50,613 Works

The space-soup theory of life: Tiny primordial soups on interstellar dust

Alexandre Harvey-Tremblay
In the abiogenesis hypothesis, self-replicating RNA is generally assumed to have arisen out of a primordial soup of amino acids no later than 500 million years before life on Earth. Prebiotic molecules such as glycolaldehyde and amino acetonitrile are found to be abundant in nebulas such as Sagittarius B2. In this paper I show how icy grains within nebulas can act as tiny primordial soups. I further show that a typical nebula would be 1011...

Dataset 'Fixed muscle synergies and their potential to improve the intuitive control of myoelectric assistive technology for upper extremities.'

Tim A. Valk, Leonora J. Mouton, Egbert Otten & Raoul M. Bongers
Data set on which conclusions of Valk et al. (2019): 'Fixed muscle synergies and their potential to improve the intuitive control of myoelectric assistive technology for upper extremities.' are based.

Dataset 'Fixed muscle synergies and their potential to improve the intuitive control of myoelectric assistive technology for upper extremities.'

Tim Valk
Data set on which conclusions of Valk et al., (2018): 'Fixed muscle synergies and their potential to improve the intuitive control of myoelectric assistive technology for upper extremities.' are based.

Dataset 'Fixed muscle synergies and their potential to improve the intuitive control of myoelectric assistive technology for upper extremities.'

Tim Valk
Data set on which conclusions of Valk et al., (2018): 'Fixed muscle synergies and their potential to improve the intuitive control of myoelectric assistive technology for upper extremities.' are based.

Media perceptions of Tommy John surgery

Stan A. Conte, Justin L. Hodgins, Neal S. ElAttrache, Nancy Patterson-Flynn & Christopher S. Ahmad

Manchester Fly Facility Resources

Man Fly
These resources were made available by the Manchester Fly Facility (see link below)

Uso de altmetrics para avaliação de periódicos científicos brasileiros em Ciência da Informação

Andrea Nascimento & Nanci Oddone
Explora a aplicação de métricas alternativas para avaliação de periódicos científicos brasileiros na área de Ciência da Informação. Empregando a ferramenta Altmetric Explorer, identifica as citações recebidas pelos artigos publicados nos periódicos da área no período de 2011 a 2015. Os resultados encontrados demonstram que ainda são poucos os periódicos científicos brasileiros na área de Ciência da Informação para os quais é possível gerar métricas alternativas de citação. No entanto, dentro desse reduzido universo, observou-se...

MALAT1 functions as a competing endogenous RNA to mediate Rac1 expression by sequestering miR-101b in liver fibrosis

Fujun Yu, Zhongqiu Lu, Jing Cai, Kate Huang, Bicheng Chen, Guojun Li, Peihong Dong & Jianjian Zheng
Emerging evidence shows that Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a pivotal role in cell proliferation, migration, and invasion in tumors. However, the biological role and underlying mechanism of MALAT1 in liver fibrosis remains undefined. In this study, up-regulation of MALAT1 was observed in fibrotic liver tissues and in activated hepatic stellate cells (HSCs). In addition, depletion of MALAT1 inhibited the activation of HSCs in vitro and attenuated collagen deposits in vivo. Our results...

A DDB2 mutant protein unable to interact with PCNA promotes cell cycle progression of human transformed embryonic kidney cells

Paola Perucca, Sabrina Sommatis, Roberto Mocchi, Ennio Prosperi, Lucia Anna Stivala & Ornella Cazzalini
DNA damage binding protein 2 (DDB2) is a protein involved in the early step of DNA damage recognition of the nucleotide excision repair (NER) process. Recently, it has been suggested that DDB2 may play a role in DNA replication, based on its ability to promote cell proliferation. We have previously shown that DDB2 binds PCNA during NER, but also in the absence of DNA damage; however, whether and how this interaction influences cell proliferation is...

DEK over-expression promotes mitotic defects and micronucleus formation

Marie C Matrka, Robert F Hennigan, Ferdinand Kappes, Monica L DeLay, Paul F Lambert, Bruce J Aronow & Susanne I Wells
The DEK gene encodes a nuclear protein that binds chromatin and is involved in various fundamental nuclear processes including transcription, RNA splicing, DNA replication and DNA repair. Several cancer types characteristically over-express DEK at the earliest stages of transformation. In order to explore relevant mechanisms whereby DEK supports oncogenicity, we utilized cancer databases to identify gene transcripts whose expression patterns are tightly correlated with that of DEK. We identified an enrichment of genes involved in...

ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex

Zhe Yang, Qiao Zhang, Qin Lu, Zhuqing Jia, Ping Chen, Kangtao Ma, Weiping Wang & Chunyan Zhou
Islet-1 (ISL-1), a LIM-homeodomain transcription factor, has been recently found to be essential for promoting postnatal pancreatic islet proliferation. However, the detailed mechanism has not yet been elucidated. In the present study, we investigated the mechanism by which ISL-1 promotes β-cell proliferation through regulation of CyclinD1 in HIT-T15 and NIT-1 cells, as well in rat islet mass. Our results provide the evidence that ISL-1 promotes adult pancreatic islet β-cell proliferation by activating CyclinD1 transcription through...

SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A–B56

Wing Ki Wong, Terrenz Kelly, Jingjing Li, Hoi Tang Ma & Randy YC Poon
Shugoshin (SGO1) plays a pivotal role in sister chromatid cohesion during mitosis by protecting the centromeric cohesin from mitotic kinases and WAPL. Mammalian cells contain at least 6 alternatively spliced isoforms of SGO1. The relationship between the canonical SGO1A with shorter isoforms including SGO1C remains obscure. Here we show that SGO1C was unable to replace the loss of SGO1A. Instead, expression of SGO1C alone induced aberrant mitosis similar to depletion of SGO1A, promoting premature sister...

Gamma-actin is involved in regulating centrosome function and mitotic progression in cancer cells

Sela T Po‘Uha & Maria Kavallaris
Reorganization of the actin cytoskeleton during mitosis is crucial for regulating cell division. A functional role for γ-actin in mitotic arrest induced by the microtubule-targeted agent, paclitaxel, has recently been demonstrated. We hypothesized that γ-actin plays a role in mitosis. Herein, we investigated the effect of γ-actin in mitosis and demonstrated that γ-actin is important in the distribution of β-actin and formation of actin-rich retraction fibers during mitosis. The reduced ability of paclitaxel to induce...

Phosphorylation of Xenopus p31comet potentiates mitotic checkpoint exit

Min Mo, Alexei Arnaoutov & Mary Dasso
p31comet plays an important role in spindle assembly checkpoint (SAC) silencing. However, how p31comet's activity is regulated remains unclear. Here we show that the timing of M-phase exit in Xenopus egg extracts (XEEs) depends upon SAC activity, even under conditions that are permissive for spindle assembly. p31comet antagonizes the SAC, promoting XEE progression into anaphase after spindles are fully formed. We further show that mitotic p31comet phosphorylation by Inhibitor of nuclear factor κ-B kinase-β (IKK-β)...

Rev7/Mad2B plays a critical role in the assembly of a functional mitotic spindle

Audesh Bhat, Zhaojia Wu, Veronica M Maher, J Justin McCormick & Wei Xiao
The spindle assembly checkpoint (SAC) acts as a guardian against cellular threats that may lead to chromosomal missegregation and aneuploidy. Mad2, an anaphase-promoting complex/cyclosome-Cdc20 (APC/CCdc20) inhibitor, has an additional homolog in mammals known as Mad2B, Mad2L2 or Rev7. Apart from its role in Polζ-mediated translesion DNA synthesis and double-strand break repair, Rev7 is also believed to inhibit APC/C by negatively regulating Cdh1. Here we report yet another function of Rev7 in cultured human cells. Rev7,...

Micro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance

Yuko Takeda & Ashok R Venkitaraman
The DNA damage response (DDR) triggers widespread changes in gene expression, mediated partly by alterations in micro(mi) RNA levels, whose nature and significance remain uncertain. Here, we report that miR-34a, which is upregulated during the DDR, modulates the expression of protein phosphatase 1γ (PP1γ) to regulate cellular tolerance to DNA damage. Multiple bio-informatic algorithms predict that miR-34a targets the PP1CCC gene encoding PP1γ protein. Ionising radiation (IR) decreases cellular expression of PP1γ in a dose-dependent...

Erk5 contributes to maintaining the balance of cellular nucleotide levels and erythropoiesis

Maria Angulo-Ibáñez, Xavier Rovira-Clavé, Alba Granados-Jaén, Bradley Downs, Yeong C Kim, San Ming Wang, Manuel Reina & Enric Espel
An adequate supply of nucleotides is essential for accurate DNA replication, and inappropriate deoxyribonucleotide triphosphate (dNTP) concentrations can lead to replication stress, a common source of DNA damage, genomic instability and tumourigenesis. Here, we provide evidence that Erk5 is necessary for correct nucleotide supply during erythroid development. Mice with Erk5 knockout in the haematopoietic lineage showed impaired erythroid development in bone marrow, accompanied by altered dNTP levels and increased DNA mutagenesis in erythroid progenitors as...

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