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In vitro immunotoxicological assessment of a potent microbicidal nanocomposite based on graphene oxide and silver nanoparticles

Luis Augusto Visani De Luna, Nahiara Esteves Zorgi, Ana Carolina Mazarin De Moraes, Douglas Soares Da Silva, Sílvio Roberto Consonni, Selma Giorgio & Oswaldo Luiz Alves
Graphene oxide (GO) and silver nanoparticles (AgNPs) can be formed into a hybrid nanomaterial, known as GOAg nanocomposite, which presents high antibacterial activity. The successful translation of this nanomaterial into medical use depends on critical information about its toxicological profile. In keeping with a Safe-by-design approach, we evaluated the immunotoxicity of GOAg using J774 and primary murine macrophages. The interaction between GOAg and macrophages was investigated with a scanning electron microscope (SEM). High-throughput technologies were...

In vitro immunotoxicological assessment of a potent microbicidal nanocomposite based on graphene oxide and silver nanoparticles

Luis Augusto Visani De Luna, Nahiara Esteves Zorgi, Ana Carolina Mazarin De Moraes, Douglas Soares Da Silva, Sílvio Roberto Consonni, Selma Giorgio & Oswaldo Luiz Alves
Graphene oxide (GO) and silver nanoparticles (AgNPs) can be formed into a hybrid nanomaterial, known as GOAg nanocomposite, which presents high antibacterial activity. The successful translation of this nanomaterial into medical use depends on critical information about its toxicological profile. In keeping with a Safe-by-design approach, we evaluated the immunotoxicity of GOAg using J774 and primary murine macrophages. The interaction between GOAg and macrophages was investigated with a scanning electron microscope (SEM). High-throughput technologies were...

Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model

Asif Manzoor Khan, Barbara Korzeniowska, Vladimir Gorshkov, Muhammad Tahir, Henrik Schrøder, Lilian Skytte, Kaare Lund Rasmussen, Surabhi Khandige, Jakob Møller-Jensen & Frank Kjeldsen
Silver nanoparticles (AgNPs) have been reported to penetrate the central nervous system (CNS) and induce neurotoxicity. However, there is a paucity of understanding of the toxicity of AgNPs and their effect on the blood-brain barrier (BBB) including the underlying molecular mechanism(s) of action. Such information is important for the formulation of new strategies for delivery of biological therapeutics to central nervous system (CNS) targets. Using an in vitro BBB model and mass spectrometry-based proteomics, we...

Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model

Asif Manzoor Khan, Barbara Korzeniowska, Vladimir Gorshkov, Muhammad Tahir, Henrik Schrøder, Lilian Skytte, Kaare Lund Rasmussen, Surabhi Khandige, Jakob Møller-Jensen & Frank Kjeldsen
Silver nanoparticles (AgNPs) have been reported to penetrate the central nervous system (CNS) and induce neurotoxicity. However, there is a paucity of understanding of the toxicity of AgNPs and their effect on the blood-brain barrier (BBB) including the underlying molecular mechanism(s) of action. Such information is important for the formulation of new strategies for delivery of biological therapeutics to central nervous system (CNS) targets. Using an in vitro BBB model and mass spectrometry-based proteomics, we...

Universal existence of fluorescent carbon dots in beer and assessment of their potential toxicity

Haitao Wang, Shan Liu, Yukun Song, Bei-Wei Zhu & Mingqian Tan
Nanosized materials may produce adverse physiological effects or potential health risks due to their unique physical and chemical properties. Herein, the universal presence of fluorescent carbon dots (CDs) in commercial beers was confirmed through a systematic survey. The beer CDs were roughly spherically shaped in appearance and emitted bright blue fluorescence under ultraviolet light with quantum yields (QYs) ranging from 1.42% to 3.92%. Furthermore, digestion, biodistribution, and cytotoxicity assessments of CDs from Snow beer were...

