15,634,558 Works

Recursive subspace identification in a Hilbert Space framework

Andreas Bathelt
Since the introduction of model-based methods for control or monitoring of industrial plants, e.g., chemical processes or rolling mills, more and more emphasis is placed on modeling of these processes. In this context, the experimental modeling, i.e., system identification, provides and easier way to achieve this goal than theoretical modeling, i.e., modeling based on first principles. Although the plants are essentially of non-linear nature, they are often operated over long periods of time in one...

Exploring predictors of teachers’ intentions towards the inclusion of students with disabilities in regular primary schools in Bangladesh

Masud Ahmmed
Over the last three decades, there has been a policy shift towards Inclusive Education (IE) across the world. This has led to reform initiatives aimed at access and equity for all students within regular classrooms, irrespective of children’s individual differences on the basis of abilities, disabilities or any conditions due to their socio-economic or cultural background. Like many developing countries, Bangladesh has commenced IE reform to educate all school-aged children in its regular education system,...

Decision support system considering risks in combined transport: with a case study of risk management in railway transport

Jia Hu
Combined transport (CT) is characterised by highly environment-friendly traffic modes and minimal congestion. However, in the context of the reality of logistics, operators are not in favour of CT because of its high complexity. Therefore, finding a well-structured solution to quickly solve problems in CT is difficult, especially in the operational level. In other words, less-structured problems, whose solutions are not available in a short time, are common for CT participants. Many reasons contribute to...

Rewriting the past, pluralizing the present: renegotiating Canadianness in the works of Dionne Brand, George Elliott Clarke and Lawrence Hill

Gregor Benedikt Pudzich
This dissertation, titled Rewriting the past: pluralizing the present: renegotiating Canadianness in the works of Dionne Brand, George Elliott Clarke and Lawrence Hill, written by Gregor Pudzich, analyses the critical engagement with Canada’s colonial history, especially with the history of the African-Canadian minority, in the literary works of the three authors named in the title. In the context of current literary and cultural theories on different forms of memory, the literary works of Brand, Clarke...

Determinants of continuous intention of contributors to open-source software projects: definition and empirical testing of the open-source software work characteristics theory

Désirée Sottek
Open-source software (OSS) nowadays holds a very large share of the software market. Furthermore, a great number of companies save millions of Dollars by using open-source instead of proprietary software. Additionally, many governmental and educational institutions, alongside millions of private users, profit financially by using open source software, e.g. the operative system Linux, instead of a proprietary software, such as Microsoft's Windows or Apple's OS X. With this increasing economic power of OSS the number...

Causes of corruption in the MENA region: a cross-national comparative study

Dina Talaat Badr Elsayed
With the growing political and scientific attention given to the MENA region in the aftermath of the Arab Uprisings, this study analyzed a key dimension in the context of such political upheavals. Corruption has presented a main drive for the Arab Spring, where there is general consensus that grand and petty corruption are widespread among the countries of the region. In this concern, this research intends to fill the gap regarding corruption studies in the...

Millimeter wave direction of arrival estimation and UE beamforming in a 3D environment

Andre Janßen
The demand for higher mobile data rates and data volumes has been increased during the recent years. Decreasing prices made many from the wired internet known applications also available on mobile devices. In 2000 the price for 1 Mega Byte (MB) data was more than one euro, in 2018 the price has changed to a fraction of a cent. This makes it possible to transmit higher data volumes mobile, for example movies in High Definition...

Synthesis and in-depth characterization of mono- and bimetallic nanoparticles

Kevin Pappert
Topic: Synthesis and in-depth characterization of mono- and bimetallic nanoparticles. Due to their high surface to volume ratio and differing properties to the bulk material, nanoparticles play a major role in modern science. Especially silver nanomaterials and the antibacterial and antifungal silver ions are particular interesting in medical applications to replace, for example, antibiotics. In the scope of this work, different monometallic and bimetallic nanoparticles based on silver were synthesized and characterized. In subsequently dissolution...

Tools to consider larger scales and the recolonisation potential in river restoration planning

Veronica Claudia Dahm
Due to long-lasting ecological deterioration and fragmentation of freshwater systems the success of local river restoration measures that target the improvement of the ecological status as defined by the European Water Framework Directive is limited. To better account for the fragmentation of river networks, river restoration planning needs to target larger scales but tools to support large-scale strategies are widely missing. This dissertation aims to stimulate the consideration of larger scales in river restora¬tion planning...

Hierarchical assembly of DNA origami structures: theoretical aspects and biological applications

Wolfgang Pfeifer
Nature uses hierarchical self-assembly to realize fascinating structures with complex architectures from rather simple building blocks. Utilizing this approach, emergent properties arise which are surpassing the sum of properties from the individual components and are inherently coupled to the building blocks and the forces linking them together. Since the advent of structural DNA nanotechnology, scientists strive to realize artificial structures with ever growing complexity and functionality. DNA origami is a method of choice for the...

