88,778 Works

Structures of nucleic acid-active agents incorporated in the study

Kevin B. Turner, Nathan A. Hagan & Daniele Fabris
Copyright information:Taken from "Inhibitory effects of archetypical nucleic acid ligands on the interactions of HIV-1 nucleocapsid protein with elements of Ψ-RNA"Nucleic Acids Research 2006;34(5):1305-1316.Published online 6 Mar 2006PMCID:PMC1390681.© The Author 2006. Published by Oxford University Press. All rights reserved Intercalators included: () ethidium bromide; () acridine; () tetracycline R = H; chlorotetracycline R = Cl. Mixed-mode binders included: () mitoxantrone; () daunomycin. Minor groove-binders included: () Hoechst33258 R = OH; Hoechst 33342 R = OEt;...

Association between BAFF -871 T/C polymorphism and BAFF mRNAin 40 patients with pSS

Jacques-Eric Gottenberg, Jérémie Sellam, Marc Ittah, Frédéric Lavie, Alexis Proust, Habib Zouali, Christelle Sordet, Jean Sibilia, Robert P Kimberly, Xavier Mariette & Corinne Miceli-Richard
Copyright information:Taken from "No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren's syndrome"Arthritis Research & Therapy 2006;8(1):R30-R30.Published online 9 Jan 2006PMCID:PMC1526574. Bars represent median levels of BAFF mRNA. BAFF = B-cell-activating factor; pSS, primary Sjögren's syndrome.

Malarial pigment haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes-6

Oleksii A Skorokhod, Evelin Schwarzer, Monica Ceretto & Paolo Arese
Copyright information:Taken from "Malarial pigment haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes"http://www.malariajournal.com/content/6/1/73Malaria Journal 2007;6():73-73.Published online 2 Jun 2007PMCID:PMC1904226.d probed with anti-JAK-2 in Western blot. One representative experiments out of 3 with similar results.

Evaluation of proteoglycan loss in human tumour necrosis factor transgenic (hTNFtg) and hTNFtg mice

Marcus Köller, Silvia Hayer, Kurt Redlich, Romeo Ricci, Jean-Pierre David, Günter Steiner, Josef S Smolen, Erwin F Wagner & Georg Schett
Copyright information:Taken from "JNK1 is not essential for TNF-mediated joint disease"Arthritis Research & Therapy 2004;7(1):R166-R173.Published online 7 Dec 2004PMCID:PMC1064897.Copyright © 2004 Köller et al.; licensee BioMed Central Ltd. As shown by toluidine blue staining , arthritis leads to loss of proteoglycan (arrows) in the cartilage of hTNFtg and intercrossed hTNFtg mice (magnification 100×). The area of early cartilage damage was similar in the two groups with arthritis, whereas the joints of wild-type (wt) and JNK1...

Discretization of the coordinate probability distribution in one dimension

Vadim Alexandrov & Mark Gerstein
Copyright information:Taken from "Using 3D Hidden Markov Models that explicitly represent spatial coordinates to model and compare protein structures"BMC Bioinformatics 2004;5():2-2.Published online 9 Jan 2004PMCID:PMC344530.Copyright © 2004 Alexandrov and Gerstein; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

Quantification of micro-dystrophin protein expression

Louise R Rodino-Klapac, Paul ML Janssen, Chrystal L Montgomery, Brian D Coley, Louis G Chicoine, K Reed Clark & Jerry R Mendell
Copyright information:Taken from "A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure for treatment of Duchenne muscular dystrophy"http://www.translational-medicine.com/content/5/1/45Journal of Translational Medicine 2007;5():45-45.Published online 24 Sep 2007PMCID:PMC2082019. Micro-dystrophin distribution in muscle sections (4, 8, 12) weeks was quantified by visual fiber counts (images from 4 random fields) of the number of positive fibers/total fibers and represented as a percent mean ± SEM (n = 4–8 per group).

Alignment of the sea urchin () tRNA for asparagine and the corresponding region of the Amphi-Alu element

Linda Z. Holland
Copyright information:Taken from "A SINE in the genome of the cephalochordate amphioxus is an Alu element"International Journal of Biological Sciences 2006;2(2):61-65.Published online 10 Apr 2006PMCID:PMC1458429.© Ivyspring International Publisher. This is an open access article. Reproduction is permitted for personal and noncommerical use, provided that the article is in whole, unmodified, and properly cited. The regions with high identity to the A and B binding sites for RNA polymerase III are boxed.