Universal existence of fluorescent carbon dots in beer and assessment of their potential toxicity

Haitao Wang, Shan Liu, Yukun Song, Bei-Wei Zhu & Mingqian Tan
Nanosized materials may produce adverse physiological effects or potential health risks due to their unique physical and chemical properties. Herein, the universal presence of fluorescent carbon dots (CDs) in commercial beers was confirmed through a systematic survey. The beer CDs were roughly spherically shaped in appearance and emitted bright blue fluorescence under ultraviolet light with quantum yields (QYs) ranging from 1.42% to 3.92%. Furthermore, digestion, biodistribution, and cytotoxicity assessments of CDs from Snow beer were...

Istori Manokwari: Interview IM50

P. Van Der Gaag
Project ISTORIMANOKWARI / Interviewtype IMM (maatschappelijke achtergrond); interviewer: PvdG*1998. Duur interview totaal (uren/min): 1 uur, 49 min. Dit interview bevat de reflectie van geïnterviewde op zijn werkzaamheden als KNIL-officier, vakbondsman en politicus en zijn (toenmalige) visie op de toekomst van het Nederlandse gebiedsdeel Nieuw Guinea. Geïnterviewde groeide met Indische ouders wisselend op in Salatiga en Amstelveen. Maar pas in het Jappenkamp ontdekte hij wat het begrip Indo inhield. Kernbegrip in zijn leven werd het credo:...

Istori Manokwari: Interview IM48

E. Markus
Project ISTORIMANOKWARI / Interviewer: EM*2017. Duur interview totaal (uren/min): 1 uur, 17 min. (deel 1) Interview in meerdere delen: 2 Dit interview bevat een levensbeschrijving van geïnterviewde. Geïnterviewde groeide op in een groot gezin. Aan het begin van de Japanse bezetting is hij getuige van het overlijden van vader (hoofdopzichter in de mijnbouw) aan een hartaanval. Moeder en de acht kinderen belanden in Japanse kampen en ondergaan ook tijdens de Bersiap grote angst en zware...

Istori Manokwari: Interview IM47

P. Van Der Gaag
Project ISTORIMANOKWARI / Interviewtype IMM (maatschappelijke achtergrond);IMA (anekdotische getuigenissen) ; interviewer: PvdG*1998. Duur interview totaal (uren/min): 1 uur, 33 min. Dit interview geeft vanuit Indisch perspectief een haarscherp beeld van de ontwikkeling van Manokwari in de vijftiger jaren. Geïnterviewde kwam(1949) als contractarbeider met honderden Indische migranten aan in een desolaat Manokwari, waar geen enkele opvang was geregeld. In de jaren daarna werkte hij mee in de huizen- en wegenbouwprojecten. Hij vertelt over een onevenwichtig (onrechtvaardig)...

Very singular solutions to a nonlinear parabolic equation with absorption. I - Existence

Said Benachour & Philippe Laurençot
We prove the existence of a very singular solution to ut - Δu + I∇uIp = 0 in (0,+∞) × ℝN, when 1 < p < (N+2)/(N+1).

Istori Manokwari: Interview IM46

E. Markus
Project ISTORIMANOKWARI / Interviewtype IMH (human interest); interviewer: EM*2003 Duur interview totaal (uren/min): 1 uur, 59 min. Dit interview bevat een levensbeschrijving van geïnterviewde. Geïnterviewde groeide op in de Staatsliedenbuurt. Na lagere school, ambachtsschool en werk als stratenmaker volgde dienstplicht en uitzending naar Nieuw Guinea. Waar hij met zijn mariniers-peloton ongebriefd aankwam in de Manokwari-kazerne. Willem vertelt over de militaire hiërarchie, patrouilles, krijgsgevangen infiltranten en tropenziekten. en de hierbij grote steun van “thuispost”. Hij beschrijft...

Personality in wild juvenile lemon sharks: Consistency, behavioral syndrome and ontogeny

Jean Sebastien Finger
In dieser Doktorarbeit behandle ich verschiedene Persönlichkeitsaspekte von jugendlichen Zitronenhaien (Negaprion brevirostris). Ich habe wiederholt Individuen in einem neuartigen Testfeld untersucht. Diese Experimente zeigten, dass jugendliche Zitronenhaie sich konstant verschieden verhalten. Außerdem konnte ich durch eine wiederkehrende Exposition in dem neuartigen Testfeld ein Gewöhnungsverhalten aufzeigen. Gewöhnung war ein Indikator, dass dieser Test es möglich macht, Reaktionen auf Veränderungen zu erforschen. Und endlich zeigte dieses Experiment dass Individuen verschiedene Gewöhnungsraten besitzen. Zweitens testete ich konsistente individuelle...