Effect of hypoxia-inducible factor 1α (HIF-1α) deficiency in tumor cells and murine tumor stroma on radiation sensitivity and growth of tumors

Alexandra Wolf
Poor prognosis of many solid tumors is often associated with hypoxic regions and an increased level of hypoxia-inducible factor-1α (HIF-1α). Previous findings indicate that HIF-1α expression is relevant for radiation resistance. Furthermore, there are evidences that the tumor microenvironment is also involved in protecting tumor cells from irradiation (IR). To clarify the role of HIF-1α deficiency in apoptosis, DNA damage repair and radiosensitization in vitro, murine Lewis Lung Carcinoma (LLC) cells with a doxycycline-inducible knockdown...

Enhancement of energy efficiency in stirred tank reactors by use of computational fluid dynamics

Alexander Stefan
The research subject of this work is the fluid and heat flow in a stirred tank reactor with immersing internals like heating elements and baffles. On the basis of an industrial esterification process, the investigation is focused on the efficiency improvement of the reactors unit operations and the interaction between stirrer and static elements. Since flow field measurements are not possible on the industrial precedent, the investigation is approached by computational fluid dynamics (CFD) simulation....

Das therapeutische Potenzial von Fingolimod in der Sauerstoff-induzierten Hirnschädigung des unreifen Gehirns

Meray Serdar
In industralisierten Ländern werden 5.5-11.4% der Kinder zu früh geboren (Geburten zwischen der 23-37 Schwangerschaftswoche). Trotz der großen Vorteile in der Geburtshilfe und der Neonatalversorgung, zeigen Frühgeborene ein erhöhtes Risiko langfristig neurologische Defizite zu entwickeln. Das unreife Gehirn ist sehr vulnerabel gegenüber verschiedenen Noxen wie der Hypoxie oder Hyperoxie. In Experimentellen Studien wurde bereits gezeigt, dass eine neonatale Hyperoxie eine Schädigung der weißen Substanz verursacht, die mit einer Degeneration der Oligodendrozyten und Hypomyelinisierung assoziiert ist....

Ein methodischer Ansatz zur nutzerspezifischen Bewertung von (teil-)elektrischen Fahrzeugkonzepten

Martin Koppers
Zahlreiche Randbedingungen, darunter nicht zuletzt klimatische Aspekte und gesellschaftliche Diskussionen, führen bei aktuellen und künftigen Kraftfahrzeugen zu einer weiteren Steigerung der Anforderungen hinsichtlich Energieeffizienz, Treibhausgasemission und Wirtschaftlichkeit. Insbesondere die Verdichtung des Verkehrs in Ballungszentren sowie die hohe Treibhausgas- und Schadstoffemission des Verkehrssektors sind neben der zu erwartenden Verteuerung des erdölbasierten Kraftstoffs maßgebliche Treiber dieser Forderungen. Durch die Serienreife der Lithium-Ionen-Batterietechnik wurden in den vergangenen Jahren insbesondere batterieelektrische Fahrzeuge und Hybridfahrzeuge als Alternative zu konventionell angetriebenen...

Dynamic performance of electrical power systems with high penetration of power electronic converters: analysis and new control methods for mitigation of instability threats and restoration

Abdul Wahab Korai
The increasing penetration of the power electronic converter-based generation units in the electrical power system have given rise to many challenges to power system operation. Three of the most important challenges are the voltage control, frequency control and the grid restoration by the power electronic converter-based generation units in absence of conventional generation units. Moreover, the controllers of power electronic converter-based generation units can interact with the power system elements i.e. natural resonances and can...

The role of terminal protein in adenovirus nuclear delivery

Vidyaporn Chailertvanitkul
The future of gene therapy is dependent on the development of vectors that can selectively and efficiently deliver therapeutic DNA to target cells in vivo with minimal toxicity. Virus vectors are the most widely used transducing systems. However, there are many ethical and safety concerns associated with the use of viruses in humans. Non-viral vectors are more suitable because of the lack of a specific immune response; but these are currently inefficient due to the...

Advanced analysis of polyphenols and phytosterols from grapes and grape byproducts

Siti Nur Nazathul Shima Hashim
In the food and nutraceutical industries, increasing emphasis is being placed on value-added products. This high worldwide demand for health-beneficial natural compounds can be met by intensifying the focus on using phytochemicals for enriching food. Epidemiological studies have shown that phytochemicals, including polyphenols and phytosterols, derived from vegetables and fruits are substantial sources of bioactive compounds that are beneficial to human health. The polyphenols phytoalexin (E)-resveratrol has attracted considerable interest because of its remarkable pharmacological...

