14,330,501 Works

Experiences and Senses: An Experimental Based Methodology for the Design Optimization

Elia Gatti, Monica Bordegoni & Serena Camere
Understanding users’ points of view is rapidly becoming an urgent issue for companies and designers, as well as User Experience and Experience Design proving to be of wide interest for academic research. This paper presents an experimental-based methodology aimed at guiding designers during product optimisation. It is meant to support designers in choosing the right strategy to assess the users’ emotional reaction towards a product at an early stage of product development. The methodology consists...

Experiences and Senses: An Experimental Based Methodology for the Design Optimization

Elia Gatti, Monica Bordegoni & Serena Camere
Understanding users’ points of view is rapidly becoming an urgent issue for companies and designers, as well as User Experience and Experience Design proving to be of wide interest for academic research. This paper presents an experimental-based methodology aimed at guiding designers during product optimisation. It is meant to support designers in choosing the right strategy to assess the users’ emotional reaction towards a product at an early stage of product development. The methodology consists...

Dryad Item 10.5061/DRYAD.26HB35Q/1

(:Tba)
(:tba)

Dryad Item 10.5061/DRYAD.26HB35Q

(:Tba)

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.

Jonathan Gilley, Kunie Ando, Anjan Seereeram, Teresa Rodríguez-Martín, Amy M Pooler, Laura Sturdee, Brian H Anderton, Jean-Pierre Brion, Diane P Hanger & Michael Coleman

Shallow whole genome sequencing for robust copy number profiling of formalin-fixed paraffin-embedded breast cancers.

Suet Chin, Angela Santonja, Marta Grzelak, Soomin Ahn, Stephen Sammut, Harry Clifford, Oscar Rueda, Michelle Pugh, Mae Goldgraben, Helen A Bardwell, Eun Yoon Cho, Elena Provenzano, Federico Rojo, Emilio Alba & Carlos Caldas
Pathology archives with linked clinical data are an invaluable resource for translational research, with the limitation that most cancer samples are formalin-fixed paraffin-embedded (FFPE) tissues. Therefore, FFPE tissues are an important resource for genomic profiling studies but are under-utilised due to the low amount and quality of extracted nucleic acids. We profiled the copy number landscape of 356 breast cancer patients using DNA extracted FFPE tissues by shallow whole genome sequencing. We generated a total...

Absence of SARM1 rescues development and survival of NMNAT2-deficient axons.

Jonathan Gilley, Giuseppe Orsomando, Isabel Nascimento-Ferreira & Michael Coleman

Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution.

Tobias Messmer, Ferdinand Von Meyenn, Aurora Savino, Fátima Santos, Hisham Mohammed, Aaron Lun, John Marioni & Wolf Reik

Waves of Maturation and Senescence in Micro-structural MRI Markers of Human Cortical Myelination over the Lifespan.

Håkon Grydeland, Petra Vértes, František Váša, Rafael Romero-Garcia, Kirstie Whitaker, Aaron F Alexander-Bloch, Atle Bjørnerud, Ameera X Patel, Donatas Sederevicius, Christian K Tamnes, Lars T Westlye, Simon White, Kristine B Walhovd, Anders M Fjell & Edward Bullmore
Seminal human brain histology work has demonstrated developmental waves of myelination. Here, using a micro-structural magnetic resonance imaging (MRI) marker linked to myelin, we studied fine-grained age differences to deduce waves of growth, stability, and decline of cortical myelination over the life-cycle. In 484 participants, aged 8-85 years, we fitted smooth growth curves to T1- to T2-weighted ratio in each of 360 regions from one of 7 cytoarchitectonic classes. From the first derivatives of these...

Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer.

Dana Wai Yi Tsui, Muhammed Murtaza, Alvin Seng Cheong Wong, Oscar Rueda, Christopher Smith, Sandunie Chandrananda, Ross A Soo, Hong Liang Lim, Boon Cher Goh, Carlos Caldas, Tim Forshew, Davina Gale, Wei Liu, James Morris, Francesco Marass, Timothy Eisen, Tan Min Chin & Nitzan Rosenfeld
Tumor heterogeneity leads to the development of multiple resistance mechanism during targeted therapies. Identifying the dominant driver(s) is critical for treatment decision. We studied the relative dynamics of multiple oncogenic drivers in longitudinal plasma of 50 EGFR-mutant non-small cell lung cancer patients receiving gefitinib and hydroxychloroquine. We performed digital PCR and targeted sequencing in all patients and shallow whole genome sequencing from three patients who underwent histological transformation to small-cell lung cancer. In 43 patients...

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

Alejandra Bruna, Oscar Rueda, Wendy Greenwood, Ankita Sati Batra, Maurizio Callari, Rajbir Nath Batra, Katherine Pogrebniak, Jose Sandoval, John W Cassidy, Ana Tufegdzic-Vidakovic, Stephen Sammut, Linda Jones, Elena Provenzano, Richard Baird, Peter Eirew, James Hadfield, Matthew Eldridge, Anne McLaren-Douglas, Andrew Barthorpe, Howard Lightfoot, Mark J O’Connor, Joe Gray, Javier Cortes, Jose Baselga, Elisabetta Marangoni … & Carlos Caldas
The inter- and intra-tumor heterogeneity of breast cancer needs to be adequately captured in pre-clinical models. We have created a large collection of breast cancer patient-derived tumor xenografts (PDTXs), in which the morphological and molecular characteristics of the originating tumor are preserved through passaging in the mouse. An integrated platform combining in vivo maintenance of these PDTXs along with short-term cultures of PDTX-derived tumor cells (PDTCs) was optimized. Remarkably, the intra-tumor genomic clonal architecture present...

