WAN, Meinan Wang, MEINAN WANG, Xianming Chen & XIANMING CHEN
Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a destructive disease of wheat in the USA and fungicides have been used to manage the disease. However, it is not clear whether Pst has developed resistance to the commonly used fungicides. In this study, historical and recent Pst isolates were tested for sensitivity to Tilt, a propiconazole demethylation inhibitor fungicide, and Headline, a pyraclostrobin quinone outside inhibitor fungicide. Both Tilt and Headline at...

Pathovar specific molecular detection of Xanthomonas campestris pv. campestris, the causal agent of black rot disease in cabbage

Mehede H. Rubel, MEHEDE H. RUBEL, Sathishkumar Natarajan, SATHISHKUMAR NATARAJAN, Mohammad R. Hossain, MOHAMMAD R. HOSSAIN, Ujjal K. Nath, UJJAL K. NATH, Khandker S. Afrin, KHANDKER S. AFRIN, Ji-Hee Lee, JI-HEE LEE, Hee-Jeong Jung, HEE-JEONG JUNG, Hoy-Taek Kim, HOY-TAEK KIM, Jong-In Park, JONG-IN PARK, Ill-Sup Nou & ILL-SUP NOU
Various pathovars (pv.) of Xanthomonas campestris (Xc) are prevalent in South Korea, of which pv. campestris causing black rot threatens the production of cabbage in this major cabbage producing country of the world. Rapid and sensitive detection of the pathovar is an essential prerequisite for any plant protection programme. This study took an approach of re-aligning the whole genome sequences (upon availability) of representative strains of the bacteria and identified pathovar-specific genomic regions that are...

Pathovar specific molecular detection of Xanthomonas campestris pv. campestris, the causal agent of black rot disease in cabbage

Mehede H. Rubel, Sathishkumar Natarajan, Mohammad R. Hossain, Ujjal K. Nath, Khandker S. Afrin, Ji-Hee Lee, Hee-Jeong Jung, Hoy-Taek Kim, Jong-In Park & Ill-Sup Nou
Various pathovars (pv.) of Xanthomonas campestris (Xc) are prevalent in South Korea, of which pv. campestris causing black rot threatens the production of cabbage in this major cabbage producing country of the world. Rapid and sensitive detection of the pathovar is an essential prerequisite for any plant protection programme. This study took an approach of re-aligning the whole genome sequences (upon availability) of representative strains of the bacteria and identified pathovar-specific genomic regions that are...

Fusarium and Alternaria mycotoxins present in Canadian wheat and durum harvest samples

Sheryl A. Tittlemier, Richard Blagden, Jason Chan, Don Gaba, Twylla Mckendry, Kerri Pleskach & Mike Roscoe
The objectives of this work were to investigate the presence of a variety of mycotoxins in Canadian wheat and durum and to characterize the relationship between concentrations of the Fusarium-produced deoxynivalenol (DON) and the presence of visible Fusarium damage. There is a lack of reported mycotoxin surveillance data for Canadian wheat and durum; this work addresses this information gap. Wheat and durum harvest samples from the 2010, 2011 and 2013–2016 growing seasons were analysed for...

Pathovar specific molecular detection of Xanthomonas campestris pv. campestris, the causal agent of black rot disease in cabbage

Mehede H. Rubel, MEHEDE H. RUBEL, Sathishkumar Natarajan, SATHISHKUMAR NATARAJAN, Mohammad R. Hossain, MOHAMMAD R. HOSSAIN, Ujjal K. Nath, UJJAL K. NATH, Khandker S. Afrin, KHANDKER S. AFRIN, Ji-Hee Lee, JI-HEE LEE, Hee-Jeong Jung, HEE-JEONG JUNG, Hoy-Taek Kim, HOY-TAEK KIM, Jong-In Park, JONG-IN PARK, Ill-Sup Nou & ILL-SUP NOU
Various pathovars (pv.) of Xanthomonas campestris (Xc) are prevalent in South Korea, of which pv. campestris causing black rot threatens the production of cabbage in this major cabbage producing country of the world. Rapid and sensitive detection of the pathovar is an essential prerequisite for any plant protection programme. This study took an approach of re-aligning the whole genome sequences (upon availability) of representative strains of the bacteria and identified pathovar-specific genomic regions that are...

Chemical Investigation Of Secondary Metabolites Produced By Mangrove Endophytic Fungus Phyllosticta Capitalensis

Zhiyong Xu, Bingxue Xiong & Jing Xu
Chemical investigation of endophytic fungus Phyllosticta capitalensis, isolated from the hypocotyls of the Chinese mangrove Bruguiera sexangula led to the isolation of eight known secondary metabolites, including four meroterpenes guignardone A (1), 12-hydroxylated guignardone A (2), guignardone J (3), guignardone M (4), and four polyketides xenofuranone B (5), 6,8-dihydroxy-5-methoxy-3-methyl-1H-isochromen-1-one (6), regiolone (7), 3,4-dihydroxybenzoic acid (8). Their structures were elucidated unambiguously based on the comprehensive spectroscopic analysis and comparison with literature data. This is the first...

Chemical Investigation Of Secondary Metabolites Produced By Mangrove Endophytic Fungus Phyllosticta Capitalensis

Zhiyong Xu, Bingxue Xiong & Jing Xu
Chemical investigation of endophytic fungus Phyllosticta capitalensis, isolated from the hypocotyls of the Chinese mangrove Bruguiera sexangula led to the isolation of eight known secondary metabolites, including four meroterpenes guignardone A (1), 12-hydroxylated guignardone A (2), guignardone J (3), guignardone M (4), and four polyketides xenofuranone B (5), 6,8-dihydroxy-5-methoxy-3-methyl-1H-isochromen-1-one (6), regiolone (7), 3,4-dihydroxybenzoic acid (8). Their structures were elucidated unambiguously based on the comprehensive spectroscopic analysis and comparison with literature data. This is the first...

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