260,579 Works

Small-mammal indicators of biochronology at Cueva Negra del Estrecho del Río Quípar (Caravaca de la Cruz, Murcia, SE Spain)

Antonio López Jiménez, María Haber Uriarte, Mariano López Martínez & Michael John Walker
Abundant small-mammal teeth excavated at the Palaeolithic site of Cueva Negra del Estrecho del Río Quípar have morphological and metric characteristics that are shown to correspond to Iberomys huescarensis, Stenocranius gregaloides, Terricola arvalidens, Victoriamys chalinei, Mimomys savini, Pliomys episcopalis, Crictetulus (Allocricetus) bursae, Apodemus cf. sylvaticus, Eliomys quercinus, Sciurus sp., Oryctolagus giberti, Lepus sp., Prolagus calpensis, Crocidura kornfeldi, Neomys sp., Sorex sp., Erinaceus cf. europaeus). These taxa have been described in the late Early Pleistocene of...

Fourier analysis applied to Cricetodon and Hispanomys (Rodentia, Mammalia): its use as a taxonomical criterion

Patricia María Carro-Rodríguez, Paloma López-Guerrero & Mª Ángeles Álvarez-Sierra
Cricetodon and Hispanomys are two extinct rodent genera belonging to the same tribe. Cricetodon presents generally a more primitive morphology than Hispanomys. However, they share some traits and some species present a combination of primitive and derived characters (called mosaic morphological pattern) that difficult assessing the evolutionary stage of the species or their attribution into a genus. Fourier Shape Analysis, a geometric morphometrics method, is used to quantify the outline form of the upper first...

Fourier analysis applied to Cricetodon and Hispanomys (Rodentia, Mammalia): its use as a taxonomical criterion

Patricia María Carro-Rodríguez, Paloma López-Guerrero & Mª Ángeles Álvarez-Sierra
Cricetodon and Hispanomys are two extinct rodent genera belonging to the same tribe. Cricetodon presents generally a more primitive morphology than Hispanomys. However, they share some traits and some species present a combination of primitive and derived characters (called mosaic morphological pattern) that difficult assessing the evolutionary stage of the species or their attribution into a genus. Fourier Shape Analysis, a geometric morphometrics method, is used to quantify the outline form of the upper first...

Small-mammal indicators of biochronology at Cueva Negra del Estrecho del Río Quípar (Caravaca de la Cruz, Murcia, SE Spain)

Antonio López Jiménez, María Haber Uriarte, Mariano López Martínez & Michael John Walker
Abundant small-mammal teeth excavated at the Palaeolithic site of Cueva Negra del Estrecho del Río Quípar have morphological and metric characteristics that are shown to correspond to Iberomys huescarensis, Stenocranius gregaloides, Terricola arvalidens, Victoriamys chalinei, Mimomys savini, Pliomys episcopalis, Crictetulus (Allocricetus) bursae, Apodemus cf. sylvaticus, Eliomys quercinus, Sciurus sp., Oryctolagus giberti, Lepus sp., Prolagus calpensis, Crocidura kornfeldi, Neomys sp., Sorex sp., Erinaceus cf. europaeus). These taxa have been described in the late Early Pleistocene of...

Monopole magnets, and the method of separating north and south poles of a magnet

Rick Smith
The method of creating a monopole magnet, and the method of separating north and south poles of a magnet, and applications of monopole magnets are explains in detail in this paper.

Research on monopole magnet and its application

Rick Smith
The method to create a monopolonopole magnetmagnet, and applicationapplications of monopole magnet magnets are explains in detail in t this paperpaper.

COCI CSV dataset of all the citation data

OpenCitations ​
This dataset contains all the citation data (in CSV format) included in COCI, released on the 12th of November 2018. In particular, each line of the CSV file defines a citation, and includes the following information:[field "oci"] the Open Citation Identifier (OCI) for the citation;[field "citing"] the DOI of the citing entity;[field "cited"] the DOI of the cited entity;[field "creation"] the creation date of the citation (i.e. the publication date of the citing entity);[field "timespan"]...