ETL-Prozesse für bibliothekarische Metadaten: Die Migration lokaler Katalogisate im GBV

Ursula Klute
Bei allen IT-gestützten Anwendungen spielt die Datenhaltung eine zentrale Rolle. Verfahren für eine Migration der gespeicherten Daten werden aus unterschiedlichen Gründen benötigt; dazu zählen technische Weiterentwicklungen der verwendeten Hard- oder Software, ein Wechsel des Anbieters der genutzten Anwendung sowie der Wunsch nach Zusammenführung und Vereinheitlichung von Daten aus unterschiedlichen Quellen, z.B. in einem Data Warehouse. Hierbei kommen ETL-Prozesse zur Anwendung, die die Schritte Datenextraktion, Datentransformation und das Laden der Daten in die Zielumgebung umfassen. Im...

Istori Manokwari: Interview IM45

E. Markus
Project ISTORIMANOKWARI / Interviewtype IMH (human interest); interviewer: EM*2009. Duur interview totaal (uren/min): 1 uur, 6 min. (deel 1) Interview in meerdere delen: 2 Dit interview bevat een levensbeschrijving van geïnterviewde. Geïnterviewde kwam na in 1942 terecht in het Jappenkamp. Tijdens de Bersiap werden vader en opa (verdacht van sabotage) vermoord. Uit veiligheidsoverwegingen vertrok moeder met kinderen (1949) met KPM-“Waibalong” naar Manokwari, waarna zij als snel naar het internaat in Sorong ging. Weer in Manokwari...

Effects of gleno-humeral joint centre mislocation on gleno-humeral kinematics and kinetics

Mathieu Lempereur, Sylvain Brochard, Julien Leboucher, Fabien Leboeuf, Olivier Rémy-Néris & Bhushan Borotikar
The gleno-humeral (GH) rotation centre is typically estimated using predictive or functional methods, however these methods may lead to location errors. This study aimed at determining a location error threshold above which statistically significant changes in the values of kinematic and kinetic GH parameters occur. The secondary aims were to quantify the effects of the direction of mislocation (X, Y or Z axis) of the GH rotation centre on GH kinematic and kinetic parameters. Shoulder...

Effects of gleno-humeral joint centre mislocation on gleno-humeral kinematics and kinetics

Mathieu Lempereur, Sylvain Brochard, Julien Leboucher, Fabien Leboeuf, Olivier Rémy-Néris & Bhushan Borotikar
The gleno-humeral (GH) rotation centre is typically estimated using predictive or functional methods, however these methods may lead to location errors. This study aimed at determining a location error threshold above which statistically significant changes in the values of kinematic and kinetic GH parameters occur. The secondary aims were to quantify the effects of the direction of mislocation (X, Y or Z axis) of the GH rotation centre on GH kinematic and kinetic parameters. Shoulder...

Istori Manokwari: Interview IM44

P. Van Der Gaag
Project ISTORIMANOKWARI / Interviewtype IMM (maatschappelijke achtergrond); interviewer: PvdG*1998. Duur interview totaal (uren/min): 1 uur, 20 min. Dit interview bevat de reflectie van geïnterviewde op zijn werkzaamheden als missionaris binnen het bisdom Sorong/Manokwari, en visie op de multiculturele samenleving in de Indonesische Manokwari. Geïnterviewde vertelt over zijn werk sinds 1970 als missionaris in Manokwari. Binnen een eigen netwerk van het bisdom van rechtswinkels, steunpunten in de wijken (gezinsbudgettering, family planning, huwelijks-counseling), poliklinieken, scholen en een...

A Novel Ultrasonic Cavitation Peening Approach Assisted by Water Jet

Fushi Bai, Liang Wang, Kai-Alexander Saalbach & Jens Twiefel
Ultrasonic cavitation peening is an environmentally friendly technology to improve surface properties. In the traditional ultrasonic cavitation peening process, specimens have to be immersed in a liquid and temperature control is required, which limits the wide usage of this technology due to the geometry and complicated setup. In order to improve this process, water is slowly jetted (75 mL/min) into the gap between the sonotrode tip and specimen surface. The water jet makes the gap...