Pancreatic allograft thrombosis: Suggestion for a CT grading system and management algorithm.

A Hakeem, J Chen, S Iype, Menna Clatworthy, Christopher Watson, EM Godfrey, S Upponi & Kourosh Saeb-Parsy

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

Hans Kristian Moen Vollan, Oscar Rueda, Suet Chin, Christina Curtis, Gulisa Turashvili, Sohrab Shah, Ole Christian Lingjærde, Yinyin Yuan, Charlotte K Ng, Mark Dunning, Ed Dicks, Elena Provenzano, Stephen Sammut, Steven McKinney, Ian O Ellis, Sarah Pinder, Arnie Purushotham, Leigh C Murphy, Vessela N Kristensen, METABRIC Group, James Brenton, Paul Pharoah, Anne-Lise Børresen-Dale, Samuel Aparicio & Carlos Caldas

Inferring Paleoenvironment from Anura Fossils

Lucas Almeida Barcelos, Fellipe, Annie Hisiou², Douglas S Riff¹ & Vanessa Kruth Verdade

The light skin allele of SLC24A5 in South Asians and Europeans shares identity by descent.

Chandana Basu Mallick, Florin Mircea Iliescu, Märt Möls, Sarah Hill, Rakesh Tamang, Gyaneshwer Chaubey, Rie Goto, Simon YW Ho, Irene Gallego Romero, Federica Crivellaro, Georgi Hudjashov, Niraj Rai, Mait Metspalu, Christopher Mascie-Taylor, Ramasamy Pitchappan, Lalji Singh, Marta Mirazon-Lahr, Kumarasamy Thangaraj, Richard Villems & Toomas Kivisild

Safety and Usability Guidelines of Clinical Information Systems Integrating Clinical Workflow: A Systematic Review.

Yura Lee, Min-Young Jung, Gee Won Shin, Sabine Bahn, Taezoon Park, Insook Cho & Jae-Ho Lee

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.

Teresa Rodríguez-Martín, Amy M Pooler, Dawn HW Lau, Gábor M Mórotz, Kurt J De Vos, Jonathan Gilley, Michael Coleman & Diane P Hanger

ecophys_traits_by_family

James M. Sobel, Sean Stankowski & Matthew A. Streisfeld
This file contains summarized drought, leaf area, vegetative anthocyanin and resin data, with individual replicates averaged by family. See M&M section 2.5.

population_climate

James M. Sobel, Sean Stankowski & Matthew A. Streisfeld
This data file contains population level information about climatological variables collected from WORLDCLIM. See M&M section 2.5.

droughtdata_main

James M. Sobel, Sean Stankowski & Matthew A. Streisfeld
This file contains the drought sensitivity metric calculated from raw drought scores as described in M&M section 2.3 (both untransformed and transformed). It also contains leaf area measurements for each individual (untransformed and transformed).

myb2_antho_cosegregation

James M. Sobel, Sean Stankowski & Matthew A. Streisfeld
This data file contains myb2 genotypes, and visible stem and leaf anthocyanins for a population of f2's from a cross between red and yellow parents.

pairwise_fst

James M. Sobel, Sean Stankowski & Matthew A. Streisfeld
This data file contains a square matrix of Fst values between each population in the ecophys experiments. See M&M section 2.5. These data were originally estimated and presented in Stankowski et al 2015 (Evolution 69:3054-3068).

Registration Year

  • 2004
    21
  • 2005
    99,092
  • 2006
    70,301
  • 2007
    33,870
  • 2008
    24,013
  • 2009
    76,385
  • 2010
    331,477
  • 2011
    152,956
  • 2012
    458,555
  • 2013
    470,942
  • 2014
    1,416,246
  • 2015
    1,834,814
  • 2016
    2,331,255
  • 2017
    3,021,690
  • 2018
    3,576,036
  • 2019
    426,680

Resource Types

  • Dataset
    5,553,309
  • Text
    3,723,534
  • Image
    1,142,304
  • PhysicalObject
    877,867
  • Collection
    613,031
  • Other
    466,784
  • Software
    85,586
  • Workflow
    83,288
  • Audiovisual
    66,003
  • InteractiveResource
    55,219
  • Event
    8,566
  • Sound
    5,660
  • Model
    3,223
  • Film
    1,605
  • DataPaper
    597

Data Centers

  • figshare Academic Research System
    1,123,239
  • International Treaty on Plant Genetic Resources for Food and Agriculture
    830,073
  • The Cambridge Crystallographic Data Centre
    773,336
  • E-Periodica
    758,559
  • Plutof. Data Management and Publishing Platform
    686,078
  • ResearchGate
    656,101
  • Zenodo
    622,478
  • Global Biodiversity Information Facility
    567,752
  • University of Southern California Digital Library
    446,260
  • E-Pics Bildarchiv
    436,054
  • PANGAEA
    374,520
  • Deutsches Institut für Erwachsenenbildung
    373,193
  • Columbia University Libraries
    372,181
  • Data Planet
    313,921
  • Harvard IQSS Dataverse
    312,297