COCI CSV dataset of all the citation data

OpenCitations ​
This dataset contains all the citation data (in CSV format) included in COCI, released on the 21st of January 2020. In particular, each line of the CSV file defines a citation, and includes the following information:[field "oci"] the Open Citation Identifier (OCI) for the citation;[field "citing"] the DOI of the citing entity;[field "cited"] the DOI of the cited entity;[field "creation"] the creation date of the citation (i.e. the publication date of the citing entity);[field "timespan"]...

COCI CSV dataset of the provenance information of all the citation data

OpenCitations ​
This dataset contains the provenance information (in CSV format) of all the citation data included in COCI, released on the 12th of November 2018. In particular, each line of the CSV file defines a citation, and includes the following information:[field "oci"] the Open Citation Identifier (OCI) for the citation;[field "agent"] the name of the agent that have created the citation data;[field "source"] the URL of the source dataset from where the citation data have been...

COCI CSV dataset of the provenance information of all the citation data

OpenCitations ​
This dataset contains the provenance information (in CSV format) of all the citation data included in COCI, released on the 21st of January 2020. In particular, each line of the CSV file defines a citation, and includes the following information:[field "oci"] the Open Citation Identifier (OCI) for the citation;[field "agent"] the name of the agent that have created the citation data;[field "source"] the URL of the source dataset from where the citation data have been...

COCI N-Triples dataset of all the citation data

OpenCitations ​
This dataset contains all the citation data (in N-Triples format) included in COCI, released on the 12th of November 2018. In particular, any citation in the dataset, defined as an individual of the class cito:Citation, includes the following information:[citation IRI] the Open Citation Identifier (OCI) for the citation, defined in the final part of the URL identifying the citation (https://w3id.org/oc/index/coci/ci/[OCI]);[property "cito:hasCitingEntity"] the citing entity identified by its DOI URL (http://dx.doi.org/[DOI]);[property "cito:hasCitedEntity"] the cited entity identified...

COCI N-Triples dataset of all the citation data

OpenCitations ​
This dataset contains all the citation data (in N-Triples format) included in COCI, released on the 21st of January 2020. In particular, any citation in the dataset, defined as an individual of the class cito:Citation, includes the following information:[citation IRI] the Open Citation Identifier (OCI) for the citation, defined in the final part of the URL identifying the citation (https://w3id.org/oc/index/coci/ci/[OCI]);[property "cito:hasCitingEntity"] the citing entity identified by its DOI URL (http://dx.doi.org/[DOI]);[property "cito:hasCitedEntity"] the cited entity identified...

COCI N-Triples dataset of the provenance information of all the citation data

OpenCitations ​
This dataset contains the provenance information (in N-Triples format) of all the citation data included in COCI, released on the 12th of November 2018. In particular, any citation in the dataset includes the following provenance information:[citation IRI] the Open Citation Identifier (OCI) for the citation, defined in the final part of the URL identifying the citation (https://w3id.org/oc/index/coci/ci/[OCI]);;[property "prov:wasAttributedTo"] the IRI of the agent that have created the citation data;[property "prov:hadPrimarySource"] the IRI of the source...

COCI N-Triples dataset of the provenance information of all the citation data

OpenCitations ​
This dataset contains the provenance information (in N-Triples format) of all the citation data included in COCI, released on the 21st of January 2020. In particular, any citation in the dataset includes the following provenance information:[citation IRI] the Open Citation Identifier (OCI) for the citation, defined in the final part of the URL identifying the citation (https://w3id.org/oc/index/coci/ci/[OCI]);;[property "prov:wasAttributedTo"] the IRI of the agent that have created the citation data;[property "prov:hadPrimarySource"] the IRI of the source...

A negative feedback regulation of MTORC1 activity by the lysosomal Ca2+ channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism

Xue Sun, Yiming Yang, Xi Zoë Zhong, Qi Cao, Xin-Hong Zhu, Xiaojuan Zhu & Xian-Ping Dong
Macroautophagy/autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. The lysosome plays an essential role in autophagy regulation. For example, the activity of MTORC1, a master regulator of autophagy, is regulated by nutrients within the lysosome. Starvation inhibits MTORC1 causing autophagy induction. Given that MTORC1 is critical for protein synthesis and cellular homeostasis, a feedback regulatory mechanism must exist to restore MTORC1 during starvation. However, the molecular mechanism underlying...

