Understanding users’ points of view is rapidly becoming an urgent issue for companies and designers, as well as User Experience and Experience Design proving to be of wide interest for academic research. This paper presents an experimental-based methodology aimed at guiding designers during product optimisation. It is meant to support designers in choosing the right strategy to assess the users’ emotional reaction towards a product at an early stage of product development. The methodology consists...

Understanding users’ points of view is rapidly becoming an urgent issue for companies and designers, as well as User Experience and Experience Design proving to be of wide interest for academic research. This paper presents an experimental-based methodology aimed at guiding designers during product optimisation. It is meant to support designers in choosing the right strategy to assess the users’ emotional reaction towards a product at an early stage of product development. The methodology consists...

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Pathology archives with linked clinical data are an invaluable resource for translational research, with the limitation that most cancer samples are formalin-fixed paraffin-embedded (FFPE) tissues. Therefore, FFPE tissues are an important resource for genomic profiling studies but are under-utilised due to the low amount and quality of extracted nucleic acids. We profiled the copy number landscape of 356 breast cancer patients using DNA extracted FFPE tissues by shallow whole genome sequencing. We generated a total...

Seminal human brain histology work has demonstrated developmental waves of myelination. Here, using a micro-structural magnetic resonance imaging (MRI) marker linked to myelin, we studied fine-grained age differences to deduce waves of growth, stability, and decline of cortical myelination over the life-cycle. In 484 participants, aged 8-85 years, we fitted smooth growth curves to T1- to T2-weighted ratio in each of 360 regions from one of 7 cytoarchitectonic classes. From the first derivatives of these...

Tumor heterogeneity leads to the development of multiple resistance mechanism during targeted therapies. Identifying the dominant driver(s) is critical for treatment decision. We studied the relative dynamics of multiple oncogenic drivers in longitudinal plasma of 50 EGFR-mutant non-small cell lung cancer patients receiving gefitinib and hydroxychloroquine. We performed digital PCR and targeted sequencing in all patients and shallow whole genome sequencing from three patients who underwent histological transformation to small-cell lung cancer. In 43 patients...

The inter- and intra-tumor heterogeneity of breast cancer needs to be adequately captured in pre-clinical models. We have created a large collection of breast cancer patient-derived tumor xenografts (PDTXs), in which the morphological and molecular characteristics of the originating tumor are preserved through passaging in the mouse. An integrated platform combining in vivo maintenance of these PDTXs along with short-term cultures of PDTX-derived tumor cells (PDTCs) was optimized. Remarkably, the intra-tumor genomic clonal architecture present...

This file contains summarized drought, leaf area, vegetative anthocyanin and resin data, with individual replicates averaged by family. See M&M section 2.5.

This data file contains population level information about climatological variables collected from WORLDCLIM. See M&M section 2.5.

This file contains the drought sensitivity metric calculated from raw drought scores as described in M&M section 2.3 (both untransformed and transformed). It also contains leaf area measurements for each individual (untransformed and transformed).

This data file contains myb2 genotypes, and visible stem and leaf anthocyanins for a population of f2's from a cross between red and yellow parents.

This data file contains a square matrix of Fst values between each population in the ecophys experiments. See M&M section 2.5. These data were originally estimated and presented in Stankowski et al 2015 (Evolution 69:3054-3068).