Three-dimensional matrix of numbers representing stimulus qualities, where each element is similar to its neighbors in proportion to their Euclidean distance

Thomas A Cleland & Praveen Sethupathy
Copyright information:Taken from "Non-topographical contrast enhancement in the olfactory bulb"BMC Neuroscience 2006;7():7-7.Published online 24 Jan 2006PMCID:PMC1368991.Copyright © 2006 Cleland and Sethupathy; licensee BioMed Central Ltd. For clarity, each digit identifies the location of an element in one of these dimensions; hence, the element is at the center of the 5 × 5 × 5 cube depicted. The same three-dimensional matrix as in A, projected onto one dimension and only partially depicted. The six nearest neighbors...

Y-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspective-3

Alexandra Rosa, Carolina Ornelas, Mark A Jobling, António Brehm & Richard Villems
Copyright information:Taken from "Y-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspective"http://www.biomedcentral.com/1471-2148/7/124BMC Evolutionary Biology 2007;7():124-124.Published online 27 Jul 2007PMCID:PMC1976131.nclature and defining mutations assayed in this study, shown along the branches of the phylogeny, are as proposed by the YCC [60]. The bold link indicates the root, determined by comparisons with primates [2,79].

Sequence and structure of MSP1a tandem repeats in the Zaria isolate of

Zorica Zivkovic, Ard M Nijhof, José De La Fuente, Katherine M Kocan & Frans Jongejan
Copyright information:Taken from "Experimental transmission of by male "http://www.biomedcentral.com/1746-6148/3/32BMC Veterinary Research 2007;3():32-32.Published online 30 Nov 2007PMCID:PMC2217534. (A) The one letter amino acid code was used to depict the different sequences found in MSP1a repeats. Asterisks indicate identical amino acids and gaps indicate deletions/insertions with respect to the reference repeat A. (B) The structure of the MSP1a repeats region was represented using the repeat forms described in (A). Description of MSP1a repeats was updated after de...

SmpB binds the 30S and the 50S subunits in 70S ribosomes and SmpB is released from the 50S by tmRNA upon 70S dissociation

Marc Hallier, Jessie Desreac & Brice Felden
Copyright information:Taken from "Small protein B interacts with the large and the small subunits of a stalled ribosome during -translation"Nucleic Acids Research 2006;34(6):1935-1943.Published online 12 Apr 2006PMCID:PMC1435831.© The Author 2006. Published by Oxford University Press. All rights reserved () Analysis of SmpB (lanes 1 and 2), tmRNA (lanes 3 and 4) and ribosomal 16S RNA (lanes 5 and 6) levels in purified 70S-SmpB (lanes 2, 4 and 6) or 70S-SmpB-tmRNA (lanes 1, 3 and 5)...

Cytotoxic effects of indole–CBI conjugated Py–Im polyamides

Ken-Ichi Shinohara, Shunta Sasaki, Masafumi Minoshima, Toshikazu Bando & Hiroshi Sugiyama
Copyright information:Taken from "Alkylation of template strand of coding region causes effective gene silencing"Nucleic Acids Research 2006;34(4):1189-1195.Published online 25 Feb 2006PMCID:PMC1383623.© The Author 2006. Published by Oxford University Press. All rights reserved HCT116 cells were treated with Indole–CBI conjugated Py–Im polyamides containing 0.1% DMF for 24 h. After treatment, cell viability was determined by colorimetric assay using WST-8 and estimated by comparison with untreated control as 100%. White, gray and black blocks indicate the treatment...

Comments on the biology, systematics and distribution of Scoliocentra (Leriola) nigrinervis (WAHLGREN, 1918) in Poland and Europe (Diptera: Heleomyzidae)

Soszyńska-Maj Agnieszka & Andrzej Jozef Woznica
New records of Scoliocentra (Leriola) nigrinervis (Wahlgren, 1918) from the snow in Poland and Romania are given; geographical distribution and biology of the species are annotated. Based on the material examined, the species is compared with other European Scoliocentra of the nigrinervis species group, and the systematic position and diagnostic characters of adults are illustrated and discussed. A key to European species of the subgenus Leriola is also given.