The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity

E. Piano Mortari, V. Folgiero, V. Marcellini, P. Romania, E. Bellacchio, V. D'Alicandro, C. Bocci, R. Carrozzo, D. Martinelli, S. Petrini, E. Axiotis, C. Farroni, F. Locatelli, U. Schara, D.T. Pilz, H. Jungbluth, C. Dionisi-Vici & R. Carsetti
Vici syndrome is a human inherited multi-system disorder caused by recessive mutations in EPG5, encoding the EPG5 protein that mediates the fusion of autophagosomes with lysosomes. Immunodeficiency characterized by lack of memory B cells and increased susceptibility to infection is an integral part of the condition, but the role of EPG5 in the immune system remains unknown. Here we show that EPG5 is indispensable for the transport of the TLR9 ligand CpG to the late...

Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation

Faxiang Li, Daichao Xu, Yingli Wang, Zixuan Zhou, Jianping Liu, Shichen Hu, Yukang Gong, Junying Yuan & Lifeng Pan
OPTN (optineurin), a ubiquitin-binding scaffold protein, functions as an important macroautophagy/autophagy receptor in selective autophagy processes. Mutations in OPTN have been linked with human neurodegenerative diseases including ALS and glaucoma. However, the mechanistic basis underlying the recognition of ubiquitin by OPTN and its regulation by TBK1-mediated phosphorylation are still elusive. Here, we demonstrate that the UBAN domain of OPTN preferentially recognizes linear ubiquitin chain and forms an asymmetric 2:1 stoichiometry complex with the linear diubiquitin....

Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant

Guan-Sheng Liu, Hongyan Zhu, Wen-Feng Cai, Xiaohong Wang, Min Jiang, Kobina Essandoh, Elizabeth Vafiadaki, Kobra Haghighi, Chi Keung Lam, George Gardner, George Adly, Persoulla Nicolaou, Despina Sanoudou, Qiangrong Liang, Jack Rubinstein, Guo-Chang Fan & Evangelia G. Kranias
HSPB6/Hsp20 (heat shock protein family B [small] member 6) has emerged as a novel cardioprotector against stress-induced injury. We identified a human mutant of HSPB6 (HSPB6S10F) exclusively present in dilated cardiomyopathy (DCM) patients. Cardiac expression of this mutant in mouse hearts resulted in remodeling and dysfunction, which progressed to heart failure and early death. These detrimental effects were associated with reduced interaction of mutant HSPB6S10F with BECN1/Beclin 1, leading to BECN1 ubiquitination and its proteosomal...

The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity

E. Piano Mortari, V. Folgiero, V. Marcellini, P. Romania, E. Bellacchio, V. D'Alicandro, C. Bocci, R. Carrozzo, D. Martinelli, S. Petrini, E. Axiotis, C. Farroni, F. Locatelli, U. Schara, D.T. Pilz, H. Jungbluth, C. Dionisi-Vici & R. Carsetti
Vici syndrome is a human inherited multi-system disorder caused by recessive mutations in EPG5, encoding the EPG5 protein that mediates the fusion of autophagosomes with lysosomes. Immunodeficiency characterized by lack of memory B cells and increased susceptibility to infection is an integral part of the condition, but the role of EPG5 in the immune system remains unknown. Here we show that EPG5 is indispensable for the transport of the TLR9 ligand CpG to the late...

Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation

Faxiang Li, Daichao Xu, Yingli Wang, Zixuan Zhou, Jianping Liu, Shichen Hu, Yukang Gong, Junying Yuan & Lifeng Pan
OPTN (optineurin), a ubiquitin-binding scaffold protein, functions as an important macroautophagy/autophagy receptor in selective autophagy processes. Mutations in OPTN have been linked with human neurodegenerative diseases including ALS and glaucoma. However, the mechanistic basis underlying the recognition of ubiquitin by OPTN and its regulation by TBK1-mediated phosphorylation are still elusive. Here, we demonstrate that the UBAN domain of OPTN preferentially recognizes linear ubiquitin chain and forms an asymmetric 2:1 stoichiometry complex with the linear diubiquitin....

