262,812 Works

Additional file 7: of Transcriptome-wide identification of optimal reference genes for expression analysis of Pyropia yezoensis responses to abiotic stress

Dong Gao, Fanna Kong, , &
Figure S6. Three boxplot graphs representing the pairwise differences in the gene expression values of 9 candidate reference genes under all conditions (A), dehydration stress (B) and temperature stress (C) respectively. (PDF 368 kb)

An internet-based intervention for people with psychosis (EviBaS): study protocol for a randomized controlled trial

Nina Rüegg, Steffen Moritz, Thomas Berger, Thies Lüdtke & Stefan Westermann
Abstract Background Evidence shows that internet-based self-help interventions are effective in reducing symptoms for a wide range of mental disorders. To date, online interventions treating psychotic disorders have been scarce, even though psychosis is among the most burdensome disorders worldwide. Furthermore, the implementation of cognitive-behavioral therapy (CBT) for psychosis in routine health care is challenging. Internet-based interventions could narrow this treatment gap. Thus, a comprehensive CBT-based online self-help intervention for people with psychosis has been...

ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells

Xia Kong, Pin Xu, Wei-Jie Cai, , Bin-Bin Li, Guo-Liang Huang, Zhi-Wei He, George Chen &
Abstract Background Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain. It is not clear if other GC-rich binding factors, such as Sp family members, can interact with ZBPp-89 on Bak expression. This study aims to elucidate the mechanism of Bak expression regulation by ZBP-89 and Sp proteins, based on in vitro experiment and The Cancer Genome Atlas (TCGA) hepatocellular carcinoma (HCC) data...

Additional file 16: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Wei-Hung Pan, Felix Sommer, Maren Falk-Paulsen, Thomas Ulas, Philipp Best, Antonella Fazio, , Anne Luzius, Marlene Jentzsch, , Fabian Müller, Thomas Lengauer, Jörn Walter, Sven Künzel, John Baines, Stefan Schreiber, Andre Franke, Joachim Schultze, Fredrik Bäckhed & Philip Rosenstiel
Venn diagram of differentially expressed genes (CONV-R versus GF) that also contain DMPs within a 5-kb window. (PDF 377 kb)

Additional file 17: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Wei-Hung Pan, Felix Sommer, Maren Falk-Paulsen, Thomas Ulas, Philipp Best, Antonella Fazio, , Anne Luzius, Marlene Jentzsch, , Fabian Müller, Thomas Lengauer, Jörn Walter, Sven Künzel, John Baines, Stefan Schreiber, Andre Franke, Joachim Schultze, Fredrik Bäckhed & Philip Rosenstiel
List of differentially expressed genes (CONV-R versus GF) that also contain DMPs as depicted in Additional file 13. (XLSX 45 kb)

Additional file 1: of Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer

Hai-Ning Liu, Hao Wu, , Yan-Jie Chen, , Lin Zhu, Ling Dong, & Tao-Tao Liu
Table S1. List of the included studies. (DOCX 20Â kb)

Additional file 2: of Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer

Hai-Ning Liu, Hao Wu, , Yan-Jie Chen, , Lin Zhu, Ling Dong, & Tao-Tao Liu
Table S2. Characteristics of the included studies. Abbreviations: GC, gastric cancer; NA, not available. (DOCX 23Â kb)

Additional file 4: of Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer

Hai-Ning Liu, Hao Wu, , Yan-Jie Chen, , Lin Zhu, Ling Dong, & Tao-Tao Liu
Table S3. MicroRNA expressions and the results of the statistical test. Z value was performed when Wilcoxon-Mann-Whitney test was used in the GC patients versus the control group, and t value was performed when Studentâ s t-test was used. Abbreviations: GC, gastric cancer. (DOCX 14Â kb)

Additional file 2: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Wei-Hung Pan, Felix Sommer, Maren Falk-Paulsen, Thomas Ulas, Philipp Best, Antonella Fazio, , Anne Luzius, Marlene Jentzsch, , Fabian Müller, Thomas Lengauer, Jörn Walter, Sven Künzel, John Baines, Stefan Schreiber, Andre Franke, Joachim Schultze, Fredrik Bäckhed & Philip Rosenstiel
R code used for the integrated analysis shown in Fig. 5a. (R 1 kb)