A limnological assessment of the diverse waterscape in the Cordillera Vilcanota, Peruvian Andes

Neal Michelutti, Pedro M. Tapia, Andrew L. Labaj, Christopher Grooms, Xiaowa Wang & John P. Smol
The Cordillera Vilcanota in the Cusco region of Peru is experiencing dramatic environmental changes due to recent warming. An understudied component of this mountain range is the diverse waterscape, which serves as a vital water source to cities and communities downstream and is critical to supporting the region’s rich biodiversity. A survey of 19 sites comprising lakes, ponds, proglacial systems, and a glacial meltwater stream produced 3 main findings. First, the study sites recorded large...

A limnological assessment of the diverse waterscape in the Cordillera Vilcanota, Peruvian Andes

Neal Michelutti, Pedro M. Tapia, Andrew L. Labaj, Christopher Grooms, Xiaowa Wang & John P. Smol
The Cordillera Vilcanota in the Cusco region of Peru is experiencing dramatic environmental changes due to recent warming. An understudied component of this mountain range is the diverse waterscape, which serves as a vital water source to cities and communities downstream and is critical to supporting the region’s rich biodiversity. A survey of 19 sites comprising lakes, ponds, proglacial systems, and a glacial meltwater stream produced 3 main findings. First, the study sites recorded large...

PENGEMBANGAN MODEL PERMAINAN SIRKUIT KARDIO UNTUK MENINGKATKAN KEBUGARAN JASMANI PADA ANAK USIA 6-9 TAHUN

Andi Nur Cahyo
Penelitian pengembangan ini bertujuan untuk mengembangkan model permainan untuk meningkatkan kebugaran jasmani pada anak usia 6-9 tahun dan mengetahui efektivitas model permainan tersebut dalam meningkatkan kebugaran jasmani. Penelitian ini dilakukan dengan cara mendesain produk model permainan, melakukan uji coba kelompok kecil, uji validasi dan uji coba lapangan. Uji coba lapangan dilaksanakan pada anak usia 6-9 tahun sebanyak 87 anak yang tersebar di SD N 02, SD N 03 dan SD N 04 Kuningan Semarang Utara,...

PENGEMBANGAN MODEL PERMAINAN SIRKUIT KARDIO UNTUK MENINGKATKAN KEBUGARAN JASMANI PADA ANAK USIA 6-9 TAHUN

Andi Nur Cahyo
Penelitian pengembangan ini bertujuan untuk mengembangkan model permainan untuk meningkatkan kebugaran jasmani pada anak usia 6-9 tahun dan mengetahui efektivitas model permainan tersebut dalam meningkatkan kebugaran jasmani. Penelitian ini dilakukan dengan cara mendesain produk model permainan, melakukan uji coba kelompok kecil, uji validasi dan uji coba lapangan. Uji coba lapangan dilaksanakan pada anak usia 6-9 tahun sebanyak 87 anak yang tersebar di SD N 02, SD N 03 dan SD N 04 Kuningan Semarang Utara,...

Parathyroid hormone-related protein activates HSCs via hedgehog signalling during liver fibrosis development

Shuying He, Jing Tang, Na Diao, Yan Liao, Jie Shi, Xiaoping Xu, Fang Xie & Lan Bai
Recently, we showed that parathyroid hormone-like hormone (PTHLH), a cytokine-like polyprotein, is critical for extracellular matrix (ECM) deposition through the activation of hepatic stellate cells (HSCs). Here, we show that N-terminal PTHLH is secreted into the supernatant of injured hepatocytes, its expression is positively correlated with liver fibrosis severity based on mice liver biopsies, and it is primarily expressed in the cytoplasm of hepatocytes along the fibrous septa of fibrotic livers. PTHLH overexpression in mice...

Parathyroid hormone-related protein activates HSCs via hedgehog signalling during liver fibrosis development

Shuying He, Jing Tang, Na Diao, Yan Liao, Jie Shi, Xiaoping Xu, Fang Xie & Lan Bai
Recently, we showed that parathyroid hormone-like hormone (PTHLH), a cytokine-like polyprotein, is critical for extracellular matrix (ECM) deposition through the activation of hepatic stellate cells (HSCs). Here, we show that N-terminal PTHLH is secreted into the supernatant of injured hepatocytes, its expression is positively correlated with liver fibrosis severity based on mice liver biopsies, and it is primarily expressed in the cytoplasm of hepatocytes along the fibrous septa of fibrotic livers. PTHLH overexpression in mice...

Bioinspired thymine functionalized polymeric systems: from synthesis to nano applications

Gagan Deep Kaur
Nature is an abundant source of elegant examples of synthesis of materials, and as in many other areas of science, polymer chemists have been drawing on bioinspiration to create sophisticated functional materials. Thymine, one of the nucleic bases in DNA, is well known for its ability to form relatively strong hydrogen bonds as well as its propensity to undergo reversible photo-dimerization upon UV exposure. The focus of this thesis is to develop a bioinspired thymine...

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