Rabbit anti-PvDBPII serum binding to fixed merozoite, trophozoite, and schizont (uninfected cells not shown) was confirmed by immunofluorescence microscopy

Brian T Grimberg, Rachanee Udomsangpetch, Jia Xainli, Amy McHenry, Tasanee Panichakul, Jetsumon Sattabongkot, Liwang Cui, Moses Bockarie, Chetan Chitnis, John Adams, Peter A Zimmerman & Christopher L King
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Schematic representation of the proposed processing of MDS-1

Grégory Eot-Houllier, Séverine Eon-Marchais, Didier Gasparutto & Evelyne Sage
Copyright information:Taken from "Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins"Nucleic Acids Research 2005;33(1):260-271.Published online 12 Jan 2005PMCID:PMC546153.© 2005, the authors ©

Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas-5

Kenneth A Field, Soratree Charoenthongtrakul, J Michael Bishop & Yosef Refaeli
S. The percent of viable splenocytes positive for both markers is shown for unmanipulated C57BL/6 mice (Wild-type) or mice transplanted with 10tumor cells 18 days earlier (Transplant recipient). Results from untreated mice are shown with black bars and from transplant-recipient mice treated with 1.56 mg SCH66336 by oral gavage twice daily for 3 days with shaded bars. The average and standard deviation for 4 mice in each group is shown.Copyright information:Taken from "Farnesyl transferase inhibitors...

Autocorrelation analysis reveals widespread spatial biases in microarray experiments-7

Amnon Koren, Itay Tirosh & Naama Barkai
Copyright information:Taken from "Autocorrelation analysis reveals widespread spatial biases in microarray experiments"http://www.biomedcentral.com/1471-2164/8/164BMC Genomics 2007;8():164-164.Published online 12 Jun 2007PMCID:PMC1913520.oarray is from Spellman 1998 [27], and the Affymetrix YE6100 is from Cho 1998 [24]. Labeled cDNA prepared form the same RNA source of cells traversing the cell cycle was hybridized onto UHN and UMC microarrays. Despite the similar, or identical, underlying biology, the autocorrelation periods are different and reminiscent of each microarray design. Thus, the characteristic period...

Conventional HLA immunohistochemistry of formalin-fixed paraffin-embedded tissue

Jan Willem F Dierssen, Noel FCC De Miranda, Arend Mulder, Marjo Van Puijenbroek, Willem Verduyn, Frans HJ Claas, Cornelis JH Van De Velde, Gert Jan Fleuren, Cees J Cornelisse, Willem E Corver & Hans Morreau
Copyright information:Taken from "High-resolution analysis of HLA class I alterations in colorectal cancer"BMC Cancer 2006;6():233-233.Published online 2 Oct 2006PMCID:PMC1599746. Using HCA2 (HLA-A heavy chain), HC10 (HLA-B/C heavy chain) and anti-B2M antibodies, loss of HLA A and B expression as detected by flow cytometry (see Figures 1 and 2) could be confirmed. In the top panel, membranous staining (arrows) of B2M, HCA2, and HC10 is observed in the moderately differentiated sigmoid adenocarcinoma of case 122. In...

Effect of lipopolysaccharide (LPS) on ileal mucosal O consumption

Mitchell P Fink
Copyright information:Taken from "Bench-to-bedside review: Cytopathic hypoxia"Critical Care 2002;6(6):491-499.Published online 12 Sep 2002PMCID:PMC153437.Copyright © 2002 BioMed Central Ltd Rats in the NS/NS group were injected at = 0 hours with normal saline (NS) and were treated with NS. Rats in the LPS/NS group were injected with LPS (5 mg/kg) at = 0 hours and were treated with NS. Rats in the LPS/AG group were challenged with the same dose of LPS and treated with aminoguanidine...

TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells-0

Silke Kaske, Gabriele Krasteva, Peter König, Wolfgang Kummer, Thomas Hofmann, Thomas Gudermann & Vladimir Chubanov
Copyright information:Taken from "TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells"http://www.biomedcentral.com/1471-2202/8/49BMC Neuroscience 2007;8():49-49.Published online 4 Jul 2007PMCID:PMC1931605. lysates of mock- (line 1), TRPM5- (line 2) and YFP-TRPM5- (line 3) transfected HEK 293 cells. Positions of TRPM5- and YFP-TRPM5-specific bands are indicated by arrowheads. () Overlay of confocal and corresponding differential interference contrast (DIC) images of immunofluorescence staining of HEK 293 cells transiently expressing wild-type TRPM5. () Immunohistochemistry of...

Observed and recalculated survival distribution functions of genomic occurrences of protein topologies (a) and domains (b) among all the studied genomes combined

Artem Cherkasov, Shannan J Ho Sui, Robert C Brunham & Steven JM Jones
Copyright information:Taken from "Structural characterization of genomes by large scale sequence-structure threading: application of reliability analysis in structural genomics"BMC Bioinformatics 2004;5():101-101.Published online 26 Jul 2004PMCID:PMC499543.Copyright © 2004 Cherkasov et al; licensee BioMed Central Ltd.

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