A comparison study on jacket substructures for offshore wind turbines based on optimization

Jan Häfele, Christian G. Gebhardt & Raimund Rolfes
The structural optimization problem of jacket substructures for offshore wind turbines is commonly regarded as a pure tube dimensioning problem, minimizing the entire mass of the structure. However, this approach goes along with the assumption that the given topology is fixed in any case. The present work contributes to the improvement of the state of the art by utilizing more detailed models for geometry, costs, and structural design code checks. They are assembled in an...

One-Hour Prediction of the Global Solar Irradiance from All-Sky Images Using Artificial Neural Networks

Cristian Crisosto, Martin Hofmann, Riyad Mubarak & Gumther Seckmeyer
We present a method to predict the global horizontal irradiance (GHI) one hour ahead in one-minute resolution using Artificial Neural Networks (ANNs). A feed-forward neural network with Levenberg–Marquardt Backpropagation (LM-BP) was used and was trained with four years of data from all-sky images and measured global irradiance as input. The pictures were recorded by a hemispheric sky imager at the Institute of Meteorology and Climatology (IMuK) of the Leibniz Universität Hannover, Hannover, Germany (52.23° N,...

Headscarf and job recruitment - lifting the veil of labour market discrimination

Attakrit Leckcivilize & Alexander Straub
This paper investigates effects of appearance and religious practice of job applicants on the hiring decision. We asked participants in our laboratory experiment to select fictitious candidates for an interview from a pool of CVs with comparable characteristics but different photos. Some photos were of the same Turkish women with and without a headscarf. We demonstrate the effects of appearance, ethnicity, and veiling simultaneously and propose underlying mechanisms. We find robust effects of appearance but...

Why is it so hard to gain enough Vitamin D by solar exposure in the European winter?

Gunther Seckmeyer, Christopher Mustert, Michael| McKenzie Schrempf, Ben Liley, Michael Kotkamp, Alkiviadis Bais, Didier Gillotay, Harry Slaper, Anna-Maria Siani, Andrew Smedley & Ann Webb
UV exposure, which is the main source for a sufficient level of vitamin D in the human body, is found to be up to a factor of 7 lower in Northern Germany (52° N) in the winter months compared to UV levels in thecentral region of New Zealand’s South Island (45° S). When corrected for the influence of solar zenith angle, the vitamin D-weighted exposure is still a factor of 2 higher in the southern...

Complete homotopy invariants for translation invariant symmetric quantum walks on a chain

C. Cedzich, T. Geib, C. Stahl, L. Velázquez, A.H. Werner & R.F. Werner
We provide a classification of translation invariant one-dimensional quantum walks with respect to continuous deformations preserving unitarity, locality, translation invariance, a gap condition, and some symmetry of the tenfold way. The classification largely matches the one recently obtained (arXiv:1611.04439) for a similar setting leaving out translation invariance. However, the translation invariant case has some finer distinctions, because some walks may be connected only by breaking translation invariance along the way, retaining only invariance by an...

Gesteuerte Regeneration periimplantärer Knochendefekte unter Anwendung verschiedener Kollagene, xenogener Wachstumsfaktoren und autologer PDLSCs

Maria Baudisch
Untere Prämolaren wurden von 15 Minischweinen extrahiert. Aus dem Desmodont wurden PDLSCs isoliert und kultiviert. 90 Tage später wurden 46 Implantate inseriert, zirkuläre Defekte geschaffen und mit verschiedenen Kollagenen, Stammzellen, Wachstumsfaktoren therapiert oder unbehandelt gelassen und mit einer Membran abgedeckt. Nach 120 Tagen Heilung wurde in allen Gruppen eine Knochenneubildung nachgewiesen. Im Vergleich zur Kontrollgruppe führte weder die Anwendung der Kollagene noch die Kombination mit Wachstumsfaktoren oder Stammzellen zu einer signifikanten Steigerung der Osseointegration.

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