Additional file 4: of Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer

Hai-Ning Liu, Hao Wu, , Yan-Jie Chen, , Lin Zhu, Ling Dong, & Tao-Tao Liu
Table S3. MicroRNA expressions and the results of the statistical test. Z value was performed when Wilcoxon-Mann-Whitney test was used in the GC patients versus the control group, and t value was performed when Studentâ s t-test was used. Abbreviations: GC, gastric cancer. (DOCX 14Â kb)

Additional file 6: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Wei-Hung Pan, Felix Sommer, Maren Falk-Paulsen, Thomas Ulas, Philipp Best, Antonella Fazio, , Anne Luzius, Marlene Jentzsch, , Fabian Müller, Thomas Lengauer, Jörn Walter, Sven Künzel, John Baines, Stefan Schreiber, Andre Franke, Joachim Schultze, Fredrik Bäckhed & Philip Rosenstiel
Gene ontology (GO) analysis of the microbially regulated genes from each developmental stage. (XLSX 39 kb)

Additional file 7: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Wei-Hung Pan, Felix Sommer, Maren Falk-Paulsen, Thomas Ulas, Philipp Best, Antonella Fazio, , Anne Luzius, Marlene Jentzsch, , Fabian Müller, Thomas Lengauer, Jörn Walter, Sven Künzel, John Baines, Stefan Schreiber, Andre Franke, Joachim Schultze, Fredrik Bäckhed & Philip Rosenstiel
Alternative splicing analysis. a Overview of the five categories of alternative splicing (skipped exon, alternative 5′ splice site, alternative 3′ splice site, mutually exclusive exons, and retained intron) as analyzed by the rMATS program. b Pie charts of the relative composition of alternative splicing events in each sample group. The relative composition patterns of alternative splicing do not differ significantly among the groups. c Count of significantly different (CONV-R versus GF, p

Additional file 8: of Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Wei-Hung Pan, Felix Sommer, Maren Falk-Paulsen, Thomas Ulas, Philipp Best, Antonella Fazio, , Anne Luzius, Marlene Jentzsch, , Fabian Müller, Thomas Lengauer, Jörn Walter, Sven Künzel, John Baines, Stefan Schreiber, Andre Franke, Joachim Schultze, Fredrik Bäckhed & Philip Rosenstiel
Alternative splicing events (total and only significant events in CONV-R versus GF) in the three developmental stages. (XLSX 9 kb)

流速流向

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Additional file 2: Figure S1. of A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling

Edward Ballister, Jessica Rodgers, Franck Martial & Robert Lucas
Pertussis toxin, GsX point mutations, and comparison to JellyOp. a–c HEK293T cells transfected with Glo22F and rod opsin were treated with or without pertussis toxin (PTX) as indicated. Forskolin was added to elevate cAMP after 5 mins, and cells were flashed with light at varying intensities at 33 mins. The signal for each trial was normalized to pre-flash and the minimum cAMP post-flash was recorded for each trial. a,b Time courses of the GloSensor cAMP...

Additional file 6: Figure S4. of A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein eqFP578

Yi Shen, Hod Dana, Ahmed Abdelfattah, Ronak Patel, , Rosana Molina, , Vladimir Rancic, Yu-Fen Chang, , , Yong Qian, Matthew Wiens, Nathan Hambleton, Klaus Ballanyi, Thomas Hughes, Mikhail Drobizhev, Douglas Kim, Minoru Koyama, Eric Schreiter & Robert Campbell
K-GECO1 expression patterns in zebrafish Rohonâ Beard (RB) cells. a Schematic view of the image window. b Representative images of K-GECO1 expression in RB cells. c Representative images of jRGECO1a (with NES) expression in RB cells. (TIF 1782 kb)

MOESM2 of Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response

Kenta Iijima, Junya Kobayashi &
Additional file 2: Figure S2. The interaction between Vpr and RPA70 (a) or T4gp32 (b) was not detected. a FLAG-Strep-Vpr (0.1, 0.317. 1.0 pmol) was incubated with rRPA70 (1.0 pmol), and pulled-down with Streptavidine M280 beads. Proteins were analysed by WB with indicated antibodies. b FLAG-Strep-Vpr (1, 3.17, 10 pmol) was incubated with T4gp32 (100 pmol), and pulled-down with Streptavidine M280 beads. Proteins were visualized by Oriole fluorescent gel staining.