A negative feedback regulation of MTORC1 activity by the lysosomal Ca2+ channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism

Xue Sun, Yiming Yang, Xi Zoë Zhong, Qi Cao, Xin-Hong Zhu, Xiaojuan Zhu & Xian-Ping Dong
Macroautophagy/autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. The lysosome plays an essential role in autophagy regulation. For example, the activity of MTORC1, a master regulator of autophagy, is regulated by nutrients within the lysosome. Starvation inhibits MTORC1 causing autophagy induction. Given that MTORC1 is critical for protein synthesis and cellular homeostasis, a feedback regulatory mechanism must exist to restore MTORC1 during starvation. However, the molecular mechanism underlying...

Antioxidant role of autophagy in maintaining the integrity of glomerular capillaries

Jun Matsuda, Tomoko Namba, Yoshitsugu Takabatake, Tomonori Kimura, Atsushi Takahashi, Takeshi Yamamoto, Satoshi Minami, Shinsuke Sakai, Ryuta Fujimura, Jun-Ya Kaimori, Isao Matsui, Takayuki Hamano, Yoko Fukushima, Keiko Matsui, Tomoyoshi Soga & Yoshitaka Isaka
Autophagy is a lysosomal degradation system by which cytosolic materials and damaged organelles are broken down into basic components. To explore the physiological role of autophagy in glomerular endothelial cells (GEnCs), we compared the autophagic flux among cells in the kidney under starvation. Inhibition of autophagy by chloroquine administration significantly increased the number of autophagosomes or autolysosomes in GEnCs and proximal tubular cells, but not in podocytes, suggesting that the GEnCs exhibit substantial autophagic activity....

Antioxidant role of autophagy in maintaining the integrity of glomerular capillaries

Jun Matsuda, Tomoko Namba, Yoshitsugu Takabatake, Tomonori Kimura, Atsushi Takahashi, Takeshi Yamamoto, Satoshi Minami, Shinsuke Sakai, Ryuta Fujimura, Jun-Ya Kaimori, Isao Matsui, Takayuki Hamano, Yoko Fukushima, Keiko Matsui, Tomoyoshi Soga & Yoshitaka Isaka
Autophagy is a lysosomal degradation system by which cytosolic materials and damaged organelles are broken down into basic components. To explore the physiological role of autophagy in glomerular endothelial cells (GEnCs), we compared the autophagic flux among cells in the kidney under starvation. Inhibition of autophagy by chloroquine administration significantly increased the number of autophagosomes or autolysosomes in GEnCs and proximal tubular cells, but not in podocytes, suggesting that the GEnCs exhibit substantial autophagic activity....

Soil carbon stock and Plinthosol fertility in smallholder land-use systems in the eastern Amazon, Brazil

Ceália Cristine Dos Santos, Altamiro Souza De Lima Ferraz Junior, Sandra Oliveira Sá, Jhonatan Andrés Muñoz Gutiérrez, Heder Braun, Max Sarrazin, Michel Brossard & Thierry Desjardins
The soil organic carbon (SOC) stock is an important attribute in the maintenance of ecosystem services by natural and agricultural ecosystems. In the humid tropics, slash-and-burn cultivation for food production and establishment of pastures has frequently led to soil degradation. In the eastern Brazilian Amazonia, we assessed impacts of different land-use systems on the SOC stock and some chemical properties of soils. Four land-use systems were studied: shifting cultivation (SC), pasture (PA), mixed fallow (MF)...

Soil carbon stock and Plinthosol fertility in smallholder land-use systems in the eastern Amazon, Brazil

Ceália Cristine Dos Santos, Altamiro Souza De Lima Ferraz Junior, Sandra Oliveira Sá, Jhonatan Andrés Muñoz Gutiérrez, Heder Braun, Max Sarrazin, Michel Brossard & Thierry Desjardins
The soil organic carbon (SOC) stock is an important attribute in the maintenance of ecosystem services by natural and agricultural ecosystems. In the humid tropics, slash-and-burn cultivation for food production and establishment of pastures has frequently led to soil degradation. In the eastern Brazilian Amazonia, we assessed impacts of different land-use systems on the SOC stock and some chemical properties of soils. Four land-use systems were studied: shifting cultivation (SC), pasture (PA), mixed fallow (MF)...

Registration Year

  • 2018
    260,579

Resource Types

  • Text
    91,998
  • Collection
    87,152
  • Dataset
    41,743
  • Image
    23,878
  • Audiovisual
    11,542
  • Other
    2,831
  • Software
    1,434