Additional file 9: of A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein eqFP578

Yi Shen, Hod Dana, Ahmed Abdelfattah, Ronak Patel, , Rosana Molina, , Vladimir Rancic, Yu-Fen Chang, , , Yong Qian, Matthew Wiens, Nathan Hambleton, Klaus Ballanyi, Thomas Hughes, Mikhail Drobizhev, Douglas Kim, Minoru Koyama, Eric Schreiter & Robert Campbell
Numeric data for Fig. 3a,b. (XLSX 86 kb)

A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling

Edward Ballister, Jessica Rodgers, Franck Martial & Robert Lucas
Abstract Background Animal opsins are light-sensitive G-protein-coupled receptors (GPCRs) that enable optogenetic control over the major heterotrimeric G-protein signaling pathways in animal cells. As such, opsins have potential applications in both biomedical research and therapy. Selecting the opsin with the best balance of activity and selectivity for a given application requires knowing their ability to couple to a full range of relevant GÎą subunits. We present the GsX assay, a set of tools based on...

Effect of exercise versus cognitive behavioural therapy or no intervention on anxiety, depression, fitness and quality of life in adults with previous methamphetamine dependency: a systematic review

, Jessica Stander, , Stephanie Eksteen, , & Annemarie Wessels
Abstract Background Methamphetamine (MA) is a highly addictive psychostimulant used by approximately 52 million people worldwide. Chronic MA abuse leads to detrimental physiological and neurological changes, as well as increases in anxiety and depression, and decreases in overall fitness and quality of life. Exercise has been reported to possibly reverse physiological and neurological damage caused by previous MA use, and to reduce anxiety and depression in this population. The aim of this systematic review was...

MOESM1 of Effect of exercise versus cognitive behavioural therapy or no intervention on anxiety, depression, fitness and quality of life in adults with previous methamphetamine dependency: a systematic review

, Jessica Stander, , Stephanie Eksteen, , & Annemarie Wessels
Additional file 1. Search strategy. Detailed search strategies, specifically developed for each database according its functions.

MOESM6 of Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response

Kenta Iijima, Junya Kobayashi &
Additional file 6: Figure S5. Forced accumulation of Vpr induced DDR in the vicinity of chromatin. aâ e Forced accumulation of Vpr induces phosphorylation of H2AX at Ser139 (a), ATM at Ser1981 (b), RPA32 at Ser33 (c), Rad17 at Ser645 (d), and accumulation of mono- and poly-ubiquitin conjugates (e), on surrounding region.

MOESM3 of Effect of exercise versus cognitive behavioural therapy or no intervention on anxiety, depression, fitness and quality of life in adults with previous methamphetamine dependency: a systematic review

, Jessica Stander, , Stephanie Eksteen, , & Annemarie Wessels
Additional file 3. The PEDro scale. The PEDro scale, including notes on administration (used for methodological appraisal of included studies).

Additional file 8: Figure S6. of A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling

Edward Ballister, Jessica Rodgers, Franck Martial & Robert Lucas
Opsin sensitivity. Selectivity comparison without normalization to rod opsin. a Log10(EC50) values from best-fitting sigmoid curves in Fig. 3d are plotted (see also Additional file 10). EC50 values were compared within each GsX by ANOVA. α = 0.0033 (reflecting Bonferroni correction, 15 comparisons). Asterisks (*) indicate significant differences. b Response amplitudes as shown in Fig. 3d were analyzed by ANOVA, comparing the responses of each Gsi, Gso, and Gst within each opsin, without prior normalization...

MOESM4 of Effect of exercise versus cognitive behavioural therapy or no intervention on anxiety, depression, fitness and quality of life in adults with previous methamphetamine dependency: a systematic review

, Jessica Stander, , Stephanie Eksteen, , & Annemarie Wessels
Additional file 4. Adapted Joanna Briggs Institute Data Extraction Form. Data extraction form, adapted from the standardized Joanna Briggs Institute data extraction form for the purposes of this review.

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